phytoestrogens and Hypophosphatemia

phytoestrogens has been researched along with Hypophosphatemia* in 1 studies

Other Studies

1 other study(ies) available for phytoestrogens and Hypophosphatemia

ArticleYear
Genistein affects parathyroid gland and NaPi 2a cotransporter in an animal model of the andropause.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2013, Volume: 64, Issue:3

    This study aimed to examine the effects of genistein on the structural and functional changes in parathyroid glands (PTG) and sodium phosphate cotransporter 2a (NaPi 2a) in orchidectomized rats. Sixteen-month-old Wistar rats were divided into sham-operated (SO), orchidectomized (Orx) and genistein-treated orchidectomized (Orx+G) groups. Genistein (30 mg/kg/day) was administered subcutaneously for 3 weeks, while the controls received vehicle alone. PTG was analyzed histomorphometrically, while the expressions of NaPi 2a mRNA/protein levels from kidneys were determined by real time PCR and Western blots. Serum and urine parameters were determined biochemically. The PTG volume in Orx rats was increased by 30% (p<0.05), compared to the SO group. Orx+G treatment increased the PTG volume by 35% and 75% (p<0.05) respectively, comparing to Orx and SO animals. Orchidectomy led to increment of serum PTH by 27% (p<0.05) compared to the SO group, Orx+G decreased it by 18% (p<0.05) comparing to Orx animals. NaPi 2a expression in Orx animals was reduced in regards to its abundance in SO animals, although it was increased in Orx+G group compared to the Orx. Phosphorus urine content of Orx animals was raised by 12% (p<0.05) compared to that for the SO group, while Orx+G induced a 17% reduction (p<0.05) in regards to Orx animals. Our study shows that Orx increases PTG volume and serum PTH level, while protein expression of NaPi 2a is reduced. Application of genistein attenuates the orchidectomy-induced changes in serum PTH level, stimulates the expression of NaPi 2a and reduces urinary Pi excretion, implying potential beneficial effects on andropausal symptoms.

    Topics: Andropause; Animals; Calcium; Gene Expression Regulation; Genistein; Hypocalcemia; Hypophosphatemia; Injections, Subcutaneous; Kidney; Male; Orchiectomy; Organ Size; Parathyroid Glands; Parathyroid Hormone; Phosphorus; Phytoestrogens; Rats; Rats, Wistar; Sodium-Phosphate Cotransporter Proteins, Type IIa; Water-Electrolyte Imbalance

2013