pica and beta-Thalassemia

This study investigated the prevalence of iron-deficiency anaemia, glucose-6-phosphate dehydrogenase (G6PD) deficiency and β-thalassaemia trait among Arab migrating nomad children in southern Islamic Republic of Iran. Blood samples were analysed from 134 schoolchildren aged < 18 years (51 males, 83 females). Low serum ferritin (< 12 ng/dL) was present in 17.9% of children (21.7% in females and 11.8% in males). Low haemoglobin (Hb) correlated significantly with a low serum ferritin. Only 1 child had G6PD deficiency. A total of 9.7% of children had HbA2 ≥ 3.5 g/dL, indicating β-thalassaemia trait (10.8% in females and 7.8% in males). Mean serum iron, serum ferritin and total iron binding capacity were similar in males and females. Serum ferritin index was as accurate as Hb index in the diagnosis of iron-deficiency anaemia. A high prevalence of β-thalassaemia trait was the major potential risk factor in this population.. انتشار الثلاسيميَّة، وفقر الدم بعوز الحديد، وعوز نازعة هيدْرُجين الغلوكوز -6- فُسْفات بين أطفال البدو المهاجرين العرب، جنوب جمهورية إيران الإسلامية. مهدي باسالار، داوود مهرباني، عبد الرضا أفراسيابي، زهرة مهرآور، إيرما ريحاني، رقية حميدي، مهران كريمي. لقد تم في هذه الدراسة الاستقصاءُ عن انتشار فقر الدم بعوز الحديد، وعوز نازعة هيدْرُجين الغلوكوز –6– فُسْفات (G6PD)، وخَلَّة الثلاسيمية بيتا بين أطفال البدو المهاجرين العرب في جنوب جمهورية إيران الإسامية. حيث تم تحليل عينات دم من 134 طفاً من أطفال المدارس الذين تقل أعمارهم عن 18 عاماً (51 ذكور، 83 إناث). فوُجد انخفاض في فيرِّيتين المصل (<12 نانوغرام/دل) لدى 17.9% من الأطفال (21.7% لدى الإناث و 11.8% لدى الذكور). وكان انخفاض خضاب الدم (الهيموغلوبين) مرتبطاً – بشكل كبير – مع انخفاض فيرِّيتين المصل. وكان لدى طفل واحد فقط عوز في عوز نازعة هيدروجين الغلوكوز –6– فوسفات. وكان الخضاب 3.5 ≥ HbA2 غ/دل لدى 9.7% من مجموع الأطفال، مما يدل على وجود خلة الثلاسيمية بيتا (10.8% لدى الإناث و 7.8% لدى الذكور). وكان هناك تشابه بين الخضاب في متوسط حديد المصل وفيرِّيتن المصل والسعة الإجمالية الرابطة للحديد لدى الذكور والإناث. وكان لمؤشر فيرِّيتن المصل نفس دقة مؤشر الهيموغلوبين في تشخيص فقر الدم بعوز الحديد. وكان ارتفاع معدل انتشار خلة الثلاسيمية بيتا يمثّل عاملَ الخطر المحتمل الرئيي لدى هذه الفئة من السكان.. Prévalence de la thalassémie, de l'anémie ferriprive et du déficit en glucose-6-phosphate déshydrogénase chez des enfants nomades et migrants arabes (sud de la République islamique d'Iran).. La présente étude a évalué la prévalence de l'anémie ferriprive, du déficit en glucose-6-phosphate déshydrogénase et de la bêta-thalassémie mineure chez des enfants nomades et migrants arabes dans le sud de la République islamique d'Iran. Des échantillons de sang de 134 écoliers de moins de 18 ans ont été analysés (51 garçons, 83 filles). Des taux de ferritine sérique faibles (< 12 ng/dL) ont été observés chez 17,9 % des enfants (21,7 % chez les filles et 11,8 % chez les garçons). Un faible taux d'hémoglobine (Hb) était significativement corrélé à un faible taux de ferritine sérique. Seul un enfant était atteint de déficit en glucose-6-phosphate déshydrogénase. Au total, 9,7 % des enfants présentaient un taux d’HbA2 supérieur ou égal à 3,5 g/dL, signe d'une bêta-thalassémie mineure (10,8 % des filles et 7,8 % des garçons). Le taux moyen de fer sérique, de la ferritine sérique et la capacité de liaison du fer total étaient similaires chez les deux sexes. Le taux de ferritine sérique était aussi précis que le taux d’Hb pour le diagnostic de l'anémie ferriprive. La forte prévalence de la bêta-thalassémie mineure représentait le principal facteur de risque dans cette population.

Topics: Adolescent; Anemia, Iron-Deficiency; Anorexia; Arabs; beta-Thalassemia; Child; Cross-Sectional Studies; Female; Ferritins; Genetic Predisposition to Disease; Glucosephosphate Dehydrogenase Deficiency; Hemoglobin A2; Humans; Iran; Iron; Male; Pica; Prevalence; Risk Factors; Transients and Migrants; Water Supply

Children and adolescents with sickle cell disease demonstrate an increased incidence of pica. Pica involving polyurethane foam has been previously reported, but effective management of such cases remains unclear. We present the case of a 17-year-old African American adolescent girl with sickle β+ thalassemia who presented with a long history of foam rubber pica resulting in intestinal obstruction. Conservative management was unsuccessful, and the patient ultimately required operative intervention. We advocate for a low threshold for early operation in cases of foam rubber bezoar.

Topics: Abdominal Pain; Adolescent; beta-Thalassemia; Bezoars; Depression; Female; Heterozygote; Humans; Ileal Diseases; Ileum; Intestinal Perforation; Peritonitis; Pica; Polyurethanes; Radiography; Sickle Cell Trait; Zinc

In this study, we evaluated the prevalence of fibromyalgia (FM) in iron deficiency anemia (IDA) and thalassemia minor (TM) patients and associated factors. In addition, we investigated the prevalence of IDA in outpatients with fibromyalgia, and its effect on clinical findings. The study included 205 IDA, 40 TM patients and 100 healthy controls. FM was diagnosed according to 1990 ACR criteria. Whole blood count, biochemical tests, and serum iron parameters were determined. Pain, fatigue, and FM Impact Questionnaire (FIQ) functional item scores were assessed in FM subjects. In addition, the prevalence of IDA in FM patients diagnosed at the Rheumatology Outpatient Clinic was determined. The prevalences of FM in IDA (17.6%) and TM (20%) groups were higher than in controls (6%; p values 0.006 and 0.025, respectively). When IDA patients with FM were compared to those without FM, it was seen that a higher percentage were females, married, and a higher percentage had history of pica (all p values < 0.05). Serum hemoglobin and iron parameters did not differ between IDA patients with and without FM. IDA was detected in 48 (24.5%) of 196 FM patients. FM patients without IDA had higher sleep disturbance scores (p = 0.012) and longer duration of FM (p = 0.045). FM was a common finding in patients with IDA and TM. FM was associated with female sex and history of pica in IDA patients, and not associated with serum hemoglobin and selected iron parameters. The presence of FM in TM had no association with any of the above-mentioned parameters.

Topics: Adult; Anemia, Iron-Deficiency; beta-Thalassemia; Female; Fibromyalgia; Hemoglobins; Humans; Male; Pica; Prevalence; Sex Factors