phosphotyrosine has been researched along with Cell Transformation, Neoplastic in 165 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 32 (19.39) | 18.7374 |
| 1990's | 97 (58.79) | 18.2507 |
| 2000's | 27 (16.36) | 29.6817 |
| 2010's | 8 (4.85) | 24.3611 |
| 2020's | 1 (0.61) | 2.80 |
| Authors | Studies |
|---|---|
| Allen, S; Madan, LK; Welsh, CL | 1 |
| Aceto, N; Alajati, A; Bentires-Alj, M; Bonenfant, D; Duss, S; Sarret, S; Sausgruber, N; Voshol, H | 1 |
| Bai, Y; Iliuk, A; Tao, WA; Walls, CD; Wang, M; Zhang, ZY | 1 |
| Hatakeyama, M; Murata-Kamiya, N; Senda, Y | 1 |
| Farooq, A; Frangou, C; Guo, J; Li, J; Li, YW; Mussell, AL; Qu, J; Shen, H; Sudol, M; Wilson, KE; Yang, N; Zhang, J; Zhang, Y | 1 |
| Barilà, D; Cenci, C; Fianco, G | 1 |
| Elabd, M; Freund, P; Gouilleux, F; Groner, B; Hager, M; Han, X; Kerenyi, MA; Krämer, OH; Moriggl, R; Pham, HTT; Sexl, V; Valent, P; Wagner, T; Wingelhofer, B | 1 |
| Cavenee, WK; Cheng, SY; Cheng, T; Feng, H; Fenton, T; Furnari, FB; Hamilton, RL; Hu, B; Jarzynka, MJ; Johns, TG; Keezer, S; Li, Y; Nishikawa, R; Sarkaria, JN; Tang, CK; Vuori, K | 1 |
| Chen, SY; Chiu, HY; Jwo, SC; Lee, MY; Sun, GH; Sun, KH; Tang, SJ; Tsou, YC; Wang, HH | 1 |
| Buckwalter, TL; Cho, JY; Jhiang, SM; La Perle, KM; Lavender, M; Robinson, ML; Venkateswaran, A | 1 |
| Drexler, HG; Quentmeier, H; Reinhardt, J; Zaborski, M | 1 |
| Coluccia, AM; Gambacorti-Passerini, C; Marchesi, E; Ruchatz, H; Stano, P | 1 |
| Boerner, JL; Danielsen, AJ; Darce, JR; Faupel-Badger, JM; Juneja, SC; Lovejoy, CA; Maihle, NJ; Wang, Z | 1 |
| Kim, M; Tanaka, K; Tezuka, T; Yamamoto, T | 1 |
| Jin, W; Kim, SJ; Lannon, CL; Martin, MJ; Sorensen, PH; Tognon, CE | 1 |
| Chuang, YC; Huang, CC; Leu, TH; Maa, MC; Su, SL; Yeh, HH | 1 |
| Dhôtel, H; Garbay, C; Lenoir, C; Liu, WQ; Million, E; Olszowy, C; Vidal, M | 1 |
| Healy, NC; Huigsloot, M; Kedersha, NL; Kiely, PA; Loughran, G; O'Connor, R | 1 |
| Arulanandam, R; Jove, R; Niu, G; Raptis, L; Turkson, J; Vultur, A | 1 |
| Bolton, E; Mohi, MG; Morrione, A; Neel, BG; Ren, SY; Skorski, T | 1 |
| Alaoui-Jamali, MA; Benlimame, N; He, Q; Jie, S; Loignon, M; Schlaepfer, DD; Xiao, D; Xu, YJ | 1 |
| Hatakeyama, M; Higashi, H | 1 |
| Cole, PA; Molina, H; Pandey, A; Qiao, Y; Zhang, J | 1 |
| Bumm, T; Corbin, AS; Deininger, MW; Druker, BJ; Goss, VL; Griswold, IJ; Johnson, K; Lee, KA; MacPartlin, M; Moseson, EM; O'Hare, T; Polakiewicz, RD; Smith, C; Stoffregen, EP; Wood, LJ | 1 |
| Baird, D; Cerione, RA; Feng, Q; Guan, JL; Ly, T; Peng, X; Wang, J | 1 |
| Chuang, NN; Huang, JW | 1 |
| Azuma, T; Hatakeyama, M; Higashi, H; Iwabuchi, K; Matsui, A; Miura, M; Musashi, M; Ohnishi, N; Sawa, H; Suzuki, M; Tanaka, S; Yamada, G; Yuasa, H | 1 |
| Gilmore, T; Martin, GS; Radke, K | 1 |
| Blomberg, J; Reynolds, FH; Stephenson, JR; Van de Ven, WJ | 1 |
| Blomberg, J; Nalewaik, RP; Reynolds, FH; Stephenson, JR; Van de Ven, WJ | 1 |
| Newmark, P | 1 |
| Marquardt, H; Reynolds, FH; Stephenson, JR; Todaro, GJ; Twardzik, DR | 1 |
| Albert, D; Chen, AP; de Noronha, F; Essex, M; Kelliher, M; Niederkorn, JY; Shadduck, JA | 1 |
| Hirano, A; Neil, JC; Vogt, PK | 1 |
| Rohrschneider, L; Rosok, MJ | 1 |
| Martinez, R; Nakamura, KD; Weber, MJ | 1 |
| Chen, AP; de Noronha, F; Essex, M | 1 |
| Bishop, JM; Snyder, MA | 1 |
| Comoglio, PM; Di Renzo, MF; Marchisio, PC | 1 |
| Hunter, T | 1 |
| Ihara, S; Ogawa, R; Ohtsuka, M; Watanabe, T; Watanabe, Y | 1 |
| Hayman, MJ; Morimoto, AM | 1 |
| Brautigan, DL; Chen, J; Parsons, S | 1 |
| Goga, A; Havlik, M; McLaughlin, J; Sawyers, CL; Witte, O | 1 |
| Carlberg, K; Rohrschneider, L | 1 |
| Iyer, AP; Kochhar, KS; Linnekin, D | 1 |
| Huang, TS; Kuo, ML; Lin, JK; Yang, NC | 1 |
| Daniel, J; McCrea, PD; Reynolds, AB; Wheelock, MJ; Wu, J; Zhang, Z | 1 |
| Wang, LH; Zong, CS | 1 |
| Afar, DE; Maru, Y; Peters, KL; Shibuya, M; Smithgall, TE; Witte, ON | 1 |
| Calalb, MB; Hanks, SK; Polte, TR | 1 |
| Bibbins, KB; Boeuf, H; Murphy, J; Varmus, HE | 1 |
| Asai, N; Iwashita, T; Matsuyama, M; Takahashi, M | 1 |
| Avila, MA; Cho, C; Lupu, R; Notario, V; Velasco, JA; Wen, D | 1 |
| Havlik, MH; Li, T; Park, H; Satterthwaite, A; Takatsu, K; Tsukada, S; Witte, ON | 1 |
| Aaronson, SA; Alimandi, M; Curia, MC; Di Fiore, PP; Fedi, P; Kraus, MH; Muraro, R; Romano, A | 1 |
| Davis, RL; Denhardt, DT; Lopez, CA; Mou, K | 1 |
| Campbell, GS; Carter-Su, C; Jove, R; Larner, AC; Meyer, DJ; Schwartz, J; Yu, CL | 1 |
| Burridge, K; Clark, GJ; Der, CJ; Kinch, MS | 1 |
| Bockholt, SM; Bouton, A; Burridge, K; Parsons, JT; Petch, LA | 1 |
| Bacus, SS; Chang, CJ; Hung, MC; Zhang, L | 1 |
| Ruoslahti, E; Vuori, K | 1 |
| Iyer, A; Johnson, M; Kochhar, K; Koukoulis, G; Kubo, C; Nakamura, T | 1 |
| Esselman, WJ; Kang, S; Welsch, CW; Wirth, J; Zhai, Y | 1 |
| Arighi, E; Bongarzone, I; Borrello, MG; Carcano, C; Della Porta, G; Ferraresi, G; Mondellini, P; Monzini, N; Pierotti, MA | 1 |
| Hung, MC; Matin, A | 1 |
| Fukui, Y; Hanafusa, H; Scholz, G; Sternberg, DW | 1 |
| Engleka, KA; Forough, R; Friedman, S; Maciag, T; MacPhee, M; Sayers, T; Wiltrout, RH; Xi, Z | 1 |
| Havlik, MH; Muller, AJ; Parmar, K; Pendergast, AM; Rosenberg, N; Witte, ON | 1 |
| Cool, DE; Diltz, CD; Fischer, EH; Krebs, EG; Rohrschneider, LR; Zander, NF | 1 |
| Greathead, P; Pories, SE; Simpson, H; Steele, G; Summerhayes, IC; Weber, TK | 1 |
| Areces, LB; Feldman, RA; Jücker, M; Miyajima, A; Mui, A; San Miguel, JA | 1 |
| Bruder, J; Foster, DA; Gupta, R; Hendrickson, M; Joseph, CK; Qureshi, SA; Rapp, U; Song, J | 1 |
| Chan, TC; Chang, CJ; Geahlen, RL; Koonchanok, NM | 1 |
| Hung, MC; Reardon, DB | 1 |
| Barbacid, M; Bustelo, XR; Pawson, T; Suen, KL | 1 |
| Di Fiore, PP; Fazioli, F; Matoskova, B; Minichiello, L; Wong, WT | 1 |
| DeClue, JE; Johnson, MR; Lowy, DR; Stacey, DW; Vass, WC | 1 |
| Gelman, IH; Hanafusa, H; Khan, S | 1 |
