pica and Body-Weight

Topics: Body Weight; Deficiency Diseases; Diet, Diabetic; Diet, Reducing; Edema; Female; Fetus; Folic Acid Deficiency; Humans; Infant Mortality; Infant, Newborn; Nutritional Physiological Phenomena; Obesity; Physician-Patient Relations; Pica; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Pregnancy in Diabetics

Topics: Aggression; Animal Nutritional Physiological Phenomena; Animals; Behavior, Animal; Body Weight; Columbidae; Conditioning, Operant; Drinking Behavior; Drive; Eating; Escape Reaction; Feeding Behavior; Food Deprivation; Haplorhini; Humans; Locomotion; Macaca; Models, Theoretical; Motor Activity; Pica; Probability; Rats; Reinforcement Schedule; Time Factors

Topics: Adolescent; Adult; Aged; Body Height; Body Weight; Child; Child Nutritional Physiological Phenomena; Child, Preschool; Deficiency Diseases; Diet; Emaciation; Female; Growth Disorders; Humans; Infant; Infant Nutritional Physiological Phenomena; Infant, Newborn; Male; Middle Aged; Nutrition Surveys; Nutritional Requirements; Pica; Pregnancy; Puerto Rico; Socioeconomic Factors; United States; West Indies

Forty-six children, aged 24 to 47 months (25 controls and 21 subjects) chosen according to low and high blood lead levels respectively, were studied to ascertain the presence or absence of a relationship between dietary intake and the occurrence of plumbism (in children of low-income families). Through single-blind interviews by a nutritionist, dietary intakes were gathered, and the average daily intake of calories, protein, and iron was calculated. Hemoglobins, hematocrits, heights, weights, blood lead levels, and social demographic data had been gathered during the routine check for lead poisoning and at registration at the clinic. The mean caloric and protein intake as percent of recommended dietary allowances were equal and adequate for both controls and subjects. There was no statistically significant difference between the controls and subjects with respect to iron intake which was low in both groups. Mean hemoglobin and hematocrit levels were in the anemic range for both groups. The subjects were shorter and weighed less than the control group. Pica was more prevalent among children with plumbism. The findings of this study suggest that some factors other than dietary intake must account for the occurrence of lead poisoning in the subjects and that Blacks have a higher prevalence of plumbism in our area.

Topics: Body Height; Body Weight; Child Nutritional Physiological Phenomena; Child, Preschool; Clinical Trials as Topic; Connecticut; Demography; Diet; Dietary Proteins; Hematocrit; Hemoglobins; Humans; Iron; Lead; Lead Poisoning; Nutritional Requirements; Pica; Socioeconomic Factors

The effects of cyclophosphamide on 5-hydroxytryptamine (5-HT) synthesis in the intestinal tissue of rats were investigated. Rats received 120 mg/kg cyclophosphamide intraperitoneally as a single administration, and kaolin and food intake was measured by an automatic monitoring apparatus. Ileal tissues were collected at either 24 or 72 h after administration. Cyclophosphamide caused a significant increase in kaolin intake at the acute and the delayed phases and was associated with a decrease in food intake, and body weight. Cyclophosphamide had no significant effect on intestinal mucosal morphology, or inducible nitric oxide synthase and cyclooxygenase-2 expression in the intestine. Cyclophosphamide significantly increased tryptophan hydroxylase 1 (TPH1) mRNA expression, number of anti-TPH antibody-positive cells, and 5-HT content in the intestine. Cyclophosphamide also significantly increased the expression of Tac1 mRNA, encoding preprotachykinin-1, which is a preprotein of substance P, and the number of anti-substance P antibody-positive cells in the intestine. Cyclophosphamide significantly increased Lgr5, Bmi1, and Atoh1 mRNA levels, which are markers for the proliferation and differentiation of stem cells. This study demonstrated that cyclophosphamide induced pica in rats, and potentiated 5-HT synthesis associated with hyperplasia of substance P-containing enterochromaffin cells without causing severe intestinal injury.

