Page last updated: 2024-08-23

phosphotyrosine and Lung Neoplasms

phosphotyrosine has been researched along with Lung Neoplasms in 42 studies

Research

Studies (42)

TimeframeStudies, this research(%)All Research%
pre-19901 (2.38)18.7374
1990's10 (23.81)18.2507
2000's17 (40.48)29.6817
2010's13 (30.95)24.3611
2020's1 (2.38)2.80

Authors

AuthorsStudies
Bekker-Jensen, DB; Emdal, KB; Francavilla, C; Franciosa, G; Gnosa, SP; Jensen, LJ; Kelstrup, CD; Kveiborg, M; Lundby, A; Maurya, SR; Mendez, BL; Montoya, G; Olsen, JV; Paul, I; Refsgaard, JC; Secher, A1
Chen, SY; Chiu, TY; Chiu, YL; Fan, CC; Hsieh, WC; Huang, TC; Huang, YJ; Hung, ZC; Juan, YH; Liao, JC; Lin, CT; Lin, RS; Lin, SY; Lin, XH; Liu, C; Lu, HH; Tsai, HC; Weng, RR; Wu, YC; Yu, CJ1
Awasthi, S; Bansal, M; Belkina, N; Biswas, R; Califano, A; Chaerkady, R; Charles Jacob, HK; Cultraro, CM; Gao, S; Guha, U; Kashyap, MK; Kirkali, G; Maity, T; Marimuthu, A; Pandey, A; Pitts, S; Singh, S; Venugopalan, A; Zhang, X1
Broncel, M; Huang, PH1
Chu, H; Gao, H; Li, G; Liang, J; Liu, R; Wang, X; Wei, P; Wu, X; Yang, W; Yu, H; Zhu, H; Zhu, W1
Gutierrez, JA; Johnson, H; Lescarbeau, RS; White, FM1
Aceto, N; Alajati, A; Bentires-Alj, M; Bonenfant, D; Duss, S; Sarret, S; Sausgruber, N; Voshol, H1
Groisman, B; Jurisica, I; Kotlyar, M; Krykbaeva, I; Kurat, CF; Lindquist, S; Mattiazzi Usaj, M; Moffat, J; Nachman, A; Pawson, T; Petschnigg, J; Sayad, A; Sierra, JR; Snider, J; Stagljar, I; Taipale, M; Tsao, MS; Zheng, Y1
Chin, YE; Deng, J; Gao, Y; Han, B; Li, Q; Liao, Y; Lin, X; Liu, J; Sun, B; Wang, Y; Yang, X; Yao, F; Ye, X; Zhang, J; Zhong, S; Zhou, BP1
Rapp, UR; Sperl, B; Ulaganathan, VK; Ullrich, A1
Geng, F; Hu, P; Shi, B; Wu, W; Wu, XZ; Zhang, C1
Bader, JS; Chaerkady, R; Guha, U; Harsha, HC; Kashyap, MK; Lash, AE; Marimuthu, A; Minna, JD; Pandey, A; Patterson, AS; Sato, M; Varmus, HE1
Beauchemin, N; Breton, V; Davis, EC; Ergun, S; Gratton, JP; Jastrow, H; Kammerer, R; Leblanc, S; Nouvion, AL; Oubaha, M; Turbide, C1
Di Florio, A; Jensen, RT; Moody, TW1
Jadwin, JA; Machida, K; Mayer, BJ; Ogiue-Ikeda, M; Oh, D; Yu, J1
Dong, Z; Hardy, WR; Kaplan, A; Ngan, E; Northey, JJ; Pawson, T; Siegel, PM1
Arcaro, A; Khanzada, UK; Seckl, MJ; Tetley, TD; Vanhaesebroeck, B; Waterfield, MD1
Casibang, M; Jensen, RT; Leyton, J; Moody, TW; Pisegna, J1
Abrams, TJ; Cherrington, JM; Lee, LB; Murray, LJ; Pryer, NK1
Alberti, A; Chow, YH; De las Heras, M; Grego, E; Jones, L; Palmarini, M; Pretto, C; Zavala, G1
