physostigmine has been researched along with Disease Models, Animal in 83 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (27.71) | 18.7374 |
| 1990's | 9 (10.84) | 18.2507 |
| 2000's | 19 (22.89) | 29.6817 |
| 2010's | 29 (34.94) | 24.3611 |
| 2020's | 3 (3.61) | 2.80 |
| Authors | Studies |
|---|---|
| Darekar, MN; Gurjar, AS; Ooi, L; Yeong, KY | 1 |
| Braisted, J; Dranchak, P; Earnest, TW; Gu, X; Hoon, MA; Inglese, J; Oliphant, E; Solinski, HJ | 1 |
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Chen, XQ; Kleschevnikov, AM; Maccecchini, M; Mobley, WC; Nguyen, PD; Overk, C; Pearn, ML; Salehi, A | 1 |
| Iwasa, H; Iwasa, M; Katsuyama, S; Kurokawa, K; Miyagawa, K; Mochida-Saito, A; Nakagawasai, O; Tadano, T; Takahashi, K; Takeda, H; Tsuji, M | 1 |
| Amaral, JD; Bernardi, J; Brandão, R; Costa, L; da Costa, M; Fiuza, T; Pereira, ME; Ribeiro, MF; Rodrigues, CMP | 1 |
| Haeri-Rouhani, SA; Javad-Moosavi, BZ; Nasehi, M; Vaezi, G; Zarrindast, MR | 1 |
| Nuñez, A; Reyes-Marin, KE | 1 |
| Barros, DM; Cordeiro, MF; Fernandes, SS; Kaszubowski, E; Koth, AP; Moreira, FP; Oses, JP; Parfitt, GM; Peixoto, CS; Soubhia, A; Wiener, CD | 1 |
| Bader, M; Becker, RE; Greig, NH; Hoffer, BJ; Hoffman, AF; Hsueh, SC; Jung, YJ; Lecca, D; Lupica, CR; Pick, CG; Tweedie, D | 1 |
| Bendix, I; Bührer, C; Endesfelder, S; Felderhoff-Mueser, U; Kalb, A; Sifringer, M; Spies, CD; von Haefen, C | 1 |
| Gonzalez, D; Greig, NH; Lilja, AM; Marutle, A; Mustafiz, T; Nordberg, A; Röjdner, J; Storelli, E; Thomé, CM; Unger-Lithner, C | 1 |
| Daphna, J; Joel, D; Roni, YY; Yankelevitch-Yahav, R | 1 |
| Cerny, V; Hung, O; Kern, H; Lehmann, C; Masur, S; Pavlovic, D; Rüb, J; Saleh Abdo, I; Shukla, R; Spassov, A; Whynot, S; Zhou, J | 1 |
| Büchler, MW; Hackert, T; Hofer, S; Jabrailova, B; Schneider, L; Soliman, H; Strobel, O; Werner, J | 1 |
| Bobal, MG; Savage, LM | 1 |
| Barnet, RC; Hunt, PS | 1 |
| de Groot, H; Petrat, F; Verhaegh, R | 1 |
| Addy, NA; Nunes, EJ; Wickham, RJ | 1 |
| Geyer, MA; Milienne-Petiot, M; van Enkhuizen, J; Young, JW | 1 |
| Brookes, S; Costa, M; Gibbins, I; Keightley, L; Nicholas, S; Zagorodnyuk, V | 1 |
| Fricke, F; Kopitz, J; Plaschke, K; Weigand, MA | 1 |
| Barak, S; Becker, KG; Becker, RE; Fukui, K; Greig, NH; Hoffer, BJ; Holloway, HW; Lehrmann, E; Li, Y; Luo, Y; Perez, E; Pick, CG; Rubovitch, V; Tamargo, IA; Tweedie, D; Van Praag, H; Wood, WH; Yu, QS; Zhang, Y | 1 |
| Barak, S; Weiner, I | 1 |
| Bartolini, A; Di Cesare Mannelli, L; Ghelardini, C | 1 |
| Kamei, C; Masuoka, T | 1 |
| Grubbs, RD; Lucot, JB; Mauck, B; Paton, S | 1 |
| Cho, KW; Park, JK; Zhao, C | 1 |
| Ilavazhagan, G; Maiti, P; Muthuraju, S; Pati, S; Prasad, D; Sharma, AK; Singh, SB; Solanki, P | 1 |
| Lam, HA; Maidment, N; Nienhuis, R; Siegel, JM; Wu, MF | 1 |
| Araujo, JA; de Rivera, C; Greig, NH; Ingram, DK; Milgram, NW; Sandin, J | 1 |
| Chang, SL; Chen, YI; Cheng, YW; Ho, WJ; Lee, YC; Li, TM; Lin, JG; Tzeng, CY | 1 |
| Hong, E; Liy-Salmeron, G; Meneses, A; Ponce-Lopez, T | 1 |
| Mikroulis, AV; Psarropoulou, C | 1 |
| Guo, Y; Holschneider, DP; Roch, M; Scremin, OU; Wang, Z | 1 |
| Bania, TC; Chu, J | 1 |
| Bertchume, A; Csernansky, CA; Csernansky, JG; Dong, H; Martin, MV; Vallera, D | 1 |
| Araujo, JA; Milgram, NW; Studzinski, CM | 1 |
| Armstrong, S; Mumford, H; Price, M; Scott, L; Wetherell, J | 1 |
| Brundin, P; Chung, H; Colgan, L; Englund, E; Faull, RL; Li, JY; Liu, YJ; Maat-Schieman, ML; Roos, RA; Rundquist, S; Smith, R | 1 |
| Klein, J | 1 |
