phosphotyrosine has been researched along with Leukemia, Myelogenous, Chronic, BCR-ABL Positive in 42 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.38) | 18.7374 |
| 1990's | 19 (45.24) | 18.2507 |
| 2000's | 16 (38.10) | 29.6817 |
| 2010's | 6 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bossé, R; Chevet, E; Delom, F; Higa, A; Mahon, FX; Palcy, S; Pasquet, JM; Ségui, B; Taouji, S | 1 |
| Airiau, K; Belloc, F; Jeanneteau, M; Josselin, M; Mahon, FX | 1 |
| Chen, J; Chen, L; Jiang, P; Li, D; Li, J; Sun, X; Wu, Y; Xie, W; Xu, W; Yang, Y | 1 |
| Bewry, NN; Boulware, D; Emmons, MF; Hazlehurst, LA; Nair, RR; Pinilla-Ibarz, J | 1 |
| Angelo, LS; Kohanim, S; Kurzrock, R; Wu, JY; Yang, DJ | 1 |
| Cheng, H; Pan, XY; Tian, J; Xu, KL | 1 |
| Kolch, W; Preisinger, C | 1 |
| Bosi, A; Buchi, F; Ferrari, G; Gozzini, A; Pastorelli, R; Santini, V; Sassolini, F; Spinelli, E; Tombaccini, D | 1 |
| Alessandro, R; Corrado, C; De Leo, G; Flugy, AM; Guggino, G; Karmali, R; Raimondo, S; Taverna, S | 1 |
| Anderson, KI; Bleijerveld, OB; Corradini, E; Heck, AJ; Kolch, W; Müller, PJ; Preisinger, C; Scholten, A; Schwarz, JP | 1 |
| Belloc, F; Chollet, C; Goldman, JM; Lagarde, V; Mahon, FX; Melo, JV; Moreau-Gaudry, F; Reiffers, J | 1 |
| Abdullah, OM; Bohacek, RS; Clackson, T; Dalgarno, D; Deininger, MW; Druker, BJ; Keats, JA; Metcalf, CA; Moseson, EM; O'Hare, T; Pollock, R; Rivera, VM; Sawyer, TK; Shakespeare, WC; Stoffregen, EP; Sundaramoorthi, R; Tang, H; Wang, Y | 1 |
| Belloc, F; Chollet, C; Desplat, V; Lagarde, V; Leguay, T; Mahon, FX; Pasquet, JM; Praloran, V | 1 |
| Bornmann, WG; Clarkson, B; Ilaria, RL; Tong, WP; Veach, DR; Wolff, NC | 1 |
| Apperley, JF; Mahon, FX; Melo, JV; Schultheis, B; Szydlo, R | 1 |
| Deininger, MW; Druker, BJ; Heinrich, MC; O'Hare, T; Sherbenou, DW; Stoffregen, EP; Walters, DK | 1 |
| Comb, MJ; Goss, VL; Lee, KA; MacNeill, J; Moritz, A; Nardone, J; Polakiewicz, RD; Rush, J; Spek, EJ | 1 |
| Bumm, T; Corbin, AS; Deininger, MW; Druker, BJ; Goss, VL; Griswold, IJ; Johnson, K; Lee, KA; MacPartlin, M; Moseson, EM; O'Hare, T; Polakiewicz, RD; Smith, C; Stoffregen, EP; Wood, LJ | 1 |
| Chang, Y; Chen, SS; Jiang, B; Li, JL; Liu, YR; Lu, DP; Qin, YZ; Ruan, GR; Zhu, HH | 1 |
| Bhalla, K; Jove, R; Lee, FY; List, A; Nam, S; Smith, D; Vultur, A; Williams, A | 1 |
| Alessandro, R; Colomba, P; Corrado, C; De Leo, G; Flugy, AM; Fontana, S; Giordano, M; Kohn, EC; Santoro, A | 1 |
| de Jong, R; Groffen, J; Haataja, L; Heisterkamp, N; Voncken, JW | 1 |
| Clark, JW; Frackelton, AR; Kannan, B; Kumar, PS | 1 |
| Anafi, M; Ben-Neriah, Y; Gazit, A; Levitzki, A; Zehavi, A | 1 |
| Goodwyn, D; Itaya, T; Kawamura, K; Miyagishima, T; Miyazaki, T; Okabe, M; Sakurada, K; Shoji, M; Uehara, M; Vogler, WR | 1 |
| Arlinghaus, RB; Groffen, J; Guo, JQ; Heisterkamp, N; ten Hoeve, J | 1 |