Burger, JA; Burger, M; Fujii, N; Glodek, A; Hartmann, TN1
Foulke, JG; Han, W; Tang, CK; Yu, H; Zhang, T1
Lin, C; Liu, ZR; Sun, SY; Yang, L; Zhao, S1
Barry, ST; Copley, C; James, NH; Jürgensmeier, JM; Kendrew, J; Oakley, I; Smith, NR; Wainwright, A; Wedge, SR; Womersley, LM1
Dittmann, K; Kehlbach, R; Mayer, C; Rodemann, HP; Wanner, G1
Jia, L; Kiyono, T; Narisawa-Saito, M; Sakai, R; Uekita, T; Yokota, J1
Bakalarski, CE; Comb, MJ; Gu, TL; Guo, A; Gygi, SP; Haack, H; Hu, Y; Kornhauser, JM; Lee, K; Li, D; Li, Y; Macneill, J; Mitchell, J; Nardone, J; Polakiewicz, RD; Possemato, A; Reeves, C; Ren, JM; Rikova, K; Rush, J; Smith, B; Stokes, M; Sullivan, L; Tan, Z; Villen, J; Wetzel, R; Yu, J; Yuan, J; Zeng, Q; Zhou, X1
Comb, MJ; Guo, A; Gygi, SP; Innocenti, G; Kornhauser, J; Lee, KA; MacNeill, J; Mitchell, J; Nardone, J; Polakiewicz, RD; Possemato, A; Rikova, K; Rush, J; Stokes, MP; Villén, J; Wang, Y; Wetzel, R1
Annis, MG; Chmielecki, J; Muller, WJ; Ngan, E; Northey, JJ; Russo, C; Siegel, PM1
Daya-Makin, M; Hogg, JC; Lipp, M; Mogentale, TL; Parchomchuk, J; Pelech, SL; Sanghera, JS1
Jia, XS; Sun, AJ; Zhang, DR1
Bacus, SS; Chace, D; Chin, DM; Cohen, BD; Goetze, A; Green, JM; Hellström, I; Mixan, B; Plowman, GD; Siegall, CB1
Chang, KT; Hung, MC; Ibrahim, NK; Perng, RP; Tsai, CM; Wu, LH; Yu, D1
Katoh, I; Kyushiki, H; Sakamoto, Y; Yoshinaka, Y1
Chilvers, ER; Dransfield, I; Hannah, S; Haslett, C; Lawson, MF; Sethi, T; Tallett, A1
Chilvers, ER; Haslett, C; MacKinnon, AC; Sethi, T; Tallett, A1
Hamaguchi, M; Imaizumi, M; Murase, M; Nishimura, M; Takeuchi, S1
Janssen, YM; Low, RB; Mossman, BT; Pache, JC; Quinlan, TR; Taatjes, DJ; Walsh, ES; Zanella, CL1
Birchmeier, W; Burger, MM; Comoglio, P; Giordano, S; Hartmann, G; Lin, S; Lorenzoni, P; Rusciano, D1
Bertotti, A; Comoglio, PM; Trusolino, L1
Beebe, JS; Dmitrovsky, E; Dragnev, KH; Freemantle, SJ; Knauth, EA; Lonardo, F; Ma, Y; Memoli, N; Sekula, D1
Cirillo, D; Comoglio, PM; Gaudino, G; Naldini, L; Rossino, P1

Other Studies

42 other study(ies) available for phosphotyrosine and Lung Neoplasms

ArticleYear
Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites.
    Cell, 2019, 10-03, Volume: 179, Issue:2

    Topics: A549 Cells; Animals; Carcinogenesis; ErbB Receptors; Humans; Lung Neoplasms; Mass Spectrometry; Mutation; Phosphoproteins; Phosphorylation; Phosphotyrosine; Proteomics; Rats; Rats, Sprague-Dawley; Zebrafish