| Andersson, LC; Auvinen, M; Hirai, H; Hölttä, E; Paasinen-Sohns, A | 1 |
| Kung, HJ; Ling, L | 1 |
| Grunicke, HH; Obermeier, A; Tinhofer, I; Ullrich, A | 1 |
| Denning, MF; Dlugosz, AA; Magnuson, T; Threadgill, DW; Yuspa, SH | 1 |
| Martin, GS; Tian, M | 1 |
| Carlesso, N; Frank, DA; Griffin, JD | 1 |
| Afar, DE; Maru, Y; Shibuya, M; Witte, ON | 1 |
| Cho, L; Gorman, DM; Kinoshita, S; Kitamura, T; Miyajima, A; Morikawa, Y; Mui, AL; Nolan, GP; Onishi, M | 1 |
| Garrison, JC; Liu, WW; Mattingly, RR | 1 |
| Band, H; Langdon, WY; Lupher, ML; Miyake, S; Reedquist, KA | 1 |
| Burky, SA; Chen, LB; Griffin, JD; Hirai, H; Li, JL; Pisick, E; Salgia, R; Sattler, M; Uemura, N; Wong, WK | 1 |
| Kristt, DA; Yarden, Y | 1 |
| Bacon, CM; Johnston, JA; O'Shea, JJ; Riedy, MC | 1 |
| Cohen, BD; Fell, HP; Foy, L; Green, JM; Kiener, PA; Zhang, K | 1 |
| Pawson, T | 1 |
| Birge, RB; Greulich, H; Hanafusa, H; Nievers, MG; van Bergen en Henegouwen, PM; Verkleij, AJ | 1 |
| Hirai, H; Iwamatsu, A; Mitani, K; Nakamoto, T; Odai, H; Sasaki, K; Ueno, H; Yamagata, T; Yazaki, Y | 1 |
| Gilmer, TM; Kanner, SB; Lansing, TJ; Turk, BF | 1 |
| Baserga, R; Morrione, A; Taylor, SJ; Valentinis, B | 1 |
| Davis, JG; Greene, MI; Kajino, K; Kajino, Y; O'Rourke, DM; Wang, Q; Weber, BL; Zhang, HB; Zhang, HT; Zhang, X; Zhao, HZ | 1 |
| Afar, DE; Colicelli, J; Dhaka, A; Han, L; McLaughlin, J; Parmar, K; Rosenberg, N; Witte, ON; Wong, S | 1 |
| Band, H; Bonita, DP; Langdon, WY; Lupher, ML; Miyake, S | 1 |
| Birnbaum, D; Blaikie, PA; Borg, JP; Dilworth, SM; Fournier, E; Margolis, B | 1 |
| Bortecen, KH; Efstathiou, JA; Kidd, M; Luque, EA; Modlin, IM; Tang, LH; Tarasova, NI | 1 |
| Hanada, M; Hashimoto, K; Hirota, S; Ishiguro, S; Isozaki, K; Kanakura, Y; Kawano, K; Kitamura, Y; Kurata, A; Matsuzawa, Y; Moriyama, Y; Muhammad Tunio, G; Nishida, T; Shinomura, Y; Takeda, M | 1 |
| Patarca, R | 1 |
| DiMaio, D; Irusta, PM; Petti, LM | 1 |
| Ballinari, D; Bardelli, A; Basilico, C; Comoglio, PM; Giordano, S; Gramaglia, D; Longati, P; Michieli, P; Tamagnone, L | 1 |
| Attié, T; Billaud, M; Chappuis-Flament, S; De Vita, G; Fusco, A; Lenoir, GM; Pasini, A; Santoro, M; Ségouffin-Cariou, C | 1 |
| Hatase, O; Masaki, T; Nishioka, M; Okada, M; Omata, M; Shirai, M; Shiratori, Y; Tokuda, M | 1 |
| Ahn, HY; Hadizadeh, KR; Sachinidis, A; Seul, C; Vetter, H; Yun, YP | 1 |
| Braga, VM; Cano, A; Espada, J; Pérez-Moreno, M; Rodriguez-Viciana, P | 1 |
| Fu, X; Kamps, MP; McGrath, S; Nakazawa, S; Pasillas, M | 1 |
| Chang, JS; Iwashita, S; Kim, MJ; Lee, YH; Ryu, SH; Suh, PG | 1 |
| Horvath, CM; Iyengar, R; Ram, PT | 1 |
| Aster, JC; Fletcher, JA; McCarthy, JG; Xiao, S | 1 |
| de Aos, IE; Ilaria, RL; Roumiantsev, S; Van Etten, RA; Varticovski, L | 1 |
| Kamikura, DM; Lamorte, L; Park, M | 1 |
| Chen, Z; Hamilton, AD; Haura, E; Jove, R; Kim, JS; Laudano, A; Ryan, D; Sebti, S; Turkson, J; Zhang, Y | 1 |
| Beebe, JS; Dmitrovsky, E; Dragnev, KH; Freemantle, SJ; Knauth, EA; Lonardo, F; Ma, Y; Memoli, N; Sekula, D | 1 |
| Griffin, JD; Husson, H; Lipkowitz, S; Malouf, NA; Pride, YB; Quinnan, LR; Salgia, R; Sattler, M; Verma, S | 1 |
| Akhand, AA; Hamaguchi, M; Iwashita, T; Kato, M; Kawamoto, Y; Nakashima, I; Senga, T; Sobue, G; Takahashi, M; Takeda, K; Yamamoto, M | 1 |
| Asano, S; Iijima, Y; Kruh, GD; Okuda, K; Sakaki, Y; Sato, Y; Setoyama, M; Tojo, A; Tokunaga, K; Tri, NK | 1 |
| Glenney, JR; Soppet, D | 1 |
| Chou, MM; Fajardo, JE; Hanafusa, H | 1 |
| Andersson, LC; Auvinen, M; Hölttä, E; Paasinen, A | 1 |
| Baltimore, D; Jackson, PK; Mayer, BJ; Van Etten, RA | 1 |
| Dixon, JE; Rhodes, JD; Woodford-Thomas, TA | 1 |
| Brugge, JS; Foster, DA; Maroney, AC; Qureshi, SA | 1 |
| Kozma, LM; Reynolds, AB; Weber, MJ | 1 |
| Ellis, C; McCormick, F; Moran, M; Pawson, T | 1 |
| Dutta, A; Hamaguchi, M; Hanafusa, H | 1 |
| Cohen, B; Piwnica-Worms, H; Roberts, TM; Schaffhausen, BS; Yoakim, M | 1 |
| Hanafusa, H; Mayer, BJ | 1 |
| Engelman, A; Rosenberg, N | 1 |
| Aaronson, SA; Giese, N; LaRochelle, WJ; May-Siroff, M; Robbins, KC | 1 |
| Fitzgerald, DL; Payne, DM; Wasilenko, WJ; Weber, MJ | 1 |
| Baltimore, D; Jackson, PK; Mayer, BJ | 1 |
| Hirai, H; Varmus, HE | 1 |
| Hanafusa, H; Matsuda, M; Mayer, BJ | 1 |
| Alitalo, K; Comoglio, PM; Di Renzo, MF; Koskinen, P; Lehtola, L; Lehväslaiho, H; Sistonen, L | 1 |
| Li, W; Stanley, ER; Yeung, YG | 1 |
| Abraham, KM; Forbush, KA; Levin, SD; Marth, JD; Perlmutter, RM | 1 |
| Havlik, MH; Maru, Y; Muller, AJ; Pendergast, AM; Witte, ON | 1 |
| Faller, DV; Mundschau, LJ; Quiñones, MA; Rake, JB | 1 |
| Aaronson, SA; Arnstein, P; Artrip, J; Di Fiore, PP; DiMarco, E; Kraus, MH; Lonardo, F; Pierce, JH | 1 |
| Hanafusa, H | 1 |
| Kozma, LM; Rossomando, AJ; Weber, MJ | 1 |
| Klarlund, JK | 1 |
| Chieco-Bianchi, L; Comoglio, PM; Di Renzo, MF; Ferracini, R; Naldini, L; Saggioro, D | 1 |
| Comoglio, PM; Di Renzo, MF; Ferracini, R; Giordano, S; Naldini, L | 1 |
| Wang, JY | 1 |
| Bauer, H; Niemann, H; Simon, E; Snoek, GT; Tamura, T | 1 |
| Kipreos, ET; Lee, GJ; Wang, JY | 1 |
| Cantley, L; Kaplan, DR; Pallas, DC; Roberts, TM; Schaffhausen, B; White, M; Whitman, M | 1 |
| Browning, PJ; Morrison, DK; Roberts, TM; White, MF | 1 |
| Comoglio, PM; Di Renzo, MF; Gaudino, G | 1 |
| Comoglio, PM; D'Urso, N; Giancotti, FG; Marchisio, PC; Tarone, G | 1 |
| Kaplan, JM; Varmus, HE; Verderame, MF | 1 |
| Deuel, TF; Kawahara, RS; Pierce, GF; Shawver, LK | 1 |
| Mizuno, S; Murakami, Y; Sugimoto, Y; Uehara, Y | 1 |
| Cao, H; Kamps, MP; Stern, DF | 1 |
| Gilmer, TM; Kanner, SB; Parsons, JT; Reynolds, AB | 1 |
| Lau, AF | 1 |
| Glenney, JR | 1 |
| Gavazzi, I; Marchisio, PC; Nermut, MV | 1 |
7 review(s) available for phosphotyrosine and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Setting sail: Maneuvering SHP2 activity and its effects in cancer.
