phytosterols and Myocardial-Ischemia

Topics: Food, Fortified; Humans; Hypercholesterolemia; Myocardial Ischemia; Phytosterols; Stroke

Topics: Anticholesteremic Agents; Cholesterol; Cholesterol, LDL; Clinical Trials as Topic; Esters; Humans; Hypolipidemic Agents; Myocardial Ischemia; Phytosterols; Sitosterols

Patients may present with a variety of syndromes related to ischaemic heart disease. These include unstable or stable angina pectoris, acute myocardial infarction, and occasionally cardiac failure without prior anginal pain or infarction. For the purposes of this review, it will generally be assumed that the condition has been stabilised, though one important aspect of the rehabilitation process is the recognition of continuing or recurrent problems such as angina pectoris and cardiac decompensation. This should then be followed by appropriate intervention. The key components of post-hospital management of such patients are: (i) support; (ii) education; (iii) assessment; (iv) intervention (if necessary); (v) therapy; and (vi) lifestyle modification.

Topics: Adrenergic beta-Antagonists; Alcohol Drinking; Angiotensin-Converting Enzyme Inhibitors; Antioxidants; Coronary Restenosis; Exercise Therapy; Heart Failure; Humans; Myocardial Ischemia; Patient Compliance; Patient Education as Topic; Phytosterols; Risk Assessment; Smoking Cessation; Social Support; Thrombolytic Therapy; Weight Loss

We studied effect of antiatherogenic diet with inclusion of a sour milk product Danacor enriched with phytosterols on clinical and biochemical parameters of patients with cardiovascular diseases. Results of the study showed that antiatherogenic diet with phytosterols facilitated improvement of clinical status, anthropometric parameters, and lipid spectrum of blood.

Topics: Cultured Milk Products; Double-Blind Method; Female; Follow-Up Studies; Humans; Hyperlipidemias; Lipids; Male; Middle Aged; Myocardial Ischemia; Phytosterols; Treatment Outcome

The aim of the present study was to evaluate in vivo the potential anti-ischemic and antiatheromatic activity of Chios Mastic gum, the resin of the trunk and branches of "Pistacia lentiscus var. chia", used since antiquity in traditional Greek medicine. The main compounds of mastic are triterpenes, possessing phytosterol-like structures. This led to the hypothesis that mastic and particularly its neutral fraction, enriched in phytosterol-like compounds, possess antiatheromatic activities.. Total Mastic Extract without Polymer (TMEWP) and the neutral mastic fraction (NMF) were administered orally for 6 weeks to normal fed and to cholesterol fed rabbits in the form of sunflower oil solution. All the animals were randomly divided into 6 groups, anesthetized and subjected to 30min ischemia of the heart, followed by 3h reperfusion: At the end of the experiment the area at risk and the infarct zone were determined with the aid of fluorescent particles and triphenyl tetrazolium chloride staining, and small segments of the ascending and descending aorta and the heart were taken for histologic examination. Blood samples were collected at different time points of ischemia and reperfusion, for malondialdehyde (MDA) evaluation as an index of lipid peroxidation, for total and LDL cholesterol determination and for evaluation of oxidized LDL.. In the normal fed animals the NMF and the TMEWP reduced significantly the infarct size, while in the hypercholesterolemic rabbits both treatments were ineffective. Atherosclerosis was detected in all the animals fed cholesterol enriched diet in the form of subintimal accumulation of lipids and foamy macrophages. There was no detection of atherosclerosis in Groups treated with TMEWP and NMF, which both reduced the total cholesterol levels by 47 and 88% respectively, whilst had not effect on LDL oxidation. TMEWP and NMF reduced the MDA concentration in normal fed rabbits, but had no effect on MDA levels in cholesterol fed animals. TMEWP and NMPF reduce the infarct size in normal animals and possess significant antiatheromatic and hypolipidemic activities in rabbits fed cholesterol enriched diet.

Topics: Animal Feed; Animals; Anticholesteremic Agents; Greece; Hypercholesterolemia; Male; Mastic Resin; Myocardial Ischemia; Phytosterols; Pistacia; Plant Extracts; Rabbits; Resins, Plant; Triterpenes

The investigation of influent of antiatherosclerotic diets with phytosterols on clinical and metabolic parameters in patients with cardiovascular diseases. Results of the study show that enrichment of a diets with phytosterols in patients with ischemic heart disease and hypertension improved clinic status, antropometric levels and lipid spectrum of blood. The research has shown, that the use in the treat-preventive purposes phytosterols is rather perspective.

Topics: Diet; Dietary Supplements; Female; Humans; Hypertension; Lipids; Male; Middle Aged; Myocardial Ischemia; Phytosterols