phytochlorin and Osteosarcoma

The multifunctional combined nanoplatform has a wide application prospect in the synergistic treatment of cancer. Nevertheless, the traditional treatment of phototherapy is limited by the catalytic nanomaterial itself, so the effect is not satisfactory. Here, the arris of the anisotropic truncated octahedral Au (TOh Au) was coated with noble metal Pt to form a spatial separation structure, which enhanced the local surface plasmonic resonance and thus boosted the photocatalytic effect. In this system, the highly efficient photocatalysis provides a strong guarantee for oncotherapy. On the one hand, the structure of arris deposition adequately improves the efficiency of photothermal conversion, which substantially improves the effectiveness of photothermal therapy. On the other hand,

Topics: Animals; Anisotropy; Antineoplastic Agents; Catalysis; Chlorophyllides; Gold; Hyaluronic Acid; Infrared Rays; Metal Nanoparticles; Mice, Nude; Osteosarcoma; Oxygen; Photochemotherapy; Photosensitizing Agents; Photothermal Therapy; Platinum; Polyethylene Glycols; Porphyrins; Reactive Oxygen Species; Surface Plasmon Resonance

Surgery combined with adjuvant or neoadjuvant chemotherapy is still the standard treatment for osteosarcoma. However, the high risk of tumor recurrence and side effects of chemotherapy usually lead to high mortality for cancer patients. Herein, the multi-targeted receptor tyrosine kinase (RTK) inhibitor sunitinib (Sun) and photodynamic therapy (PDT) drug chlorin e6 (Ce6) were locally delivered to the postoperative tumor site via a zwitterionic hydrogel. This hydrogel exhibited excellent biocompatibility and redox responsiveness. In vitro study demonstrated that Sun/Ce6@Gel induced 143B human osteosarcoma cell apoptosis via downregulating the expression of Bcl-2 and upregulating the expression levels of Bax and caspase-3. Similarly, the in vivo study showed that Sun/Ce6@Gel provided sustained drug release under redox conditions, and then synergistically induced tumor apoptosis to prevent tumor recurrence without systemic toxicity. Therefore, local implantation of Sun/Ce6@Gel may be a promising topical therapeutic method for prevention of the recurrence of osteosarcoma after surgery.

Topics: Animals; Antineoplastic Agents; bcl-2-Associated X Protein; Biocompatible Materials; Caspase 3; Chlorophyllides; Combined Modality Therapy; Drug Carriers; Drug Compounding; Drug Liberation; Gene Expression Regulation; Hemolysis; Humans; Hydrogels; Male; Mice, Inbred BALB C; Mice, Nude; Neoplasm Recurrence, Local; Osteosarcoma; Photochemotherapy; Photosensitizing Agents; Porphyrins; Proto-Oncogene Proteins c-bcl-2; Sunitinib