phosphotyrosine has been researched along with Invasiveness, Neoplasm in 50 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (20.00) | 18.2507 |
| 2000's | 18 (36.00) | 29.6817 |
| 2010's | 20 (40.00) | 24.3611 |
| 2020's | 2 (4.00) | 2.80 |
| Authors | Studies |
|---|---|
| Choi, JH; Hwang, YE; Jeong, J; Kang, T; Keum, S; Kim, JW; Park, D; Park, E; Rhee, S; Yang, SJ | 1 |
| Cao, N; Cha, JH; Chen, Y; Lan, HY; Yan, X; Yang, MH; Yang, WH | 1 |
| Condeelis, J; Gil-Henn, H; Halo, T; Koleske, AJ; Machida, K; Mader, CC; Rosenberg, BJ; Wu, YI; Yin, T | 1 |
| Deng, Y; Ding, Q; He, K; Li, H; Mu, G; Wu, L; Xu, M; Yang, D; Yu, H; Zhang, L; Zhou, J | 1 |
| Ali, AY; Parr, C | 1 |
| Cho, E; Choi, KM; Chung, YH; Han, EH; Kang, M; Kim, B; Kim, E; Kim, JY; Shin, JH | 1 |
| Chang, WC; Chen, CH; Du, Y; Hsu, JL; Hung, MC; Huo, L; James, BP; Khotskaya, YB; Lam, YC; Lim, SO; Liu, CG; Liu, X; Nakanishi, K; Patel, DJ; Shen, J; Wang, Y; Wu, Y; Xia, W | 1 |
| Diakonova, M; Oladimeji, P; Rider, L | 1 |
| Akita, K; Furukawa, K; Hamamura, K; Matsumoto, Y; Nakada, H; Okajima, T; Tsuchida, A; Urano, T; Zhang, Q | 1 |
| Cheng, X; Lü, W; Ma, D; Sima, N; Xie, X; Ye, F | 1 |
| Kim, NS; Morita, A; Nakahira, K; Yanagihara, I | 1 |
| Guo, S; Inoue, K; Leng, T; Liu, M; Xiong, ZG | 1 |
| Chin, YE; Deng, J; Gao, Y; Han, B; Li, Q; Liao, Y; Lin, X; Liu, J; Sun, B; Wang, Y; Yang, X; Yao, F; Ye, X; Zhang, J; Zhong, S; Zhou, BP | 1 |
| Ingley, E; Kendrick, TS; Kucera, N; Le, C; Louw, A; McCarthy, DJ; Phillips, M; Satiaputra, J; Tie, SR | 1 |
| Breslin, P; Cao, Q; Hao, C; Hu, C; Li, J; Sun, J; Tang, M; Volk, A; Wei, W; Xin, J; Xu, Y; Zhang, J | 1 |
| Hatakeyama, M; Murata-Kamiya, N; Senda, Y | 1 |
| Diakonova, M; Hammer, A | 1 |
| Cai, Z; Hua, Y; Li, J; Li, S; Lin, B; Wang, H; Wang, Z; Xu, J; Yi, C; Yin, F; Zhang, T; Zhou, Z; Zou, D | 1 |
| He, M; Jiang, L; Ren, Z; Wang, G; Wang, J | 1 |
| Beaulieu, E; Béliveau, R; Fontaine, N; Gingras, D; Michaud, M; Nyalendo, C; Sartelet, H | 1 |
| Marra, P; Marshall, CJ; Smith, HW | 1 |
| Dang, D; Dent, P; Fang, X; Greenbaum, S; Lee, Z; Mukherjee, A; Oyesanya, RA; Wu, J | 1 |
| Chen, SY; Chiu, HY; Jwo, SC; Lee, MY; Sun, GH; Sun, KH; Tang, SJ; Tsou, YC; Wang, HH | 1 |
| Dong, Z; Hardy, WR; Kaplan, A; Ngan, E; Northey, JJ; Pawson, T; Siegel, PM | 1 |
| Imamura, F; Inoue, M; Iwasaki, T; Kobayashi, S; Mukai, M; Murakami-Murofushi, K; Nakamura, H; Tatsuta, M; Togawa, A | 1 |
| Boerner, JL; Danielsen, AJ; Darce, JR; Faupel-Badger, JM; Juneja, SC; Lovejoy, CA; Maihle, NJ; Wang, Z | 1 |
| Blake, RA; Chan, J; Harris, D; Howlett, AR; Kiewlich, D; Le, P; Liang, C; Lipson, KE; McMahon, G; Miller, T; Patel, N; Rice, A; Sun, L; Vasile, S; Wang, X | 1 |