Topics: Animals; Antineoplastic Agents, Alkylating; Body Weight; Cyclophosphamide; Eating; Enterochromaffin Cells; Hyperplasia; Infusions, Parenteral; Intestines; Kaolin; Male; Pica; Rats, Wistar; Serotonin; Substance P; Tryptophan Hydroxylase

Despite potentially severe medical consequences of pica and rumination disorder (RD), little is known about their prevalence and association with other psychopathology in childhood. As a part of a larger population-based study, 804 children aged 7-14 years and their parents were asked about their experience of pica and RD behaviors, and associated eating, feeding and general psychopathology. A total of 12.31 and 11.49% of the participants reported having engaged in pica or RD behaviors, respectively, at least once. Recurring pica or RD behaviors had been experienced by 4.98 and 1.49% of the participants, respectively. The behaviors showed a significant but small correlation with one another (r = 0.28, p < 0.01). Correlations with symptoms of avoidant/restrictive food intake disorder (ARFID) were significant but small (pica: r = 0.18, RD: r = 0.27, both p < 0.01). Prevalence rates of recurring pica behavior were significantly increased if recurring RD was present (58.33%), and also vice versa (17.50%). The prevalence rates of recurrent pica and RD behaviors were also increased in the presence of an ARFID diagnosis (both behaviors 12.0%). However, correlations with restraint and eating, weight, and shape concern were non-significant (all p > 0.05). Additionally, RD behavior was positively correlated with emotional and conduct problems (r = 0.15 and 0.22, both p < 0.01), and both behaviors were negatively correlated with prosocial behavior (r = -  0.10 and - 0.09, both p < 0.05). Our findings underscore the clinical significance of pica and RD behaviors. More research is warranted on both disorders and their association and relation with ARFID to deepen the understanding of their presentation and to ascertain diagnostic validity.

Topics: Adolescent; Body Weight; Child; Emotions; Feeding and Eating Disorders; Feeding and Eating Disorders of Childhood; Feeding Behavior; Female; Humans; Male; Parents; Pica; Population Surveillance; Prevalence; Problem Behavior; Psychopathology

While chemotherapy-induced nausea and vomiting are clinically controlled in the acute (<24 h) phase following treatment, the anorexia, nausea, fatigue, and other illness-type behaviors during the delayed phase (>24 h) of chemotherapy are largely uncontrolled. As the hindbrain glucagon-like peptide-1 (GLP-1) system contributes to energy balance and mediates aversive and stressful stimuli, here we examine the hypothesis that hindbrain GLP-1 signaling mediates aspects of chemotherapy-induced nausea and reductions in feeding behavior in rats. Specifically, hindbrain GLP-1 receptor (GLP-1R) blockade, via 4th intracerebroventricular (ICV) exendin-(9-39) injections, attenuates the anorexia, body weight reduction, and pica (nausea-induced ingestion of kaolin clay) elicited by cisplatin chemotherapy during the delayed phase (48 h) of chemotherapy-induced nausea. Additionally, the present data provide evidence that the central GLP-1-producing preproglucagon neurons in the nucleus tractus solitarius (NTS) of the caudal brainstem are activated by cisplatin during the delayed phase of chemotherapy-induced nausea, as cisplatin led to a significant increase in c-Fos immunoreactivity in NTS GLP-1-immunoreactive neurons. These data support a growing body of literature suggesting that the central GLP-1 system may be a potential pharmaceutical target for adjunct anti-emetics used to treat the delayed-phase of nausea and emesis, anorexia, and body weight loss that accompany chemotherapy treatments.