| Chang, Q; Gold, PE | 1 |
| Flood, P | 1 |
| Bekker, A; Blanck, T; Gingrich, K; Gorny, A; Haile, M; Quartermain, D; Wenning, L | 1 |
| Bierhaus, A; Bode, K; Brueckmann, M; Dalpke, AH; Eisenbach, C; Encke, J; Hofer, S; Krammer, PH; Lukic, IK; Martin, E; Mautner, S; Nawroth, PP; Schneider, L; Stremmel, W; Weigand, MA; Wente, MN; Werner, J | 1 |
| Akaike, A; Goto, Y; Hongo, H; Kihara, T; Niidome, T; Sugimoto, H | 1 |
| Georgiev, N; Markov, M; Zheliazkov, D | 1 |
| Buccafusco, JJ; Finberg, JP; Spector, S | 1 |
| Gillin, JC; Sitaram, N | 1 |
| Bazzani, C; Bertolini, A; Guarini, S | 1 |
| Honda, K; Mignot, E; Nishino, S; Okura, M; Riehl, J | 1 |
| Hala, K; Kúbek, A; Plachý, J; Vasícek, D | 1 |
| Karan, RS; Pandhi, P; Ravishankar, P | 1 |
| Brossi, A; De Micheli, E; Deutsch, J; Greig, NH; Holloway, HW; Ingram, DK; Lahiri, DK; Perry, TA; Soncrant, TT; Utsuki, T; Yu, QS | 1 |
| Erb, C; Klein, J; Kopf, S; Löffelholz, K; Schmitt, U; Soreq, H; Troost, J | 1 |
| Kurasawa, M; Nakamura, K | 1 |
| Berger, PA; Davis, KL; Hollister, LE; Vento, AL | 1 |
| Pasik, P; Pasik, T | 1 |
| Anlezark, GM; Marsden, CD; Meldrum, BS | 1 |
| Chiou, CY; Matthews, RT | 1 |
| Harris, KE; Miller, MM; Patterson, R | 1 |
| Chakrin, LW; Krell, RD; Wardell, JR | 1 |
| Georgieva, A; Rainova, L; Staneva-Stoytcheva, D | 1 |
| Egbe, P; Wray, SR | 1 |
| Maeda, N; Matsuoka, N; Ohkubo, Y; Yamaguchi, I; Yamazaki, M | 1 |
| D'Mello, GD; Sidell, FR | 1 |
| Davis, KL; Haroutunian, V; Santucci, AC | 2 |
| Miyoshi, K; Ueki, A | 1 |
| Bazzani, C; Bertolini, A; Ferrante, F; Guarini, S; Tagliavini, S | 1 |
| Boyce, S; Iversen, SD; Rupniak, NM; Steventon, MJ; Tye, SJ | 1 |
| Haigh, JR; Lines, CR; Poppleton, P; Preston, GC; Traub, M; Ward, C | 1 |
| Jenner, P; Marsden, CD; Rupniak, NM | 1 |
| Campbell, GA; Davis, KL; Haroutunian, V; Kanof, PD; Tsuboyama, GK | 1 |
| Hashizume, K; Manaka, S; Sasaki, M; Takakura, K | 1 |
| Britton, KT; Downs, NS; Gibbs, DM; Koob, GF; Swerdlow, NR | 1 |
| Iga, Y; Kawanishi, G; Mizobe, F; Nakahara, N | 1 |
| Camarena, ML; Moss, DE; Reyes, E; Rodriguez, LA | 1 |
| Krip, G; Vazquez, AJ | 1 |
| Bouhuys, A; Douglas, JS; Lewis, A | 1 |
| Gloor, P; Guberman, A; Testa, G | 1 |
| Baker, WW; Lalley, PM; Rossi, GV | 1 |
| Tokoro, T | 1 |
3 review(s) available for physostigmine and Disease Models, Animal
| Article | Year |
|---|---|
Further evidence for the cholinergic hypothesis of aging and dementia from the canine model of aging.
Topics: Acetylcholine; Aging; Animals; Cognition Disorders; Dementia; Disease Models, Animal; Dogs; Humans; Physostigmine; Scopolamine | 2005 |
Phenserine.
Topics: Alzheimer Disease; Animals; Clinical Trials, Phase II as Topic; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Drug Administration Schedule; Drugs, Investigational; Female; Follow-Up Studies; Humans; Male; Maximum Tolerated Dose; Mice; Physostigmine; Risk Assessment; Sensitivity and Specificity; Treatment Outcome | 2007 |
Acute dystonia induced by neuroleptic drugs.
Topics: Acute Disease; alpha-Methyltyrosine; Animals; Antipsychotic Agents; Brain; Chlorpromazine; Disease Models, Animal; Drug Synergism; Dystonia; Fluphenazine; Haloperidol; Histamine H1 Antagonists; Levodopa; Mastication; Methyltyrosines; Movement Disorders; Parasympatholytics; Physostigmine; Primates; Rats | 1986 |
1 trial(s) available for physostigmine and Disease Models, Animal
| Article | Year |
|---|---|
Studies on choline chloride in neuropsychiatric disease: human and animal data.