| Carragher, NO; Frame, MC | 1 |
| Hirohashi, S; Kanai, Y; Kokubu, A; Sekine, S; Shibata, T | 1 |
| Hakomori, Y; Matsuura, N; Misu, Y; Miyake, I; Nakadate, H; Sakai, R; Sakamoto, M | 1 |
| Dietrich, S; Koschinsky, F; Ludwig, A; Proksch, E; Sadowski, T; Sedlacek, R; Titz, B | 1 |
| Alaoui-Jamali, MA; Benlimame, N; He, Q; Jie, S; Loignon, M; Schlaepfer, DD; Xiao, D; Xu, YJ | 1 |
| Bowden, ET; Mueller, SC; Myoui, A; Onikoyi, E; Slack, R; Yamada, KM; Yoneda, T | 1 |
| Athauda, G; Bottaro, DP; Peruzzi, B | 1 |
| Olson, MF | 1 |
| Furukawa, K; Hamamura, K; Miyazaki, S; Nakashima, H; Ohkawa, Y; Tsuji, M; Ueda, M; Urano, T; Yamamoto, N | 1 |
| Annis, MG; Chmielecki, J; Muller, WJ; Ngan, E; Northey, JJ; Russo, C; Siegel, PM | 1 |
| Kramer, RH; Matsumoto, K; Nakamura, T | 1 |
| Doki, Y; Inoue, M; Iwazawa, T; Kadowaki, T; Matsui, S; Oka, H; Shimaya, K; Shiozaki, H; Takeichi, M; Tamura, S | 1 |
| Akedo, H; Imamura, F; Iwasaki, T; Komagome, R; Mukai, M; Shinkai, K; Yoshioka, K | 1 |
| Bruyneel, E; Chastre, E; Comoglio, P; Courtneidge, S; Di Gioia, Y; Djelloul, S; Empereur, S; Gespach, C; Mareel, M; Paraskeva, C; Van Hengel, J; Van Roy, F | 1 |
| Guvakova, MA; Surmacz, E | 1 |
| Aprikian, AG; Chevalier, S; Han, K; Tremblay, L | 1 |
| Akedo, H; Furukawa, H; Imaoka, S; Ishikawa, O; Matumoto, Y; Monden, M; Mukai, M; Nakamori, S; Ohigashi, H; Okamoto, H; Shinkai, K | 1 |
| Ballinari, D; Bardelli, A; Basilico, C; Comoglio, PM; Giordano, S; Gramaglia, D; Longati, P; Michieli, P; Tamagnone, L | 1 |
| Aggarwal, BB; Chintala, SK; Gokslan, Z; Kyritsis, AP; Mohan, PM; Mohanam, S; Rao, JS; Sawaya, R; Steck, P; Uhm, JH; Yung, WK | 1 |
| Eisenmann, KM; Furcht, LT; Guan, JL; Iida, J; Keely, PJ; Lim, L; Manser, E; McCarthy, JB; Simpson, MA; Tachibana, K | 1 |
| Bertotti, A; Comoglio, PM; Trusolino, L | 1 |
| Akedo, H; Iwasaki, T; Kakishita, E; Mukai, M; Nakata, A; Sabe, H; Schaefer, E; Shinkai, K; Tatsuta, M; Terada, N; Tsujimura, T; Yano, H | 1 |
| Dubois, R; Hayashi, N; Hori, M; Ito, T; Kakiuchi, Y; Kawai, N; Kawano, S; Kimura, A; Komori, M; Sasaki, Y; Tsuji, S; Tsujii, M; Yasumaru, M | 1 |
1 review(s) available for phosphotyrosine and Invasiveness, Neoplasm
| Article | Year |
|---|---|
Focal adhesion and actin dynamics: a place where kinases and proteases meet to promote invasion.
Topics: Actins; Animals; Cell Movement; Focal Adhesions; Humans; Neoplasm Invasiveness; Peptide Hydrolases; Phosphotransferases; Phosphotyrosine | 2004 |
49 other study(ies) available for phosphotyrosine and Invasiveness, Neoplasm
| Article | Year |
|---|---|
Beta-Pix-dynamin 2 complex promotes colorectal cancer progression by facilitating membrane dynamics.