| Golde, DW; Lacomis, L; Nichols, GL; Raines, MA; Tempst, P; Vera, JC | 1 |
| Harrison-Findik, D; Susa, M; Varticovski, L | 1 |
| Fujii, T; Hirai, H; Honda, H; Mano, H; Takatoku, M; Witte, ON; Yazaki, Y | 1 |
| Bergan, RC; Connell, Y; Kyle, E; Neckers, L | 1 |
| Bühring, HJ; Busch, FW; Handgretinger, R; Jallal, B; Ludwig, WD; Sures, I; Ullrich, A; Waller, HD; Weiss, FU | 1 |
| de Jong, R; Groffen, J; Heisterkamp, N; ten Hoeve, J | 1 |
| Boswell, HS; Broxmeyer, HE; Gotoh, A; Miyazawa, K; Ohyashiki, K; Tauchi, T; Toyama, K | 1 |
| Carpino, N; Clarkson, B; Kobayashi, R; Marshak, D; Stillman, B; Strife, A; Wisniewski, D | 1 |
| Carpino, N; Clarkson, BD; Lambek, C; Strife, A; Wisniewski, D | 1 |
| Hirai, H; Honda, H; Ohno, S; Takahashi, T; Takatoku, M; Yazaki, Y | 1 |
| Brizzi, MF; Dentelli, P; Ferrero, D; Lanfrancone, L; Pegoraro, L; Rosso, A | 1 |
| Clarkson, B; Erdjument-Bromage, H; Geromanos, S; Kavanaugh, WM; Strife, A; Swendeman, S; Tempst, P; Wisniewski, D | 1 |
| de Aos, IE; Ilaria, RL; Roumiantsev, S; Van Etten, RA; Varticovski, L | 1 |
| Andersson, LC; Autero, M; Mustelin, T; Oetken, C; Ruutu, T; von Willebrand, M | 1 |
| Hirata, J; Nawata, H; Nishimura, J; Okamura, J; Sadamura, S; Shibata, K; Takahira, H; Umemura, T | 1 |
| Nawata, H; Nishimura, J; Shibata, K; Takahira, H | 1 |
1 review(s) available for phosphotyrosine and Leukemia, Myelogenous, Chronic, BCR-ABL Positive
| Article | Year |
|---|---|
New understanding of the pathogenesis of CML: a prototype of early neoplasia.
Topics: Adolescent; Adult; Apoptosis; Bone Marrow; Cell Division; Cell Separation; Cell Survival; Female; Fusion Proteins, bcr-abl; Hematopoiesis; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Phosphoproteins; Phosphotyrosine; Stem Cell Factor | 1997 |
41 other study(ies) available for phosphotyrosine and Leukemia, Myelogenous, Chronic, BCR-ABL Positive
| Article | Year |
|---|---|
Phosphorylation of serine palmitoyltransferase long chain-1 (SPTLC1) on tyrosine 164 inhibits its activity and promotes cell survival.
Topics: Amino Acid Substitution; Animals; Antineoplastic Agents; Apoptosis; Benzamides; Cell Nucleus; Cell Survival; Ceramides; Dogs; Drug Resistance, Neoplasm; Endoplasmic Reticulum; Fusion Proteins, bcr-abl; Gene Knockdown Techniques; Golgi Apparatus; Humans; Imatinib Mesylate; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Microsomes; Peptide Fragments; Phosphorylation; Phosphotyrosine; Piperazines; Protein Processing, Post-Translational; Protein Transport; Proteome; Pyrimidines; RNA, Small Interfering; Serine C-Palmitoyltransferase; Transcription, Genetic | 2013 |
PI3K/mTOR pathway inhibitors sensitize chronic myeloid leukemia stem cells to nilotinib and restore the response of progenitors to nilotinib in the presence of stem cell factor.