Topics: Animals; Choline; Clinical Trials as Topic; Disease Models, Animal; Drug Evaluation; Dyskinesia, Drug-Induced; Humans; Huntington Disease; Physostigmine; Rats | 1978 |
79 other study(ies) available for physostigmine and Disease Models, Animal
| Article | Year |
|---|---|
In silico studies, synthesis and pharmacological evaluation to explore multi-targeted approach for imidazole analogues as potential cholinesterase inhibitors with neuroprotective role for Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Electrophorus; Female; Horses; Imidazoles; Male; Maze Learning; Memory Disorders; Mice; Molecular Structure; Neuroprotective Agents; Structure-Activity Relationship | 2018 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, Spinal; Humans; Mice, Inbred C57BL; Mice, Knockout; Neurons; Pruritus; Receptors, Atrial Natriuretic Factor; Reproducibility of Results; Signal Transduction; Small Molecule Libraries | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
Targeting increased levels of APP in Down syndrome: Posiphen-mediated reductions in APP and its products reverse endosomal phenotypes in the Ts65Dn mouse model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cholinesterase Inhibitors; Disease Models, Animal; Down Syndrome; Endosomes; Humans; Mice; Neurons; Phenotype; Phosphorylation; Physostigmine | 2021 |
Activation of cholinergic system partially rescues olfactory dysfunction-induced learning and memory deficit in mice.
Topics: Animals; Astringents; Choline O-Acetyltransferase; Cholinesterase Inhibitors; Disease Models, Animal; Hippocampus; Male; Memory Disorders; Memory, Long-Term; Memory, Short-Term; Mice; Olfaction Disorders; Olfactory Bulb; Physostigmine; Zinc Sulfate | 2021 |
N-acetylcysteine treatment attenuates the cognitive impairment and synaptic plasticity loss induced by streptozotocin.
Topics: Acetylcholinesterase; Acetylcysteine; Animals; Cerebral Cortex; Cognitive Dysfunction; Disease Models, Animal; Hippocampus; Immunohistochemistry; Male; Maze Learning; Mice; Motor Activity; Neuronal Plasticity; Neuroprotective Agents; Oxidative Stress; Physostigmine; Receptor, trkB; Streptozocin; Superoxide Dismutase | 2017 |
Critical role of CA1 muscarinic receptors on memory acquisition deficit induced by total (TSD) and REM sleep deprivation (RSD).
Topics: Animals; CA1 Region, Hippocampal; Cholinesterase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Memory; Memory Disorders; Motor Activity; Muscarinic Antagonists; Nootropic Agents; Physostigmine; Rats, Wistar; Receptors, Muscarinic; Scopolamine; Sleep Deprivation; Sleep, REM | 2017 |
Seizure susceptibility in the APP/PS1 mouse model of Alzheimer's disease and relationship with amyloid β plaques.
Topics: Alzheimer Disease; Animals; Benzylamines; Cerebral Cortex; Disease Models, Animal; Disease Susceptibility; Electrocorticography; Female; Male; Mice, Inbred C57BL; Mice, Transgenic; Pentylenetetrazole; Physostigmine; Plaque, Amyloid; Seizures | 2017 |
Enhanced cholinergic-tone during the stress induce a depressive-like state in mice.
Topics: Acetylcholinesterase; Anhedonia; Animals; Anxiety; Cholinesterase Inhibitors; Depressive Disorder; Disease Models, Animal; Dominance-Subordination; Helplessness, Learned; Hydrocortisone; Male; Mice, Inbred C57BL; Motor Activity; Physostigmine; Random Allocation; Stress, Psychological | 2018 |
(-)-Phenserine and the prevention of pre-programmed cell death and neuroinflammation in mild traumatic brain injury and Alzheimer's disease challenged mice.
Topics: Alzheimer Disease; Animals; Brain Concussion; Cell Death; Cerebral Cortex; Disease Models, Animal; Hippocampus; Mice; Mice, Transgenic; Neurons; Physostigmine | 2019 |
Oxygen toxicity is reduced by acetylcholinesterase inhibition in the developing rat brain.
Topics: Animals; Animals, Newborn; Blotting, Western; Brain; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Female; Hyperoxia; Immunohistochemistry; Indans; Male; Nerve Degeneration; Oxidative Stress; Oxygen; Physostigmine; Piperidines; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction | 2013 |
Age-dependent neuroplasticity mechanisms in Alzheimer Tg2576 mice following modulation of brain amyloid-β levels.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cell Proliferation; Disease Models, Animal; Doublecortin Protein; Female; Hippocampus; Interleukin-1beta; Male; Mice; Mice, Transgenic; Neuronal Plasticity; Neurons; Physostigmine; Plaque, Amyloid; Synapses; Tumor Necrosis Factor-alpha | 2013 |
The role of the cholinergic system in the signal attenuation rat model of obsessive-compulsive disorder.
Topics: Acetylcholine; Animals; Behavior, Animal; Compulsive Behavior; Conditioning, Operant; Disease Models, Animal; Dose-Response Relationship, Drug; Extinction, Psychological; Male; Mecamylamine; Nicotine; Obsessive-Compulsive Disorder; Oxotremorine; Physostigmine; Rats; Rats, Sprague-Dawley; Scopolamine | 2013 |
Physostigmine reverses disturbances of the intestinal microcirculation during experimental endotoxemia.
Topics: Animals; Cholinesterase Inhibitors; Disease Models, Animal; Endotoxemia; Male; Microcirculation; Physostigmine; Rats; Rats, Inbred Lew; Sepsis | 2014 |
Pharmacological cholinergic stimulation as a therapeutic tool in experimental necrotizing pancreatitis.
Topics: Animals; Cholinergic Agents; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Glycodeoxycholic Acid; HMGB1 Protein; Humans; Male; Neostigmine; Nicotine; Pancreas; Pancreatitis, Acute Necrotizing; Peroxidase; Physostigmine; Rats; Rats, Wistar | 2014 |
The role of ventral midline thalamus in cholinergic-based recovery in the amnestic rat.