Topics: Carcinogenesis; Cell Differentiation; Cell Transformation, Neoplastic; Humans; Neoplasms; Phosphotyrosine | 2023 |
Helicobacter pylori CagA: a new paradigm for bacterial carcinogenesis.
Topics: Amino Acid Sequence; Antigens, Bacterial; Bacterial Proteins; Cell Division; Cell Movement; Cell Polarity; Cell Transformation, Neoplastic; Gastric Mucosa; Helicobacter Infections; Helicobacter pylori; Humans; Molecular Sequence Data; Phosphorylation; Phosphotyrosine; Signal Transduction; Stomach Neoplasms | 2005 |
Signaling by IL-2 and related cytokines: JAKs, STATs, and relationship to immunodeficiency.
Topics: Cell Transformation, Neoplastic; Chromosome Mapping; DNA-Binding Proteins; Enzyme Precursors; Genes; Humans; Interleukin-12; Interleukin-2; Intracellular Signaling Peptides and Proteins; Janus Kinase 3; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Lymphocytes; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Cytokine; Severe Combined Immunodeficiency; Signal Transduction; src Homology Domains; src-Family Kinases; STAT1 Transcription Factor; Syk Kinase; Trans-Activators | 1996 |
Tyrosine kinase signalling pathways.
Topics: Amino Acid Sequence; Animals; Cell Transformation, Neoplastic; Humans; Intracellular Signaling Peptides and Proteins; Molecular Sequence Data; Neoplasm Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; ras Proteins; Receptor Protein-Tyrosine Kinases; Sequence Alignment; SH2 Domain-Containing Protein Tyrosine Phosphatases; Signal Transduction; src Homology Domains | 1994 |
Protein phosphorylation and dephosphorylation in physiologic and oncologic processes.
Topics: Animals; Cell Transformation, Neoplastic; Humans; Neoplasms; Oncogene Proteins; Phosphorylation; Phosphotyrosine; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proteins | 1996 |
Protein phosphorylation and cell transformation.
Topics: 1-Phosphatidylinositol 4-Kinase; Cell Transformation, Neoplastic; Cell Transformation, Viral; Genes, src; Humans; Neoplasm Proteins; Oncogene Protein pp60(v-src); Oncogene Protein v-crk; Phosphorylation; Phosphotransferases; Phosphotyrosine; Protein Binding; Retroviridae Proteins, Oncogenic; Signal Transduction; Tyrosine | 1991 |
Protein tyrosine kinases associated with human malignancies.
Topics: Antibodies, Neoplasm; Carcinoma, Small Cell; Cell Division; Cell Transformation, Neoplastic; Fusion Proteins, bcr-abl; Humans; Leukemia, Myeloid; Neoplasm Proteins; Oncogenes; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Bombesin; Receptors, Cell Surface; Receptors, Neurotransmitter; Recombinant Fusion Proteins; Tyrosine | 1987 |
158 other study(ies) available for phosphotyrosine and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Mammary tumor formation and metastasis evoked by a HER2 splice variant.
Topics: Alternative Splicing; Animals; Apoptosis; Biomarkers, Tumor; Breast; Breast Neoplasms; Cell Culture Techniques; Cell Cycle; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Chromatography, Liquid; Epithelial-Mesenchymal Transition; Female; Gene Expression Profiling; Humans; Immunoenzyme Techniques; Lung Neoplasms; Mammary Glands, Human; Mammary Neoplasms, Animal; Mice; Mice, SCID; Oligonucleotide Array Sequence Analysis; Phosphorylation; Phosphotyrosine; Real-Time Polymerase Chain Reaction; Receptor, ErbB-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tandem Mass Spectrometry | 2013 |
Phosphatase of regenerating liver 3 (PRL3) provokes a tyrosine phosphoproteome to drive prometastatic signal transduction.
Topics: Amino Acid Sequence; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Clone Cells; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; HEK293 Cells; Humans; Integrins; Molecular Sequence Annotation; Molecular Sequence Data; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphotyrosine; Protein Binding; Protein Tyrosine Phosphatases; Receptors, Eph Family; Receptors, Platelet-Derived Growth Factor; rho GTP-Binding Proteins; Signal Transduction; src-Family Kinases; STAT Transcription Factors | 2013 |
C-terminal Src kinase-mediated EPIYA phosphorylation of Pragmin creates a feed-forward C-terminal Src kinase activation loop that promotes cell motility.
Topics: Amino Acid Motifs; Animals; Biocatalysis; Carrier Proteins; Cell Movement; Cell Shape; Cell Transformation, Neoplastic; Cells, Cultured; CSK Tyrosine-Protein Kinase; Enzyme Activation; Feedback, Physiological; Focal Adhesions; Humans; Intracellular Signaling Peptides and Proteins; Mice; Multiprotein Complexes; Neoplasm Invasiveness; Phosphorylation; Phosphotyrosine; Protein Binding; src-Family Kinases; Substrate Specificity | 2016 |
Phosphorylation of Tyr188 in the WW domain of YAP1 plays an essential role in YAP1-induced cellular transformation.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Breast Neoplasms; Cell Line, Tumor; Cell Transformation, Neoplastic; Humans; Immunoprecipitation; Mass Spectrometry; Morphogenesis; Oncogenes; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Domains; Protein Processing, Post-Translational; Transcription Factors; YAP-Signaling Proteins | 2016 |
Caspase-8 expression and its Src-dependent phosphorylation on Tyr380 promote cancer cell neoplastic transformation and resistance to anoikis.
Topics: Anoikis; Apoptosis; Caspase 8; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Colonic Neoplasms; Enzyme Activation; Humans; Mutant Proteins; Phosphorylation; Phosphotyrosine; src-Family Kinases | 2016 |
O-GlcNAcylation of STAT5 controls tyrosine phosphorylation and oncogenic transcription in STAT5-dependent malignancies.
Topics: Acetylglucosamine; Animals; Cell Line; Cell Transformation, Neoplastic; Female; Gene Expression Regulation, Neoplastic; Genes, Reporter; Glycosylation; Humans; Interleukin-3; Lymphoid Tissue; Male; Mice; Mutagenesis, Site-Directed; Myeloproliferative Disorders; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Radiation Chimera; Recombinant Fusion Proteins; Signal Transduction; STAT5 Transcription Factor; T-Lymphocytes; Threonine; Transcriptional Activation; Tumor Suppressor Proteins | 2017 |
Phosphorylation of dedicator of cytokinesis 1 (Dock180) at tyrosine residue Y722 by Src family kinases mediates EGFRvIII-driven glioblastoma tumorigenesis.