Topics: Apoptosis; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Fusion Proteins, bcr-abl; Hematopoietic Stem Cells; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Models, Biological; Neoplastic Stem Cells; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphotyrosine; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Pyrimidines; Signal Transduction; Stem Cell Factor; TOR Serine-Threonine Kinases | 2013 |
Flow cytometric assay of phosphotyrosine levels in Bcr-Abl-positive chronic myelogenous leukemias: a potential prognostic marker.
Topics: Biomarkers; Flow Cytometry; Humans; In Situ Hybridization, Fluorescence; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Phosphotyrosine; Polymerase Chain Reaction; Prognosis; Sensitivity and Specificity | 2009 |
Stat3 contributes to resistance toward BCR-ABL inhibitors in a bone marrow microenvironment model of drug resistance.
Topics: Benzamides; Bone Marrow; Cell Death; Cell Line, Tumor; Culture Media, Conditioned; Dasatinib; Drug Resistance, Neoplasm; Fusion Proteins, bcr-abl; Gene Expression Regulation, Leukemic; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Phosphotyrosine; Piperazines; Protein Kinase Inhibitors; Pyrimidines; RNA, Small Interfering; STAT3 Transcription Factor; Thiazoles | 2008 |
Molecular imaging of Bcr-Abl phosphokinase in a xenograft model.
Topics: Animals; Antibodies; Benzamides; Cysteine; Female; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Indium Radioisotopes; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Mice, Nude; Phosphotyrosine; Piperazines; Protein-Tyrosine Kinases; Pyrimidines; Radioimmunodetection; Tumor Burden; Xenograft Model Antitumor Assays | 2009 |
[Detection of phosphotyrosine in chronic myeloid leukemia cells with PY20 antibody and its clinical applications].
Topics: Adolescent; Adult; Antibodies, Monoclonal; Female; Flow Cytometry; Fusion Proteins, bcr-abl; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Philadelphia Chromosome; Phosphotyrosine; Reverse Transcriptase Polymerase Chain Reaction; Sensitivity and Specificity; Young Adult | 2009 |
The Bcr-Abl kinase regulates the actin cytoskeleton via a GADS/Slp-76/Nck1 adaptor protein pathway.
Topics: Actins; Adaptor Proteins, Signal Transducing; Cell Membrane; Cell Surface Extensions; Cytoskeleton; Fusion Proteins, bcr-abl; Gene Knockdown Techniques; Humans; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Oncogene Proteins; Phosphoproteins; Phosphotyrosine; Protein Binding; Protein Transport; Protein-Tyrosine Kinases; RNA, Small Interfering; Signal Transduction | 2010 |
Acetylome and phosphoproteome modifications in imatinib resistant chronic myeloid leukaemia cells treated with valproic acid.
Topics: Acetylation; Apoptosis; Benzamides; Blotting, Western; Cell Proliferation; Drug Resistance, Neoplasm; Electrophoresis, Gel, Two-Dimensional; Fusion Proteins, bcr-abl; Histone Deacetylase Inhibitors; Humans; Imatinib Mesylate; Immunoprecipitation; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Phosphotyrosine; Piperazines; Protein Kinase Inhibitors; Proteome; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tumor Cells, Cultured; Valproic Acid | 2011 |
Carboxyamidotriazole-orotate inhibits the growth of imatinib-resistant chronic myeloid leukaemia cells and modulates exosomes-stimulated angiogenesis.