Topics: Amino Acid Sequence; Cell Line, Tumor; Cell Membrane; Cell Movement; Colorectal Neoplasms; Disease Progression; Dynamin II; Gene Expression Regulation, Neoplastic; Gold; HEK293 Cells; Humans; Matrix Metalloproteinase 14; Metal Nanoparticles; Neoplasm Invasiveness; Phosphorylation; Phosphotyrosine; Protein Binding; Pseudopodia; rac1 GTP-Binding Protein; Rho Guanine Nucleotide Exchange Factors; RNA, Messenger; src Homology Domains; Up-Regulation | 2021 |
MT4-MMP promotes invadopodia formation and cell motility in FaDu head and neck cancer cells.
Topics: Adaptor Proteins, Vesicular Transport; Cardiac Myosins; cdc42 GTP-Binding Protein; Cell Line, Tumor; Cell Movement; Gelatin; Head and Neck Neoplasms; HEK293 Cells; Humans; Matrix Metalloproteinases, Membrane-Associated; Myosin Light Chains; Neoplasm Invasiveness; Phosphorylation; Phosphotyrosine; Podosomes; Protein Binding; Receptor, Platelet-Derived Growth Factor alpha; rho GTP-Binding Proteins; Signal Transduction; src-Family Kinases | 2020 |
Phosphorylated cortactin recruits Vav2 guanine nucleotide exchange factor to activate Rac3 and promote invadopodial function in invasive breast cancer cells.
Topics: Actins; Breast Neoplasms; Cell Line, Tumor; Cortactin; Extracellular Matrix; Guanine Nucleotide Exchange Factors; Humans; Neoplasm Invasiveness; Phosphorylation; Phosphotyrosine; Podosomes; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-vav; Pseudopodia; rac GTP-Binding Proteins | 2017 |
Gastrin stimulates pancreatic cancer cell directional migration by activating the Gα12/13-RhoA-ROCK signaling pathway.
Topics: Animals; Cell Line, Tumor; Cell Movement; Cell Polarity; Disease Progression; Focal Adhesions; Gastrins; Golgi Apparatus; GTP-Binding Protein alpha Subunits, G12-G13; Humans; Mice, Inbred BALB C; Mice, Nude; Models, Biological; Neoplasm Invasiveness; Organic Chemicals; Pancreatic Neoplasms; Paxillin; Phosphorylation; Phosphotyrosine; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Time Factors | 2018 |
Boswellia frereana suppresses HGF-mediated breast cancer cell invasion and migration through inhibition of c-Met signalling.
Topics: Boswellia; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell-Matrix Junctions; Endothelial Cells; Female; Hepatocyte Growth Factor; Humans; Neoplasm Invasiveness; Phosphorylation; Phosphotyrosine; Plant Extracts; Proto-Oncogene Proteins c-met; Signal Transduction; Spheroids, Cellular | 2018 |
Prolonged MEK inhibition leads to acquired resistance and increased invasiveness in KRAS mutant gastric cancer.
Topics: Cell Line, Tumor; Crizotinib; Drug Resistance, Neoplasm; Humans; Imidazoles; Mitogen-Activated Protein Kinase Kinases; Mutation; Neoplasm Invasiveness; Niacinamide; Phenotype; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotyrosine; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Proto-Oncogene Proteins p21(ras); Quinolines; Stomach Neoplasms; TOR Serine-Threonine Kinases | 2018 |
EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2.
Topics: Argonaute Proteins; Breast Neoplasms; Cell Hypoxia; Cell Line, Tumor; Cell Survival; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs; Neoplasm Invasiveness; Nucleic Acid Conformation; Phosphorylation; Phosphotyrosine; Prognosis; Protein Binding; Ribonuclease III; RNA Precursors; Survival Analysis | 2013 |
PAK1 regulates breast cancer cell invasion through secretion of matrix metalloproteinases in response to prolactin and three-dimensional collagen IV.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Collagen Type IV; Enzyme Activation; Female; Gene Expression Regulation, Neoplastic; Humans; Matrix Metalloproteinases; Mitogen-Activated Protein Kinases; Models, Biological; Mutant Proteins; Neoplasm Invasiveness; NF-kappa B; p21-Activated Kinases; Phosphorylation; Phosphotyrosine; Prolactin; Rats; Transcription, Genetic | 2013 |
Trimeric Tn antigen on syndecan 1 produced by ppGalNAc-T13 enhances cancer metastasis via a complex formation with integrin α5β1 and matrix metalloproteinase 9.