Topics: Animal Feed; Animals; Cholinesterase Inhibitors; Disease Models, Animal; Functional Laterality; GABA-A Receptor Agonists; Hippocampus; Korsakoff Syndrome; Male; Maze Learning; Muscimol; Physostigmine; Prefrontal Cortex; Pyrithiamine; Random Allocation; Rats, Sprague-Dawley; Thiamine Deficiency; Ventral Thalamic Nuclei | 2015 |
An animal model of fetal alcohol spectrum disorder: Trace conditioning as a window to inform memory deficits and intervention tactics.
Topics: Adolescent; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Body Weight; Central Nervous System Depressants; Child; Choline; Conditioning, Classical; Disease Models, Animal; Ethanol; Fetal Alcohol Spectrum Disorders; Humans; Memory Disorders; Nootropic Agents; Physostigmine; Rats; Rats, Sprague-Dawley; Reaction Time | 2015 |
Attenuation of intestinal ischemic injury and shock by physostigmine.
Topics: Administration, Intravenous; Animals; Cholinesterase Inhibitors; Disease Models, Animal; Drug Evaluation, Preclinical; Intestine, Small; Male; Mesenteric Artery, Superior; Physostigmine; Rats, Wistar; Reperfusion Injury; Shock | 2015 |
Ventral tegmental area cholinergic mechanisms mediate behavioral responses in the forced swim test.
Topics: Acetylcholine; Animals; Cholinergic Antagonists; Cholinesterase Inhibitors; Depressive Disorder; Disease Models, Animal; Dose-Response Relationship, Drug; Locomotion; Male; Mecamylamine; Neuropsychological Tests; Nicotinic Antagonists; Physostigmine; Rats, Sprague-Dawley; Scopolamine; Swimming; Ventral Tegmental Area | 2015 |
Modeling bipolar disorder in mice by increasing acetylcholine or dopamine: chronic lithium treats most, but not all features.
Topics: Acetylcholine; Animals; Antimanic Agents; Behavior, Animal; Bipolar Disorder; Cholinesterase Inhibitors; Depression; Disease Models, Animal; Dopamine; Dopamine Uptake Inhibitors; Exploratory Behavior; Female; Hindlimb Suspension; Lithium Compounds; Male; Mice; Mice, Inbred C57BL; Physostigmine; Piperazines; Prepulse Inhibition; Sensory Gating; Swimming | 2015 |
Conscious voiding during bladder obstruction in guinea pigs correlates with contractile activity of isolated bladders.
Topics: Animals; Bethanechol; Cholinesterase Inhibitors; Consciousness; Disease Models, Animal; Dose-Response Relationship, Drug; Guinea Pigs; Male; Muscarinic Agonists; Muscle Contraction; Muscle, Smooth; Organ Size; Physostigmine; Urinary Bladder; Urinary Bladder Neck Obstruction; Urination | 2015 |
Neuroinflammation: effect of surgical stress compared to anaesthesia and effect of physostigmine.
Topics: Acetylcholine; Anesthesia; Animals; Cholinesterase Inhibitors; Cholinesterases; Corticosterone; Cytokines; Disease Models, Animal; Encephalitis; Liver; Male; Physostigmine; Postoperative Complications; Rats; Rats, Wistar; Statistics, Nonparametric; Stress, Psychological | 2016 |
Cognitive Impairments Induced by Concussive Mild Traumatic Brain Injury in Mouse Are Ameliorated by Treatment with Phenserine via Multiple Non-Cholinergic and Cholinergic Mechanisms.
Topics: Animals; Brain Concussion; Cholinergic Agents; Cholinesterase Inhibitors; Cognitive Dysfunction; Disease Models, Animal; Gene Expression Regulation; Glutamic Acid; Hippocampus; Humans; Lipid Peroxidation; Maze Learning; Mice; Neurons; Oxidative Stress; Physostigmine | 2016 |
Towards an animal model of an antipsychotic drug-resistant cognitive impairment in schizophrenia: scopolamine induces abnormally persistent latent inhibition, which can be reversed by cognitive enhancers but not by antipsychotic drugs.
Topics: Animals; Antipsychotic Agents; Attention; Cholinergic Antagonists; Clozapine; Cognition Disorders; Conditioning, Psychological; Disease Models, Animal; Dose-Response Relationship, Drug; Drinking Behavior; Glycine; Haloperidol; Inhibition, Psychological; Male; Physostigmine; Rats; Rats, Wistar; Schizophrenia; Scopolamine | 2009 |
Neuropathy-induced apoptosis: protective effect of physostigmine.
Topics: Acetylcholine; Animals; Apoptosis; Axons; Caspase 3; Cholinesterase Inhibitors; Cytochromes c; Cytoprotection; Disease Models, Animal; DNA Fragmentation; Energy Metabolism; Male; Mitochondria; Nerve Degeneration; Neuroprotective Agents; Peripheral Nervous System Diseases; Physostigmine; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Sciatic Neuropathy; Sensory Receptor Cells | 2009 |
The role of nicotinic receptors in the amelioration of cholinesterase inhibitors in scopolamine-induced memory deficits.
Topics: Animals; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Drug Interactions; Hippocampus; Indans; Learning Disabilities; Male; Maze Learning; Mecamylamine; Muscarinic Agonists; Nicotine; Nicotinic Antagonists; Physostigmine; Pilocarpine; Piperidines; Rats; Rats, Wistar; Receptors, Nicotinic; Scopolamine; Theta Rhythm | 2009 |
Cholinesterase inhibitors and stress: effects on brain muscarinic receptor density in mice.
