Page last updated: 2024-08-17

physostigmine and Aging

physostigmine has been researched along with Aging in 82 studies

Research

Studies (82)

Timeframe	Studies, this research(%)	All Research%
pre-1990	32 (39.02)	18.7374
1990's	33 (40.24)	18.2507
2000's	11 (13.41)	29.6817
2010's	6 (7.32)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Mellios, G	1
Furey, ML; Pietrini, P; Rapoport, SI; Ricciardi, E; Schapiro, MB	1
Chanoine, JP; Ni, H; Walia, P	1
Hisatsune, T; Itou, Y; Kuribayashi, H; Nochi, R; Saito, Y	1
Heintz, N; Hensch, TK; Miwa, JM; Morishita, H	1
Araujo, JA; de Rivera, C; Greig, NH; Ingram, DK; Milgram, NW; Sandin, J	1
Escabí, MA; Hinman, JR; Howe, MD; Jacobson, TK; Markus, EJ; Schmidt, B	1
ROZANOVA, VD	1
Ewers, M; Shiotani, T; Tanaka, M; Watabe, S; Wenk, GL; Woodruff-Pak, DS	1
Araujo, JA; Milgram, NW; Studzinski, CM	1
Czambel, RK; Miller, TH; Rhodes, ME; Rubin, RT	1
Birthelmer, A; Cassel, JC; Jackisch, R; Lazaris, A	1
Drake, MJ; Gillespie, J; Harvey, I; Kirkwood, T; Lagou, M	1
Akaike, A; Goto, Y; Hongo, H; Kihara, T; Niidome, T; Sugimoto, H	1
Bartolini, A; Giotti, A	1
Maggi, CA; Meli, A; Santicioli, P	1
Gershon, S; Goodnick, P	1
Vlk, J	2
Barclay, L; Blass, J; Gibson, G	1
Davis, KL; Levy, MI; Mohs, RC; Rosen, WG	1
Bland, BH; Creery, BL	1
Drachman, DA; Sahakian, BJ	1
Bassant, MH; Jazat-Poindessous, F; Lamour, Y	1
Brossi, A; Greig, NH; Ikari, H; Ingram, DK; Patel, N; Pei, XF; Spangler, EL; Speer, D	1
Fitten, LJ; Halgren, E; O'Neill, J; Perryman, KM	1
Lacombe, P; MacKenzie, ET; Sercombe, R; Seylaz, J; Springhetti, V	1
Dobie, DJ; Dorsa, DM; Murray, S; Pascualy, M; Peskind, ER; Raskind, MA; Sikkema, C; Thal, LJ; Veith, RC; Wingerson, D	1
Minamoto, Y; Ono, M; Shibata, S; Watanabe, S	1
Arrigoni, J; Ciaranello, RD; Dement, WC; Edgar, DM; Mignot, E; Nishino, S; Reid, MS; Sharp, LH; Siegel, JM	1
Glasky, AJ; Heydari, N; Melchior, CL; Pirzadeh, B; Ritzmann, RF	1
Cella, SG; Imbimbo, BP; Müller, EE; Pieretti, F	1
Kodama, K; Koga, Y; Shibata, S; Ueki, S; Watanabe, S	1
Glasky, AJ; Kling, A; Melchior, CL; Ritzmann, RF	1
Jäkälä, P; Riekkinen, P	1
Acs, Z; Barna, I; Koenig, JI; Makara, GB	1
Büyükuysal, RL; Kiran, BK; Ulus, IH	1
Garrone, B; Landolfi, C; Luparini, MR; Magnani, M; Milanese, C; Tolu, L	1
Disterhoft, JF; Moriearty, PL; Oh, MM; Power, JM; Thompson, LT	1
Cassel, JC; Kelche, C; Stemmelin, J; Will, B	1
Bahro, M; Conway, A; Dukoff, R; Friz, J; Lasser, R; Peskind, ER; Sunderland, T; Wilkinson, CW	1
Capretti, L; Cataldo, S; Chiodera, P; Coiro, V; Pilla, S; Volpi, R	1
Kurasawa, M; Nakamura, K; Tanaka, Y	1
Braida, D; Ottonello, F; Sala, M	1
Erb, C; Klein, J; Kopf, S; Löffelholz, K; Schmitt, U; Soreq, H; Troost, J	1
Abdel-Latif, AA	1
Mizukami, H; Vanker, AD	1
Bland, BH; Leblanc, MO	1
Bartus, RT	1
Davis, KL; Yamamura, HI	1
Artusio, JF; Okamoto, M; Riker, WF; Walewski, JL	1
Maeda, N; Matsuoka, N; Ohkubo, Y; Yamaguchi, I; Yamazaki, M	1
Holmgren, B; Leon, BA; Ugarte, A; Urbá-Holmgren, R	1
Ignar, DM; Kuhn, CM; Windh, RT	1
Kulkarni, SK; Sharma, AC	1
Bresnahan, EL; Ingram, DK; Muth, NJ; Wiser, PR	1
Feuerstein, TJ; Jackisch, R; Lehmann, J; Sauermann, W; van Velthoven, V	1
Machida, N	1
Allen, R; Boublik, J; Brown, MR; Hauger, RL; Rivier, J; Scott, N	1
Matsumoto, K; Ni, XH; Ohta, H; Watanabe, H	1
Leff, AR; Mitchell, RW; Murphy, TM; Phillips, IJ	1
Dorsa, DM; Federighi, D; Peskind, ER; Raskind, MA; Veith, RC; Wilkinson, CW	1
Dunnett, SB; Martel, FL	1
Forster, MJ; Lal, H	1
Kelly, E; Leff, AR; Mitchell, RW; Murphy, TM	1
Nahorski, SR; Rooney, TA	1
Esbenshade, TA; Gerald, MC; Kolta, MG; Ordway, GA; Wallace, LJ	1
Dunnett, SB; Evenden, JL; Iversen, SD	1
Lu, WH; Shou, J; Tang, XC	1
Kishimoto, O	1
Forster, MJ; Frantz, N; Lal, H; Retz, KC	1
Björklund, A; Gage, FH	1
Stead, A; Whitcomb, ER	1
Kanungo, MS; Moudgil, VK	1
Drachman, DA; Leavitt, J	1
Löffelholz, K; Pappano, AJ	1
Schlesinger, K; Uphouse, LL	1
Marley, E; Seller, TJ	1
Fong, KT; McFarlane, JE	1
Dawson, RG; Egger, GJ; Livesey, PJ	1
Brownson, RH; Vijayan, VK	1
Fleisher, JH; Harris, LW	1

Reviews

5 review(s) available for physostigmine and Aging

Article	Year
Further evidence for the cholinergic hypothesis of aging and dementia from the canine model of aging. Progress in neuro-psychopharmacology & biological psychiatry, 2005, Volume: 29, Issue:3 Topics: Acetylcholine; Aging; Animals; Cognition Disorders; Dementia; Disease Models, Animal; Dogs; Humans; Physostigmine; Scopolamine	2005
Chemotherapy of cognitive disorders in geriatric subjects. The Journal of clinical psychiatry, 1984, Volume: 45, Issue:5 Topics: Adrenocorticotropic Hormone; Aged; Aging; Alzheimer Disease; Arecoline; Brain Chemistry; Choline; Cognition Disorders; Cyclandelate; Electroencephalography; Humans; Memory; Methylphenidate; Pentylenetetrazole; Phosphatidylcholines; Physostigmine; Piracetam; Procaine; Vasodilator Agents; Vasopressins	1984
