phytosterols has been researched along with Biliary-Fistula* in 1 studies
1 other study(ies) available for phytosterols and Biliary-Fistula
| Article | Year |
|---|---|
Studies on the formation of C7-oxygenated cholesterol and beta-sitosterol metabolites in cell-free preparations of rat liver.
The microsomal fraction and the 18,000 g supernatant fluid obtained from livers from normal rats, cholestyraminetreated rats, or from rats with a bile fistula have been used to compare the 7alpha-hydroxylation of [4-(14)C]cholesterol and beta-[4-(14)C]sitosterol (24alpha-ethyl-cholesterol). It was not possible to increase the specific formation of 7alpha-hydroxy-beta-sitosterol above 0.05% with any of the preparations. This conversion was less than 1% of that found for cholesterol. The inhibitory effect of added 7-oxo- and 7beta-hydroxy-beta-sitosterol on the 7alpha-hydroxylation of cholesterol was found to be much less than that of the corresponding cholesterol compounds. 7alpha-Hydroxy-beta-sitosterol was without effect. It is concluded that the activity of the cholesterol 7alpha-hydroxylase is dependent upon the structure of the steroid side chain. Topics: Animals; Biliary Fistula; Carbon Isotopes; Cell-Free System; Cholesterol; Cholestyramine Resin; Chromatography, Gas; Chromatography, Ion Exchange; Chromatography, Thin Layer; Circadian Rhythm; Hydroxylation; Liver; Male; Mass Spectrometry; Microsomes, Liver; Phenobarbital; Phytosterols; Rats; Sitosterols; Steroid Hydroxylases; Time Factors; Triolein | 1973 |