phosphotyrosine has been researched along with Diabetes Mellitus, Adult-Onset in 23 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.35) | 18.7374 |
| 1990's | 7 (30.43) | 18.2507 |
| 2000's | 11 (47.83) | 29.6817 |
| 2010's | 4 (17.39) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Davis, RJ; Dittmann, A; Kennedy, NJ; Mana, MD; Morshed, N; Soltero, NL; White, FM; Yilmaz, ÖH | 1 |
| Liu, M; Sun, X; Wang, L; Zhao, X | 1 |
| Daniel, H; Ecker, J; Giesbertz, P; Höfle, AS; Padberg, I; Rein, D; Spanier, B | 1 |
| Abengoechea, S; Ballester, J; Elizalde, J; Fernández-Novell, JM; Nadal, J; Ramió-Lluch, L; Reverter, JL; Rivera, MM; Rodriguez, JE | 1 |
| Hassid, A; Lin, Y; Sreejayan, N | 1 |
| Abella, A; Camps, M; Carpéné, C; Claret, M; Fernández-Alvarez, J; Gomis, R; Gumà, A; Marti, L; Palacín, M; Testar, X; Viguerie, N; Zorzano, A | 1 |
| Bouzakri, K; Espinosa, S; Gual, P; Guebre-Egziabher, F; Laville, M; Le Marchand-Brustel, Y; Riou, JP; Roques, M; Tanti, JF; Vidal, H | 1 |
| Advani, A; Marshall, SM; Thomas, TH | 1 |
| Hernández-Cruz, JM; Pariente, JA; Redondo, PC; Rosado, JA; Saavedra, FR; Salido, GM | 1 |
| Jardín, I; Pariente, JA; Redondo, PC; Rosado, JA; Salido, GM | 1 |
| Budavari, A; Hotamisligil, GS; Murray, D; Spiegelman, BM | 1 |
| Björnholm, M; Kawano, Y; Lehtihet, M; Zierath, JR | 1 |
| Begum, N; Ragolia, L | 1 |
| Accili, D; Brüning, JC; Goodyear, LJ; Hayashi, T; Hörsch, D; Kahn, CR; Michael, MD; Winnay, JN | 1 |
| Chan, CC; Cheng, A; Collins, S; Cromlish, W; Elchebly, M; Gresser, MJ; Himms-Hagen, J; Kennedy, BP; Loy, AL; Michaliszyn, E; Normandin, D; Payette, P; Ramachandran, C; Tremblay, ML | 1 |
| Almind, K; Ambye, L; Berglund, L; Bernal, D; Ekstrøm, CT; Frederiksen, SK; Hansen, T; Lithell, H; Pedersen, O; Reneland, R; Urhammer, S; Van Obberghen, E; White, MF | 1 |
| Björnholm, M; Fahlman, R; Galuska, D; Jiang, XJ; Krook, A; Myers, MG; Wallberg-Henriksson, H; Zierath, JR | 1 |
| Kranz, A; Lange, J; Waltenberger, J | 1 |
| Björnholm, M; Jensen, CB; Madsbad, S; Song, XM; Storgaard, H; Vaag, A; Zierath, JR | 1 |
| Bogardus, C; Funahashi, T; Havel, PJ; Lindsay, RS; Matsuzawa, Y; Pratley, RE; Stefan, N; Tataranni, PA; Vozarova, B; Weyer, C; Youngren, JF | 1 |
| Eckel, J; Janez, A; Kocijancic, A; Sharma, PM; Sketelj, A; Tomazic, M | 1 |
| Bonner-Weir, S; Kahn, CR; Meyerovitch, J; Rothenberg, P; Shechter, Y | 1 |
| Brillon, DJ; Freidenberg, GR; Henry, RR; Olefsky, JM | 1 |
23 other study(ies) available for phosphotyrosine and Diabetes Mellitus, Adult-Onset
| Article | Year |
|---|---|
High-fat diet in a mouse insulin-resistant model induces widespread rewiring of the phosphotyrosine signaling network.
Topics: Animals; Cell Line, Tumor; Diabetes Mellitus, Type 2; Diet, High-Fat; Disease Models, Animal; Fatty Acids; Hepatocytes; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Obesity; Phosphorylation; Phosphotyrosine; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Proteomics; Rats; Reactive Oxygen Species; Signal Transduction; src-Family Kinases | 2019 |
Investigating the impact of Asp181 point mutations on interactions between PTP1B and phosphotyrosine substrate.
Topics: Binding Sites; Catalytic Domain; Diabetes Mellitus, Type 2; Humans; Hydrogen Bonding; Insulin; Leptin; Molecular Dynamics Simulation; Phosphotyrosine; Point Mutation; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Signal Transduction; Substrate Specificity | 2014 |
Metabolite profiling in plasma and tissues of ob/ob and db/db mice identifies novel markers of obesity and type 2 diabetes.