The role of the cholinergic system in thiamin deficiency. Annals of the New York Academy of Sciences, 1982, Volume: 378 Topics: Acetyl Coenzyme A; Acetylcholine; Aging; Animals; Arecoline; Atropine; Behavior, Animal; Brain; Diet; Electrophysiology; Ganglia, Sympathetic; Humans; Male; Oxythiamine; Parasympathetic Nervous System; Physostigmine; Pyrithiamine; Pyruvates; Pyruvic Acid; Rats; Synapses; Thiamine Deficiency; Tissue Distribution	1982
Cholinergic underactivity in human memory disorders. Life sciences, 1978, Oct-30, Volume: 23, Issue:17-18 Topics: Aging; Brain Chemistry; Dementia; Humans; Memory Disorders; Parasympathetic Nervous System; Physostigmine; Receptors, Muscarinic	1978
Pyridoxine dependency and central nervous system excitability. Advances in biochemical psychopharmacology, 1972, Volume: 4 Topics: Acoustic Stimulation; Aging; Aminobutyrates; Animals; Brain Chemistry; Drug Interactions; Electric Stimulation; Genotype; Mice; Mice, Inbred Strains; Norepinephrine; Pentylenetetrazole; Phenylalanine; Phenylalanine Hydroxylase; Physostigmine; Pyridoxine; Reserpine; Seizures; Serotonin; Tetrabenazine; Thiosemicarbazones	1972

Other Studies

77 other study(ies) available for physostigmine and Aging

Article	Year
Donepezil: It is time to replace physostigmine in Anesthesiology. Medical hypotheses, 2016, Volume: 94 Topics: Aging; Anesthesia, General; Anesthesiology; Anesthetics; Brain; Cholinergic Neurons; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Humans; Indans; Infusions, Intravenous; Learning; Memory; Physostigmine; Piperidines; Postoperative Period; Quality of Life; Time Factors	2016
Cholinergic modulation of visual working memory during aging: a parametric PET study. Brain research bulletin, 2009, Jun-30, Volume: 79, Issue:5 Topics: Acetylcholine; Adult; Aged; Aging; Analysis of Variance; Brain; Brain Mapping; Cerebrovascular Circulation; Cholinesterase Inhibitors; Female; Humans; Linear Models; Male; Memory, Short-Term; Pattern Recognition, Visual; Photic Stimulation; Physostigmine; Positron-Emission Tomography; Reaction Time	2009
Ontogeny of acylated ghrelin degradation in the rat. Peptides, 2010, Volume: 31, Issue:2 Topics: Acetylation; Aging; Animals; Animals, Newborn; Butyrylcholinesterase; Carboxylesterase; Cholinesterase Inhibitors; Female; Fetus; Ghrelin; Injections, Intraperitoneal; Male; Nitrophenols; Physostigmine; Pregnancy; Rats; Rats, Sprague-Dawley; Serine Proteinase Inhibitors; Serum; Sex Characteristics; Sulfones	2010
Cholinergic activation of hippocampal neural stem cells in aged dentate gyrus. Hippocampus, 2011, Volume: 21, Issue:4 Topics: Acetylcholine; Aging; Animals; Cell Proliferation; Cholinesterase Inhibitors; Dentate Gyrus; Donepezil; Humans; Indans; Mice; Mice, Transgenic; Microscopy, Confocal; Muscarinic Agonists; Neural Stem Cells; Neurogenesis; Neurons; Nootropic Agents; Physostigmine; Piperidines; Receptors, Muscarinic	2011
Lynx1, a cholinergic brake, limits plasticity in adult visual cortex. Science (New York, N.Y.), 2010, Nov-26, Volume: 330, Issue:6008 Topics: Adaptor Proteins, Signal Transducing; Aging; Amblyopia; Animals; Cholinesterase Inhibitors; Dominance, Ocular; Evoked Potentials, Visual; Mecamylamine; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Neural Inhibition; Neuronal Plasticity; Neuropeptides; Nicotinic Antagonists; Physostigmine; Receptors, Nicotinic; Sensory Deprivation; Signal Transduction; Vision, Ocular; Visual Cortex; Visual Pathways	2010
Cholinesterase inhibitors improve both memory and complex learning in aged beagle dogs. Journal of Alzheimer's disease : JAD, 2011, Volume: 26, Issue:1 Topics: Aging; Analysis of Variance; Animals; Behavior, Animal; Cholinergic Antagonists; Cholinesterase Inhibitors; Discrimination, Psychological; Disease Models, Animal; Dogs; Donepezil; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Indans; Learning Disabilities; Male; Memory Disorders; Neuropsychological Tests; Odorants; Physostigmine; Piperidines; Scopolamine	2011
Hippocampal theta, gamma, and theta-gamma coupling: effects of aging, environmental change, and cholinergic activation. Journal of neurophysiology, 2013, Volume: 109, Issue:7 Topics: Aging; Animals; Brain Waves; Cholinesterase Inhibitors; Exploratory Behavior; Hippocampus; Male; Maze Learning; Physostigmine; Rats; Rats, Inbred F344; Theta Rhythm	2013
[ON THE ANALYSIS OF THE ROLE AND NATURE OF CHOLINERGIC AND ADRENERGIC SUBSTANCES OF THE RETICULAR FORMATION IN DOGS OF VARIOUS AGES]. Trudy - Institut normal'noi i patologicheskoi fiziologii, 1964, Volume: 117 Topics: Acetylcholine; Adrenergic Agents; Aging; Animals; Atropine; Brain; Cerebral Cortex; Chlorpromazine; Cholinergic Agents; Dogs; Electrophysiology; Epinephrine; Norepinephrine; Physostigmine; Research; Reticular Formation	1964