Topics: Animals; Anorexia; Body Weight; Cisplatin; Glucagon-Like Peptide-1 Receptor; Infusions, Intraventricular; Male; Nausea; Neurons; Peptide Fragments; Pica; Proglucagon; Rats; Rhombencephalon; Solitary Nucleus

Nausea and vomiting are considered as the foremost unpleasant side effects of chemotherapy experienced by 20-90% of cancer patients.. In the present study, the effects of Korean Panax ginseng C.A. Meyer (Araliaceae) (RG), ginseng saponin (GS) and non-saponin (GNS) on cisplatin (CP)-induced pica and gastric damage in rats were investigated.. Rats were treated with RG (25, 50, 100 mg/kg b.wt.), GS (5 and 10 mg/kg 100 mg/kg b.wt.) and GNS (50 and 100 mg/kg b.wt.) before or after a single intraperitoneal injection of CP (6 mg/kg b.wt.). Kaolin together with normal food intake, normal food alone, body weight, histological examination of stomach and small intestine were used as indices of CP-induced pica in rats.. Pre-treatment with RG (50 and 100 mg/kg b.wt.) attenuated CP-induced kaolin intake at 24 h. CP-induced kaolin intake decreased upon post-treatment of rats with RG (50 and 100 mg/kg b.wt.) at 48 h. The incidence of body weight reduction at 48 and 72 h diminished in rats post-treated with RG (50 mg/kg b.wt.). Pre-treatment with GS (5 and 10 mg/kg b.wt.) and GNS (50 and 100 mg/kg b.wt.) attenuated CP-induced kaolin intake while normal food intake was not improved in 24 and 48 h.. The gastro-protective effects of RG, GS and GNS were further confirmed by histopathological (damage in glandular portion and villi with dilated appearance) findings. The study indicates that both the red GS and GNS improve feeding behavior against CP-induced pica in rats.

Topics: Animals; Antineoplastic Agents; Body Weight; Cisplatin; Disease Models, Animal; Dose-Response Relationship, Drug; Eating; Injections, Intraperitoneal; Intestine, Small; Kaolin; Male; Panax; Pica; Plant Extracts; Rats; Rats, Sprague-Dawley; Saponins; Stomach; Time Factors

Panax ginseng is an indigenous medicinal herb and has traditionally been used among Asian population for relief of many human ailments. We investigated the prophylactic role of Korean P. ginseng extract (KG) against X-ray irradiation-induced emesis in an acute rat pica model. Rats were treated with KG (12.5, 25, 50 mg/kg orally at -48, -24 and 0 h) prior to X-ray irradiation (6 Gy), and intake of kaolin and normal food and body weight changes examined as an index of the acute emetic stimulus. Levels of serotonin in small intestine tissue were assessed and histopathology of gastric tissue, small intestine and colon examined specific staining. Pre-treatment with KG (12.5 and 25 mg/kg) reduced X-ray irradiation-induced kaolin intake at 24h. Normal food intake was improved in rats treated with 25 mg/kg KG. The anti-emetic effect of KG was further confirmed on the basis of serotonin release, histopathological findings. Our findings collectively indicate that KG protects against X-ray irradiation-induced acute pica to a moderate extent, leading to improved feeding behavior in rats.

Topics: Animals; Body Weight; Colon; Energy Intake; Feeding Behavior; Ginsenosides; Intestine, Small; Kaolin; Male; Panax; Phytotherapy; Pica; Plant Extracts; Rats; Rats, Sprague-Dawley; Serotonin; Stomach; Vomiting; X-Rays

In the present study, we investigate the effect of Korean ginseng root extract (KG) on cisplatin-induced pica in a rat model. Rats were treated with KG before (25, 50, and 100 mg/kg) or after (12.5, 25, and 50 mg/kg) a single intraperitoneal injection of cisplatin (7 and 6 mg/kg, respectively). We examined intake of kaolin and normal food as an indicator of the emetic stimulus every 24 h for 120 h. Changes in body weight, haematology and histopathology were additionally assessed. Pre-treatment with KG (25 and 50 mg/kg) significantly attenuated cisplatin-induced kaolin intake (24, 48, and 72 h) and markedly improved intake of normal food by rats at 48, 72, 96, and 120 h. Cisplatin-induced kaolin intake was markedly decreased upon post-treatment of rats with KG (12.5, 25, and 50 mg/kg) at 24 h. Notably, post-treatment with the lowest KG dose resulted in a significant anti-pica effect and improved food intake until 72 h. The magnitude of body weight reduction was significantly diminished in rats pre-treated/post-treated with 25, 50, and 12.5 mg/kg KG. The anti-pica effects of KG were further confirmed with haematological and histopathological findings. Our findings collectively indicate that KG improves the resistance of rats against emesis.