Topics: Animals; Brain; Cholinesterase Inhibitors; Cholinesterases; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C57BL; Physostigmine; Protein Binding; Pyridostigmine Bromide; Receptors, Muscarinic; Stress, Psychological | 2010 |
Three phases of corporal tracing elicited by electrical field stimulation on rabbit corpus cavernosum smooth muscle in penile perfusion model.
Topics: Animals; Area Under Curve; Cholinesterase Inhibitors; Disease Models, Animal; Electric Stimulation; Isometric Contraction; Male; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Penile Erection; Penis; Physostigmine; Rabbits; Signal Transduction | 2011 |
Possible role of cholinesterase inhibitors on memory consolidation following hypobaric hypoxia of rats.
Topics: Acetylcholine; Air Pressure; Altitude Sickness; Animals; Cholinesterase Inhibitors; Disease Models, Animal; Galantamine; Hypoxia, Brain; Male; Maze Learning; Memory; Memory Disorders; Physostigmine; Rats; Rats, Sprague-Dawley; Time Factors; Treatment Outcome | 2011 |
Role of the hypocretin (orexin) receptor 2 (Hcrt-r2) in the regulation of hypocretin level and cataplexy.
Topics: Animals; Blood Pressure; Cataplexy; Cholinesterase Inhibitors; Disease Models, Animal; Dogs; Female; Gene Expression Regulation; Heart Rate; Hypnotics and Sedatives; Intracellular Signaling Peptides and Proteins; Male; Mutation; Neuropeptides; Orexin Receptors; Orexins; Phenylephrine; Physostigmine; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Respiration; Sympathomimetics; Thiopental | 2011 |
Cholinesterase inhibitors improve both memory and complex learning in aged beagle dogs.
Topics: Aging; Analysis of Variance; Animals; Behavior, Animal; Cholinergic Antagonists; Cholinesterase Inhibitors; Discrimination, Psychological; Disease Models, Animal; Dogs; Donepezil; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Indans; Learning Disabilities; Male; Memory Disorders; Neuropsychological Tests; Odorants; Physostigmine; Piperidines; Scopolamine | 2011 |
Electroacupuncture-induced cholinergic nerve activation enhances the hypoglycemic effect of exogenous insulin in a rat model of streptozotocin-induced diabetes.
Topics: Animals; Atropine; Blood Glucose; Cholinergic Agents; Cholinergic Fibers; Diabetes Mellitus, Experimental; Disease Models, Animal; Electroacupuncture; Fatty Acids, Nonesterified; Hemicholinium 3; Hypoglycemic Agents; Insulin; Male; Physostigmine; Rats; Rats, Wistar; Signal Transduction; Streptozocin | 2011 |
Lithium, phenserine, memantine and pioglitazone reverse memory deficit and restore phospho-GSK3β decreased in hippocampus in intracerebroventricular streptozotocin induced memory deficit model.
Topics: Animals; Conditioning, Classical; Disease Models, Animal; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Hippocampus; Hypoglycemic Agents; Infusions, Intraventricular; Lithium; Male; Memantine; Memory Disorders; Neuroprotective Agents; Physostigmine; Pioglitazone; Prefrontal Cortex; Rats; Rats, Wistar; Statistics, Nonparametric; Streptozocin; Thiazolidinediones | 2011 |
Endogenous ACh effects on NMDA-induced interictal-like discharges along the septotemporal hippocampal axis of adult rats and their modulation by an early life generalized seizure.
Topics: Acetylcholine; Analysis of Variance; Animals; Atropine; Cholinesterase Inhibitors; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Hippocampus; In Vitro Techniques; Male; Muscarinic Antagonists; N-Methylaspartate; Neurons; Pentylenetetrazole; Physostigmine; Rats; Rats, Sprague-Dawley; Seizures; Sex Factors; Valine | 2012 |
Remote brain network changes after unilateral cortical impact injury and their modulation by acetylcholinesterase inhibition.
Topics: Acetylcholinesterase; Animals; Autoradiography; Brain; Brain Injuries; Brain Mapping; Cholinesterase Inhibitors; Disease Models, Animal; Functional Laterality; Image Processing, Computer-Assisted; Male; Nerve Net; Physostigmine; Rats; Rats, Sprague-Dawley | 2013 |
Physostigmine does not effect arousal but produces toxicity in an animal model of severe gamma-hydroxybutyrate intoxication.
Topics: Animals; Arousal; Cholinesterase Inhibitors; Coma; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Overdose; Fasciculation; Heart Rate; Male; Physostigmine; Random Allocation; Rats; Rats, Sprague-Dawley; Reflex; Respiratory Mechanics; Seizures; Sodium Oxybate | 2005 |
Acetylcholinesterase inhibitors ameliorate behavioral deficits in the Tg2576 mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Behavior, Animal; Cholinesterase Inhibitors; Conditioning, Psychological; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Fear; Genetics, Behavioral; Heterozygote; Humans; Indans; Learning; Memory; Memory Disorders; Mice; Mice, Transgenic; Physostigmine; Piperidines; Plaque, Amyloid; Spatial Behavior | 2005 |
Development of next generation medical countermeasures to nerve agent poisoning.
Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Dipeptides; Disease Models, Animal; Drug Therapy, Combination; Guinea Pigs; Ileal Diseases; Intussusception; Lethal Dose 50; Male; Neurotoxicity Syndromes; Oximes; Physostigmine; Pyridinium Compounds; Scopolamine Derivatives; Soman; Time Factors | 2007 |
Cholinergic neuronal defect without cell loss in Huntington's disease.