Nefiracetam and physostigmine: separate and combined effects on learning in older rabbits. Neurobiology of aging, 2004, Volume: 25, Issue:6 Topics: Acetylcholinesterase; Aging; Analysis of Variance; Animals; Brain; Brain Chemistry; Cholinesterase Inhibitors; Conditioning, Psychological; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Female; Learning; Neuroprotective Agents; Physostigmine; Pyrrolidinones; Rabbits	2004
Growth hormone responses to low-dose physostigmine in elderly vs. young women and men. Gerontology, 2006, Volume: 52, Issue:2 Topics: Adolescent; Adult; Age Factors; Aged; Aging; Case-Control Studies; Cholinesterase Inhibitors; Female; Growth Hormone; Humans; Hypothalamo-Hypophyseal System; Male; Middle Aged; Physostigmine; Pituitary-Adrenal System; Sex Characteristics	2006
Spatial reference- (not working- or procedural-) memory performance of aged rats in the water maze predicts the magnitude of sulpiride-induced facilitation of acetylcholine release by striatal slices. Neurobiology of aging, 2007, Volume: 28, Issue:8 Topics: Acetylcholine; Age Factors; Aging; Animals; Behavior, Animal; Cholinesterase Inhibitors; Corpus Striatum; Dopamine Agonists; Dopamine Antagonists; Dopamine Uptake Inhibitors; Electric Stimulation; Female; In Vitro Techniques; Maze Learning; Memory; Muscarinic Agonists; Nomifensine; Oxotremorine; Physostigmine; Quinpirole; Rats; Rats, Long-Evans; Sulpiride	2007
Muscarinic stimulation of the mouse isolated whole bladder: physiological responses in young and ageing mice. Autonomic & autacoid pharmacology, 2006, Volume: 26, Issue:3 Topics: Age Factors; Aging; Animals; Arecoline; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Mice; Mice, Inbred C57BL; Muscarinic Agonists; Muscle Contraction; Muscle, Smooth; Physostigmine; Receptors, Muscarinic; Urinary Bladder; Urination Disorders	2006
Impaired muscarinic regulation of excitatory synaptic transmission in the APPswe/PS1dE9 mouse model of Alzheimer's disease. European journal of pharmacology, 2008, Mar-31, Volume: 583, Issue:1 Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Blotting, Western; Cholinesterase Inhibitors; Disease Models, Animal; Electric Stimulation; Electrophysiology; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Mice; Mice, Transgenic; Muscarinic Antagonists; Nicotinic Antagonists; Patch-Clamp Techniques; Physostigmine; Presenilin-1; Receptors, Muscarinic; Receptors, Nicotinic; Synaptic Transmission	2008
[Influence of age on the content and liberation of acetylcholine in the atria of guinea pigs]. Bollettino della Societa italiana di biologia sperimentale, 1967, Sep-15, Volume: 43, Issue:17 Topics: Acetylcholine; Aging; Animals; Guinea Pigs; Heart Atria; Heart Rate; Myocardium; Physostigmine	1967
Postnatal development of myogenic contractile activity and excitatory innervation of rat urinary bladder. The American journal of physiology, 1984, Volume: 247, Issue:6 Pt 2 Topics: Aging; Animals; Animals, Newborn; Atropine; Drug Resistance; Electric Stimulation; Hemicholinium 3; Hexamethonium; Hexamethonium Compounds; Muscle Contraction; Physostigmine; Quaternary Ammonium Compounds; Rats; Tetrodotoxin; Urinary Bladder	1984
Cholinesterases and postnatal development of the negative chronotropic effects of acetylcholine in albino rats. Physiologia Bohemoslovaca, 1981, Volume: 30, Issue:6 Topics: Acetylcholine; Aging; Animals; Cholinesterases; Depression, Chemical; Female; Male; Myocardial Contraction; Myocardium; Physostigmine; Rats	1981
Research subject recruitment for gerontological studies of pharmacological agents. Neurobiology of aging, 1982,Spring, Volume: 3, Issue:1 Topics: Aged; Aging; Alzheimer Disease; Clinical Trials as Topic; Female; Humans; Male; Memory Disorders; Middle Aged; Physostigmine	1982
Ontogeny of fascia dentata electrical activity and motor behavior in the Dutch belted rabbit (Oryctolagus cuniculus). Experimental neurology, 1980, Volume: 67, Issue:3 Topics: Aging; Animals; Animals, Newborn; Atropine; Evoked Potentials; Grooming; Hippocampus; Motor Activity; Motor Skills; Physostigmine; Rabbits; Sleep, REM; Theta Rhythm	1980
Memory and cognitive function in the elderly. A preliminary trial of physostigmine. Archives of neurology, 1980, Volume: 37, Issue:10 Topics: Aged; Aging; Cognition; Dementia; Humans; Memory; Middle Aged; Physostigmine; Wechsler Scales	1980
Metabolic response to tacrine (THA) and physostigmine in the aged rat brain. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1995, Volume: 15, Issue:6 Topics: Aging; Animals; Autoradiography; Brain; Carbon Radioisotopes; Cholinesterase Inhibitors; Deoxyglucose; Glucose; Male; Physostigmine; Rats; Rats, Sprague-Dawley; Tacrine	1995