Topics: Animals; Antineoplastic Agents; Benzamides; Cell Adhesion; Cell Adhesion Molecules; Cell Line, Tumor; Cell Movement; Cell Proliferation; Drug Resistance, Neoplasm; Exosomes; Extracellular Signal-Regulated MAP Kinases; Fusion Proteins, bcr-abl; Gene Expression Regulation, Leukemic; Human Umbilical Vein Endothelial Cells; Humans; Imatinib Mesylate; Interleukin-8; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Mice; Neovascularization, Pathologic; Orotic Acid; Phosphorylation; Phosphotyrosine; Piperazines; Proto-Oncogene Proteins c-akt; Pyrimidines; RNA, Messenger; Triazoles; Xenograft Model Antitumor Assays | 2012 |
Imatinib-dependent tyrosine phosphorylation profiling of Bcr-Abl-positive chronic myeloid leukemia cells.
Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Benzamides; Blast Crisis; Cell Membrane; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Immunoprecipitation; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Phosphorylation; Phosphotyrosine; Piperazines; Pyrimidines; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tumor Cells, Cultured; Tyrosine | 2013 |
MDR1 gene overexpression confers resistance to imatinib mesylate in leukemia cell line models.
Topics: Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzamides; Cell Death; Cell Division; Colony-Forming Units Assay; Cyclosporins; Doxorubicin; Drug Resistance, Neoplasm; Flow Cytometry; Gene Expression; Genes, MDR; Humans; Imatinib Mesylate; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Phosphotyrosine; Piperazines; Pyrimidines; Transfection; Tumor Cells, Cultured; Verapamil | 2003 |
Inhibition of wild-type and mutant Bcr-Abl by AP23464, a potent ATP-based oncogenic protein kinase inhibitor: implications for CML.
Topics: Adaptor Proteins, Signal Transducing; Adenosine Triphosphate; Amino Acids; Apoptosis; Benzamides; Cell Cycle; Cell Division; DNA-Binding Proteins; Enzyme Inhibitors; Fusion Proteins, bcr-abl; Gene Expression Regulation, Neoplastic; HL-60 Cells; Humans; Imatinib Mesylate; Inhibitory Concentration 50; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Milk Proteins; Models, Molecular; Mutation; Nuclear Proteins; Phosphorylation; Phosphotyrosine; Piperazines; Protein Structure, Tertiary; Pyridones; Pyrimidines; STAT5 Transcription Factor; Trans-Activators | 2004 |
Rapid detection of phosphotyrosine proteins by flow cytometric analysis in Bcr-Abl-positive cells.
Topics: Animals; Benzamides; Biomarkers, Tumor; Bone Marrow Cells; Cell Line, Tumor; Cell Separation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Flow Cytometry; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Intracellular Signaling Peptides and Proteins; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukocytes, Mononuclear; Mice; Phosphorylation; Phosphotyrosine; Piperazines; Protein-Tyrosine Kinases; Pyrimidines | 2004 |
PD166326, a novel tyrosine kinase inhibitor, has greater antileukemic activity than imatinib mesylate in a murine model of chronic myeloid leukemia.
Topics: Animals; Antineoplastic Agents; Benzamides; Cell Line; Cell Proliferation; Disease Models, Animal; Drug Resistance, Neoplasm; Fusion Proteins, bcr-abl; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Molecular Structure; Mutation; Phosphorylation; Phosphotyrosine; Piperazines; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Signal Transduction; Stem Cell Factor; Survival Rate; Time Factors | 2005 |
Analysis of total phosphotyrosine levels in CD34+ cells from CML patients to predict the response to imatinib mesylate treatment.
Topics: Antigens, CD34; Antineoplastic Agents; Benzamides; Cell Proliferation; Cryopreservation; Dose-Response Relationship, Drug; Flow Cytometry; Humans; Imatinib Mesylate; Immunomagnetic Separation; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukocytes, Mononuclear; Phosphotyrosine; Pilot Projects; Piperazines; Pyrimidines; Remission Induction; Reproducibility of Results; Time Factors; Treatment Outcome | 2005 |
Combined Abl inhibitor therapy for minimizing drug resistance in chronic myeloid leukemia: Src/Abl inhibitors are compatible with imatinib.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Benzamides; Cell Proliferation; Dasatinib; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Genetic Vectors; Hematopoietic Stem Cells; Humans; Imatinib Mesylate; Immunoblotting; Inhibitory Concentration 50; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Mutation; Phosphotyrosine; Piperazines; Point Mutation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-abl; Pyrimidines; src-Family Kinases; Stem Cells; Thiazoles; Time Factors | 2005 |
A common phosphotyrosine signature for the Bcr-Abl kinase.