Topics: Animals; Brain; Brain Chemistry; Case-Control Studies; Choline O-Acetyltransferase; Cholinergic Fibers; Disease Models, Animal; Humans; Huntingtin Protein; Huntington Disease; Male; Maze Learning; Membrane Transport Proteins; Memory; Mice; Mice, Transgenic; Motor Endplate; Muscular Atrophy; Nerve Tissue Proteins; Neurons; Nuclear Proteins; Physostigmine; Repressor Proteins; Transcription Factors; Vesicular Acetylcholine Transport Proteins | 2006 |
Age-related changes in memory and in acetylcholine functions in the hippocampus in the Ts65Dn mouse, a model of Down syndrome.
Topics: Acetylcholine; Age Factors; Animals; Cholinesterase Inhibitors; Disease Models, Animal; Down Syndrome; Hippocampus; Memory Disorders; Mice; Microdialysis; Physostigmine; Septum Pellucidum | 2008 |
A new treatment for hypoxic brain injury?
Topics: Acetylcholine; Acetylcholinesterase; Animals; Behavior, Animal; Brain; Cholinesterase Inhibitors; Cognition; Cognition Disorders; Disease Models, Animal; Exploratory Behavior; Humans; Hypoxia, Brain; Memory; Nootropic Agents; Physostigmine; Research Design; Severity of Illness Index; Time Factors | 2007 |
Physostigmine reverses cognitive dysfunction caused by moderate hypoxia in adult mice.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Behavior, Animal; Brain; Cholinesterase Inhibitors; Cognition; Cognition Disorders; Disease Models, Animal; Exploratory Behavior; Hypoxia, Brain; Male; Memory; Mice; Nootropic Agents; Physostigmine; Severity of Illness Index; Time Factors | 2007 |
Pharmacologic cholinesterase inhibition improves survival in experimental sepsis.
Topics: Animals; Cholinesterase Inhibitors; Cytokines; Disease Models, Animal; Female; Inflammation Mediators; Mice; Mice, Inbred C57BL; Neostigmine; NF-kappa B; Nicotine; Nicotinic Agonists; Physostigmine; Sepsis | 2008 |
Impaired muscarinic regulation of excitatory synaptic transmission in the APPswe/PS1dE9 mouse model of Alzheimer's disease.
Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Blotting, Western; Cholinesterase Inhibitors; Disease Models, Animal; Electric Stimulation; Electrophysiology; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Mice; Mice, Transgenic; Muscarinic Antagonists; Nicotinic Antagonists; Patch-Clamp Techniques; Physostigmine; Presenilin-1; Receptors, Muscarinic; Receptors, Nicotinic; Synaptic Transmission | 2008 |
[Antihypertensive effect of isoteolin in model hypertension].
Topics: Animals; Antihypertensive Agents; Aporphines; Blood Pressure; Cats; Clonidine; Disease Models, Animal; Drug Evaluation, Preclinical; Hypertension; Physostigmine; Rats; Rats, Inbred SHR | 1984 |
Mechanism of the antihypertensive action of clonidine on the pressor response to physostigmine.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Blood Pressure; Brain Chemistry; Clonidine; Dimethylphenylpiperazinium Iodide; Disease Models, Animal; Dose-Response Relationship, Drug; Hypothalamus; Male; Medulla Oblongata; Mesencephalon; Physostigmine; Pons; Rats | 1980 |
Development and use of pharmacological probes of the CNS in man: evidence of cholinergic abnormality in primary affective illness.
Topics: Acetylcholine; Arecoline; Central Nervous System; Choline; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Evoked Potentials; Humans; Memory; Mood Disorders; Pain; Physostigmine; Scopolamine; Sleep; Time Factors | 1980 |
Physostigmine has a life-saving effect in rats subjected to prolonged respiratory arrest.
Topics: Animals; Blood Pressure; Disease Models, Animal; Female; Heart Arrest; Heart Rate; Male; Parasympathomimetics; Physostigmine; Rats; Rats, Wistar; Time Factors | 1997 |
Neuronal activity in the cholinoceptive basal forebrain of freely moving narcoleptic dobermans.
Topics: Acetylcholine; Animals; Cholinergic Fibers; Cholinesterase Inhibitors; Disease Models, Animal; Dogs; Electric Stimulation; Electroencephalography; Electromyography; Electrooculography; Female; Locomotion; Male; Narcolepsy; Physostigmine; Prosencephalon; Sleep, REM; Wakefulness | 1998 |
Expression of nonspecific esterase (NSE) by thyroid follicular epithelium as a marker for the target organ susceptibility to immune system attack.
Topics: Age Factors; Animals; Biomarkers; Carboxylesterase; Carboxylic Ester Hydrolases; Chickens; Disease Models, Animal; Enzyme Inhibitors; Epithelial Cells; Hydroxymercuribenzoates; Immunohistochemistry; Macrophages; Physostigmine; Taurocholic Acid; Thyroid Gland; Thyroiditis, Autoimmune | 2000 |
Effect of muscarinic receptor agonists on animal models of psychosis.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Catalepsy; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Muscarinic Agonists; Physostigmine; Pilocarpine; Psychotic Disorders; Rats; Rats, Wistar; Stereotyped Behavior | 2000 |
The experimental Alzheimer drug phenserine: preclinical pharmacokinetics and pharmacodynamics.
Topics: Administration, Oral; Alzheimer Disease; Animals; Brain; Cholinesterase Inhibitors; Disease Models, Animal; Half-Life; Infusions, Intravenous; Male; Physostigmine; Rats; Rats, Inbred F344; Tacrine | 2000 |
Compensatory mechanisms enhance hippocampal acetylcholine release in transgenic mice expressing human acetylcholinesterase.