Maze learning in aged rats is enhanced by phenserine, a novel anticholinesterase. Neuroreport, 1995, Feb-15, Volume: 6, Issue:3 Topics: Aging; Animals; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Male; Maze Learning; Memory; Physostigmine; Rats; Rats, Inbred F344	1995
Influence of cholinesterase inhibitors on cortical slow-wave activity in aging nonhuman primate. Pharmacology, biochemistry, and behavior, 1994, Volume: 49, Issue:1 Topics: Aging; Amodiaquine; Animals; Cerebral Cortex; Cholinesterase Inhibitors; Electrodes; Electroencephalography; Female; Macaca radiata; Physostigmine; Scopolamine; Tacrine	1994
Basal forebrain control of cortical blood flow and tissue gases in conscious aged rats. Brain research, 1994, Oct-31, Volume: 662, Issue:1-2 Topics: Aging; Animals; Blood Gas Analysis; Blood Pressure; Carbon Dioxide; Cerebral Cortex; Cerebrovascular Circulation; Electric Stimulation; Gases; Male; Oxygen Consumption; Physostigmine; Prosencephalon; Rats; Rats, Inbred F344; Substantia Innominata	1994
Enhanced hypothalamic-pituitary-adrenocortical axis responses to physostigmine in normal aging. The journals of gerontology. Series A, Biological sciences and medical sciences, 1995, Volume: 50, Issue:2 Topics: Adrenocorticotropic Hormone; Adult; Aged; Aging; beta-Endorphin; Blood Pressure; Female; Heart Rate; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Male; Nausea; Physostigmine; Pituitary-Adrenal System; Sex Factors; Vomiting	1995
Attenuating effect of arecoline and physostigmine on an impairment of mealtime-associated activity rhythm in old rats. Physiology & behavior, 1995, Volume: 57, Issue:1 Topics: Activity Cycles; Aging; Animals; Arecoline; Feeding Behavior; Male; Memory; Models, Biological; Motor Activity; Physostigmine; Rats; Rats, Wistar; Time Perception	1995
Heterozygosity at the canarc-1 locus can confer susceptibility for narcolepsy: induction of cataplexy in heterozygous asymptomatic dogs after administration of a combination of drugs acting on monoaminergic and cholinergic systems. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1993, Volume: 13, Issue:3 Topics: Aging; Animals; Azepines; Biogenic Amines; Brain; Cataplexy; Chromosome Mapping; Crosses, Genetic; Dog Diseases; Dogs; Dopamine Agents; Ergolines; Female; Genes, Recessive; Genetic Predisposition to Disease; Heterozygote; Humans; Male; Narcolepsy; Parasympathomimetics; Pedigree; Physostigmine; Prazosin; Quinpirole; Sleep	1993
Effect of AIT-082, a purine analog, on working memory in normal and aged mice. Pharmacology, biochemistry, and behavior, 1994, Volume: 47, Issue:2 Topics: Aging; Aminobenzoates; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Hypoxanthines; Male; Memory, Short-Term; Mice; Physostigmine; Psychotropic Drugs; Purines; Tacrine	1994
Eptastigmine augments basal and GHRH-stimulated growth hormone release in young and old dogs. Life sciences, 1993, Volume: 53, Issue:5 Topics: Aging; Animals; Cholinesterase Inhibitors; Cholinesterases; Dogs; Dose-Response Relationship, Drug; Female; Growth Hormone; Male; Physostigmine	1993
Improving effect of acetylcholine receptor agonists on a deficit of 2-deoxyglucose uptake in cerebral cortical and hippocampal slices in aged and AF64A-treated rats. Brain research, 1993, Feb-19, Volume: 603, Issue:2 Topics: Acetylcholine; Aging; Animals; Aziridines; Cerebral Cortex; Cerebral Ventricles; Choline; Deoxyglucose; Hippocampus; In Vitro Techniques; Injections, Intraventricular; Male; Neuromuscular Blocking Agents; Nicotine; Oxotremorine; Parasympathomimetics; Physostigmine; Rats; Rats, Wistar; Receptors, Cholinergic; Scopolamine	1993
Effect of age and strain on working memory in mice as measured by win-shift paradigm. Pharmacology, biochemistry, and behavior, 1993, Volume: 44, Issue:4 Topics: Aging; Animals; Male; Memory, Short-Term; Mice; Mice, Inbred C57BL; Models, Psychological; Physostigmine; Species Specificity; Tacrine	1993
Combined cholinergic and 5-HT2 receptor activation suppresses thalamocortical oscillations in aged rats. Pharmacology, biochemistry, and behavior, 1997, Volume: 56, Issue:4 Topics: Aging; Amphetamines; Animals; Cerebral Cortex; Cholinesterase Inhibitors; Drug Synergism; Electroencephalography; Ketanserin; Male; Physostigmine; Rats; Rats, Wistar; Reaction Time; Receptors, Cholinergic; Receptors, Serotonin; Tacrine; Thalamus	1997
Age-dependent muscarinic stimulation of beta-endorphin secretion from rat neurointermediate lobe in vitro. Brain research bulletin, 1997, Volume: 44, Issue:6 Topics: Acetylcholine; Aging; Animals; Animals, Newborn; beta-Endorphin; Female; In Vitro Techniques; Male; Muscarinic Agonists; Muscarinic Antagonists; Physostigmine; Pituitary Gland; Rats; Rats, Wistar	1997