2019
Epigenetic modulation of immune synaptic-cytoskeletal networks potentiates γδ T cell-mediated cytotoxicity in lung cancer.
    Nature communications, 2021, 04-12, Volume: 12, Issue:1

    Topics: Actin Cytoskeleton; Animals; Cell Line, Tumor; Cytoskeleton; Cytotoxicity, Immunologic; Decitabine; DNA (Cytosine-5-)-Methyltransferases; Enzyme Inhibitors; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Immunological Synapses; Isotope Labeling; Lung Neoplasms; Lymphocyte Activation; Lymphocyte Subsets; Male; Mice, Inbred NOD; Phosphotyrosine; Receptors, Antigen, T-Cell, gamma-delta; RNA, Messenger; Survival Analysis; Tumor Suppressor Protein p53; Up-Regulation; Xenograft Model Antitumor Assays

2021
Quantitative Tyrosine Phosphoproteomics of Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor-treated Lung Adenocarcinoma Cells Reveals Potential Novel Biomarkers of Therapeutic Response.
    Molecular & cellular proteomics : MCP, 2017, Volume: 16, Issue:5

    Topics: Adenocarcinoma; Adenocarcinoma of Lung; Afatinib; Biomarkers, Tumor; Cell Line, Tumor; Cluster Analysis; ErbB Receptors; Erlotinib Hydrochloride; Humans; Isotope Labeling; Lung Neoplasms; Mass Spectrometry; Mutation; Phosphorylation; Phosphotyrosine; Protein Kinase Inhibitors; Proteomics; Quinazolines; Reproducibility of Results; Signal Transduction; Tyrosine

2017
Analysis of Phosphotyrosine Signaling Networks in Lung Cancer Cell Lines.
    Methods in molecular biology (Clifton, N.J.), 2017, Volume: 1636

    Topics: Cell Line, Tumor; Chromatography, Affinity; Chromatography, Liquid; Humans; Immunoprecipitation; Lung Neoplasms; Mass Spectrometry; Phosphoproteins; Phosphotyrosine; Proteome; Proteomics; Signal Transduction; Statistics as Topic; Workflow

2017
UDP-glucose accelerates SNAI1 mRNA decay and impairs lung cancer metastasis.
    Nature, 2019, Volume: 571, Issue:7763

    Topics: Animals; Cell Line, Tumor; Cell Movement; ELAV-Like Protein 1; Epithelial-Mesenchymal Transition; Female; Humans; Lung Neoplasms; Mice; Mice, Nude; Neoplasm Metastasis; Phosphotyrosine; Prognosis; RNA Stability; RNA, Messenger; RNA, Neoplasm; Snail Family Transcription Factors; Uridine Diphosphate Glucose; Uridine Diphosphate Glucose Dehydrogenase; Uridine Diphosphate Glucuronic Acid

2019
Phosphotyrosine profiling of NSCLC cells in response to EGF and HGF reveals network specific mediators of invasion.
    Journal of proteome research, 2013, Apr-05, Volume: 12, Issue:4

    Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Epidermal Growth Factor; ErbB Receptors; Hepatocyte Growth Factor; Humans; Lung Neoplasms; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins c-met; Signal Transduction

2013
Mammary tumor formation and metastasis evoked by a HER2 splice variant.
    Cancer research, 2013, Sep-01, Volume: 73, Issue:17

    Topics: Alternative Splicing; Animals; Apoptosis; Biomarkers, Tumor; Breast; Breast Neoplasms; Cell Culture Techniques; Cell Cycle; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Chromatography, Liquid; Epithelial-Mesenchymal Transition; Female; Gene Expression Profiling; Humans; Immunoenzyme Techniques; Lung Neoplasms; Mammary Glands, Human; Mammary Neoplasms, Animal; Mice; Mice, SCID; Oligonucleotide Array Sequence Analysis; Phosphorylation; Phosphotyrosine; Real-Time Polymerase Chain Reaction; Receptor, ErbB-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tandem Mass Spectrometry