Topics: Animals; Antigens, Tumor-Associated, Carbohydrate; Base Sequence; Carcinoma, Lewis Lung; Cell Adhesion; Fibronectins; Focal Adhesion Protein-Tyrosine Kinases; Gene Knockdown Techniques; Integrin alpha5beta1; Matrix Metalloproteinase 9; Membrane Microdomains; Mice; Models, Biological; Molecular Sequence Data; N-Acetylgalactosaminyltransferases; Neoplasm Invasiveness; Neoplasm Metastasis; Paxillin; Phosphotyrosine; Polypeptide N-acetylgalactosaminyltransferase; Protein Multimerization; Signal Transduction; Syndecan-1 | 2013 |
The overexpression of scaffolding protein NEDD9 promotes migration and invasion in cervical cancer via tyrosine phosphorylated FAK and SRC.
Topics: Adaptor Proteins, Signal Transducing; Cadherins; Cell Line, Tumor; Cell Movement; Female; Focal Adhesion Kinase 1; Gene Silencing; Humans; Neoplasm Invasiveness; Phosphoproteins; Phosphorylation; Phosphotyrosine; src-Family Kinases; Uterine Cervical Neoplasms; Vimentin; Viral Proteins | 2013 |
Phosphorylation of FOXP3 by LCK downregulates MMP9 expression and represses cell invasion.
Topics: Amino Acid Sequence; Down-Regulation; Forkhead Transcription Factors; Gene Expression Regulation, Neoplastic; Humans; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Matrix Metalloproteinase 9; MCF-7 Cells; Molecular Sequence Data; Neoplasm Invasiveness; Phosphorylation; Phosphotyrosine; Protein Binding; Real-Time Polymerase Chain Reaction; S-Phase Kinase-Associated Proteins; Sequence Alignment; Transcription, Genetic; Two-Hybrid System Techniques; Vascular Endothelial Growth Factor A | 2013 |
TRPM7 channels regulate glioma stem cell through STAT3 and Notch signaling pathways.
Topics: Aldehyde Dehydrogenase 1 Family; Base Sequence; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Fluorescent Antibody Technique; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Glioma; Humans; Isoenzymes; Models, Biological; Molecular Sequence Data; Neoplasm Invasiveness; Neoplastic Stem Cells; Phosphotyrosine; Promoter Regions, Genetic; Protein Binding; Protein Serine-Threonine Kinases; Real-Time Polymerase Chain Reaction; Receptors, Notch; Retinal Dehydrogenase; RNA, Messenger; Signal Transduction; STAT3 Transcription Factor; Subcellular Fractions; TRPM Cation Channels; Up-Regulation | 2014 |
EGFR phosphorylates and inhibits lung tumor suppressor GPRC5A in lung cancer.
Topics: Amino Acid Sequence; Carcinoma, Non-Small-Cell Lung; Cell Adhesion; Cell Line, Tumor; ErbB Receptors; Genes, Tumor Suppressor; HEK293 Cells; Humans; Lung Neoplasms; Molecular Sequence Data; Neoplasm Invasiveness; Phosphorylation; Phosphotyrosine; Protein Binding; Receptors, G-Protein-Coupled | 2014 |
Regulation of sarcoma cell migration, invasion and invadopodia formation by AFAP1L1 through a phosphotyrosine-dependent pathway.
Topics: Actins; Adaptor Proteins, Signal Transducing; Animals; Cell Division; Cell Line, Tumor; Humans; Mice; Microfilament Proteins; Neoplasm Invasiveness; Neoplasm Metastasis; Phosphorylation; Phosphotyrosine; Sarcoma | 2016 |
Hematopoietic Stem Cell Activity Is Regulated by Pten Phosphorylation Through a Niche-Dependent Mechanism.
Topics: Animals; Cell Differentiation; Cell Line, Tumor; Cell Movement; Cell Proliferation; Contact Inhibition; Focal Adhesion Protein-Tyrosine Kinases; Hematopoietic Stem Cells; Human Umbilical Vein Endothelial Cells; Humans; Mice, Inbred C57BL; Myeloid Progenitor Cells; Neoplasm Invasiveness; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; src-Family Kinases; Stem Cell Niche; Time Factors; Transduction, Genetic | 2016 |
C-terminal Src kinase-mediated EPIYA phosphorylation of Pragmin creates a feed-forward C-terminal Src kinase activation loop that promotes cell motility.
Topics: Amino Acid Motifs; Animals; Biocatalysis; Carrier Proteins; Cell Movement; Cell Shape; Cell Transformation, Neoplastic; Cells, Cultured; CSK Tyrosine-Protein Kinase; Enzyme Activation; Feedback, Physiological; Focal Adhesions; Humans; Intracellular Signaling Peptides and Proteins; Mice; Multiprotein Complexes; Neoplasm Invasiveness; Phosphorylation; Phosphotyrosine; Protein Binding; src-Family Kinases; Substrate Specificity | 2016 |
Prolactin-induced PAK1 tyrosyl phosphorylation promotes FAK dephosphorylation, breast cancer cell motility, invasion and metastasis.