Topics: Animals; Anorexia; Antineoplastic Agents; Body Weight; Chromatography, High Pressure Liquid; Cisplatin; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Panax; Pica; Plant Extracts; Plant Roots; Rats; Rats, Sprague-Dawley; Vomiting

It is known that pica, the consumption of non-nutritive substances such as kaolin, can be induced by administration of toxins or emetic agents in rats. In the present study, we examined the effects of intraperitoneal (i.p.) administration of cyclophosphamide on pica behavior and on the concentration of 5-hydroxyindoleacetic acids (5HIAA) in cerebrospinal fluid (CSF) in the following five strains of adult male rats: Sprague Dawley (SD), Wistar, Fischer 344 (F344), Wistar-Imamichi (WI) and Long Evans (LE). Cyclophosphamide (25 mg or 50 mg/kg) was injected (i.p.) into the rats and kaolin and food intake were measured at 24 hr after injection. The animals were anesthetized with urethane (1 g/kg) at 3 hr after injection of cyclophosphamide, and CSF was collected from the cisterna magna. WI and LE rats clearly showed pica behavior as compared with the other strains. In LE rats, the concentration of 5HIAA in CSF also increased in a dose-dependent manner of cyclophosphamide. The pretreatment with ondansetron (5-HT(3) antagonist) restored both changes (kaolin consumption and 5HIAA levels) induced by cyclophosphamide. These results suggest that the LE rat is sensitive to cyclophosphamide, that pica induced by cyclophosphamide mimics many aspects of emesis including the serotonergic response in the central nervous system and that use of the pica model would be a practical method for evaluating the effects of antiemetic drugs in addition to the mechanism of emesis.

Topics: Animals; Antineoplastic Agents, Alkylating; Body Weight; Cyclophosphamide; Eating; Hydroxyindoleacetic Acid; Kaolin; Male; Ondansetron; Pica; Rats; Rats, Inbred F344; Rats, Long-Evans; Rats, Sprague-Dawley; Rats, Wistar; Serotonin Antagonists

To evaluate the effect of Armillariella tabescens on cisplatin chemotherapy-induced gastrointestinal tract reaction.. Forty-eight male Sprague-Dawley rats were randomized into control group, model group, low dose Armillariella tabescens group, middle dose Armillariella tabescens group, high dose Armillariella tabescens group and ondansetron group. The rats were injected intraperitoneally with cisplatin to induce pica, and observe the effect of Armillariella tabescens on consumption of kaolin, food, water and body weight.. 24-72 h after cisplatin administration, in the middle dose Armillariella tabescens group, the high dose Armillariella tabescens group and the ondansetron group, the kaolin intake was significantly lower than that in the model group, respectively (P<0.05). The most significant difference was between the high dose Armillariella tabescens group [(0.58 +/- 0.23) g/24 h] and the control group [(2.16 +/- 0.98) g/24 h] at 24 h after cisplatin administration. The variables, such as consumption of food during 48-72 h (P<0.05), water during 48-72 h (P<0.05), and body weight at 72 h (P<0.05) in the middle dose Armillariella tabescens group were significantly higher than those in the model group, but no statistically significant difference between the ondansetron group and the model group (P>0.05).. Armillariella tabescens can effectively inhibit the cisplatin-induced pica response, and the middle dose Armillariella tabescens group is significantly better than the model group in improving the food intake reduction, water intake reduction and body weight loss.