2013
The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells.
    Nature methods, 2014, Volume: 11, Issue:5

    Topics: Carcinoma, Non-Small-Cell Lung; Cell Membrane; Cell Survival; Cytosol; ErbB Receptors; HEK293 Cells; High-Throughput Nucleotide Sequencing; Humans; Lung Neoplasms; Membrane Proteins; Microscopy, Fluorescence; Mutation; Phosphorylation; Phosphotyrosine; Plasmids; Protein Binding; Protein Interaction Mapping; Protein Structure, Tertiary; Signal Transduction; Systems Biology; Transcription Factors; Two-Hybrid System Techniques; Ubiquitin

2014
EGFR phosphorylates and inhibits lung tumor suppressor GPRC5A in lung cancer.
    Molecular cancer, 2014, Oct-14, Volume: 13

    Topics: Amino Acid Sequence; Carcinoma, Non-Small-Cell Lung; Cell Adhesion; Cell Line, Tumor; ErbB Receptors; Genes, Tumor Suppressor; HEK293 Cells; Humans; Lung Neoplasms; Molecular Sequence Data; Neoplasm Invasiveness; Phosphorylation; Phosphotyrosine; Protein Binding; Receptors, G-Protein-Coupled

2014
Germline variant FGFR4  p.G388R exposes a membrane-proximal STAT3 binding site.
    Nature, 2015, Dec-24, Volume: 528, Issue:7583

    Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Binding Sites; Breast Neoplasms; Cell Line; Cell Membrane; Disease Models, Animal; Disease Progression; Exons; Female; Gene Knock-In Techniques; Germ-Line Mutation; Humans; Lung Neoplasms; Male; Mice; Mice, Transgenic; Molecular Sequence Data; Phosphorylation; Phosphotyrosine; Polymorphism, Single Nucleotide; Receptor, Fibroblast Growth Factor, Type 4; Signal Transduction; STAT3 Transcription Factor

2015
E-cadherin core fucosylation regulates nuclear beta-catenin accumulation in lung cancer cells.
    Glycoconjugate journal, 2008, Volume: 25, Issue:9

    Topics: beta Catenin; Cadherins; Cell Line, Tumor; Cell Nucleus; Fucose; Fucosyltransferases; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Phosphotyrosine; Protein Binding; Protein Processing, Post-Translational; TCF Transcription Factors; Transcription, Genetic; Transfection

2008
Comparisons of tyrosine phosphorylated proteins in cells expressing lung cancer-specific alleles of EGFR and KRAS.
    Proceedings of the National Academy of Sciences of the United States of America, 2008, Sep-16, Volume: 105, Issue:37

    Topics: Alleles; Amino Acid Sequence; Bronchi; Cells, Cultured; Endothelial Cells; ErbB Receptors; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Mass Spectrometry; Mutation; Phosphotyrosine; Protein Binding; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); ras Proteins; Signal Transduction

2008
CEACAM1: a key regulator of vascular permeability.
    Journal of cell science, 2010, Dec-15, Volume: 123, Issue:Pt 24

    Topics: Amino Acid Motifs; Animals; Aorta; Capillary Permeability; Carcinoembryonic Antigen; Cattle; Cells, Cultured; Endothelial Cells; Enzyme Activation; Gene Knockdown Techniques; Lung; Lung Neoplasms; Mice; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatase, Non-Receptor Type 6; src-Family Kinases; Structure-Activity Relationship; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2

2010
PYK-2 is tyrosine phosphorylated after activation of pituitary adenylate cyclase activating polypeptide receptors in lung cancer cells.
    Journal of molecular neuroscience : MN, 2012, Volume: 48, Issue:3