Topics: Benzamides; Biomarkers, Tumor; Drug Resistance, Neoplasm; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; mRNA Cleavage and Polyadenylation Factors; Oncogene Proteins, Fusion; Phosphotyrosine; Piperazines; Protein Kinase Inhibitors; Proteomics; Pyrimidines; Receptor, Platelet-Derived Growth Factor alpha; Signal Transduction | 2006 |
Kinase domain mutants of Bcr-Abl exhibit altered transformation potency, kinase activity, and substrate utilization, irrespective of sensitivity to imatinib.
Topics: Amino Acid Sequence; Animals; Benzamides; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Colony-Forming Units Assay; Disease Models, Animal; Female; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Mutation; Myeloid Progenitor Cells; Phosphotransferases; Phosphotyrosine; Piperazines; Protein Structure, Tertiary; Pyrimidines; Signal Transduction; Substrate Specificity | 2006 |
[Detection of phosphotyrosine in bcr-abl-positive cells with PY20 antibody and its clinical applications].
Topics: Antibodies, Monoclonal; Bone Marrow Cells; Flow Cytometry; Fusion Proteins, bcr-abl; Humans; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Phosphotyrosine | 2006 |
Dasatinib (BMS-354825) inhibits Stat5 signaling associated with apoptosis in chronic myelogenous leukemia cells.
Topics: Apoptosis; bcl-X Protein; Cell Count; Cell Survival; Cyclin D1; Dasatinib; DNA, Neoplasm; Down-Regulation; Drug Resistance, Neoplasm; HL-60 Cells; Humans; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Phosphotyrosine; Protein Binding; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Pyrimidines; Signal Transduction; src-Family Kinases; STAT5 Transcription Factor; Thiazoles | 2007 |
Effects of carboxyamidotriazole on in vitro models of imatinib-resistant chronic myeloid leukemia.
Topics: Apoptosis; Benzamides; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Drug Resistance, Neoplasm; Enzyme Activation; Enzyme Inhibitors; Fusion Proteins, bcr-abl; Gene Expression Regulation, Neoplastic; Humans; Imatinib Mesylate; In Situ Hybridization, Fluorescence; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; MAP Kinase Signaling System; Molecular Probes; Phosphotyrosine; Piperazines; Pyrimidines; ras Proteins; Triazoles | 2008 |
Tyrosine phosphorylation of murine Crkl.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Base Sequence; DNA Primers; Fusion Proteins, bcr-abl; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Mice, Transgenic; Molecular Sequence Data; Nuclear Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Sequence Alignment; Sequence Homology, Amino Acid; src Homology Domains | 1995 |
Tyrosine phosphorylated proteins in chronic myelogenous leukemia.
Topics: Fusion Proteins, bcr-abl; Gene Expression Regulation, Leukemic; GTPase-Activating Proteins; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Neoplasm Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein-Tyrosine Kinases; Proteins; ras GTPase-Activating Proteins; Tumor Cells, Cultured; Tyrosine; Ultracentrifugation | 1993 |
Tyrphostin-induced inhibition of p210bcr-abl tyrosine kinase activity induces K562 to differentiate.
Topics: 3T3 Cells; Animals; Benzoquinones; Catechols; Cell Differentiation; Cell Division; Cell Line; ErbB Receptors; Fusion Proteins, bcr-abl; Humans; Kinetics; Lactams, Macrocyclic; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Molecular Structure; Nitriles; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Receptors, Platelet-Derived Growth Factor; Rifabutin; Time Factors; Tumor Cells, Cultured; Tyrosine; Tyrphostins | 1993 |
Effect of herbimycin A, an inhibitor of tyrosine kinase, on protein tyrosine kinase activity and phosphotyrosyl proteins of Ph1-positive leukemia cells.
