picibanil and Dysgerminoma

T cells bearing IgG Fc receptors (Tr cells) were determined in 40 cases of brain tumor using the double rosette method, and compared with the changes of PHA reaction, immunoglobulin (IgG A M), performance status, and mass effect on CT in 20 pre-and post-operative and/or radio-clinico-immunotherapeutic patients. The proportion of control Tr cells was 8-19% in 20 healthy adults. Values of Tr cells over 20% were correlated with a poor grade of performance status, and large mass effects on CT. Post-therapeutic change in the value was well correlated with change in performance status, mass effects, and IgG. Our results suggest a correlation between the value of Tr cells and clinico-radiological findings. Immunological analysis of Tr cells serves as a parameter of tumor expansion or prognosis, and could be of significant importance clinically.

Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dysgerminoma; Humans; Immunoglobulin A; Immunoglobulin Fc Fragments; Immunoglobulin Fragments; Immunoglobulin M; Lymphocyte Activation; Nimustine; Nitrosourea Compounds; Phytohemagglutinins; Picibanil; Receptors, IgG; Receptors, Immunologic; T-Lymphocytes