Topics: Acetylcholine; Acetylcholinesterase; Aging; Anesthetics, Inhalation; Animals; Choline; Cholinesterase Inhibitors; Cognition Disorders; Disease Models, Animal; Exploratory Behavior; Extracellular Space; Genes, Synthetic; Halothane; Hippocampus; Homeostasis; Humans; Inositol Phosphates; Mice; Mice, Transgenic; Microdialysis; Motor Activity; Nerve Tissue Proteins; Physostigmine; Promoter Regions, Genetic; Secretory Rate; Species Specificity; Synaptosomes; Transgenes | 2001 |
Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Bromocriptine; Diazepam; Disease Models, Animal; Dopamine Antagonists; Dose-Response Relationship, Drug; Fear; Fluvoxamine; Haloperidol; Indophenol; Male; Maze Learning; Mecamylamine; Mice; Mice, Inbred ICR; Moclobemide; Motor Activity; Nicotine; Nicotinic Antagonists; Nortriptyline; Physostigmine; Picolinic Acids; Pyrrolidinones; Serotonin Antagonists; Serotonin Receptor Agonists; Social Behavior; Stress, Psychological | 2001 |
Experimental models of oculomotor dysfunction in the rhesus monkey.
Topics: Adrenergic alpha-Antagonists; Animals; Corpus Callosum; Disease Models, Animal; Eye Diseases; Eye Movements; Eyelids; Ganglia, Autonomic; Guanethidine; Hyperthyroidism; Macaca mulatta; Movement Disorders; Nystagmus, Pathologic; Oculomotor Nerve; Ophthalmoplegia; Physostigmine; Pons; Pupil | 1975 |
Acute dystonia as an idiosyncratic response to neuroleptics in baboons.
Topics: 5-Hydroxytryptophan; Acute Disease; Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Haloperidol; Haplorhini; Humans; Levodopa; Movement Disorders; Papio; Parasympatholytics; Physostigmine; Pimozide; Receptors, Dopamine; Reserpine; Syndrome; Tranquilizing Agents | 1977 |
Effects of diethylcholine in two animal models of Parkinsonism tremors.
Topics: Animals; Brain Chemistry; Carbachol; Choline; Disease Models, Animal; Male; Mice; Parkinson Disease, Secondary; Physostigmine; Rats; Trihexyphenidyl | 1979 |
A comparison of immunologic asthma to two types of cholinergic respiratory responses in the rhesus monkey.
Topics: Acetylcholine; Aerosols; Airway Resistance; Animals; Antigens; Ascaris; Asthma; Atropine; Carbachol; Cholinergic Fibers; Disease Models, Animal; Female; Haplorhini; Lidocaine; Macaca mulatta; Male; Peak Expiratory Flow Rate; Physostigmine; Respiration; Vagus Nerve | 1976 |
The effect of cholinergic agents on a canine model of allergic asthma.
Topics: Administration, Intranasal; Airway Resistance; Animals; Antigens; Ascaris; Asthma; Atropine; Chlorisondamine; Disease Models, Animal; Dogs; Histamine; Lung Compliance; Male; Parasympathomimetics; Physostigmine | 1976 |
Changes in the arterial blood pressure responses of hypertensive rats to some drugs acting on the central sympathetic mechanisms.
Topics: Adrenal Glands; Animals; Blood Pressure; Clonidine; Disease Models, Animal; Hypertension; Male; Physostigmine; Rats | 1975 |
Studies of the hyperkinetic syndrome -- Part I. An experimental analysis.
Topics: Amphetamine; Animals; Carbachol; Disease Models, Animal; Female; Humans; Hyperkinesis; Locomotion; Physostigmine; Rats; Syndrome | 1975 |
Effect of FR121196, a novel cognitive enhancer, on the memory impairment of rats in passive avoidance and radial arm maze tasks.
Topics: Aging; Animals; Avoidance Learning; Brain; Choline O-Acetyltransferase; Cognition Disorders; Dementia; Discrimination Learning; Disease Models, Animal; Male; Memory Disorders; Methamphetamine; Motor Activity; Physostigmine; Piperazines; Rats; Rats, Inbred F344; Rats, Wistar; Scopolamine; Sulfonamides | 1992 |
A model for carbamate and organophosphate-induced emesis in humans.
Topics: Adolescent; Adult; Animals; Atropine; Behavior, Animal; Callitrichinae; Carbamates; Cholinesterases; Disease Models, Animal; Erythrocytes; Female; Humans; Male; Organophosphorus Compounds; Physostigmine; Species Specificity; Vomiting | 1991 |
Pharmacological alleviation of combined cholinergic/noradrenergic lesion-induced memory deficits in rats.
Topics: Alzheimer Disease; Animals; Avoidance Learning; Benzylamines; Cholinergic Agents; Cholinergic Fibers; Clonidine; Disease Models, Animal; Male; Memory; Organic Chemicals; Oxotremorine; Parasympathomimetics; Physostigmine; Rats; Rats, Inbred Strains; Substantia Innominata | 1991 |
[Cholinesterase inhibitor].
Topics: Acetylcholine; Alzheimer Disease; Animals; Brain; Cholinesterase Inhibitors; Disease Models, Animal; Humans; Learning Disabilities; Memory; Neurons; Physostigmine; Scopolamine; Tacrine | 1991 |
Implications of multiple transmitter system lesions for cholinomimetic therapy in Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Avoidance Learning; Cerebral Cortex; Choline O-Acetyltransferase; Corticotropin-Releasing Hormone; Cysteamine; Disease Models, Animal; Dopamine; Hydroxydopamines; Ibotenic Acid; Male; Norepinephrine; Oxidopamine; Physostigmine; Rats; Rats, Inbred Strains; Reference Values; Serotonin; Somatostatin | 1990 |
Intracerebroventricular injection of hemicholinium-3 prevents the ACTH-induced, but not the physostigmine-induced, reversal of hemorrhagic shock in rats.