Topics: Amino Acid Sequence; Cell Line, Tumor; Cell Movement; Cell Survival; Cell Transformation, Neoplastic; ErbB Receptors; Glioblastoma; Humans; Molecular Sequence Data; Phosphorylation; Phosphotyrosine; Prognosis; Proto-Oncogene Proteins c-fyn; rac GTP-Binding Proteins; rac1 GTP-Binding Protein; src-Family Kinases | 2012 |
Autocrine CCL2 promotes cell migration and invasion via PKC activation and tyrosine phosphorylation of paxillin in bladder cancer cells.
Topics: Animals; Autocrine Communication; Cell Line, Tumor; Cell Movement; Cell Transformation, Neoplastic; Chemokine CCL2; Enzyme Activation; Female; Gene Knockdown Techniques; Humans; Mice; Neoplasm Invasiveness; Paxillin; Phosphorylation; Phosphotyrosine; Protein Kinase C; Receptors, CCR2; Urinary Bladder Neoplasms | 2012 |
The roles of phosphotyrosines-294, -404, and -451 in RET/PTC1-induced thyroid tumor formation.
Topics: Amino Acid Substitution; Animals; Antithyroid Agents; Carcinoma, Papillary; Cell Transformation, Neoplastic; Diet; Humans; Iodine; MAP Kinase Signaling System; Mice; Mice, Transgenic; Mutagenesis, Site-Directed; Oncogene Proteins; Oncogene Proteins, Fusion; Phosphorylation; Phosphotyrosine; Propylthiouracil; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; Signal Transduction; Thyroid Neoplasms; Tubulin | 2002 |
FLT3 mutations in acute myeloid leukemia cell lines.
Topics: Acute Disease; Base Sequence; Blotting, Western; Cell Transformation, Neoplastic; DNA-Binding Proteins; fms-Like Tyrosine Kinase 3; Gene Expression Regulation, Leukemic; Humans; Leukemia, Myeloid; Milk Proteins; Molecular Sequence Data; Phosphorylation; Phosphotyrosine; Point Mutation; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Receptors, Cell Surface; Signal Transduction; STAT5 Transcription Factor; Tandem Repeat Sequences; Thymidine; Trans-Activators; Tumor Cells, Cultured | 2003 |
Constitutive activation of Jak2 contributes to proliferation and resistance to apoptosis in NPM/ALK-transformed cells.
Topics: Animals; Apoptosis; B-Lymphocytes; Caseins; Cell Division; Cell Line, Transformed; Cell Transformation, Neoplastic; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Gene Expression; Hematopoietic Stem Cells; Immunosorbent Techniques; Janus Kinase 2; Luciferases; Mice; Milk Proteins; Phosphorylation; Phosphotyrosine; Promoter Regions, Genetic; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; STAT5 Transcription Factor; Trans-Activators; Transcription, Genetic; Transfection; Tyrphostins | 2003 |
Grb2 regulation of the actin-based cytoskeleton is required for ligand-independent EGF receptor-mediated oncogenesis.
Topics: Actins; Adaptor Proteins, Signal Transducing; Agar; Animals; Calmodulin-Binding Proteins; Cell Line, Transformed; Cell Transformation, Neoplastic; Cells, Cultured; Chick Embryo; Cytoskeleton; ErbB Receptors; Fibroblasts; Glutathione Transferase; GRB2 Adaptor Protein; Ligands; Microscopy, Fluorescence; Models, Biological; Mutation; Neoplasm Invasiveness; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Structure, Tertiary; Proteins; Recombinant Fusion Proteins; Retroviridae; Signal Transduction; src Homology Domains; Tyrosine | 2003 |
Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation.
Topics: Animals; Cell Division; Cell Line; Cell Line, Transformed; Cell Size; Cell Transformation, Neoplastic; Humans; Mice; NIH 3T3 Cells; Oncogene Protein pp60(v-src); Phosphorylation; Phosphotyrosine; Protein Binding; Protein Structure, Tertiary; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Ubiquitin; Ubiquitin-Protein Ligases | 2004 |
A highly conserved NTRK3 C-terminal sequence in the ETV6-NTRK3 oncoprotein binds the phosphotyrosine binding domain of insulin receptor substrate-1: an essential interaction for transformation.
Topics: Agar; Amino Acid Sequence; Animals; Binding Sites; Cell Differentiation; Cell Line; Cell Line, Tumor; Cell Survival; Cell Transformation, Neoplastic; Conserved Sequence; DNA-Binding Proteins; DNA, Complementary; Enzyme Activation; ETS Translocation Variant 6 Protein; Fibroblasts; Genes, Dominant; Genetic Vectors; Humans; Insulin Receptor Substrate Proteins; Mice; Mice, Nude; Molecular Sequence Data; Mutagenesis, Site-Directed; Neurons; NIH 3T3 Cells; Oncogene Proteins, Fusion; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphotyrosine; Protein Binding; Protein Structure, Tertiary; Proto-Oncogene Proteins c-ets; Receptor, trkC; Repressor Proteins; Retroviridae; Sequence Homology, Amino Acid; Signal Transduction; Time Factors; Tyrosine | 2004 |
Participation of p97Eps8 in Src-mediated transformation.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Agar; Animals; Blotting, Northern; Cell Division; Cell Line; Cell Transformation, Neoplastic; Chickens; Cortactin; Cytoskeletal Proteins; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Histones; Hydroxamic Acids; Immunoblotting; Microfilament Proteins; Mutation; Paxillin; Phosphoproteins; Phosphotyrosine; Precipitin Tests; Protein-Tyrosine Kinases; Proteins; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; src-Family Kinases; Time Factors; Transfection | 2004 |
Structure-activity relationships of small phosphopeptides, inhibitors of Grb2 SH2 domain, and their prodrugs.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents; Binding, Competitive; Cell Line, Tumor; Cell Transformation, Neoplastic; Esters; GRB2 Adaptor Protein; Humans; Mice; Molecular Mimicry; NIH 3T3 Cells; Phosphopeptides; Phosphotyrosine; Prodrugs; Proteins; Receptor, ErbB-2; src Homology Domains; Structure-Activity Relationship | 2004 |
Mystique is a new insulin-like growth factor-I-regulated PDZ-LIM domain protein that promotes cell attachment and migration and suppresses Anchorage-independent growth.
Topics: Actins; Amino Acid Sequence; Animals; Cell Adhesion; Cell Line; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Collagen; Contact Inhibition; Cytoskeletal Proteins; Cytoskeleton; Fibronectins; Gene Silencing; Humans; Insulin-Like Growth Factor I; Integrin beta1; LIM Domain Proteins; Mice; Microfilament Proteins; Molecular Sequence Data; Paxillin; Phosphoproteins; Phosphotyrosine; Protein Isoforms; Protein Structure, Tertiary; Sequence Alignment | 2005 |
Stat3 is required for full neoplastic transformation by the Simian Virus 40 large tumor antigen.
Topics: Animals; Antigens, Viral, Tumor; Cell Line; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Humans; Mice; Phosphotyrosine; Protein Binding; Protein-Tyrosine Kinases; Retinoblastoma Protein; RNA, Small Interfering; Simian virus 40; Up-Regulation | 2005 |
Phosphatidylinositol 3-kinase p85{alpha} subunit-dependent interaction with BCR/ABL-related fusion tyrosine kinases: molecular mechanisms and biological consequences.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cattle; Cell Line; Cell Transformation, Neoplastic; Fusion Proteins, bcr-abl; Humans; Leukemia; Mice; Mice, SCID; Mutation; Phosphatidylinositol 3-Kinases; Phosphotyrosine; Protein Interaction Mapping; src Homology Domains | 2005 |
FAK signaling is critical for ErbB-2/ErbB-3 receptor cooperation for oncogenic transformation and invasion.
Topics: Animals; Cell Line; Cell Line, Tumor; Cell Transformation, Neoplastic; Chemotaxis; Enzyme Activation; Focal Adhesion Protein-Tyrosine Kinases; Humans; MAP Kinase Signaling System; Mice; Mice, Knockout; Mice, SCID; Neoplasm Invasiveness; Neoplasm Metastasis; Phosphorylation; Phosphotyrosine; Receptor, ErbB-2; Receptor, ErbB-3; RNA, Small Interfering; Signal Transduction; src-Family Kinases | 2005 |
Chemical rescue of a mutant enzyme in living cells.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Line; Cell Transformation, Neoplastic; Fluorescence Resonance Energy Transfer; Gene Expression Profiling; Gene Expression Regulation; Growth Substances; Humans; Imidazoles; Kinetics; Mice; Mitogen-Activated Protein Kinases; Mutation; Nuclear Proteins; Oligonucleotide Array Sequence Analysis; Phenotype; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins; Proto-Oncogene Proteins pp60(c-src); Recombinant Proteins; src Homology Domains; Transfection | 2006 |
Kinase domain mutants of Bcr-Abl exhibit altered transformation potency, kinase activity, and substrate utilization, irrespective of sensitivity to imatinib.
