picibanil and Neutropenia

The marrow granulocyte reserve (MGR) of patients with lung cancer have been estimated by measuring the maximum neutrophil increment after administration of hydrocortisone. The MGR was found to have decreased in four of 19 untreated patients, but the reason for this decrement was not clear. Further, there were no differences in the MGR between the cell types or cancer stages. The MGR in patients 70 years old or older tended to be decreased. After chemotherapy or radiation therapy, the MGR depressed significantly. However, on administration of OK 432, the MGR significantly increased in two patients who had received radiation therapy and whose MGR had been deficient initially.

Topics: Adult; Age Factors; Aged; Antineoplastic Agents; Bone Marrow; Female; Granulocytes; Humans; Hydrocortisone; Leukocyte Count; Lung Neoplasms; Male; Middle Aged; Neutropenia; Neutrophils; Picibanil; Radiation Injuries; Radiotherapy