phytosterols has been researched along with Medulloblastoma* in 1 studies
1 other study(ies) available for phytosterols and Medulloblastoma
| Article | Year |
|---|---|
Cynanbungeigenin C and D, a pair of novel epimers from Cynanchum bungei, suppress hedgehog pathway-dependent medulloblastoma by blocking signaling at the level of Gli.
Uncontrolled excessive activation of Hedgehog (Hh) signaling pathway is linked to a number of human malignant tumorigenesis. To obtain valuable Hh pathway inhibitors from natural product, in present study, a pair of novel epimers, Cynanbungeigenin C (CBC) and D (CBD) from the plant Cynanchum bungei Decne were chemically characterized by multiple spectroscopic data and chemical derivatization, and evaluated for their inhibition on Hh pathway. Mechanistically, CBC and CBD block Hh pathway signaling not through targeting Smo and Sufu, but at the level of Gli. In addition, both eipmers significantly suppress Hh pathway-dependent Ptch Topics: Animals; Cerebellar Neoplasms; Cynanchum; Hedgehog Proteins; HEK293 Cells; Humans; Medulloblastoma; Mice; NIH 3T3 Cells; Phytosterols; Plant Extracts; Signal Transduction; Xenograft Model Antitumor Assays; Zinc Finger Protein GLI1 | 2018 |