Topics: Amino Acid Sequence; Animals; Benzamides; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Colony-Forming Units Assay; Disease Models, Animal; Female; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Mutation; Myeloid Progenitor Cells; Phosphotransferases; Phosphotyrosine; Piperazines; Protein Structure, Tertiary; Pyrimidines; Signal Transduction; Substrate Specificity | 2006 |
Cool-1 functions as an essential regulatory node for EGF receptor- and Src-mediated cell growth.
Topics: Animals; cdc42 GTP-Binding Protein; Cell Cycle Proteins; Cell Proliferation; Cell Transformation, Neoplastic; Endocytosis; ErbB Receptors; Guanine Nucleotide Exchange Factors; Male; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; NIH 3T3 Cells; Oncogene Protein pp60(v-src); Phosphorylation; Phosphotyrosine; Protein Binding; Proto-Oncogene Proteins c-cbl; Rho Guanine Nucleotide Exchange Factors; RNA Interference; Signal Transduction; Transplantation, Heterologous | 2006 |
Shift syndecan-2 from RACK1 to caveolin-2 upon transformation with oncogenic ras.
Topics: Animals; Binding Sites; Caveolin 2; Cell Line; Cell Membrane; Cell Transformation, Neoplastic; GTP-Binding Proteins; Humans; Mice; Neoplasm Proteins; Oncogene Protein p21(ras); Phosphotyrosine; Protein Binding; Receptors for Activated C Kinase; Receptors, Cell Surface; Syndecan-2 | 2006 |
Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse.
Topics: Animals; Antigens, Bacterial; Bacterial Proteins; Cell Transformation, Neoplastic; Gastrointestinal Neoplasms; Gene Expression Regulation, Neoplastic; Helicobacter pylori; Hematologic Neoplasms; Mice; Mice, Transgenic; Phosphotyrosine | 2008 |
Transformation by Rous sarcoma virus: a cellular substrate for transformation-specific protein phosphorylation contains phosphotyrosine.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Chick Embryo; Oncogene Protein pp60(v-src); Phosphoproteins; Phosphorylation; Phosphotyrosine; Tyrosine; Viral Proteins | 1980 |
Differences in mechanisms of transformation by independent feline sarcoma virus isolates.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Epidermal Growth Factor; Mink; Phosphotyrosine; Protein Kinases; Rats; Retroviridae; Sarcoma Viruses, Feline; Tyrosine; Viral Proteins | 1981 |
Snyder-Theilen feline sarcoma virus P85 contains a single phosphotyrosine acceptor site recognized by its associated protein kinase.
Topics: Binding Sites; Cell Transformation, Neoplastic; Cell Transformation, Viral; Phosphorylation; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Retroviridae; Sarcoma Viruses, Feline; Serine; Tyrosine; Viral Proteins | 1981 |
Tyrosine phosphorylation and oncogenes.
Topics: Animals; Cell Transformation, Neoplastic; Humans; Mice; Oncogenic Viruses; Phosphotyrosine; Protein Kinases; Rats; Sodium-Potassium-Exchanging ATPase; Tyrosine | 1981 |
Transformation induced by Abelson murine leukemia virus involves production of a polypeptide growth factor.
Topics: Abelson murine leukemia virus; Animals; Cell Transformation, Neoplastic; Cell Transformation, Viral; ErbB Receptors; Molecular Weight; Peptides; Phosphotyrosine; Rats; Receptors, Cell Surface; Transforming Growth Factors; Tyrosine | 1982 |
Feline sarcoma virus-specific transformation-related proteins and protein kinase activity in tumor cells.
Topics: Animals; Cats; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Fibrosarcoma; Gene Products, gag; Melanoma; Mink; Peptides; Phosphotyrosine; Protein Kinases; Retroviridae; Retroviridae Proteins, Oncogenic; Sarcoma Viruses, Feline; Tumor Virus Infections; Tyrosine; Viral Proteins | 1983 |
ts Transformation mutants of avian sarcoma virus PRCII: lack of strict correlation between transforming ability and properties of the P105-associated kinase.
Topics: Animals; Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Chick Embryo; Fibroblasts; Helper Viruses; Mutation; Oncogene Protein pp60(v-src); Phosphorylation; Phosphotyrosine; Protein Kinases; Temperature; Tyrosine; Viral Proteins | 1983 |
Transformation parameters and pp60src localization in cells infected with partial transformation mutants of Rous sarcoma virus.
Topics: Animals; Cell Adhesion; Cell Compartmentation; Cell Transformation, Neoplastic; Cell Transformation, Viral; Chickens; Contractile Proteins; Cytoskeleton; Fibronectins; Filamins; Microfilament Proteins; Muscle Proteins; Mutation; Oncogene Protein pp60(v-src); Phosphoproteins; Phosphotyrosine; Tyrosine; Vinculin; Viral Proteins | 1983 |
Cultured cells transformed by Rous sarcoma virus: a genetically defined model and its phenotype.
Topics: Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Cells, Cultured; Colonic Neoplasms; Fibroblasts; Humans; Models, Biological; Neoplasm Proteins; Phenotype; Phosphorylation; Phosphotyrosine; Tyrosine | 1983 |
Detection and localization of a phosphotyrosine-containing onc gene product in feline tumor cells.
Topics: Animals; Cats; Cell Transformation, Neoplastic; Melanoma; Mink; Neoplasm Proteins; Neoplasms, Experimental; Oncogenes; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Retroviridae; Sarcoma, Experimental; Tyrosine | 1983 |
A mutation at the major phosphotyrosine in pp60v-src alters oncogenic potential.
Topics: Animals; Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Mice; Mice, Inbred BALB C; Mice, Nude; Mutation; Oncogene Protein pp60(v-src); Phenylalanine; Phosphotyrosine; Protein Kinases; Tyrosine; Viral Proteins | 1984 |
Immunofluorescence localization of phosphotyrosine containing proteins in RSV-transformed mouse fibroblasts.
Topics: Animals; Antibodies; Antigen-Antibody Complex; Avian Sarcoma Viruses; Cell Line; Cell Transformation, Neoplastic; Cross Reactions; Fibroblasts; Fluorescent Antibody Technique; Mice; Mice, Inbred BALB C; Phosphoproteins; Phosphotyrosine; Tyrosine | 1984 |
The proteins of oncogenes.
Topics: Animals; Annexins; Cell Transformation, Neoplastic; Cell Transformation, Viral; DNA; Epidermal Growth Factor; ErbB Receptors; Guanosine Triphosphate; Humans; Membrane Proteins; Neoplasm Proteins; Nucleoproteins; Oncogene Protein pp60(v-src); Oncogenes; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Binding; Protein Biosynthesis; Protein Kinases; Receptors, Cell Surface; Retroviridae; Tyrosine; Viral Proteins | 1984 |
Preparation and characterization of antibodies to O-phosphotyrosine and their use for identification of phosphotyrosine-containing proteins.
Topics: Animals; Antibodies; Antibody Specificity; Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Chick Embryo; ErbB Receptors; Female; Fluorescent Antibody Technique; Mice; Phosphorus Radioisotopes; Phosphotyrosine; Proteins; Rabbits; Receptors, Cell Surface; Tyrosine | 1984 |
Role of oligomerization of the S13 Env-Sea oncoprotein in cell transformation.
Topics: Alpharetrovirus; Animals; Blotting, Western; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Centrifugation, Density Gradient; Glycoproteins; Hexosaminidases; Oncogene Proteins, Viral; Oxidation-Reduction; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Conformation; Protein-Tyrosine Kinases; Rats; Tyrosine | 1994 |
Tyrosine phosphorylation of protein phosphatase 2A in response to growth stimulation and v-src transformation of fibroblasts.
Topics: Amino Acid Sequence; Animals; Antibodies; Cell Line; Cell Transformation, Neoplastic; Culture Media; Electrophoresis, Gel, Two-Dimensional; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Genes, src; Immunoblotting; Kinetics; Macromolecular Substances; Mice; Molecular Sequence Data; Peptides; Phosphoprotein Phosphatases; Phosphorylation; Phosphotyrosine; Protein Phosphatase 2; Tyrosine | 1994 |
The nuclear tyrosine kinase c-Abl negatively regulates cell growth.
Topics: 3T3 Cells; Animals; Cell Cycle; Cell Nucleus; Cell Transformation, Neoplastic; Gene Expression; Genes, abl; Genes, Dominant; Growth Inhibitors; Mice; Oncogenes; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-abl; Transfection; Tyrosine | 1994 |
The effect of activating mutations on dimerization, tyrosine phosphorylation and internalization of the macrophage colony stimulating factor receptor.
Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Endocytosis; Mice; Mutagenesis, Site-Directed; Mutation; Oncogene Protein gp140(v-fms); Phosphorylation; Phosphotyrosine; Protein Conformation; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Rabbits; Rats; Receptor, Macrophage Colony-Stimulating Factor; Recombinant Fusion Proteins; Tyrosine | 1994 |
PDGF-independent activation of PDGF-beta receptors in NIH-3T3 cells transformed by c-met protooncogene.
Topics: 3T3 Cells; Animals; Cell Division; Cell Transformation, Neoplastic; Enzyme Activation; In Vitro Techniques; Mice; Phosphotyrosine; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-met; Proto-Oncogenes; Receptor Protein-Tyrosine Kinases; Receptors, Platelet-Derived Growth Factor; Type C Phospholipases; Tyrosine | 1994 |
Reversion of the transformed phenotypes of v-H-ras NIH3T3 cells by flavonoids through attenuating the content of phosphotyrosine.
Topics: 3T3 Cells; Animals; Cell Division; Cell Line, Transformed; Cell Transformation, Neoplastic; Cell Transformation, Viral; Chamomile; Culture Media; Cyclic AMP; Dose-Response Relationship, Drug; Flavonoids; Genes, ras; Genistein; Isoflavones; Kaempferols; Mice; Oils, Volatile; Phenotype; Phosphotyrosine; Plants, Medicinal; Protein-Tyrosine Kinases; Quercetin; Tyrosine | 1994 |
Identification of a new catenin: the tyrosine kinase substrate p120cas associates with E-cadherin complexes.
Topics: 3T3 Cells; Alternative Splicing; Amino Acid Sequence; Animals; Antibodies, Monoclonal; beta Catenin; Cadherins; Catenins; Cattle; Cell Adhesion Molecules; Cell Line; Cell Transformation, Neoplastic; Cytoskeletal Proteins; Delta Catenin; Macromolecular Substances; Mice; Molecular Sequence Data; Phosphoproteins; Phosphotyrosine; Protein Binding; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Trans-Activators; Tyrosine | 1994 |
Modulatory effect of the transmembrane domain of the protein-tyrosine kinase encoded by oncogene ros: biological function and substrate interaction.
Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Chick Embryo; In Vitro Techniques; Membrane Glycoproteins; Mitogens; Mutagenesis, Site-Directed; Oncogene Proteins, Viral; Peptide Mapping; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Structure-Activity Relationship; Tyrosine | 1994 |
Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOS.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Line; Cell Transformation, Neoplastic; ErbB Receptors; Fusion Proteins, gag-onc; GRB2 Adaptor Protein; Guanine Nucleotide Exchange Factors; Humans; Oncogene Proteins; Oncogenes; Phosphorylation; Phosphotyrosine; Protein Binding; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcr; ras Guanine Nucleotide Exchange Factors; Recombinant Fusion Proteins; Recombinant Proteins; Restriction Mapping; Sequence Deletion; Spodoptera; Transfection; Tyrosine | 1995 |
Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases.
Topics: 3T3 Cells; Adenosine Triphosphate; Amino Acid Sequence; Animals; Avian Sarcoma Viruses; Base Sequence; Binding Sites; Cell Adhesion; Cell Adhesion Molecules; Cell Transformation, Neoplastic; Chlorocebus aethiops; Electrophoresis, Gel, Two-Dimensional; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Peptide Mapping; Phosphopeptides; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Receptor, Insulin; Recombinant Proteins; Transfection; Tyrosine | 1995 |
Binding in vitro of phosphotyrosine-containing proteins to pp60c-src SH2 domain does not correlate with CEF transformation.
Topics: 3T3 Cells; Animals; Cell Line; Cell Transformation, Neoplastic; Chick Embryo; Fibroblasts; Mice; Mutation; Phosphoproteins; Phosphotyrosine; Protein Binding; Proto-Oncogene Proteins pp60(c-src); Recombinant Fusion Proteins; Tyrosine | 1995 |
Mechanism of activation of the ret proto-oncogene by multiple endocrine neoplasia 2A mutations.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Biotin; Blotting, Western; Cadherins; Cell Transformation, Neoplastic; Cytomegalovirus; Drosophila Proteins; Gene Expression Regulation, Neoplastic; Humans; Mice; Multiple Endocrine Neoplasia Type 2a; Mutagenesis, Site-Directed; Phosphotyrosine; Point Mutation; Promoter Regions, Genetic; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Proto-Oncogenes; Receptor Protein-Tyrosine Kinases; Simian virus 40; Transfection; Tyrosine | 1995 |
Hyperactive autocrine loop mediated by a NDF-related factor in neoplastic hamster embryo fibroblasts expressing an activated cph oncogene.
Topics: 3T3 Cells; Animals; Cell Line; Cell Transformation, Neoplastic; Cricetinae; Fibroblasts; Glycoproteins; Mice; Neuregulins; Oncogenes; Phosphotyrosine; Receptor, ErbB-2; Tyrosine | 1995 |
Activation of Bruton's tyrosine kinase (BTK) by a point mutation in its pleckstrin homology (PH) domain.
Topics: 3T3 Cells; Agammaglobulinaemia Tyrosine Kinase; Animals; B-Lymphocytes; Base Sequence; Cell Transformation, Neoplastic; Enzyme Activation; Gene Expression; Mice; Molecular Sequence Data; Phosphotyrosine; Point Mutation; Protein-Tyrosine Kinases; RNA, Messenger; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1995 |
Cooperative signaling of ErbB3 and ErbB2 in neoplastic transformation and human mammary carcinomas.
Topics: 3T3 Cells; Animals; Base Sequence; Breast Neoplasms; Cell Transformation, Neoplastic; DNA Primers; ErbB Receptors; Gene Expression Regulation, Neoplastic; Genes, erbB; Glycoproteins; Ligands; Mice; Molecular Sequence Data; Neuregulins; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptor Aggregation; Receptor, ErbB-2; Receptor, ErbB-3; RNA, Messenger; Signal Transduction; Tyrosine | 1995 |
Activation of a signal transduction pathway by osteopontin.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Cell Transformation, Neoplastic; Mice; Molecular Sequence Data; Oligopeptides; Osteopontin; Phosphorylation; Phosphotyrosine; Receptors, Cytoadhesin; Sialoglycoproteins; Signal Transduction; Tyrosine | 1995 |
Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein.
Topics: Animals; Base Sequence; Cell Line, Transformed; Cell Transformation, Neoplastic; DNA; DNA-Binding Proteins; Growth Inhibitors; Interferon-gamma; Interleukin-6; Leukemia Inhibitory Factor; Lymphokines; Mice; Molecular Sequence Data; Oncogene Protein pp60(v-src); Phosphorylation; Phosphotyrosine; Signal Transduction; STAT3 Transcription Factor; Trans-Activators; Tyrosine | 1995 |
Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia.
Topics: beta Catenin; Breast; Cadherins; Catenins; Cell Adhesion; Cell Adhesion Molecules; Cell Line, Transformed; Cell Transformation, Neoplastic; Cytoskeletal Proteins; Delta Catenin; Epithelial Cells; Epithelium; Female; Genes, ras; Humans; Intercellular Junctions; Phosphoproteins; Phosphorylation; Phosphotyrosine; Solubility; Trans-Activators; Tyrosine | 1995 |
Adhesion-induced tyrosine phosphorylation of the p130 src substrate.
Topics: Animals; Antibodies, Monoclonal; Avian Sarcoma Viruses; Cell Adhesion; Cell Adhesion Molecules; Cell Line; Cell Transformation, Neoplastic; Embryo, Mammalian; Fibroblasts; Fibronectins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genes, src; Microscopy, Fluorescence; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Rats; Tyrosine | 1995 |
Suppressed transformation and induced differentiation of HER-2/neu-overexpressing breast cancer cells by emodin.
Topics: Breast Neoplasms; Cell Differentiation; Cell Division; Cell Line, Transformed; Cell Transformation, Neoplastic; Drug Screening Assays, Antitumor; Emodin; Humans; Phosphorylation; Phosphotyrosine; Proto-Oncogene Mas; Receptor, ErbB-2; Tumor Cells, Cultured; Tyrosine | 1995 |
Tyrosine phosphorylation of p130Cas and cortactin accompanies integrin-mediated cell adhesion to extracellular matrix.