Topics: Adrenocorticotropic Hormone; Animals; Blood Pressure; Disease Models, Animal; Female; Heart Rate; Hemicholinium 3; Injections, Intravenous; Injections, Intraventricular; Male; Physostigmine; Rats; Rats, Inbred Strains; Respiration; Shock, Hemorrhagic | 1990 |
Spontaneous orofacial dyskinesias in a captive cynomolgus monkey: implications for tardive dyskinesia.
Topics: Animals; Benzazepines; Disease Models, Animal; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Facial Expression; Facial Muscles; Haloperidol; Macaca fascicularis; Mastication; Movement Disorders; Physostigmine; Scopolamine; Stereotyped Behavior | 1990 |
Scopolamine and benzodiazepine models of dementia: cross-reversals by Ro 15-1788 and physostigmine.
Topics: Acoustic Stimulation; Adult; Anti-Anxiety Agents; Attention; Cognition Disorders; Dementia; Disease Models, Animal; Female; Flumazenil; Humans; Male; Memory Disorders; Photic Stimulation; Physostigmine; Psychomotor Performance; Pupil; Reaction Time; Scopolamine | 1989 |
Animal models of Alzheimer's disease: behavior, pharmacology, transplants.
Topics: 4-Aminopyridine; Alzheimer Disease; Aminopyridines; Animals; Behavior, Animal; Brain; Disease Models, Animal; Fetus; Growth Substances; Humans; Nerve Growth Factors; Nerve Tissue; Nerve Tissue Proteins; Nervous System Diseases; Norepinephrine; Parasympathetic Nervous System; Physostigmine; Somatostatin | 1986 |
[The influences of neurotransmitters on the traumatic unconsciousness, immediate convulsion and mortality in the experimental mice model].
Topics: Animals; Atropine; Craniocerebral Trauma; Disease Models, Animal; Haloperidol; Male; Methamphetamine; Mice; Neurotransmitter Agents; Physostigmine; Scopolamine; Seizures; Unconsciousness | 1987 |
Supersensitive endocrine response to physostigmine in dopamine-depleted rats: a model of depression?
Topics: Adrenocorticotropic Hormone; Animals; Brain Chemistry; Depressive Disorder; Disease Models, Animal; Dopamine; Humans; Hydroxydopamines; Male; Norepinephrine; Oxidopamine; Physostigmine; Prolactin; Rats; Rats, Inbred Strains | 1986 |
Effects of intracerebroventricular injection of AF64A on learning behaviors in rats.
Topics: Alzheimer Disease; Amnesia; Animals; Avoidance Learning; Aziridines; Azirines; Choline; Choline O-Acetyltransferase; Disease Models, Animal; Hippocampus; Injections, Intraventricular; Learning; Male; Physostigmine; Rats; Rats, Inbred Strains | 1988 |
Perioral behaviors induced by cholinesterase inhibitors: a controversial animal model.
Topics: Animals; Behavior, Animal; Cholinesterase Inhibitors; Disease Models, Animal; Dopamine Antagonists; Dyskinesia, Drug-Induced; Female; Phenylmethylsulfonyl Fluoride; Physostigmine; Rats; Rats, Inbred Strains; Stereotyped Behavior; Sulfones | 1986 |
Effects of diphenylhydantoin and cholinergic agents on the neuronally isolated cerebral cortex.
Topics: Animals; Atropine; Cats; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Ethosuximide; Parasympathomimetics; Phenytoin; Physostigmine; Pilocarpine; Scopolamine; Seizures; Synaptic Transmission; Trimethadione | 1971 |
[Experimental asthma in guinea pigs and autonomic mediators].
Topics: Animals; Asthma; Atropine; Autonomic Agents; Cyclic AMP; Disease Models, Animal; Guinea Pigs; Hexamethonium Compounds; Histamine; Lung Compliance; Methacholine Compounds; Muscle Tonus; Muscle, Smooth; Physostigmine; Propranolol; Receptors, Drug; Respiratory System; Theophylline; Vagus Nerve | 1972 |
Brain-stem and cortical mechanisms in an animal model of generalized corticoreticular epilepsy.
Topics: Amobarbital; Animals; Arousal; Brain Stem; Cats; Cerebral Cortex; Cortical Synchronization; Disease Models, Animal; Electroencephalography; Epilepsy; Mesencephalon; Pentylenetetrazole; Physostigmine; Reticular Formation; Thalamus | 1973 |
Analysis of local cholinergic tremor mechanisms following selective neurochemical lesions.
Topics: Acetylcholine; Animals; Basal Ganglia; Brain; Carbachol; Cats; Cholinesterase Inhibitors; Disease Models, Animal; Dopamine; Drug Antagonism; Drug Synergism; Epinephrine; Hemicholinium 3; Isoflurophate; Ketones; Male; Oximes; Pentobarbital; Physostigmine; Pralidoxime Compounds; Receptors, Drug; Scopolamine; Tremor | 1970 |
Experimental myopia in rabbits.
Topics: Animals; Atropine; Body Temperature; Disease Models, Animal; Epinephrine; Eye; Female; Intraocular Pressure; Myopia; Physostigmine; Pilocarpine; Rabbits; Refraction, Ocular | 1970 |