Topics: Agaricales; Animals; Antiemetics; Antineoplastic Agents; Biological Therapy; Body Weight; Cisplatin; Drinking; Eating; Kaolin; Male; Ondansetron; Pica; Random Allocation; Rats; Rats, Sprague-Dawley

Methotrexate is a widely used cytostatic in chemotherapy cocktails for the treatment of cancer but is associated with cognitive impairment. Previous animal studies indicated that methorexate decreases hippocampal cell proliferation, which might contribute to the observed cognitive impairment. However, clinical studies have shown that cognitive impairment can also be noticed in some cancer patients before any systemic treatment is initiated. We aim in the present study to discern whether hippocampal cell proliferation is negatively affected by tumor growth and if the presence of a tumor amplifies the effects of methotrexate. Buffalo rats were subcutaneously injected with PBS or Morris Hepatoma 7777 cells to induce a tumor. Two weeks after this injection the animals received an intraperitoneal injection of methotrexate or saline. Three weeks later hippocampal cell proliferation was quantified using immunohistochemical staining. Treatment with Morris Hepatoma 7777 cells decreased the number of proliferating cells as compared to control animals. An overall tumor effect was absent mainly because methotrexate treatment significantly decreased cell proliferation with no differences between animals with or without a tumor. Neither methotrexate nor the tumor induced pica behavior. These findings indicate that although the presence of a tumor reduces hippocampal cell proliferation it does not affect the negative effect of methotrexate on this plasticity marker. Since sickness behavior is not induced by methotrexate or tumor presence it does not play a role in the development of cognitive deficits. This study further indicates that the effects of methotrexate on brain and behavior can be studied in healthy animals.

Topics: Animals; Antimetabolites, Antineoplastic; Body Weight; Brain Neoplasms; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Feeding Behavior; Hippocampus; Immunohistochemistry; Liver Neoplasms; Male; Methotrexate; Neoplasm Transplantation; Pica; Rats; Rats, Inbred BUF

Clay consumption can occur during illness but there has been little work to understand why. To investigate whether consuming clay confers an advantage to the sick animal, we compared the recovery from illness of adult male rats with or without access to kaolin. Illness was induced by injection of 6 mg/kg, ip, cisplatin, a toxic chemotherapy agent, and recovery was assessed by changes in daily food intake, water intake, and body weight. Relative to saline-injected controls, cisplatin-injected rats reduced food and water intake and lost weight. However, those with access to kaolin ate more food and lost less body weight than did those without access to kaolin. Thus, clay consumption appeared beneficial in that it either protected the rats from illness or enhanced recovery and might prove useful as an adjunct therapy for other animals, including humans, experiencing visceral malaise.

Topics: Animals; Body Weight; Cisplatin; Drinking; Drug Interactions; Eating; Kaolin; Male; Pica; Rats; Rats, Sprague-Dawley

Anticancer agents, such as cisplatin, induce vomiting, nausea, and anorexia. Cisplatin primarily acts on vagal afferents to produce emesis, but little is known about how this drug generates nausea and anorexia. Electrophysiology indicates that cisplatin activates vagal afferents of the common hepatic branch (CHB). Rats lack an emetic response but do ingest kaolin clay (a pica response) when made sick by toxins, and this behavior can be inhibited by antiemetic drugs. It has been postulated that pica may serve as a proxy for emesis in the rat. The goal of this study was to assess the effect of CHB or ventral gastric (Gas) or celiac (Cel) branch vagotomies on pica and anorexia produced by cisplatin in the rat. The effects of apomorphine, a dopamine receptor agonist, which induces emesis via a central mechanism, were also assessed. Cisplatin-induced pica was suppressed by CHB vagotomy (a 61% reduction) but not by Gas and Cel vagotomy. Suppression of daily food intake and body weight following cisplatin treatment was also blunted by CHB ablation but not by Gas or Cel vagotomy. No vagotomy condition exhibited altered apomorphine-induced pica. The results indicate that the CHB, which innervates primarily the duodenum, plays an important role in cisplatin-induced malaise. These data suggest that pica has sensory pathways similar to emetic systems, since a vagotomy condition inhibited cisplatin-induced pica but had no effect on apomorphine-induced pica. This investigation contributes to the delineation of the physiology of pica and neural systems involved in malaise in the nonvomiting rat.