Topics: Animals; Breast Neoplasms; Cell Movement; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Female; Focal Adhesion Protein-Tyrosine Kinases; Gene Silencing; Humans; Mice; Models, Biological; Neoplasm Invasiveness; Neoplasm Metastasis; p21-Activated Kinases; Phosphorylation; Phosphotyrosine; Prolactin; Protein Tyrosine Phosphatase, Non-Receptor Type 12 | 2016 |
Natural product pectolinarigenin inhibits osteosarcoma growth and metastasis via SHP-1-mediated STAT3 signaling inhibition.
Topics: Apoptosis; Biological Products; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromones; Epithelial-Mesenchymal Transition; Humans; Neoplasm Invasiveness; Osteosarcoma; Phenotype; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Signal Transduction; STAT3 Transcription Factor; Survival Analysis; Tumor Stem Cell Assay; Xenograft Model Antitumor Assays | 2016 |
Noscapine targets EGFR
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Bone Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; ErbB Receptors; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Structure; Molecular Targeted Therapy; Neoplasm Invasiveness; Neoplasm Proteins; Noscapine; Osteosarcoma; Papaver; Phosphorylation; Phosphotyrosine; Protein Kinase Inhibitors; Protein Processing, Post-Translational; RNA Interference; RNA, Small Interfering; Signal Transduction; Xenograft Model Antitumor Assays | 2016 |
Impaired tyrosine phosphorylation of membrane type 1-matrix metalloproteinase reduces tumor cell proliferation in three-dimensional matrices and abrogates tumor growth in mice.
Topics: Aneuploidy; Animals; Cell Cycle; Cell Division; Cell Line, Tumor; Cell Survival; Fibrosarcoma; Humans; Matrix Metalloproteinase 1; Mice; Neoplasm Invasiveness; Phosphorylation; Phosphotyrosine; Rats; Tyrosine | 2008 |
uPAR promotes formation of the p130Cas-Crk complex to activate Rac through DOCK180.
Topics: Cell Line, Tumor; Cell Surface Extensions; Crk-Associated Substrate Protein; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Humans; Integrin beta3; Neoplasm Invasiveness; Phosphorylation; Phosphotyrosine; Protein Structure, Tertiary; Proto-Oncogene Proteins c-crk; rac GTP-Binding Proteins; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator | 2008 |
Differential requirement of the epidermal growth factor receptor for G protein-mediated activation of transcription factors by lysophosphatidic acid.
Topics: Cell Line, Tumor; Cell Movement; Cell Proliferation; Epidermal Growth Factor; ErbB Receptors; Female; GTP-Binding Proteins; Hepatocyte Growth Factor; Humans; Interleukin-8; Lysophospholipids; Neoplasm Invasiveness; NF-kappa B; Phosphotyrosine; Transcription Factor AP-1 | 2010 |
Autocrine CCL2 promotes cell migration and invasion via PKC activation and tyrosine phosphorylation of paxillin in bladder cancer cells.
Topics: Animals; Autocrine Communication; Cell Line, Tumor; Cell Movement; Cell Transformation, Neoplastic; Chemokine CCL2; Enzyme Activation; Female; Gene Knockdown Techniques; Humans; Mice; Neoplasm Invasiveness; Paxillin; Phosphorylation; Phosphotyrosine; Protein Kinase C; Receptors, CCR2; Urinary Bladder Neoplasms | 2012 |
Distinct phosphotyrosine-dependent functions of the ShcA adaptor protein are required for transforming growth factor β (TGFβ)-induced breast cancer cell migration, invasion, and metastasis.
Topics: Amino Acid Motifs; Animals; Breast Neoplasms; Cell Movement; Cell Survival; Female; Humans; Lung Neoplasms; Mammary Neoplasms, Animal; Mice; Neoplasm Invasiveness; Neoplasm Metastasis; Phosphorylation; Phosphotyrosine; Receptor, ErbB-2; RNA, Small Interfering; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Transforming Growth Factor beta1 | 2013 |
Cyclic phosphatidic acid inhibits RhoA-mediated autophosphorylation of FAK at Tyr-397 and subsequent tumor-cell invasion.
Topics: Animals; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Liver Neoplasms; Liver Neoplasms, Experimental; Neoplasm Invasiveness; Phosphatidic Acids; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Rats, Inbred Strains; rhoA GTP-Binding Protein; Tyrosine | 2003 |
Grb2 regulation of the actin-based cytoskeleton is required for ligand-independent EGF receptor-mediated oncogenesis.
