phthalic acid has been researched along with Diabetes Mellitus, Type 2 in 19 studies
phthalic acid: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7178
phthalic acid : A benzenedicarboxylic acid cosisting of two carboxy groups at ortho positions.
Diabetes Mellitus, Type 2: A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The goal of this study was to compare the urine levels of bisphenol A and phthalate metabolites in subgroups of patients with metabolic syndrome composed of patients with and without three important components of metabolic syndrome (hypertension, dyslipidemia and diabetes)." | 7.83 | Urine Levels of Phthalate Metabolites and Bisphenol A in Relation to Main Metabolic Syndrome Components: Dyslipidemia, Hypertension and Type 2 Diabetes. A Pilot Study. ( Haluzík, M; Lacinová, Z; Malý, M; Matějková, D; Matoulek, M; Mráz, M; Müllerová, D; Pavloušková, J; Piecha, R; Svačina, Š; Vavrouš, A; Vrbík, K, 2016) |
| " The goal of this study was to compare the urine levels of bisphenol A and phthalate metabolites in subgroups of patients with metabolic syndrome composed of patients with and without three important components of metabolic syndrome (hypertension, dyslipidemia and diabetes)." | 3.83 | Urine Levels of Phthalate Metabolites and Bisphenol A in Relation to Main Metabolic Syndrome Components: Dyslipidemia, Hypertension and Type 2 Diabetes. A Pilot Study. ( Haluzík, M; Lacinová, Z; Malý, M; Matějková, D; Matoulek, M; Mráz, M; Müllerová, D; Pavloušková, J; Piecha, R; Svačina, Š; Vavrouš, A; Vrbík, K, 2016) |
| "We investigated the incidence of type 2 diabetes mellitus (T2DM) in Saudi subjects and correlated it with urinary phthalate metabolites' screening study." | 1.72 | Screening the incidence of diabetogensis with urinary phthalate in Saudi subjects. ( Al-Bazi, MM; Al-Malki, AL; Kumosani, TA; Moselhy, SS, 2022) |
| " Phthalate was administered in drinking water at a daily dosage of 100 mg/kg." | 1.42 | Influence of phthalates on glucose homeostasis and atherosclerosis in hyperlipidemic mice. ( Chen, MH; Shi, W; Zhou, W, 2015) |
| " Mexican-Americans and non-Hispanic blacks had stronger dose-response relationships for MnBP, MiBP, MCPP and ∑DEHP compared to non-Hispanic whites." | 1.40 | Gender and racial/ethnic differences in the associations of urinary phthalate metabolites with markers of diabetes risk: National Health and Nutrition Examination Survey 2001-2008. ( Huang, T; Isganaitis, E; James-Todd, T; Saxena, AR, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 11 (57.89) | 24.3611 |
| 2020's | 8 (42.11) | 2.80 |
| Authors | Studies |
|---|---|
| Eales, J | 1 |
| Bethel, A | 1 |
| Galloway, T | 1 |
| Hopkinson, P | 1 |
| Morrissey, K | 1 |
| Short, RE | 1 |
| Garside, R | 1 |
| Chen, Y | 2 |
| Zhang, W | 2 |
| Chen, J | 2 |
| Wang, N | 2 |
| Chen, C | 2 |
| Wang, Y | 2 |
| Wan, H | 2 |
| Chen, B | 2 |
| Lu, Y | 2 |
| Al-Bazi, MM | 1 |
| Kumosani, TA | 1 |
| Al-Malki, AL | 1 |
| Moselhy, SS | 1 |
| Liu, XK | 1 |
| Si, SW | 1 |
| Ye, Y | 1 |
| Li, JY | 1 |
| Lyu, HH | 1 |
| Ma, YM | 1 |
| Zou, CY | 1 |
| Sun, HJ | 1 |
| Xue, L | 1 |
| Xu, W | 1 |
| Geng, HF | 1 |
| Liang, J | 1 |
| Sargis, RM | 1 |
| Simmons, RA | 1 |
| Chang, JW | 1 |
| Liao, KW | 1 |
| Huang, CY | 1 |
| Huang, HB | 1 |
| Chang, WT | 1 |
| Jaakkola, JJK | 1 |
| Hsu, CC | 1 |
