phytoestrogens and Aging--Premature

phytoestrogens has been researched along with Aging--Premature* in 1 studies

Other Studies

1 other study(ies) available for phytoestrogens and Aging--Premature

ArticleYear
Methyl-Hispolon from Phellinus lonicerinus (Agaricomycetes) Affects Estrogen Signals in MCF-7 Breast Cancer Cells and Premature Aging in Rats.
    International journal of medicinal mushrooms, 2019, Volume: 21, Issue:4

    We studied Phellinus lonicerinus to determine the cytotoxic effect and the dual estrogenic activities of methyl-hispolon and their relation to estrogen signals in vivo and in vitro. The Glide scores of methyl-hispolon-estrogen receptor α (ERα) and methyl-hispolon-ERβ docked complexes were -7.29 kcal/mol and -6.68 kcal/mol in docking simulations. Methyl-hispolon had a significant antiproliferative effect for estrogen-sensitive ER(+) MCF-7 cells in the absence of estrogen, and it exhibited dual estrogen activities. Methyl-hispolon increased the serum E2 in rats with premature ovarian failure and fulfilled the estrogenic function in the uterus and ovary. Methyl-hispolon significantly inhibited the expression of Ras, API, ERα, C-myc, and cyclinDl, as well as their gene transcription in RL95-2 cells. The phosphorylation of ERK1/2 was inhibited by methyl-hispolon. Thus, methyl-hispolon has potential use in treating estrogen deficiency-related diseases, with good antitumor effects and estrogenic activity.

    Topics: Aging, Premature; Animals; Basidiomycota; Catechols; Cell Proliferation; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogen Receptor Modulators; Estrogens; Female; Hormone Replacement Therapy; Humans; MAP Kinase Signaling System; MCF-7 Cells; Molecular Docking Simulation; Ovary; Phosphorylation; Phytoestrogens; Rats; Rats, Sprague-Dawley; Uterus

2019