Topics: Actins; Adaptor Proteins, Signal Transducing; Agar; Animals; Calmodulin-Binding Proteins; Cell Line, Transformed; Cell Transformation, Neoplastic; Cells, Cultured; Chick Embryo; Cytoskeleton; ErbB Receptors; Fibroblasts; Glutathione Transferase; GRB2 Adaptor Protein; Ligands; Microscopy, Fluorescence; Models, Biological; Mutation; Neoplasm Invasiveness; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Structure, Tertiary; Proteins; Recombinant Fusion Proteins; Retroviridae; Signal Transduction; src Homology Domains; Tyrosine | 2003 |
Potent and selective inhibitors of the Met [hepatocyte growth factor/scatter factor (HGF/SF) receptor] tyrosine kinase block HGF/SF-induced tumor cell growth and invasion.
Topics: Binding Sites; Cell Division; Cell Line, Tumor; Cell Movement; Enzyme Inhibitors; Hepatocyte Growth Factor; Humans; Indoles; Models, Molecular; Neoplasm Invasiveness; Neoplasms; Phosphorylation; Phosphotyrosine; Protein Conformation; Proto-Oncogene Proteins c-met; Pyrroles; Signal Transduction | 2003 |
Cytoplasmic p120ctn regulates the invasive phenotypes of E-cadherin-deficient breast cancer.
Topics: Base Sequence; Breast Neoplasms; Cadherins; Carcinoma, Lobular; Catenins; Cell Adhesion Molecules; Cell Division; Cell Movement; Delta Catenin; Female; Humans; Immunohistochemistry; Neoplasm Invasiveness; Oligodeoxyribonucleotides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Plasmids; RNA, Small Interfering; Transfection | 2004 |
Domain-specific function of ShcC docking protein in neuroblastoma cells.
Topics: Agar; Animals; Apoptosis; Cell Adhesion; Cell Differentiation; Cell Line, Tumor; Cell Movement; Cell Proliferation; Genes, Dominant; Humans; Immunoblotting; Immunohistochemistry; In Situ Nick-End Labeling; Mice; Mice, Nude; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mutation; Neoplasm Invasiveness; Neoplasm Transplantation; Neuroblastoma; Neuropeptides; Phosphorylation; Phosphotyrosine; Plasmids; Protein Binding; Protein Structure, Tertiary; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 3; src Homology Domains; Thymidine; Time Factors; Transfection; Tretinoin; Wound Healing | 2005 |
Matrix metalloproteinase 19 processes the laminin 5 gamma 2 chain and induces epithelial cell migration.
Topics: Cell Movement; Cells, Cultured; Collagen Type IV; Epidermal Cells; Epidermis; Fibrin; Humans; Keratinocytes; Laminin; Matrix Metalloproteinases, Secreted; Metalloendopeptidases; Neoplasm Invasiveness; Neoplasms, Squamous Cell; Phosphotyrosine | 2005 |
FAK signaling is critical for ErbB-2/ErbB-3 receptor cooperation for oncogenic transformation and invasion.
Topics: Animals; Cell Line; Cell Line, Tumor; Cell Transformation, Neoplastic; Chemotaxis; Enzyme Activation; Focal Adhesion Protein-Tyrosine Kinases; Humans; MAP Kinase Signaling System; Mice; Mice, Knockout; Mice, SCID; Neoplasm Invasiveness; Neoplasm Metastasis; Phosphorylation; Phosphotyrosine; Receptor, ErbB-2; Receptor, ErbB-3; RNA, Small Interfering; Signal Transduction; src-Family Kinases | 2005 |
Co-localization of cortactin and phosphotyrosine identifies active invadopodia in human breast cancer cells.
Topics: Breast Neoplasms; Carcinoma; Cell Line, Tumor; Cell Membrane; Cortactin; CSK Tyrosine-Protein Kinase; Down-Regulation; Enzyme Activation; Extracellular Matrix; Female; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Humans; Microscopy, Electron, Transmission; Neoplasm Invasiveness; Peptide Hydrolases; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pseudopodia; src-Family Kinases; Transfection; Up-Regulation | 2006 |
The von Hippel-Lindau tumor suppressor gene product represses oncogenic beta-catenin signaling in renal carcinoma cells.