Age-related alterations in pre-synaptic and receptor-mediated cholinergic functions in rat brain. Neurochemical research, 1998, Volume: 23, Issue:5 Topics: Acetylcholine; Aging; Animals; Brain; Carbachol; Cerebral Cortex; Corpus Striatum; Hippocampus; In Vitro Techniques; Kinetics; Male; Membrane Lipids; Muscarinic Antagonists; Organ Specificity; Phosphatidylinositols; Phospholipids; Physostigmine; Quinuclidinyl Benzilate; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Synapses	1998
Effect of the subchronic treatment with the acetylcholinesterase inhibitor heptastigmine on central cholinergic transmission and memory impairment in aged rats. Neuroscience letters, 1998, Mar-27, Volume: 245, Issue:1 Topics: Acetylcholinesterase; Aging; Animals; Behavior, Animal; Brain; Cholinesterase Inhibitors; Cognition; Male; Memory Disorders; Parasympathetic Nervous System; Physostigmine; Rats; Rats, Wistar; Space Perception; Synaptic Transmission	1998
Metrifonate increases neuronal excitability in CA1 pyramidal neurons from both young and aging rabbit hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999, Mar-01, Volume: 19, Issue:5 Topics: Action Potentials; Aging; Animals; Atropine; Carbachol; Cholinergic Agonists; Cholinesterase Inhibitors; Cholinesterases; Dose-Response Relationship, Drug; Female; Hippocampus; In Vitro Techniques; Muscarinic Antagonists; Physostigmine; Pyramidal Cells; Rabbits; Time Factors; Trichlorfon	1999
Sensitivity to cholinergic drug treatments of aged rats with variable degrees of spatial memory impairment. Behavioural brain research, 1999, Volume: 98, Issue:1 Topics: Aging; Animals; Brain; Cholinergic Agents; Escape Reaction; Female; Maze Learning; Mental Recall; Motor Activity; Orientation; Physostigmine; Postural Balance; Psychomotor Performance; Rats; Rats, Long-Evans; Retention, Psychology; Scopolamine; Space Perception; Tacrine	1999
Physostigmine challenge before and after chronic cholinergic blockade in elderly volunteers. Biological psychiatry, 1999, Jul-15, Volume: 46, Issue:2 Topics: Aged; Aging; Brief Psychiatric Rating Scale; Cholinesterase Inhibitors; Cognition Disorders; Depressive Disorder; Dose-Response Relationship, Drug; Female; Glycopyrrolate; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Injections, Intravenous; Male; Muscarinic Antagonists; Neuronal Plasticity; Physostigmine; Pituitary-Adrenal System; Presynaptic Terminals; Receptors, Muscarinic; Scopolamine; Severity of Illness Index; Time Factors; Up-Regulation	1999
Effect of aging on the arginine-vasopressin response to physostigmine and angiotensin II in normal men. Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 2000, Volume: 48, Issue:3 Topics: Adult; Aged; Aging; Angiotensin II; Arginine Vasopressin; Cholinesterase Inhibitors; Clinical Chemistry Tests; Humans; Male; Middle Aged; Physostigmine; Vasoconstrictor Agents	2000
Recovery of diminished mealtime-associated anticipatory behavior by aniracetam in aged rats. Pharmacology, biochemistry, and behavior, 2000, Volume: 66, Issue:4 Topics: Aging; Animals; Circadian Rhythm; Darkness; Dose-Response Relationship, Drug; Feeding Behavior; Light; Male; Motor Activity; Nootropic Agents; Parasympathomimetics; Physostigmine; Pyrrolidinones; Rats; Rats, Wistar	2000
Eptastigmine restores the aged rat's normal cortical spectral power pattern. Pharmacological research, 2000, Volume: 42, Issue:5 Topics: Administration, Oral; Aging; Animals; Cholinesterase Inhibitors; Electroencephalography; Male; Motor Activity; Physostigmine; Rats; Rats, Wistar	2000
Compensatory mechanisms enhance hippocampal acetylcholine release in transgenic mice expressing human acetylcholinesterase. Journal of neurochemistry, 2001, Volume: 77, Issue:2 Topics: Acetylcholine; Acetylcholinesterase; Aging; Anesthetics, Inhalation; Animals; Choline; Cholinesterase Inhibitors; Cognition Disorders; Disease Models, Animal; Exploratory Behavior; Extracellular Space; Genes, Synthetic; Halothane; Hippocampus; Homeostasis; Humans; Inositol Phosphates; Mice; Mice, Transgenic; Microdialysis; Motor Activity; Nerve Tissue Proteins; Physostigmine; Promoter Regions, Genetic; Secretory Rate; Species Specificity; Synaptosomes; Transgenes	2001
Effects of neurotransmitters and neuropharmacological agents on phospholipid metabolism in the rabbit iris muscle. Advances in experimental medicine and biology, 1976, Volume: 72 Topics: Acetylcholine; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Atropine; Calcium; Carbachol; In Vitro Techniques; Iris; Norepinephrine; Phosphatidic Acids; Phosphatidylcholines; Phosphatidylethanolamines; Phosphatidylinositols; Phospholipids; Physostigmine; Propranolol; Rabbits	1976