Topics: Antibiotics, Antineoplastic; Benzoquinones; Fusion Proteins, bcr-abl; Genistein; Humans; Isoflavones; Lactams, Macrocyclic; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Neoplasm Proteins; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rifabutin; Tumor Cells, Cultured; Tyrosine | 1994 |
Tyrosine phosphorylation of CRKL in Philadelphia+ leukemia.
Topics: Adaptor Proteins, Signal Transducing; Blotting, Western; Fusion Proteins, bcr-abl; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Nuclear Proteins; Phosphorylation; Phosphotyrosine; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Cells, Cultured; Tyrosine | 1994 |
Identification of CRKL as the constitutively phosphorylated 39-kD tyrosine phosphoprotein in chronic myelogenous leukemia cells.
Topics: Adaptor Proteins, Signal Transducing; Alkaloids; Amino Acid Sequence; Fusion Proteins, bcr-abl; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Molecular Sequence Data; Molecular Weight; Neutrophils; Nuclear Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Staurosporine; Tyrosine | 1994 |
Association of phosphatidylinositol 3-kinase with SHC in chronic myelogeneous leukemia cells.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Amino Acid Sequence; Animals; Cell Line; Fusion Proteins, bcr-abl; GRB2 Adaptor Protein; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Molecular Sequence Data; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein Binding; Proteins; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Structure-Activity Relationship; Tyrosine | 1995 |
Expression of p210bcr/abl by metallothionein promoter induced T-cell leukemia in transgenic mice.
Topics: Animals; Base Sequence; Clone Cells; DNA Primers; Female; Fusion Proteins, bcr-abl; Gene Expression Regulation, Neoplastic; Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor; Genes, abl; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, T-Cell; Male; Metallothionein; Mice; Mice, Transgenic; Molecular Sequence Data; Pedigree; Phosphotyrosine; Promoter Regions, Genetic; Receptors, Antigen, T-Cell, alpha-beta; Receptors, Antigen, T-Cell, gamma-delta; RNA, Messenger; Tissue Distribution; Tyrosine | 1995 |
Inhibition of protein-tyrosine kinase activity in intact cells by the aptameric action of oligodeoxynucleotides.
Topics: Base Sequence; Cell Division; Cell Line; Fusion Proteins, bcr-abl; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Molecular Sequence Data; Oligonucleotides, Antisense; Phosphotyrosine; Protein-Tyrosine Kinases; Structure-Activity Relationship; Tumor Cells, Cultured; Tyrosine | 1995 |
The receptor tyrosine kinase p185HER2 is expressed on a subset of B-lymphoid blasts from patients with acute lymphoblastic leukemia and chronic myelogenous leukemia.
Topics: 3T3 Cells; Animals; Antibodies, Monoclonal; Antigens, CD; Antigens, CD34; B-Lymphocyte Subsets; Biomarkers, Tumor; Blast Crisis; Bone Marrow; Cell Line; Cell Separation; Flow Cytometry; Fluorescent Antibody Technique; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Phosphotyrosine; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Receptor Protein-Tyrosine Kinases; Receptor, ErbB-2; Recombinant Proteins; Transfection; Tumor Cells, Cultured; Tyrosine | 1995 |
Crkl is complexed with tyrosine-phosphorylated Cbl in Ph-positive leukemia.
Topics: Adaptor Proteins, Signal Transducing; Animals; Binding Sites; Cell Line; Electrophoresis, Polyacrylamide Gel; Fusion Proteins, bcr-abl; Glutathione Transferase; Humans; Leukemia, Erythroblastic, Acute; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Molecular Weight; Nuclear Proteins; Oncogene Protein v-cbl; Phosphorylation; Phosphotyrosine; Recombinant Fusion Proteins; Retroviridae Proteins, Oncogenic; Tumor Cells, Cultured; Tyrosine | 1995 |
Tyrosine phosphorylation and activation of focal adhesion kinase (p125FAK) by BCR-ABL oncoprotein.
