pica and Hypogonadism

Topics: Anemia, Iron-Deficiency; Animals; Dwarfism; Egypt; Hepatomegaly; Humans; Hypogonadism; Iran; Male; Pica; Splenomegaly; Syndrome; Zinc

Topics: Adolescent; Alanine Transaminase; Alkaline Phosphatase; Anemia, Hypochromic; Aspartate Aminotransferases; Bilirubin; Child; Child, Preschool; Cholesterol; Clinical Trials as Topic; Female; Glucose Tolerance Test; Hepatomegaly; Humans; Hypogonadism; Iron; Liver; Liver Function Tests; Magnesium; Male; Phosphorus; Pica; Soil; Splenomegaly; Trace Elements; Turkey; Vitamin A; Xylose

Topics: Adult; Anemia, Hypochromic; Dwarfism; History, 20th Century; Humans; Hypogonadism; Iran; Male; Pica

Oral iron and zinc tolerance tests were performed in 12 patients between 8 and 21 years of age, with iron deficiency anemia and geophagia. Decreased iron and zinc absorption were detected respectively in patients against the elevated absorption curves in control subjects. Iron and zinc malabsorption may be an additional feature of the syndrome characterized by geophagia, iron deficiency anemia, hepatosplenomegaly, hypogonadism and dwarfism observed in Turkey and Iran.

Topics: Adolescent; Adult; Anemia, Hypochromic; Child; Duodenum; Female; Hepatomegaly; Humans; Hypogonadism; Intestinal Absorption; Iron; Male; Pica; Radiography; Skull; Splenomegaly; Syndrome; Turkey; Zinc

The syndrome of dwarfism, hypogonadism, iron-deficiency anemia and geophagia, first reported in 1960 from Iran, was thought to be limited to males. In 1971-1972 two females with the same clinical features were observed over a 14-month period. The anemia responded rapidly to iron. Growth and sexual development occurred promptly when 120 mg of zinc sulfate was administered daily in conjunction with a well-balanced diet and iron supplement. This diet prior to the addition of zinc sulfate, resulted in gradual but much slower growth and sexual development. Observations in these two patients provide confirmation of the occurrence of human zinc deficiency in females, which responds to large doses of zinc salt.

Topics: Adult; Anemia, Hypochromic; Deficiency Diseases; Dwarfism; Female; Humans; Hypogonadism; Iran; Nutritional Physiological Phenomena; Pica; Sex Factors; Soil; Syndrome; Zinc

1) Geophagia characterized by, severe, anaemia, dwarfism, hypogonadism and hepatosplenomegaly is sometimes seen in young patients (and children) in Iran. 2) Haematological aspects of the syndrome are those of, severe, iron deficiency anaemia. 3) Gastric biopsies and histological findings revealed superficial or atrophic gastritis showing some resemblance to those seen in pernicious anaemia. 4) Haematological features, anaemia and many of the clinical signs of the syndrome were improved after appropriate iron therapy. 5) Histological changes of gastric mucosa improved, in 5 patients, 6 months after correction of the anaemia.

Topics: Adolescent; Adult; Anemia, Hypochromic; Biopsy; Dwarfism; Female; Gastric Mucosa; Gastritis; Hepatomegaly; Humans; Hypogonadism; Iron; Male; Pica; Soil; Time Factors

Topics: Adolescent; Alkaline Phosphatase; Anemia, Hypochromic; Child; Child, Preschool; Dwarfism; Hepatomegaly; Humans; Hypogonadism; Iron; Leukocytes; Pica; Splenomegaly

Topics: Adolescent; Age Factors; Anemia, Hypochromic; Blood Cell Count; Blood Platelets; Body Height; Body Weight; Child; Child, Preschool; Copper; Deficiency Diseases; Dwarfism; Feeding and Eating Disorders; Feeding Behavior; Female; Folic Acid; Hemoglobins; Hepatomegaly; Humans; Hypogonadism; Male; Pica; Sex Factors; Soil; Splenomegaly; Turkey; Zinc

Topics: Anemia, Hypochromic; Anemia, Iron-Deficiency; Dwarfism; Hepatomegaly; Humans; Hypogonadism; Liver Diseases; Medical Records; Pica; Splenomegaly

Topics: Anemia, Hypochromic; Anemia, Iron-Deficiency; Dwarfism; Feeding and Eating Disorders; Hepatomegaly; Humans; Hypogonadism; Liver Diseases; Pica; Splenomegaly