Topics: Animals; Anorexia; Antineoplastic Agents; Apomorphine; Body Weight; Celiac Plexus; Cisplatin; Dopamine Agonists; Drinking; Eating; Kaolin; Liver; Male; Pica; Rats; Rats, Sprague-Dawley; Stomach; Vagotomy; Vomiting

Anorexia, nausea/emesis and peripheral sensorial neuropathy are frequent adverse effects associated with chemotherapy. Cannabinoids have been proposed to alleviate these effects, but their preventive properties in long-term experimental models have not been tested. This study was conducted to determine whether or not a cannabinoid agonist (WIN-55,212-2) can prevent anorexia, pica (an indirect marker of nausea in non-vomiting species, consisting of the ingestion of non-nutritive substances such as kaolin) and mechanical allodynia (a marker of peripheral neuropathy) induced by the antineoplastic drug cisplatin chronically administered. Isolated rats with free access to food and kaolin received either saline, cannabinoid vehicle, WIN-55,212-2 (1-2 mg kg(-1)), cisplatin (1-2 mg kg(-1)), or both drugs once per week for five consecutive weeks. Modifications in temperature, body weight gain, food and kaolin intake, and the threshold for mechanical allodynia were recorded. Additionally, the acute psychoactive effects of the cannabinoid (hypomotility, hypothermia, analgesia and catalepsia) were assayed by means of the cannabinoid tetrad. WIN 55,212-2 prevented the development of mechanical allodynia but not anorexia, pica and reduction in weight gain induced by chronic cisplatin. The effect of WIN 55,212-2 was evident even at a dose lacking activity in the cannabinoid tetrad. The preventive effect on cisplatin-induced mechanical allodynia exerted by the cannabinoid could be due to a neuroprotective role, as has been suggested for other conditions. The present results support the interest in the evaluation of cannabinoids for treatment of patients suffering or likely to suffer neuropathic pain.

Topics: Analgesics; Animals; Antidiarrheals; Antineoplastic Agents; Benzoxazines; Body Temperature; Body Weight; Cisplatin; Feeding Behavior; Kaolin; Male; Morpholines; Naphthalenes; Pain; Peripheral Nervous System Diseases; Pica; Rats; Rats, Wistar

Rats lack the emetic reflex but exhibit pica in response to stimuli that induce emesis in species with an emetic reflex, hence it has been proposed that pica may be analogous to emesis in species lacking the reflex. In the present study, we investigated whether pica was present in Suncus murinus (with an emetic reflex) as well as in rats and mice (without emetic reflex) to provide a further insight to the validity of pica as a model for nausea/vomiting. Cisplatin (6 mg/kg, i.p.) induced pica in rats, indicated by a significant increase in kaolin consumption at 24 h (but not 48 h) post-treatment whereas we failed to demonstrate this effect in mice (inbred or outbred strain, 6 or 20 mg/kg i.p.) and whilst cisplatin (20 mg/kg, i.p.) induced emesis in Suncus, kaolin intake was not significantly affected. Furthermore, cisplatin significantly increased the weight of gastric contents at 48 h post-injection in rats and mice indicating delayed gastric emptying whereas this effect was not present in Suncus. These results show that Suncus and two strains of mice, unlike rats, do not develop pica in response to cisplatin which suggests that the consumption of kaolin induced by cisplatin may not be associated with whether or not an emetic reflex is present. The differences in ingestive behaviour and gastric response between species with and without an emetic reflex in response to cisplatin treatment as well as the difference between mice and rats, is discussed in relation to the selection of models for the study of nausea and vomiting.