    Topics: Calcium Signaling; Cell Line, Tumor; Chelating Agents; Cytosol; Egtazic Acid; Estrenes; Focal Adhesion Kinase 2; Humans; Isoquinolines; Lung Neoplasms; Neoplasm Proteins; Peptide Fragments; Phosphodiesterase Inhibitors; Phosphorylation; Phosphotyrosine; Pituitary Adenylate Cyclase-Activating Polypeptide; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Pyrrolidinones; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I; Sulfonamides

2012
Fast rebinding increases dwell time of Src homology 2 (SH2)-containing proteins near the plasma membrane.
    Proceedings of the National Academy of Sciences of the United States of America, 2012, Aug-28, Volume: 109, Issue:35

    Topics: Binding Sites; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Membrane; Diffusion; ErbB Receptors; Humans; Kinetics; Lung Neoplasms; Microscopy; Models, Chemical; Phosphorylation; Phosphotyrosine; Protein Structure, Tertiary; Signal Transduction; src Homology Domains

2012
Distinct phosphotyrosine-dependent functions of the ShcA adaptor protein are required for transforming growth factor β (TGFβ)-induced breast cancer cell migration, invasion, and metastasis.
    The Journal of biological chemistry, 2013, Feb-15, Volume: 288, Issue:7

    Topics: Amino Acid Motifs; Animals; Breast Neoplasms; Cell Movement; Cell Survival; Female; Humans; Lung Neoplasms; Mammary Neoplasms, Animal; Mice; Neoplasm Invasiveness; Neoplasm Metastasis; Phosphorylation; Phosphotyrosine; Receptor, ErbB-2; RNA, Small Interfering; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Transforming Growth Factor beta1

2013
Two distinct phosphoinositide 3-kinases mediate polypeptide growth factor-stimulated PKB activation.
    The EMBO journal, 2002, Oct-01, Volume: 21, Issue:19

    Topics: Animals; Carcinoma, Small Cell; Cell Line; Chlorocebus aethiops; COS Cells; Enzyme Activation; Growth Substances; Humans; Isoenzymes; Lung Neoplasms; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotyrosine; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Recombinant Proteins; Transfection; Tumor Cells, Cultured

2002
PACAP-27 tyrosine phosphorylates mitogen activated protein kinase and increases VEGF mRNAs in human lung cancer cells.
    Regulatory peptides, 2002, Nov-15, Volume: 109, Issue:1-3

    Topics: 3T3 Cells; Animals; Endothelial Growth Factors; Humans; Intercellular Signaling Peptides and Proteins; Lung Neoplasms; Lymphokines; Mice; Mitogen-Activated Protein Kinases; Neuropeptides; Phosphorylation; Phosphotyrosine; Pituitary Adenylate Cyclase-Activating Polypeptide; RNA, Messenger; Transfection; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

2002
SU11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer.
    Molecular cancer therapeutics, 2003, Volume: 2, Issue:5

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Carcinoma, Small Cell; Cell Division; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enzyme Inhibitors; Female; Humans; Imatinib Mesylate; Indoles; Lung Neoplasms; Mice; Mice, Nude; Phosphorylation; Phosphotyrosine; Piperazines; Proto-Oncogene Proteins c-kit; Pyrimidines; Pyrroles; Receptor, Platelet-Derived Growth Factor beta; Stem Cell Factor; Sunitinib; Tumor Cells, Cultured

2003
Relevance of Akt phosphorylation in cell transformation induced by Jaagsiekte sheep retrovirus.
    Virology, 2003, Jul-20, Volume: 312, Issue:1

    Topics: Animals; Cell Size; Cell Transformation, Viral; Cells, Cultured; Chick Embryo; Chickens; Fibroblasts; Jaagsiekte sheep retrovirus; Lung; Lung Neoplasms; Mutation; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphotyrosine; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pulmonary Adenomatosis, Ovine; Sheep, Domestic; Tumor Cells, Cultured; Viral Envelope Proteins

