pi103 has been researched along with Systemic-Inflammatory-Response-Syndrome* in 1 studies
1 other study(ies) available for pi103 and Systemic-Inflammatory-Response-Syndrome
| Article | Year |
|---|---|
Ring closure strategy leads to potent RIPK3 inhibitors.
Necroptosis is a form of regulated necrotic cell death that is independent of caspases. Receptor-interacting protein kinase 3 (RIPK3) has been identified as a key regulator for necroptosis, and has been proposed as a potential therapeutic target for the treatment of diseases associated with necroptosis. In this report, we describe the design, synthesis, and evaluation of a series of novel RIPK3 inhibitors. The lead compound 38 exhibited potent activity (EC Topics: Animals; Antineoplastic Agents; Cell Death; Cell Proliferation; Cell Survival; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Hypothermia; Injections, Intravenous; Mice; Mice, Inbred C57BL; Molecular Structure; Protein Kinase Inhibitors; Receptor-Interacting Protein Serine-Threonine Kinases; Structure-Activity Relationship; Systemic Inflammatory Response Syndrome; Tumor Necrosis Factor-alpha | 2021 |