picibanil and Neoplasm-Seeding

In order to improve the prognosis, intraoperative intraperitoneal administration of both mitomycin C and OK-432 was performed for the peritoneal dissemination of gastric cancer. Some 74 of 469 patients of gastric cancer, who underwent surgical treatment over the last 7 years in our department, had peritoneal dissemination and 24 of them were treated with the drugs described above. However, there was no significant difference between treated group and controlled untreated group. No severe side effects were noted except for moderate pyrexia. It is still too early to determine the effect of this treatment because of both the short duration of follow-up and the small number of analyzed cases. In the future, we are planning to apply this treatment to selected cases, for which a histological diagnosis will be made intraoperatively by use of irrigation cytology and/or stamp biopsy.

Topics: Adult; Aged; Biological Products; Female; Gastrectomy; Humans; Infusions, Parenteral; Intraoperative Care; Male; Middle Aged; Mitomycin; Mitomycins; Neoplasm Seeding; Peritoneal Neoplasms; Picibanil; Prognosis; Stomach Neoplasms; Survival Rate

Topics: Animals; Biological Products; Liver Neoplasms, Experimental; Mice; Neoplasm Invasiveness; Neoplasm Seeding; Neoplasm Transplantation; Peritoneum; Picibanil