Topics: Animals; Body Weight; Cisplatin; Disease Models, Animal; Drinking; Eating; Kaolin; Male; Mice; Nausea; Organ Size; Pica; Rats; Shrews; Species Specificity; Stomach; Time Factors

Every child with failure to thrive has at least one organic medical disease: malnutrition. It is well documented that lead and other heavy metals are absorbed more readily in the presence of both malnutrition and iron deficiency anemia. Malnutrition and lead exposure tend to be found in the same population groups. Furthermore, lead poisoning is correlated with many of the identical intellectual and behavioral deficits demonstrated in children suffering from nonorganic failure to thrive. Because of these facts, whole blood lead levels were determined for 45 children with nonorganic failure to thrive and 45 age-, race-, and socioeconomically matched comparison subjects. Children with failure to thrive had a lead level of 22.67 +/- 10.29 (micrograms/dL (mean +/- SD); for control children, it was 14.33 +/- 5.42 (P less than .001). Children with failure to thrive were more frequently anemic (P less than .0001), a possible lead effect, and had higher free erythrocyte protoporphyrin levels. Children with failure to thrive were developmentally delayed on the Denver Developmental Screening Test (unblinded observation) with high failure rates in both language (P less than .001) and gross motor skills (P less than .02). Although failure on the Denver Developmental Screening Test within the failure to thrive group was not linearly correlated with lead level, any such effects may have been masked by the effects of malnutrition and failure to thrive per se. A number of authors have suggested that lead levels formerly thought to be inconsequential are clinically toxic.(ABSTRACT TRUNCATED AT 250 WORDS)

Topics: Body Weight; Child, Preschool; Developmental Disabilities; Failure to Thrive; Humans; Infant; Lead; Pica

Topics: Animals; Avoidance Learning; Body Weight; Calcium; Calcium, Dietary; Deficiency Diseases; Drinking Behavior; Female; Humans; Iron Deficiencies; Lead Poisoning; Magnesium Deficiency; Male; Pica; Quinine; Rats; Taste; Zinc

Topics: Animals; Body Weight; Dietary Carbohydrates; Eating; Feeding Behavior; Female; Hemoglobinometry; Humans; Male; Maternal Behavior; Mice; Mice, Inbred Strains; Pica; Pregnancy; Pregnancy, Animal; Reproduction; Starch; Time Factors

Topics: Age Factors; Anemia, Hypochromic; Animals; Biological Assay; Blood Chemical Analysis; Body Height; Body Weight; California; Child; Child Nutritional Physiological Phenomena; Child, Preschool; Feeding Behavior; Female; Food; Hemoglobins; Humans; Infant; Infant Nutritional Physiological Phenomena; Iron; Male; Milk; Nutrition Disorders; Nutrition Surveys; Nutritional Physiological Phenomena; Nutritional Requirements; Parity; Pica; Rural Health; Socioeconomic Factors

Topics: Adolescent; Adult; Age Factors; Anemia, Hypochromic; Blood Proteins; Body Height; Body Weight; Edema; Female; Growth Disorders; Helminthiasis; Hemoglobinometry; Hepatomegaly; Humans; Infections; Iran; Male; Nutrition Disorders; Pica; Protein Deficiency; School Health Services; Serum Albumin; Serum Globulins; Soil; Splenomegaly; Zinc

Topics: Adolescent; Age Factors; Anemia, Hypochromic; Blood Cell Count; Blood Platelets; Body Height; Body Weight; Child; Child, Preschool; Copper; Deficiency Diseases; Dwarfism; Feeding and Eating Disorders; Feeding Behavior; Female; Folic Acid; Hemoglobins; Hepatomegaly; Humans; Hypogonadism; Male; Pica; Sex Factors; Soil; Splenomegaly; Turkey; Zinc