Topics: beta Catenin; Carcinoma, Renal Cell; Cell Movement; Cell Shape; Cytoplasm; Epithelial Cells; Hepatocyte Growth Factor; Humans; Kidney Neoplasms; Kidney Tubules, Proximal; Morphogenesis; Mutant Proteins; Neoplasm Invasiveness; Phosphorylation; Phosphotyrosine; Protein Transport; Signal Transduction; Transcriptional Activation; Tumor Cells, Cultured; Von Hippel-Lindau Tumor Suppressor Protein | 2006 |
Mechanisms of tumour cell invasion and metastasis.
Topics: Cadherins; Clinical Trials as Topic; Humans; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Neoplasms; Phosphotyrosine | 2007 |
Focal adhesion kinase as well as p130Cas and paxillin is crucially involved in the enhanced malignant properties under expression of ganglioside GD3 in melanoma cells.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Cattle; Cell Line, Tumor; Cell Proliferation; Crk-Associated Substrate Protein; Focal Adhesion Protein-Tyrosine Kinases; Gangliosides; Humans; Immunoprecipitation; Mass Spectrometry; Melanoma; Molecular Sequence Data; Mutation; Neoplasm Invasiveness; Paxillin; Phosphorylation; Phosphotyrosine; Protein Binding; Serum; Transfection | 2008 |
Signaling through ShcA is required for transforming growth factor beta- and Neu/ErbB-2-induced breast cancer cell motility and invasion.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Movement; Female; Focal Adhesions; Gene Expression; Lung Neoplasms; Mammary Neoplasms, Experimental; Mice; Mice, Nude; Neoplasm Invasiveness; Phosphotyrosine; Point Mutation; Receptor, ErbB-2; RNA, Small Interfering; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Transfection; Transforming Growth Factor beta | 2008 |
Hepatocyte growth factor/scatter factor induces tyrosine phosphorylation of focal adhesion kinase (p125FAK) and promotes migration and invasion by oral squamous cell carcinoma cells.
Topics: Benzoquinones; Carcinoma, Squamous Cell; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Hepatocyte Growth Factor; Humans; In Vitro Techniques; Integrins; Lactams, Macrocyclic; Mouth Neoplasms; Neoplasm Invasiveness; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-met; Quinones; Receptor Protein-Tyrosine Kinases; Rifabutin; Tumor Cells, Cultured; Tyrosine | 1994 |
Effect of epidermal growth factor on cadherin-mediated adhesion in a human oesophageal cancer cell line.
Topics: alpha Catenin; Benzoquinones; beta Catenin; Cadherins; Carcinoma, Squamous Cell; Cell Adhesion; Cell Aggregation; Cell Line; Culture Techniques; Cytoskeletal Proteins; Epidermal Growth Factor; ErbB Receptors; Esophageal Neoplasms; Fibroblasts; Fluorescent Antibody Technique; Gels; Humans; Lactams, Macrocyclic; Neoplasm Invasiveness; Neoplasm Proteins; Phenotype; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Quinones; Rifabutin; Signal Transduction; Trans-Activators; Tumor Cells, Cultured; Tumor Stem Cell Assay; Tyrosine; Vanadates | 1995 |
rho-Mediated protein tyrosine phosphorylation in lysophosphatidic-acid-induced tumor-cell invasion.
Topics: Animals; Cell Adhesion Molecules; Cytoskeletal Proteins; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genistein; GTP-Binding Proteins; Isoflavones; Liver Neoplasms, Experimental; Lysophospholipids; Neoplasm Invasiveness; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; rho GTP-Binding Proteins; Signal Transduction; Tumor Cells, Cultured | 1996 |
Progression of familial adenomatous polyposis (FAP) colonic cells after transfer of the src or polyoma middle T oncogenes: cooperation between src and HGF/Met in invasion.
Topics: Adenomatous Polyposis Coli; Adenomatous Polyposis Coli Protein; alpha Catenin; Animals; Antigens, Polyomavirus Transforming; Cadherins; Catenins; Cell Adhesion Molecules; Chickens; Collagen; Cytoskeletal Proteins; Delta Catenin; DNA, Neoplasm; Gels; Genes, src; Hepatocyte Growth Factor; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Transplantation; Oncogenes; Phosphoproteins; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins c-met; Receptor Protein-Tyrosine Kinases; Signal Transduction; Transfection; Transplantation, Heterologous | 1997 |
Overexpressed IGF-I receptors reduce estrogen growth requirements, enhance survival, and promote E-cadherin-mediated cell-cell adhesion in human breast cancer cells.