Topics: 3-Hydroxybutyric Acid; Adipose Tissue; Animals; Diabetes Mellitus, Type 2; Fatty Acids; Gas Chromatography-Mass Spectrometry; Gene Expression Regulation; Glyoxylates; Insulin Resistance; Leptin; Liver; Lysine; Male; Metabolome; Metabolomics; Mice; Mice, Inbred C57BL; Mice, Obese; Muscle, Skeletal; Obesity; Phosphotyrosine; Signal Transduction; Sorbitol | 2015 |
Diabetic Retinopathy Is Associated with Decreased Tyrosine Nitrosylation of Vitreous Interleukins IL-1α, IL-1β, and IL-7.
Topics: Aged; Blood Glucose; Blotting, Western; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Female; Glycated Hemoglobin; Humans; Immunoprecipitation; Interleukin-1alpha; Interleukin-1beta; Interleukin-7; Male; Middle Aged; Nitric Oxide; Phosphorylation; Phosphotyrosine; Tyrosine; Vitreous Body | 2011 |
NO attenuates insulin signaling and motility in aortic smooth muscle cells via protein tyrosine phosphatase 1B-mediated mechanism.
Topics: Animals; Animals, Newborn; Aorta, Thoracic; Butadienes; Cell Communication; Cell Movement; Cells, Cultured; Diabetes Mellitus, Type 2; Drug Synergism; Enzyme Inhibitors; Female; Insulin; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Mutation; Nitric Oxide; Nitric Oxide Donors; Nitriles; Penicillamine; Phosphotyrosine; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatase, Non-Receptor Type 12; Protein Tyrosine Phosphatases; Rats; Rats, Sprague-Dawley; Receptor, Insulin; Recombinant Proteins; Signal Transduction; src Homology Domains | 2002 |
Semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 activity exerts an antidiabetic action in Goto-Kakizaki rats.
Topics: Adipocytes; Amine Oxidase (Copper-Containing); Animals; Benzylamines; Biological Transport; Blood Glucose; Cell Adhesion Molecules; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Glucose; Insulin; Insulin Resistance; Insulin Secretion; Islets of Langerhans; Male; Muscle, Skeletal; Peroxides; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Rats; Rats, Wistar; Recombinant Proteins; Vanadates | 2003 |
Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes.
Topics: Biopsy; Cells, Cultured; Diabetes Mellitus, Type 2; Gene Expression Regulation, Enzymologic; Hexokinase; Humans; Insulin Receptor Substrate Proteins; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphotyrosine; Receptor, Insulin; Reference Values; RNA, Messenger; Serine | 2003 |
Increasing neutrophil F-actin corrects CD11b exposure in Type 2 diabetes.
Topics: Actins; Antigens, Surface; Arsenicals; CD11b Antigen; Cells, Cultured; Cytoskeleton; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Female; Humans; Immunoblotting; Male; Middle Aged; Neutrophils; Phalloidine; Phosphotyrosine; Polymers | 2004 |
Reduced plasma membrane Ca2+-ATPase function in platelets from patients with non-insulin-dependent diabetes mellitus.
Topics: Adult; Blood Platelets; Calcium; Calcium-Transporting ATPases; Cation Transport Proteins; Diabetes Mellitus, Type 2; Female; Humans; Insulin Resistance; Ionomycin; Male; Phosphorylation; Phosphotyrosine; Plasma Membrane Calcium-Transporting ATPases; Platelet Activation; Protein Processing, Post-Translational; Thapsigargin | 2004 |
Endogenously generated reactive oxygen species reduce PMCA activity in platelets from patients with non-insulin-dependent diabetes mellitus.
Topics: Antioxidants; Blood Platelets; Calcium; Calcium-Transporting ATPases; Catalase; Cell Membrane; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Humans; Ionomycin; Ionophores; Phosphotyrosine; Platelet Activation; Reactive Oxygen Species; Thapsigargin | 2006 |
Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha.
Topics: Adipose Tissue; Animals; Diabetes Mellitus; Diabetes Mellitus, Type 2; Disease Models, Animal; Immunoglobulin G; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Liver; Male; Muscles; Neutralization Tests; Obesity; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Rats, Zucker; Receptor, Insulin; Receptors, Tumor Necrosis Factor; Recombinant Fusion Proteins; Specific Pathogen-Free Organisms; Tumor Necrosis Factor-alpha; Tyrosine | 1994 |
Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation.
Topics: 3-O-Methylglucose; Biological Transport; Biopsy; Diabetes Mellitus, Type 2; Humans; Hyperinsulinism; Insulin; Insulin Receptor Substrate Proteins; Middle Aged; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Reference Values; Tumor Necrosis Factor-alpha | 1997 |
Altered regulation of insulin signaling components in adipocytes of insulin-resistant type II diabetic Goto-Kakizaki rats.
Topics: Adaptor Proteins, Signal Transducing; Adipocytes; Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Membrane; Diabetes Mellitus, Type 2; Disease Models, Animal; Enzyme Activation; Glucose Transporter Type 4; GRB2 Adaptor Protein; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; Monosaccharide Transport Proteins; Muscle Proteins; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Phosphatase 1; Proteins; Rats; Rats, Wistar; Receptor, Insulin; Signal Transduction | 1998 |
A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance.
Topics: Animals; Blood Glucose; Body Weight; Cells, Cultured; Cholesterol; Creatine Kinase; Diabetes Mellitus, Type 2; Female; Glucose; Glucose Tolerance Test; Insulin; Insulin Resistance; Integrases; Isoenzymes; Lipids; Liver; Male; Mice; Mice, Knockout; Mice, Transgenic; Muscle, Skeletal; Phosphotyrosine; Receptor, Insulin; Signal Transduction; Viral Proteins | 1998 |
Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Dietary Fats; Gene Targeting; Glucose Tolerance Test; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Liver; Male; Mice; Mice, Knockout; Muscle, Skeletal; Obesity; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Receptor, Insulin; Signal Transduction | 1999 |
Search for variants of the gene-promoter and the potential phosphotyrosine encoding sequence of the insulin receptor substrate-2 gene: evaluation of their relation with alterations in insulin secretion and insulin sensitivity.
Topics: Adolescent; Adult; Aged; Amino Acid Substitution; Base Sequence; Diabetes Mellitus, Type 2; Gene Frequency; Genetic Carrier Screening; Genetic Testing; Glucose Tolerance Test; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin Secretion; Intracellular Signaling Peptides and Proteins; Male; Middle Aged; Molecular Sequence Data; Pedigree; Phosphoproteins; Phosphotyrosine; Polymorphism, Single-Stranded Conformational; Promoter Regions, Genetic; Prospective Studies; Two-Hybrid System Techniques | 1999 |
Characterization of signal transduction and glucose transport in skeletal muscle from type 2 diabetic patients.
Topics: Biological Transport; Diabetes Mellitus, Type 2; Glucose; Glycogen Synthase; Humans; Insulin; Insulin Receptor Substrate Proteins; Male; Middle Aged; Mitogen-Activated Protein Kinases; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Receptor, Insulin; Signal Transduction; Time Factors; Tyrosine | 2000 |
Vascular endothelial growth factor-A-induced chemotaxis of monocytes is attenuated in patients with diabetes mellitus: A potential predictor for the individual capacity to develop collaterals.
Topics: Aged; Chemotaxis; Collateral Circulation; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diffusion Chambers, Culture; Endothelial Growth Factors; Female; Humans; In Vitro Techniques; Male; Middle Aged; Monocytes; Phosphotyrosine; Predictive Value of Tests; Vascular Endothelial Growth Factor A | 2000 |
Insulin signal transduction in skeletal muscle from glucose-intolerant relatives of type 2 diabetic patients [corrected].
Topics: Adult; Biopsy; Blood Glucose; Body Mass Index; Diabetes Mellitus, Type 2; Glucose Clamp Technique; Glucose Intolerance; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Lipid Peroxidation; Male; Middle Aged; Muscle, Skeletal; Oxidation-Reduction; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction | 2001 |
Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration precedes a decrease in whole-body insulin sensitivity in humans.
Topics: Adiponectin; Adolescent; Adult; Biopsy; Body Composition; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Glucose Clamp Technique; Glucose Intolerance; Glucose Tolerance Test; Humans; Indians, North American; Insulin; Intercellular Signaling Peptides and Proteins; Male; Middle Aged; Muscle, Skeletal; Phosphorylation; Phosphotyrosine; Proteins; Receptor, Insulin | 2002 |
Comparison of alterations in insulin signalling pathway in adipocytes from Type II diabetic pregnant women and women with gestational diabetes mellitus.
Topics: Adipocytes; Adult; Cesarean Section; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Humans; Insulin; Insulin Receptor Substrate Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Pregnancy; Pregnancy in Diabetics; Receptor, Insulin; Signal Transduction | 2002 |
Vanadate normalizes hyperglycemia in two mouse models of non-insulin-dependent diabetes mellitus.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Insulin; Liver; Mice; Mice, Mutant Strains; Mice, Obese; Microscopy, Electron; Phosphoprotein Phosphatases; Phosphotyrosine; Protein Tyrosine Phosphatases; Tyrosine; Vanadium | 1991 |
Mechanism of defective insulin-receptor kinase activity in NIDDM. Evidence for two receptor populations.
Topics: Adipose Tissue; Adult; Aged; Diabetes Mellitus; Diabetes Mellitus, Type 2; Humans; Insulin; Middle Aged; Obesity; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein-Tyrosine Kinases; Receptor, Insulin; Tyrosine | 1989 |