2003
CXCR4 chemokine receptor and integrin signaling co-operate in mediating adhesion and chemoresistance in small cell lung cancer (SCLC) cells.
    Oncogene, 2005, Jun-23, Volume: 24, Issue:27

    Topics: Apoptosis; Carcinoma, Small Cell; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Chemokine CXCL12; Chemokines, CXC; Collagen; Drug Resistance, Neoplasm; Etoposide; Fibronectins; Humans; Integrins; Lung Neoplasms; Peptides; Phosphotyrosine; Receptors, CXCR4; rho GTP-Binding Proteins; Signal Transduction

2005
Hypophosphorylation of residue Y1045 leads to defective downregulation of EGFRvIII.
    Cancer biology & therapy, 2006, Volume: 5, Issue:10

    Topics: Amino Acid Sequence; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; ErbB Receptors; Female; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Phosphorylation; Phosphotyrosine

2006
A double tyrosine phosphorylation of P68 RNA helicase confers resistance to TRAIL-induced apoptosis.
    Oncogene, 2007, Sep-06, Volume: 26, Issue:41

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Chromosomes, Human, X; DEAD-box RNA Helicases; Glioblastoma; Glioma; Humans; Lung Neoplasms; Mutation; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; TNF-Related Apoptosis-Inducing Ligand

2007
Acute pharmacodynamic and antivascular effects of the vascular endothelial growth factor signaling inhibitor AZD2171 in Calu-6 human lung tumor xenografts.
    Molecular cancer therapeutics, 2007, Volume: 6, Issue:8

    Topics: Animals; Antibodies, Neoplasm; Antibodies, Phospho-Specific; Antineoplastic Agents; Female; Humans; Lung Neoplasms; Mice; Mice, Nude; Neovascularization, Pathologic; Phosphorylation; Phosphotyrosine; Quinazolines; Reproducibility of Results; Signal Transduction; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; Xenograft Model Antitumor Assays

2007
The radioprotector O-phospho-tyrosine stimulates DNA-repair via epidermal growth factor receptor- and DNA-dependent kinase phosphorylation.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2007, Volume: 84, Issue:3

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Blotting, Western; Carcinoma, Bronchogenic; Cell Line, Tumor; Cetuximab; DNA Repair; DNA-Activated Protein Kinase; ErbB Receptors; Humans; Lung Neoplasms; Phosphorylation; Phosphotyrosine; Radiation-Protective Agents

2007
CUB domain-containing protein 1 is a novel regulator of anoikis resistance in lung adenocarcinoma.
    Molecular and cellular biology, 2007, Volume: 27, Issue:21

    Topics: Adenocarcinoma; Amino Acid Sequence; Animals; Anoikis; Antigens, CD; Antigens, Neoplasm; Cell Adhesion; Cell Adhesion Molecules; Cell Culture Techniques; Female; Humans; Lung Neoplasms; Mice; Mice, Nude; Molecular Sequence Data; Molecular Weight; Neoplasm Metastasis; Neoplasm Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase C-delta; src-Family Kinases

2007
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.
    Cell, 2007, Dec-14, Volume: 131, Issue:6

    Topics: Anaplastic Lymphoma Kinase; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Enzyme Activation; Gene Fusion; Humans; Lung Neoplasms; Models, Biological; Molecular Sequence Data; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor Protein-Tyrosine Kinases; Receptor, Platelet-Derived Growth Factor alpha; Signal Transduction

2007
Signaling networks assembled by oncogenic EGFR and c-Met.
    Proceedings of the National Academy of Sciences of the United States of America, 2008, Jan-15, Volume: 105, Issue:2

    Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Resistance, Neoplasm; ErbB Receptors; Gefitinib; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Models, Biological; Neoplasm Metastasis; Phosphotyrosine; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proteomics; Proto-Oncogene Proteins c-met; Quinazolines; Signal Transduction

2008
Signaling through ShcA is required for transforming growth factor beta- and Neu/ErbB-2-induced breast cancer cell motility and invasion.
    Molecular and cellular biology, 2008, Volume: 28, Issue:10

    Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Movement; Female; Focal Adhesions; Gene Expression; Lung Neoplasms; Mammary Neoplasms, Experimental; Mice; Mice, Nude; Neoplasm Invasiveness; Phosphotyrosine; Point Mutation; Receptor, ErbB-2; RNA, Small Interfering; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Transfection; Transforming Growth Factor beta

2008
Activation of a tumor-associated protein kinase (p40TAK) and casein kinase 2 in human squamous cell carcinomas and adenocarcinomas of the lung.
    Cancer research, 1994, Apr-15, Volume: 54, Issue:8

    Topics: Adenocarcinoma; Amino Acid Sequence; Antibodies; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Casein Kinases; Caseins; Chromatography, Ion Exchange; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Humans; Kinetics; Lung; Lung Neoplasms; Molecular Sequence Data; Myelin Basic Protein; Peptides; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinases; Protein Serine-Threonine Kinases; Ribosomal Protein S6; Ribosomal Proteins; Substrate Specificity; Tyrosine

1994
[The expression of C-FOS, C-JUN and phosphotyrosine gene products in lung cancer].
    Zhonghua bing li xue za zhi = Chinese journal of pathology, 1994, Volume: 23, Issue:5

    Topics: Adenocarcinoma; Carcinoma, Squamous Cell; Gene Expression; Humans; Lung Neoplasms; Phosphotyrosine; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Tyrosine

1994
HER4 expression correlates with cytotoxicity directed by a heregulin-toxin fusion protein.
    The Journal of biological chemistry, 1995, Mar-31, Volume: 270, Issue:13

    Topics: ADP Ribose Transferases; Amino Acid Sequence; Animals; Bacterial Toxins; Base Sequence; Breast Neoplasms; Cell Line; Cell Survival; DNA Primers; ErbB Receptors; Exotoxins; Female; Gene Expression; Glycoproteins; Humans; Immunotoxins; Kidney; Kinetics; Leukemia, T-Cell; Lung Neoplasms; Male; Molecular Sequence Data; Neuregulins; Ovarian Neoplasms; Phosphorylation; Phosphotyrosine; Polymerase Chain Reaction; Prostatic Neoplasms; Pseudomonas aeruginosa; Pseudomonas aeruginosa Exotoxin A; Rats; Receptor, ErbB-4; Recombinant Fusion Proteins; RNA, Messenger; Tumor Cells, Cultured; Tyrosine; Virulence Factors

1995
Enhanced chemoresistance by elevation of p185neu levels in HER-2/neu-transfected human lung cancer cells.
    Journal of the National Cancer Institute, 1995, May-03, Volume: 87, Issue:9

    Topics: Drug Resistance, Multiple; Humans; In Vitro Techniques; Lung Neoplasms; Phosphotyrosine; Receptor, ErbB-2; Transfection; Tumor Cells, Cultured; Tyrosine

1995
Alterations of the cytoskeletal organization in tumor cell lines by a cardiotonic drug, vesnarinone, through protein tyrosine phosphorylation.
    Experimental cell research, 1995, Volume: 219, Issue:1

    Topics: 3T3 Cells; Adenosine Triphosphate; Animals; Carcinoma, Squamous Cell; Cardiotonic Agents; Catechols; Cell Communication; Cell Line; Cell Line, Transformed; Cytoskeleton; Electrophoresis, Polyacrylamide Gel; ErbB Receptors; Genes, src; Humans; Immunoblotting; Lung Neoplasms; Mice; Nitriles; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Pyrazines; Quinolines; Tubulin; Tumor Cells, Cultured; Tyrosine; Tyrphostins; Vimentin

1995
Inhibition of neuropeptide-stimulated tyrosine phosphorylation and tyrosine kinase activity stimulates apoptosis in small cell lung cancer cells.
    Cancer research, 1996, Sep-15, Volume: 56, Issue:18