Changes in the activity of acetylcholinesterase from the brain of the Mongolian gerbil (Meriones unguiculatus) with age. Comparative biochemistry and physiology. C: Comparative pharmacology, 1979, Volume: 62C, Issue:1 Topics: Acetylcholinesterase; Aging; Animals; Animals, Newborn; Brain; Gerbillinae; Kinetics; Lidocaine; Mepivacaine; Physostigmine; Procaine	1979
Postnatal development of postganglionic parasympathetic neurones in the heart of the albino rat. Physiologia Bohemoslovaca, 1979, Volume: 28, Issue:6 Topics: Acetylcholine; Action Potentials; Aging; Animals; Cholinesterase Inhibitors; Depression, Chemical; Electric Stimulation; Electrophysiology; Female; Heart; In Vitro Techniques; Male; Neurons; Parasympathetic Nervous System; Physostigmine; Propranolol; Rats; Sinoatrial Node; Sympathetic Nervous System	1979
Developmental aspects of hippocampal electrical activity and motor behavior in the rat. Experimental neurology, 1979, Volume: 66, Issue:2 Topics: Aging; Animals; Electroencephalography; Hippocampus; Morphogenesis; Motor Activity; Physostigmine; Rats; Sleep, REM; Theta Rhythm	1979
Physostigmine and recent memory: effects in young and aged nonhuman primates. Science (New York, N.Y.), 1979, Nov-30, Volume: 206, Issue:4422 Topics: Acetylcholine; Aging; Animals; Cognition; Female; Haplorhini; Humans; Male; Memory; Memory Disorders; Memory, Short-Term; Physostigmine; Synaptic Transmission	1979
Neuromuscular pharmacology in rat neonates: development of responsiveness to prototypic blocking and reversal drugs. Anesthesia and analgesia, 1992, Volume: 75, Issue:3 Topics: 4-Aminopyridine; Aging; Animals; Animals, Newborn; Cholinesterase Inhibitors; Curare; Dose-Response Relationship, Drug; Drug Synergism; Edrophonium; Fasciculation; Female; Male; Muscle Contraction; Neostigmine; Nerve Endings; Neuromuscular Blocking Agents; Neuromuscular Junction; Physostigmine; Rats; Rats, Inbred Strains; Succinylcholine; Synaptic Transmission; Tubocurarine	1992
Effect of FR121196, a novel cognitive enhancer, on the memory impairment of rats in passive avoidance and radial arm maze tasks. The Journal of pharmacology and experimental therapeutics, 1992, Volume: 263, Issue:2 Topics: Aging; Animals; Avoidance Learning; Brain; Choline O-Acetyltransferase; Cognition Disorders; Dementia; Discrimination Learning; Disease Models, Animal; Male; Memory Disorders; Methamphetamine; Motor Activity; Physostigmine; Piperazines; Rats; Rats, Inbred F344; Rats, Wistar; Scopolamine; Sulfonamides	1992
Age-dependent changes in serotonergic modulation of yawning in the rat. Pharmacology, biochemistry, and behavior, 1992, Volume: 43, Issue:2 Topics: Aging; Animals; Citalopram; Male; Methiothepin; Physostigmine; Rats; Rats, Sprague-Dawley; Ritanserin; Serotonin; Serotonin Antagonists; Yawning	1992
Chronic administration of U50,488H fails to produce hypothalamo-pituitary-adrenal axis tolerance in neonatal rats. Neuropharmacology, 1992, Volume: 31, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Aging; Analgesics; Animals; Animals, Newborn; Corticosterone; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Tolerance; Hypothalamo-Hypophyseal System; Morphine; Physostigmine; Pituitary-Adrenal System; Pyrrolidines; Quipazine; Rats; Rats, Inbred Strains	1992
Evaluation of learning and memory mechanisms employing elevated plus-maze in rats and mice. Progress in neuro-psychopharmacology & biological psychiatry, 1992, Volume: 16, Issue:1 Topics: Aging; Animals; Dizocilpine Maleate; Electroshock; Female; Learning; Male; Memory; Mice; N-Methylaspartate; Physostigmine; Rats; Rats, Inbred Strains; Scopolamine	1992
Delayed matching-to-sample performance by rats in a new avoidance-motivated maze: response to scopolamine and fimbria-fornix lesions. Physiology & behavior, 1992, Volume: 51, Issue:4 Topics: Aging; Animals; Avoidance Learning; Brain Mapping; Cholinergic Fibers; Discrimination Learning; Dose-Response Relationship, Drug; Hippocampus; Male; Mental Recall; Motivation; Neural Pathways; Orientation; Physostigmine; Problem Solving; Rats; Rats, Inbred F344; Reaction Time; Receptors, Muscarinic; Retention, Psychology; Scopolamine; Social Environment	1992
The autoinhibitory feedback control of acetylcholine release in human neocortex tissue. Brain research, 1992, Feb-14, Volume: 572, Issue:1-2 Topics: Acetylcholine; Aging; Atropine; Cerebral Cortex; Electric Stimulation; Feedback; Humans; In Vitro Techniques; Muscarinic Antagonists; Oxotremorine; Physostigmine; Receptors, Cholinergic; Tacrine	1992