Topics: Breast Neoplasms; Cadherins; Cell Adhesion; Cell Aggregation; Cell Division; Cell Survival; Collagen; Drug Combinations; Estradiol; Extracellular Matrix; Fluorescent Antibody Technique; Humans; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Laminin; Neoplasm Invasiveness; Phosphoproteins; Phosphorylation; Phosphotyrosine; Proteins; Proteoglycans; Receptor, IGF Type 1; Transfection; Tumor Cells, Cultured | 1997 |
Bombesin stimulates the motility of human prostate-carcinoma cells through tyrosine phosphorylation of focal adhesion kinase and of integrin-associated proteins.
Topics: Bombesin; Cell Adhesion Molecules; Cell Movement; Cytoskeletal Proteins; Extracellular Matrix Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Immunosorbent Techniques; Integrins; Male; Neoplasm Invasiveness; Paxillin; Phosphoproteins; Phosphotyrosine; Prostatic Neoplasms; Protein-Tyrosine Kinases; Signal Transduction; Tumor Cells, Cultured | 1997 |
Down-regulation of focal adhesion kinase, pp125FAK, in endothelial cell retraction during tumor cell invasion.
Topics: Animals; Cattle; Cell Adhesion Molecules; Culture Media; Down-Regulation; Endothelium, Vascular; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Microscopy, Electron, Scanning; Molecular Weight; Neoplasm Invasiveness; Pancreatic Neoplasms; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Tumor Cells, Cultured | 1998 |
Uncoupling signal transducers from oncogenic MET mutants abrogates cell transformation and inhibits invasive growth.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Carcinoma, Papillary; Carcinoma, Renal Cell; Cell Division; Cell Transformation, Neoplastic; Cloning, Molecular; COS Cells; Humans; Kidney Neoplasms; Kinetics; Mutagenesis, Site-Directed; Neoplasm Invasiveness; Oncogenes; Peptide Fragments; Phosphorylation; Phosphotyrosine; Point Mutation; Polymerase Chain Reaction; Proto-Oncogene Proteins c-met; Recombinant Fusion Proteins; Signal Transduction; Transfection | 1998 |
Altered actin cytoskeleton and inhibition of matrix metalloproteinase expression by vanadate and phenylarsine oxide, inhibitors of phosphotyrosine phosphatases: modulation of migration and invasion of human malignant glioma cells.
Topics: Actins; Arsenicals; Cell Adhesion Molecules; Cell Movement; Cytoskeleton; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression Regulation, Neoplastic; Glioma; Humans; Matrix Metalloproteinases; Neoplasm Invasiveness; Phosphoproteins; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Vanadates | 1999 |
Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas.
Topics: cdc42 GTP-Binding Protein; Cell Movement; Chondroitin Sulfate Proteoglycans; Crk-Associated Substrate Protein; Enzyme Activation; Humans; Integrin alpha4beta1; Integrins; Melanoma; Mutation; Neoplasm Invasiveness; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Binding; Protein-Tyrosine Kinases; Proteins; Receptors, Lymphocyte Homing; Retinoblastoma-Like Protein p130; Signal Transduction; Transfection; Tumor Cells, Cultured | 1999 |
A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Antigens, Surface; Cell Adhesion; Cell Line; Female; Hepatocyte Growth Factor; Humans; Integrin alpha6beta4; Integrins; Lung Neoplasms; Mice; Mice, Nude; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; Neoplasms, Experimental; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Serine-Threonine Kinases; Protein Subunits; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-met; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Stomach Neoplasms; Transfection; Tumor Cells, Cultured | 2001 |
Involvement of phosphorylation of Tyr-31 and Tyr-118 of paxillin in MM1 cancer cell migration.
Topics: Amiloride; Animals; Blotting, Western; Cell Movement; Cytoskeletal Proteins; Dose-Response Relationship, Drug; Fibronectins; Immunoblotting; Lysophospholipids; Neoplasm Invasiveness; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Pseudopodia; Rats; Serine Endopeptidases; Signal Transduction; Time Factors; Tumor Cells, Cultured; Tyrosine | 2002 |
Tumor necrosis factor alpha stimulates invasion of Src-activated intestinal cells.
Topics: Agar; Animals; Antineoplastic Agents; Antioxidants; beta Catenin; Cadherins; Cell Line, Transformed; Cell Movement; Cytoskeletal Proteins; Hydrogen Peroxide; Intestinal Mucosa; Neoplasm Invasiveness; Oncogene Protein p21(ras); Oncogene Protein pp60(v-src); Oxidative Stress; Phosphotyrosine; Pyrrolidines; Rats; Thiocarbamates; Trans-Activators; Transfection; Tumor Necrosis Factor-alpha; Tyrosine | 2002 |