Topics: Animals; Cell Adhesion Molecules; Cell Division; Cell Line; Cytochalasin D; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Fusion Proteins, bcr-abl; Gene Expression; Humans; Interleukin-3; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-abl; Proto-Oncogenes; Recombinant Proteins; Stem Cell Factor; Transfection; Tumor Cells, Cultured | 1995 |
p62(dok): a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells.
Topics: Cloning, Molecular; CSK Tyrosine-Protein Kinase; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Fusion Proteins, bcr-abl; GTPase-Activating Proteins; Hematopoietic Stem Cells; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins c-kit; ras GTPase-Activating Proteins; RNA-Binding Proteins; Signal Transduction; src Homology Domains; src-Family Kinases; Stem Cell Factor; Tumor Cells, Cultured | 1997 |
Establishment, characterization, and chromosomal analysis of new leukemic cell lines derived from MT/p210bcr/abl transgenic mice.
Topics: Animals; Antigens, CD; B7-1 Antigen; B7-2 Antigen; Chromosome Aberrations; Chromosome Disorders; Fusion Proteins, bcr-abl; Genes, p53; Humans; Karyotyping; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Membrane Glycoproteins; Mice; Mice, Transgenic; Phosphotyrosine; Point Mutation; Polymorphism, Single-Stranded Conformational; RNA, Messenger; RNA, Neoplasm; Trisomy; Tumor Cells, Cultured | 1998 |
c-Cbl tyrosine phosphorylation and subcellular localization in human primary leukemic cells.
Topics: Adaptor Proteins, Signal Transducing; Blotting, Western; GRB2 Adaptor Protein; Humans; Immunosorbent Techniques; Leukemia; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Nuclear Proteins; Phosphorylation; Phosphotyrosine; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proteins; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; src Homology Domains; Subcellular Fractions; Ubiquitin-Protein Ligases | 1998 |
A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells.
Topics: Collagen; Fusion Proteins, bcr-abl; Hematopoietic Stem Cells; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases; Phosphoproteins; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphotyrosine; src Homology Domains; Tumor Cells, Cultured | 1999 |
The src homology 2 domain of Bcr/Abl is required for efficient induction of chronic myeloid leukemia-like disease in mice but not for lymphoid leukemogenesis or activation of phosphatidylinositol 3-kinase.
Topics: Animals; Bone Marrow Cells; Cell Line; Cell Transformation, Neoplastic; Disease Models, Animal; Enzyme Activation; Female; Fusion Proteins, bcr-abl; Interleukin-3; Leukemia, B-Cell; Leukemia, Experimental; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Mice; Mice, Inbred BALB C; Myeloid Cells; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotyrosine; Point Mutation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Binding; Signal Transduction; src Homology Domains; Stem Cells | 2001 |
Phenylarsine oxide augments tyrosine phosphorylation in hematopoietic cells.
Topics: Aged; Animals; Arsenicals; Blood Platelets; Busulfan; Cell Line; Dithiothreitol; Gene Rearrangement; Granulocytes; Humans; Hydroxyurea; Karyotyping; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Mice; Phosphates; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Tyrosine | 1992 |
Differences in tyrosine phosphorylated proteins between cells expressing P210bcr/abl and P190bcr/abl.
Topics: Fusion Proteins, bcr-abl; Humans; Leukemia, Erythroblastic, Acute; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Neoplasm Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Signal Transduction; Substrate Specificity; Tumor Cells, Cultured; Tyrosine | 1992 |
Phosphotyrosine phosphatase activity prevents the detection of P210bcr/abl protein in mature cells in chronic myelogenous leukemia even by an immunoblotting technique.
Topics: Blast Crisis; Blotting, Western; Fusion Proteins, bcr-abl; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Molecular Weight; Neoplasm Proteins; Neutrophils; Peptide Hydrolases; Phosphoprotein Phosphatases; Phosphoproteins; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Tyrosine | 1989 |