[Effects of cooling on cholinergically-mediated contractions of tracheal muscle taken from immature and mature guinea pigs]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1991, Volume: 98, Issue:6 Topics: Acetylcholine; Acetylcholinesterase; Age Factors; Aging; Animals; Carbachol; Cholinergic Fibers; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Physostigmine; Temperature; Trachea	1991
Neuropeptide Y radio-immunoassay: characterization and application. Clinical and experimental pharmacology & physiology, 1991, Volume: 18, Issue:12 Topics: Aging; Animals; Blood Platelets; Catecholamines; Chromatography, Affinity; Chromatography, High Pressure Liquid; Iodine Radioisotopes; Male; Neuropeptide Y; Physostigmine; Radioimmunoassay; Rats; Rats, Inbred F344; Rats, Inbred Strains	1991
Working memory deficit in aged rats in delayed nonmatching to position task and effect of physostigmine on performance of young and aged rats. Japanese journal of pharmacology, 1991, Volume: 56, Issue:3 Topics: Aging; Animals; Male; Memory; Parasympathetic Nervous System; Physostigmine; Rats; Rats, Inbred F344	1991
Ontogenic expression of acetylcholinesterase activity in trachealis of young swine. The American journal of physiology, 1991, Volume: 261, Issue:4 Pt 1 Topics: Acetylcholine; Acetylcholinesterase; Aging; Animals; Cholinesterase Inhibitors; Kinetics; Muscle Contraction; Muscle Development; Muscle, Smooth; Physostigmine; Swine; Trachea	1991
Differential effects of aging on neuroendocrine responses to physostigmine in normal men. The Journal of clinical endocrinology and metabolism, 1990, Volume: 70, Issue:5 Topics: Adult; Aging; Arginine Vasopressin; beta-Endorphin; Epinephrine; Growth Hormone; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Male; Neurosecretory Systems; Norepinephrine; Physostigmine	1990
Proactive interference effects on short-term memory in rats: I. Basic parameters and drug effects. Behavioral neuroscience, 1990, Volume: 104, Issue:5 Topics: Aging; Animals; Appetitive Behavior; Association Learning; Clonidine; Discrimination Learning; Dose-Response Relationship, Drug; Female; Injections, Intraperitoneal; Memory, Short-Term; Nicotine; Orientation; Physostigmine; Proactive Inhibition; Problem Solving; Rats; Rats, Inbred Strains; Reinforcement Schedule; Retention, Psychology; Time Perception	1990
Cholinergic modulation of aged-like retention deficits in young autoimmune mice. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1990, Volume: 8, Issue:6 Topics: Aging; Animals; Autoimmunity; Genotype; Habituation, Psychophysiologic; Male; Mice; Mice, Inbred C57BL; Mice, Inbred NZB; Parasympathetic Nervous System; Physostigmine; Retention, Psychology; Time Factors	1990
Maturation of acetylcholinesterase expression in tracheal smooth muscle contraction. The American journal of physiology, 1990, Volume: 259, Issue:2 Pt 1 Topics: Acetylcholine; Acetylcholinesterase; Aging; Animals; Atropine; Dose-Response Relationship, Drug; Electric Stimulation; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle Development; Muscle, Smooth; Physostigmine; Potassium Chloride; Swine; Trachea	1990
Postnatal ontogeny of agonist and depolarization-induced phosphoinositide hydrolysis in rat cerebral cortex. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 243, Issue:1 Topics: Aging; Animals; Arecoline; Calcium Channel Blockers; Carbachol; Cerebral Cortex; Hydrolysis; Male; N-Methylscopolamine; Norepinephrine; Phosphatidylinositols; Physostigmine; Potassium; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Muscarinic; Scopolamine Derivatives	1987
Effect of age on cholinergic muscarinic responsiveness and receptors in the rat urinary bladder. The Journal of urology, 1986, Volume: 136, Issue:2 Topics: Acetylcholine; Aging; Animals; Atropine; Bethanechol; Bethanechol Compounds; Male; Muscle Contraction; Muscle, Smooth; Oxotremorine; Parasympathomimetics; Phenylmethylsulfonyl Fluoride; Physostigmine; Pilocarpine; Quinuclidinyl Benzilate; Rats; Rats, Inbred F344; Receptors, Muscarinic; Urinary Bladder	1986
Delay-dependent short-term memory deficits in aged rats. Psychopharmacology, 1988, Volume: 96, Issue:2 Topics: Aging; Animals; Arecoline; Body Weight; Conditioning, Operant; Male; Memory, Short-Term; Physostigmine; Rats; Rats, Inbred Strains; Time Factors	1988
[Improving effect of huperzine A on discrimination performance in aged rats and adult rats with experimental cognitive impairment]. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1988, Volume: 9, Issue:1 Topics: Aging; Alkaloids; Animals; Cholinesterase Inhibitors; Discrimination Learning; Female; Lighting; Male; Memory; Physostigmine; Rats; Sesquiterpenes	1988
[Age-related modification of dopaminergic-cholinergic neuronal interaction in rats]. Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology, 1988, Volume: 8, Issue:4 Topics: Aging; Animals; Apomorphine; Drug Interactions; Male; Methyltyrosines; Physostigmine; Pilocarpine; Rats; Rats, Inbred Strains; Reserpine; Stereotyped Behavior; Yawning	1988
Differences in behavioral responses to oxotremorine and physostigmine in New Zealand black (NZB/BlNJ) and C57BL/6 mice. Neuropharmacology, 1987, Volume: 26, Issue:5 Topics: Aging; Animals; Autonomic Nervous System; Body Temperature; Brain; Cholinergic Fibers; Male; Mice; Mice, Inbred C57BL; Mice, Inbred NZB; Motor Activity; Oxotremorine; Physostigmine; Species Specificity	1987
Cholinergic septal grafts into the hippocampal formation improve spatial learning and memory in aged rats by an atropine-sensitive mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1986, Volume: 6, Issue:10 Topics: Aging; Animals; Atropine; Behavior, Animal; Biomechanical Phenomena; Female; Hippocampus; Learning; Memory; Parasympathetic Nervous System; Physostigmine; Rats; Rats, Inbred Strains; Septum Pellucidum; Spatial Behavior	1986
The role of acetylcholine in rhythmic spontaneous contractions of rat's duodenal smooth muscle. Bulletin of environmental contamination and toxicology, 1985, Volume: 34, Issue:4 Topics: Acetylcholine; Action Potentials; Aging; Animals; Atropine; Duodenum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Physostigmine; Rats	1985
Effect of age of the rat on induction of acetylcholinesterase of the brain by 17 beta-estradiol. Biochimica et biophysica acta, 1973, Dec-05, Volume: 329, Issue:2 Topics: Acetylcholinesterase; Aging; Animals; Brain; Castration; Cerebellum; Chromatography, DEAE-Cellulose; Dactinomycin; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Esterases; Estradiol; Female; Immunodiffusion; Immunoelectrophoresis; Kinetics; Ovary; Physostigmine; Rabbits; Rats; Spectrophotometry, Ultraviolet	1973
Human memory and the cholinergic system. A relationship to aging? Archives of neurology, 1974, Volume: 30, Issue:2 Topics: Adolescent; Adult; Aged; Aging; Brain; Cognition; Female; Humans; Intelligence; Intelligence Tests; Male; Memory; Middle Aged; Physostigmine; Receptors, Cholinergic; Scopolamine; Synaptic Transmission	1974
Increased sensitivity of sinoatrial pace-maker to acetylcholine and to catecholamines at the onset of autonomic neuroeffector transmission in chick embryo heart. The Journal of pharmacology and experimental therapeutics, 1974, Volume: 191, Issue:3 Topics: Acetylcholine; Aging; Animals; Atropine; Autonomic Fibers, Postganglionic; Chick Embryo; Electric Stimulation; Epinephrine; Heart; In Vitro Techniques; Isoproterenol; Neuroeffector Junction; Physostigmine; Propranolol; Sinoatrial Node; Synaptic Transmission; Time Factors	1974
Effects of nicotine given into the brain of fowls. British journal of pharmacology, 1974, Volume: 51, Issue:3 Topics: Aging; Animals; Atropine; Behavior, Animal; Blood Pressure; Body Temperature; Brain Stem; Cerebral Ventricles; Chickens; Conditioning, Operant; Diencephalon; Drug Synergism; Electroencephalography; Heart Rate; Injections; Movement; Nicotine; Pempidine; Physostigmine; Respiration; Scopolamine; Stereotaxic Techniques; Tachyphylaxis; Telencephalon; Time Factors	1974
Differences in the effect of drugs on young and old hearts of the house cricket, Acheta domesticus (L.). Comparative and general pharmacology, 1972, Volume: 3, Issue:11 Topics: Acetylcholine; Age Factors; Aging; Animals; Arecoline; Atropine; Heart; Heart Rate; In Vitro Techniques; Insecta; Nicotine; Norepinephrine; Physostigmine; Serotonin; Tubocurarine	1972
Ontogenetic aspects of central cholinergic involvement in spontaneous alternation behavior. Developmental psychobiology, 1973, Volume: 6, Issue:4 Topics: Age Factors; Aging; Animals; Animals, Newborn; Behavior, Animal; Body Weight; Brain; Discrimination Learning; Dose-Response Relationship, Drug; Inhibition, Psychological; Injections, Intraperitoneal; Male; Physostigmine; Rats; Scopolamine	1973
Polyacrylamide gel electrophoresis of rat brain acetylcholinesterase: isoenzymes of normal rat brain. Journal of neurochemistry, 1974, Volume: 23, Issue:1 Topics: Acetylcholinesterase; Aging; Animals; Brain; Brain Stem; Caudate Nucleus; Cerebellum; Cerebral Cortex; Electrophoresis, Polyacrylamide Gel; Female; Hydrogen-Ion Concentration; Intestine, Small; Isoenzymes; Liver; Male; Medulla Oblongata; Mesencephalon; Muscle, Smooth; Olfactory Bulb; Organ Specificity; Paraoxon; Physostigmine; Pons; Rats; Surface-Active Agents	1974
Dealkylation as a mechanism for aging of cholinesterase after poisoning with pinacolyl methylphosphonofluoridate. Biochemical pharmacology, 1965, Volume: 14, Issue:5 Topics: Acetylcholinesterase; Aging; Animals; Atropine; Brain; Brain Chemistry; Cholinesterase Inhibitors; Diaphragm; Liver; Lung; Organophosphonates; Phosphorus Isotopes; Physostigmine; Rats	1965