| Chen, PC | 1 |
| Huang, PC | 1 |
| Wang, G | 1 |
| Chen, Q | 1 |
| Tian, P | 1 |
| Wang, L | 2 |
| Li, X | 1 |
| Lee, YK | 1 |
| Zhao, J | 1 |
| Zhang, H | 2 |
| Chen, W | 1 |
| Duan, Y | 3 |
| Sun, H | 3 |
| Yao, Y | 1 |
| Han, L | 3 |
| Chen, L | 3 |
| Wang, B | 1 |
| Zhu, L | 1 |
| Luo, Y | 1 |
| Mengozzi, A | 1 |
| Carli, F | 1 |
| Biancalana, E | 1 |
| Della Latta, V | 1 |
| Seghieri, M | 1 |
| Gastaldelli, A | 1 |
| Solini, A | 1 |
| Kim, H | 1 |
| Nam, K | 1 |
| Oh, S | 1 |
| Son, S | 1 |
| Jeon, D | 1 |
| Gye, MC | 1 |
| Shin, I | 1 |
| Huang, T | 1 |
| Saxena, AR | 1 |
| Isganaitis, E | 1 |
| James-Todd, T | 1 |
| Sun, Q | 2 |
| Cornelis, MC | 1 |
| Townsend, MK | 1 |
| Tobias, DK | 1 |
| Eliassen, AH | 1 |
| Franke, AA | 1 |
| Hauser, R | 1 |
| Hu, FB | 1 |
| Zhou, W | 1 |
| Chen, MH | 1 |
| Shi, W | 1 |
| Song, Y | 2 |
| Chou, EL | 1 |
| Baecker, A | 1 |
| You, NC | 1 |
| Liu, S | 1 |
| Okada, AK | 1 |
| Teranishi, K | 1 |
| Isas, JM | 1 |
| Bedrood, S | 1 |
| Chow, RH | 1 |
| Langen, R | 1 |
| Piecha, R | 1 |
| Svačina, Š | 1 |
| Malý, M | 1 |
| Vrbík, K | 1 |
| Lacinová, Z | 1 |
| Haluzík, M | 1 |
| Pavloušková, J | 1 |
| Vavrouš, A | 1 |
| Matějková, D | 1 |
| Müllerová, D | 1 |
| Mráz, M | 1 |
| Matoulek, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Exploring the Association Between Phthalates Exposure, Measured Through Their Urinary Metabolites, and Renal Function Impairment in Individuals With TYpe 2 Diabetes - SGLT2 Subprotocol[NCT04242758] | Phase 4 | 30 participants (Actual) | Interventional | 2019-06-04 | Active, not recruiting | ||
| Exploring the Association Between Phthalates Exposure, Measured Through Their Urinary Metabolites, and Renal Function Impairment in Individuals With TYpe 2 Diabetes - Protocol 2[NCT03622957] | 200 participants (Anticipated) | Observational | 2018-08-10 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for phthalic acid and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Human health impacts of exposure to phthalate plasticizers: An overview of reviews.
Topics: Diabetes Mellitus, Type 2; Environmental Exposure; Female; Humans; Male; Phthalic Acids; Plasticizer | 2022 |
Environmental neglect: endocrine disruptors as underappreciated but potentially modifiable diabetes risk factors.
Topics: Benzhydryl Compounds; Diabetes Mellitus, Type 2; Endocrine Disruptors; Environmental Pollutants; Hum | 2019 |
Endocrine-disrupting chemicals, risk of type 2 diabetes, and diabetes-related metabolic traits: A systematic review and meta-analysis.
Topics: Benzhydryl Compounds; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Dioxins; Endocrine Disrupt | 2016 |
16 other studies available for phthalic acid and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Association of Phthalate Exposure with Thyroid Function and Thyroid Homeostasis Parameters in Type 2 Diabetes.
Topics: Aged; China; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Environmental Exposure; Female; Hom | 2021 |
Screening the incidence of diabetogensis with urinary phthalate in Saudi subjects.
Topics: C-Peptide; Diabetes Mellitus, Type 2; Environmental Exposure; Environmental Pollutants; Humans; Inci | 2022 |
The Link between Exposure to Phthalates and Type 2 Diabetes Mellitus: A Study Based on NHANES Data and Bioinformatic Analysis.