Topics: 3T3 Cells; Actin Cytoskeleton; Actins; Animals; Cell Adhesion; Cell Adhesion Molecules; Cell Transformation, Neoplastic; Cells, Cultured; Cortactin; Crk-Associated Substrate Protein; Extracellular Matrix; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genes, src; In Vitro Techniques; Integrins; Mice; Microfilament Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Rats; Retinoblastoma-Like Protein p130; Tyrosine | 1995 |
Selective tumorigenesis in non-parenchymal liver epithelial cell lines by hepatocyte growth factor transfection.
Topics: Animals; Cell Division; Cell Transformation, Neoplastic; Contact Inhibition; Hepatocyte Growth Factor; Liver; Mice; Mice, Nude; Neoplasms, Experimental; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins c-met; Rats; Receptor Protein-Tyrosine Kinases; Transfection | 1995 |
LAR-PTPase cDNA transfection suppression of tumor growth of neu oncogene-transformed human breast carcinoma cells.
Topics: Animals; Breast Neoplasms; Cell Division; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Genes, erbB-2; Genes, Tumor Suppressor; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Phosphotyrosine; Protein Tyrosine Phosphatases; Receptor, ErbB-2; RNA, Neoplasm; Transfection; Transplantation, Heterologous; Tumor Cells, Cultured; Type C Phospholipases | 1995 |
Molecular characterization of a thyroid tumor-specific transforming sequence formed by the fusion of ret tyrosine kinase and the regulatory subunit RI alpha of cyclic AMP-dependent protein kinase A.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Base Sequence; Blotting, Western; Cell Transformation, Neoplastic; Cloning, Molecular; DNA; Drosophila Proteins; Gene Expression Regulation; Gene Rearrangement; Mice; Molecular Sequence Data; Oligodeoxyribonucleotides; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Thyroid Neoplasms; Tyrosine | 1993 |
Repression of neu-induced clonogenicity by dimethylsulfoxide correlates with decreased levels of neu-encoded cell-surface p185 and changes in phosphotyrosine content of endogenous proteins.
Topics: Animals; Cell Differentiation; Cell Line, Transformed; Cell Transformation, Neoplastic; Clone Cells; Dimethyl Sulfoxide; Mice; Neoplasm Proteins; Oncogenes; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptor, ErbB-2; Tyrosine | 1993 |
Activation of a histone H1 kinase by tyrosine phosphorylation in v-src-transformed fibroblasts.
Topics: Amino Acid Sequence; Animals; Avian Sarcoma Viruses; CDC2 Protein Kinase; Cell Cycle Proteins; Cell Line; Cell Line, Transformed; Cell Transformation, Neoplastic; Chromatography, Gel; Chromatography, Ion Exchange; Enzyme Activation; Fibroblasts; Fungal Proteins; Genes, src; Homeostasis; Immunoblotting; Kinetics; Molecular Sequence Data; Phosphotyrosine; Protamine Kinase; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Recombinant Proteins; Schizosaccharomyces pombe Proteins; Tyrosine | 1993 |
Differential transforming abilities of non-secreted and secreted forms of human fibroblast growth factor-1.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Base Sequence; Cell Division; Cell Transformation, Neoplastic; Fibroblast Growth Factors; Genetic Vectors; In Vitro Techniques; Mice; Mice, Nude; Molecular Sequence Data; Neoplasm Metastasis; Neoplasms, Experimental; Oligodeoxyribonucleotides; Phosphotyrosine; Protein Sorting Signals; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Structure-Activity Relationship; Transfection; Tyrosine | 1993 |
En bloc substitution of the Src homology region 2 domain activates the transforming potential of the c-Abl protein tyrosine kinase.
Topics: Animals; Antibodies, Monoclonal; Cell Division; Cell Line; Cell Nucleus; Cell Transformation, Neoplastic; Enzyme Activation; Genes, abl; Humans; Mice; Moloney murine sarcoma virus; Phosphorylation; Phosphotyrosine; Promoter Regions, Genetic; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-abl; Rats; Restriction Mapping; Signal Transduction; Transfection; Tyrosine | 1993 |
Suppression of v-fms-induced transformation by overexpression of a truncated T-cell protein tyrosine phosphatase.
Topics: Animals; Cell Division; Cell Line; Cell Line, Transformed; Cell Transformation, Neoplastic; Cell Transformation, Viral; Genes, fms; Phosphotyrosine; Protein Tyrosine Phosphatases; Rats; T-Lymphocytes; Transfection; Tyrosine | 1993 |
Immortalization and neoplastic transformation of normal rat colon epithelium: an in vitro model of colonic neoplastic progression.
Topics: Animals; Cell Division; Cell Line, Transformed; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Cytological Techniques; Gene Expression; Intestinal Mucosa; Phosphotyrosine; Rats; Reference Values; Simian virus 40; Tyrosine | 1993 |
Ligand-dependent transformation by the receptor for human granulocyte/macrophage colony-stimulating factor and tyrosine phosphorylation of the receptor beta subunit.
Topics: 3T3 Cells; Animals; Cell Division; Cell Line, Transformed; Cell Transformation, Neoplastic; Electrophoresis, Polyacrylamide Gel; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Macromolecular Substances; Mice; Phosphorylation; Phosphotyrosine; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Recombinant Proteins; Signal Transduction; Transfection; Tyrosine | 1993 |
A dominant negative Raf-1 mutant prevents v-Src-induced transformation.
Topics: 3T3 Cells; Animals; Cell Transformation, Neoplastic; Cells, Cultured; Diglycerides; Genes, Dominant; Mice; Mice, Inbred BALB C; Mutation; Oncogene Protein pp60(v-src); Phosphotyrosine; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Tyrosine | 1993 |
Selective inhibition of the growth of ras-transformed human bronchial epithelial cells by emodin, a protein-tyrosine kinase inhibitor.
Topics: Bronchi; Cell Cycle; Cell Division; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug; Doxorubicin; Emodin; Epithelium; Genes, ras; Humans; Phosphotyrosine; Protein-Tyrosine Kinases; Tyrosine | 1993 |
Downstream signal transduction defects that suppress transformation in two revertant cell lines expressing activated rat neu oncogene.
Topics: 3T3 Cells; Animals; Blotting, Southern; Cell Division; Cell Line, Transformed; Cell Transformation, Neoplastic; DNA; Ethyl Methanesulfonate; Mice; Mutagenesis; Oncogenes; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogenes; Receptor, ErbB-2; Receptors, Cell Surface; Restriction Mapping; Signal Transduction; Tyrosine | 1993 |
Molecular cloning of the mouse grb2 gene: differential interaction of the Grb2 adaptor protein with epidermal growth factor and nerve growth factor receptors.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Base Sequence; Caenorhabditis elegans; Cell Transformation, Neoplastic; Cloning, Molecular; ErbB Receptors; Gene Expression; Genes; GRB2 Adaptor Protein; Mice; Molecular Sequence Data; Oligodeoxyribonucleotides; Oncogene Proteins; PC12 Cells; Phosphoproteins; Phosphotyrosine; Protein Binding; Proteins; Receptors, Nerve Growth Factor; Recombinant Fusion Proteins; RNA, Messenger; Sequence Alignment; Tyrosine | 1993 |
eps15, a novel tyrosine kinase substrate, exhibits transforming activity.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Base Sequence; Calcium-Binding Proteins; Cell Compartmentation; Cell Division; Cell Transformation, Neoplastic; Cloning, Molecular; ErbB Receptors; Intracellular Signaling Peptides and Proteins; Mice; Molecular Sequence Data; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptor, ErbB-2; Sequence Alignment; Signal Transduction; Tyrosine | 1993 |
Functional role of GTPase-activating protein in cell transformation by pp60v-src.
Topics: 3T3 Cells; Adenosine Triphosphate; Animals; Cell Transformation, Neoplastic; Gene Expression; Genes, ras; Genes, src; GTPase-Activating Proteins; Humans; Isoenzymes; Kinetics; Macromolecular Substances; Mice; Myristic Acid; Myristic Acids; Oncogene Protein pp60(v-src); Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein Biosynthesis; Proteins; ras GTPase-Activating Proteins; Signal Transduction; Transfection; Type C Phospholipases; Tyrosine | 1993 |
Morphological transformation, tumorigenicity and src-specific cytotoxic T-lymphocyte-mediated tumor immunity induced by murine 3T3 cells expressing src oncogenes encoding novel non-myristylated N-terminal domains.
Topics: 3T3 Cells; Animals; Base Sequence; Cell Transformation, Neoplastic; Genes, src; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Neoplasms, Experimental; Phosphotyrosine; T-Lymphocytes, Cytotoxic; Tyrosine | 1993 |
Ornithine decarboxylase- and ras-induced cell transformations: reversal by protein tyrosine kinase inhibitors and role of pp130CAS.