    Topics: Apoptosis; Bombesin; Carcinoma, Small Cell; Cell Adhesion Molecules; Cell Cycle; Cell Division; Enzyme Activation; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genistein; Humans; Isoflavones; Kinetics; Lung Neoplasms; Necrosis; Neuropeptides; Nitriles; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Neuropeptide; Substance P; Time Factors; Tumor Cells, Cultured; Tyrphostins

1996
Neuropeptides stimulate tyrosine phosphorylation and tyrosine kinase activity in small cell lung cancer cell lines.
    Peptides, 1996, Volume: 17, Issue:4

    Topics: Bombesin; Bradykinin; Carcinoma, Small Cell; Cell Adhesion Molecules; Cell Line; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gastrins; Humans; Kinetics; Lung Neoplasms; Neuropeptides; Neurotensin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Tumor Cells, Cultured; Tyrosine

1996
Role of tyrosine specific phosphorylation of cellular proteins, especially EGF receptor and p125FAK in human lung cancer cells.
    Lung cancer (Amsterdam, Netherlands), 1997, Volume: 17, Issue:1

    Topics: Adult; Aged; Cell Adhesion Molecules; Epidermal Growth Factor; ErbB Receptors; Female; Fluorescent Antibody Technique, Indirect; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Immunohistochemistry; Lung; Lung Neoplasms; Male; Middle Aged; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Receptor, ErbB-2; Survival Rate; Tumor Cells, Cultured

1997
Increased epidermal growth factor-receptor protein in a human mesothelial cell line in response to long asbestos fibers.
    The American journal of pathology, 1998, Volume: 152, Issue:2

    Topics: Asbestos; Carcinogens; Carcinoma; Cell Line, Transformed; Epithelial Cells; ErbB Receptors; Fluorescent Antibody Technique; Humans; Lung Neoplasms; Phosphotyrosine; Tissue Distribution; Tumor Cells, Cultured

1998
C-met activation is necessary but not sufficient for liver colonization by B16 murine melanoma cells.
    Clinical & experimental metastasis, 1998, Volume: 16, Issue:3

    Topics: Animals; Autocrine Communication; Enzyme Activation; Hepatocyte Growth Factor; Humans; Liver Neoplasms; Lung Neoplasms; Melanoma; Mice; Neoplasm Metastasis; Phosphotyrosine; Proto-Oncogene Proteins c-met; Tumor Cells, Cultured

1998
A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth.
    Cell, 2001, Nov-30, Volume: 107, Issue:5

    Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Antigens, Surface; Cell Adhesion; Cell Line; Female; Hepatocyte Growth Factor; Humans; Integrin alpha6beta4; Integrins; Lung Neoplasms; Mice; Mice, Nude; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; Neoplasms, Experimental; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Serine-Threonine Kinases; Protein Subunits; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-met; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Stomach Neoplasms; Transfection; Tumor Cells, Cultured

2001
Evidence for the epidermal growth factor receptor as a target for lung cancer prevention.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2002, Volume: 8, Issue:1

    Topics: Antineoplastic Agents; Blotting, Western; Carcinogens; Cell Transformation, Neoplastic; Cyclin D1; DNA Primers; ErbB Receptors; Gene Expression Regulation; Humans; Lung Neoplasms; Mitosis; Nitrosamines; Phosphotyrosine; Reverse Transcriptase Polymerase Chain Reaction; Transfection; Tretinoin

2002
Activation of the protein-tyrosine kinase associated with the bombesin receptor complex in small cell lung carcinomas.
    Proceedings of the National Academy of Sciences of the United States of America, 1988, Volume: 85, Issue:7

    Topics: Animals; Bombesin; Carcinoma, Small Cell; Cell Line; Enzyme Activation; Fibroblasts; Humans; Lung Neoplasms; Membrane Proteins; Mice; Neoplasm Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Bombesin; Receptors, Neurotransmitter; Tumor Cells, Cultured; Tyrosine

1988