Topics: Diabetes Mellitus, Type 2; Environmental Exposure; Environmental Monitoring; Environmental Pollutant | 2023 |
Phthalate exposure increased the risk of early renal impairment in Taiwanese without type 2 diabetes mellitus.
Topics: Adult; Albuminuria; Creatinine; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diethylhexyl Pht | 2020 |
Gut microbiota dysbiosis might be responsible to different toxicity caused by Di-(2-ethylhexyl) phthalate exposure in murine rodents.
Topics: Animals; Diabetes Mellitus, Type 2; Diethylhexyl Phthalate; Dysbiosis; Gastrointestinal Microbiome; | 2020 |
Perturbation of serum metabolome in relation to type 2 diabetes mellitus and urinary levels of phthalate metabolites and bisphenols.
Topics: Biomarkers; Diabetes Mellitus, Type 2; Humans; Metabolome; Metabolomics; Phthalic Acids | 2021 |
Exposure to phthalates and cardiovascular diseases in Chinese with type 2 diabetes.
Topics: Cardiovascular Diseases; Carotid Intima-Media Thickness; China; Diabetes Mellitus, Type 2; Environme | 2021 |
Exposure to phthalates in patients with diabetes and its association with oxidative stress, adiponectin, and inflammatory cytokines.
Topics: Adiponectin; Adult; Aged; Biomarkers; Diabetes Mellitus, Type 2; Environmental Exposure; Female; Hum | 2017 |
Phthalates Exposure as Determinant of Albuminuria in Subjects With Type 2 Diabetes: A Cross-Sectional Study.
Topics: Aged; Albuminuria; Biomarkers; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Environmental Exp | 2019 |
Phthalates Exposure as Determinant of Albuminuria in Subjects With Type 2 Diabetes: A Cross-Sectional Study.
Topics: Aged; Albuminuria; Biomarkers; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Environmental Exp | 2019 |
Phthalates Exposure as Determinant of Albuminuria in Subjects With Type 2 Diabetes: A Cross-Sectional Study.
Topics: Aged; Albuminuria; Biomarkers; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Environmental Exp | 2019 |
Phthalates Exposure as Determinant of Albuminuria in Subjects With Type 2 Diabetes: A Cross-Sectional Study.
Topics: Aged; Albuminuria; Biomarkers; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Environmental Exp | 2019 |
Association between phthalate exposure and glycosylated hemoglobin, fasting glucose, and type 2 diabetes mellitus: A case-control study in China.
Topics: Aged; Blood Glucose; China; Diabetes Mellitus, Type 2; Environmental Exposure; Environmental Polluta | 2019 |
Toxicological assessment of phthalates and their alternatives using human keratinocytes.
Topics: Diabetes Mellitus, Type 2; Dibutyl Phthalate; Environmental Pollutants; Humans; Keratinocytes; Phtha | 2019 |
Gender and racial/ethnic differences in the associations of urinary phthalate metabolites with markers of diabetes risk: National Health and Nutrition Examination Survey 2001-2008.
Topics: Adolescent; Adult; Aged; Black People; Blood Glucose; Child; Diabetes Mellitus, Type 2; Endocrine Di | 2014 |
Association of urinary concentrations of bisphenol A and phthalate metabolites with risk of type 2 diabetes: a prospective investigation in the Nurses' Health Study (NHS) and NHSII cohorts.
Topics: Aged; Benzhydryl Compounds; Body Mass Index; Diabetes Mellitus, Type 2; Environmental Exposure; Envi | 2014 |
Influence of phthalates on glucose homeostasis and atherosclerosis in hyperlipidemic mice.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Blood Glucose; Diabetes Mellitus, Type 2; Endocrine Dis | 2015 |
Diabetic Risk Factors Promote Islet Amyloid Polypeptide Misfolding by a Common, Membrane-mediated Mechanism.
Topics: Circular Dichroism; Diabetes Mellitus, Type 2; Humans; Islet Amyloid Polypeptide; Membranes; Microsc | 2016 |
Urine Levels of Phthalate Metabolites and Bisphenol A in Relation to Main Metabolic Syndrome Components: Dyslipidemia, Hypertension and Type 2 Diabetes. A Pilot Study.
Topics: Benzhydryl Compounds; Biomarkers; Chromatography, High Pressure Liquid; Czech Republic; Diabetes Mel | 2016 |