Topics: 3T3 Cells; Actins; Animals; Benzoquinones; Blotting, Western; Cell Line; Cell Transformation, Neoplastic; Crk-Associated Substrate Protein; Enzyme Inhibitors; Genes, ras; Humans; Lactams, Macrocyclic; Mice; Ornithine Decarboxylase; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Quinones; Rats; Recombinant Proteins; Retinoblastoma Protein; Retinoblastoma-Like Protein p130; Rifabutin; src-Family Kinases; Transfection | 1995 |
Mitogenic signals and transforming potential of Nyk, a newly identified neural cell adhesion molecule-related receptor tyrosine kinase.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Base Sequence; c-Mer Tyrosine Kinase; Cell Division; Cell Transformation, Neoplastic; DNA, Complementary; Enzyme Activation; Humans; Kinetics; Macrophage Colony-Stimulating Factor; Mice; Molecular Sequence Data; Neural Cell Adhesion Molecules; Oligodeoxyribonucleotides; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein Kinases; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Receptor, Macrophage Colony-Stimulating Factor; Recombinant Fusion Proteins; Recombinant Proteins; Signal Transduction; Thymidine; Transfection; Type C Phospholipases | 1995 |
Transforming potentials of epidermal growth factor and nerve growth factor receptors inversely correlate with their phospholipase C gamma affinity and signal activation.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell Transformation, Neoplastic; DNA Primers; Enzyme Activation; ErbB Receptors; Humans; Inositol Phosphates; Isoenzymes; Mice; Molecular Sequence Data; Phospholipase C gamma; Phosphotyrosine; Protein Binding; Receptor Protein-Tyrosine Kinases; Receptors, Nerve Growth Factor; Signal Transduction; src Homology Domains; Structure-Activity Relationship; Type C Phospholipases; Tyrosine | 1996 |
Activation of the epidermal growth factor receptor signal transduction pathway stimulates tyrosine phosphorylation of protein kinase C delta.
Topics: Alleles; Aluminum Compounds; Animals; Animals, Newborn; Cell Line; Cell Transformation, Neoplastic; Epidermal Growth Factor; ErbB Receptors; Fluorides; Gene Expression; Genes, ras; GTP-Binding Proteins; Isoenzymes; Keratinocytes; Mice; Mice, Inbred BALB C; Mice, Mutant Strains; Mutagenesis; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Proto-Oncogene Proteins pp60(c-src); Recombinant Proteins; Signal Transduction; Spodoptera; Transfection; Transforming Growth Factor alpha; Tyrosine | 1996 |
Reduced phosphotyrosine binding by the v-Src SH2 domain is compatible with wild-type transformation.
Topics: Amino Acid Sequence; Animals; Avian Sarcoma Viruses; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Chick Embryo; Conserved Sequence; DNA Primers; Fibroblasts; Genes, src; Molecular Sequence Data; Mutagenesis, Site-Directed; Oncogene Protein pp60(v-src); Phosphotyrosine; Point Mutation; Polymerase Chain Reaction; Rats; Recombinant Fusion Proteins; src Homology Domains | 1996 |
Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl.
Topics: Base Sequence; Binding Sites; Cell Line; Cell Line, Transformed; Cell Nucleus; Cell Transformation, Neoplastic; Cytokines; DNA-Binding Proteins; Enzyme Activation; Fusion Proteins, bcr-abl; Hematopoietic Stem Cells; HL-60 Cells; Humans; Milk Proteins; Molecular Sequence Data; Oligodeoxyribonucleotides; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Recombinant Proteins; Signal Transduction; STAT1 Transcription Factor; STAT5 Transcription Factor; Trans-Activators; Transfection; Tumor Cells, Cultured; Tyrosine | 1996 |
The dimerization property of glutathione S-transferase partially reactivates Bcr-Abl lacking the oligomerization domain.
Topics: Adaptor Proteins, Signal Transducing; Animals; Bone Marrow Cells; Cell Transformation, Neoplastic; Cells, Cultured; Fusion Proteins, bcr-abl; Glutathione Transferase; GRB2 Adaptor Protein; Macromolecular Substances; Mice; Phosphotyrosine; Protein Binding; Protein-Tyrosine Kinases; Proteins; Rats; Recombinant Fusion Proteins; Structure-Activity Relationship | 1996 |
Identification of an oncogenic form of the thrombopoietin receptor MPL using retrovirus-mediated gene transfer.
Topics: Animals; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; DNA-Binding Proteins; Gene Transfer Techniques; Genetic Vectors; Janus Kinase 2; Mice; Milk Proteins; Molecular Sequence Data; Neoplasm Proteins; Oncogenes; Phosphotyrosine; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Receptors, Cytokine; Receptors, Thrombopoietin; Retroviridae; Signal Transduction; STAT3 Transcription Factor; STAT5 Transcription Factor; Structure-Activity Relationship; Thrombopoietin; Trans-Activators; TYK2 Kinase | 1996 |
Transformation of Rat-1 fibroblasts with the v-src oncogene increases the tyrosine phosphorylation state and activity of the alpha subunit of Gq/G11.
Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Genes, src; GTP-Binding Proteins; Oncogene Protein pp60(v-src); Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Receptor, Endothelin A; Receptors, Endothelin; Receptors, Thrombin; Signal Transduction; Type C Phospholipases | 1996 |
A novel phosphotyrosine-binding domain in the N-terminal transforming region of Cbl interacts directly and selectively with ZAP-70 in T cells.
Topics: Cell Line; Cell Transformation, Neoplastic; Humans; Phosphoproteins; Phosphotyrosine; Protein Binding; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Signal Transduction; Structure-Activity Relationship; T-Lymphocytes; Ubiquitin-Protein Ligases; ZAP-70 Protein-Tyrosine Kinase | 1996 |
p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Binding Sites; Blood Cells; Cell Line; Cell Line, Transformed; Cell Transformation, Neoplastic; Crk-Associated Substrate Protein; Fusion Proteins, bcr-abl; Humans; Mice; Nuclear Proteins; Oncogenes; Phosphoproteins; Phosphotyrosine; Proteins; Recombinant Fusion Proteins; Retinoblastoma Protein; Retinoblastoma-Like Protein p130; Signal Transduction; src Homology Domains; Tumor Cells, Cultured | 1996 |
Differences between phosphotyrosine accumulation and Neu/ErbB-2 receptor expression in astrocytic proliferative processes. Implications for glial oncogenesis.
Topics: Adolescent; Adult; Aged; Astrocytes; Astrocytoma; Brain Neoplasms; Carcinoma; Cell Division; Cell Survival; Cell Transformation, Neoplastic; Child; Child, Preschool; DNA; Dose-Response Relationship, Drug; Female; Gene Expression Regulation, Neoplastic; Glioblastoma; Glioma; Gliosis; Humans; Male; Middle Aged; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor, ErbB-2; Tumor Cells, Cultured | 1996 |
The relationship between human epidermal growth-like factor receptor expression and cellular transformation in NIH3T3 cells.
Topics: 3T3 Cells; Animals; Calcium; Carrier Proteins; Cell Transformation, Neoplastic; Epidermal Growth Factor; ErbB Receptors; Glycoproteins; Humans; Isoenzymes; Mice; Neuregulin-1; Phospholipase C gamma; Phosphotyrosine; Proto-Oncogene Proteins; Receptor, ErbB-2; Receptor, ErbB-3; Receptor, ErbB-4; Signal Transduction; Type C Phospholipases | 1996 |
v-Crk-induced cell transformation: changes in focal adhesion composition and signaling.
Topics: 3T3 Cells; Animals; Cell Adhesion; Cell Adhesion Molecules; Cell Line, Transformed; Cell Transformation, Neoplastic; Cell Transformation, Viral; Crk-Associated Substrate Protein; Cytoskeleton; Mice; Oncogene Protein v-crk; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Retinoblastoma-Like Protein p130; Retroviridae Proteins, Oncogenic; Signal Transduction; src Homology Domains | 1997 |
Purification and molecular cloning of SH2- and SH3-containing inositol polyphosphate-5-phosphatase, which is involved in the signaling pathway of granulocyte-macrophage colony-stimulating factor, erythropoietin, and Bcr-Abl.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Amino Acid Sequence; Base Sequence; Cell Transformation, Neoplastic; Cloning, Molecular; DNA, Complementary; Erythropoietin; Fusion Proteins, bcr-abl; Genes; Granulocyte-Macrophage Colony-Stimulating Factor; GRB2 Adaptor Protein; Humans; Leukemia, Megakaryoblastic, Acute; Molecular Sequence Data; Neoplasm Proteins; Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Recombinant Fusion Proteins; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; src Homology Domains; Tumor Cells, Cultured; