physalin-a and Inflammation

physalin-a has been researched along with Inflammation* in 2 studies

Other Studies

2 other study(ies) available for physalin-a and Inflammation

Article	Year
Anti-inflammatory action of physalin A by blocking the activation of NF-κB signaling pathway. Journal of ethnopharmacology, 2021, Mar-01, Volume: 267 Physalis Calyx seu Fructus is typically used to treat inflammatory diseases such as upper respiratory tract infection and acute tonsillitis in clinical practice of China. Physalin A, a main active ingredient of this traditional Chinese medicine (TCM), has been reported for its significant anti-tumor activity. However, most reports focused on the studies of its anti-tumor activity, the anti-inflammatory activity of physalin A and its molecular mechanism are still not elucidated clearly.. The aim of the study was to investigate the anti-inflammatory activities both in vitro and in vivo and molecular mechanism of physalin A.. The potential anti-inflammatory properties of physalin A were evaluated in vitro by lipopolysaccharide (LPS)-induced RAW 264.7 macrophage cells, and in vivo via two typical acute inflammation murine models. Some important inflammation-related molecules were analyzed by enzyme-linked immuno sorbent assay (ELISA) and Western blotting.. The results showed that physalin A inhibited carrageenan-induced paw edema of rats and capillary permeability of mice induced by acetic acid in vivo. Furthermore, physalin A also significantly reduced the release of inflammatory mediators nitric oxide (NO), prostaglandin E2 (PGE. All the results clearly illustrated that the anti-inflammatory action of physalin A is due to the inactivation of NF-κB signal pathway, but is irrelevant to the MAPKs pathway. Topics: Acetic Acid; Animals; Anti-Inflammatory Agents; Capillary Permeability; Carrageenan; Disease Models, Animal; Drug Synergism; Edema; Inflammation; Inflammation Mediators; Luteolin; Macrophages; Male; Mice; NF-kappa B; Rats, Sprague-Dawley; RAW 264.7 Cells; Signal Transduction; Withanolides	2021
Physalin A attenuates inflammation through down-regulating c-Jun NH2 kinase phosphorylation/Activator Protein 1 activation and up-regulating the antioxidant activity. Toxicology and applied pharmacology, 2020, 09-01, Volume: 402 Topics: Animals; Antioxidants; Carrageenan; Cell Survival; Down-Regulation; Gene Expression Regulation; I-kappa B Proteins; Inflammation; JNK Mitogen-Activated Protein Kinases; Male; Malondialdehyde; Mice; Mice, Inbred ICR; Molecular Structure; NF-kappa B; Physalis; Random Allocation; RAW 264.7 Cells; Transcription Factor AP-1; Withanolides	2020

Article

Year

Anti-inflammatory action of physalin A by blocking the activation of NF-κB signaling pathway.

Journal of ethnopharmacology, 2021, Mar-01, Volume: 267

Physalis Calyx seu Fructus is typically used to treat inflammatory diseases such as upper respiratory tract infection and acute tonsillitis in clinical practice of China. Physalin A, a main active ingredient of this traditional Chinese medicine (TCM), has been reported for its significant anti-tumor activity. However, most reports focused on the studies of its anti-tumor activity, the anti-inflammatory activity of physalin A and its molecular mechanism are still not elucidated clearly.. The aim of the study was to investigate the anti-inflammatory activities both in vitro and in vivo and molecular mechanism of physalin A.. The potential anti-inflammatory properties of physalin A were evaluated in vitro by lipopolysaccharide (LPS)-induced RAW 264.7 macrophage cells, and in vivo via two typical acute inflammation murine models. Some important inflammation-related molecules were analyzed by enzyme-linked immuno sorbent assay (ELISA) and Western blotting.. The results showed that physalin A inhibited carrageenan-induced paw edema of rats and capillary permeability of mice induced by acetic acid in vivo. Furthermore, physalin A also significantly reduced the release of inflammatory mediators nitric oxide (NO), prostaglandin E2 (PGE. All the results clearly illustrated that the anti-inflammatory action of physalin A is due to the inactivation of NF-κB signal pathway, but is irrelevant to the MAPKs pathway.

Topics: Acetic Acid; Animals; Anti-Inflammatory Agents; Capillary Permeability; Carrageenan; Disease Models, Animal; Drug Synergism; Edema; Inflammation; Inflammation Mediators; Luteolin; Macrophages; Male; Mice; NF-kappa B; Rats, Sprague-Dawley; RAW 264.7 Cells; Signal Transduction; Withanolides

2021

Physalin A attenuates inflammation through down-regulating c-Jun NH2 kinase phosphorylation/Activator Protein 1 activation and up-regulating the antioxidant activity.

Toxicology and applied pharmacology, 2020, 09-01, Volume: 402

Topics: Animals; Antioxidants; Carrageenan; Cell Survival; Down-Regulation; Gene Expression Regulation; I-kappa B Proteins; Inflammation; JNK Mitogen-Activated Protein Kinases; Male; Malondialdehyde; Mice; Mice, Inbred ICR; Molecular Structure; NF-kappa B; Physalis; Random Allocation; RAW 264.7 Cells; Transcription Factor AP-1; Withanolides

2020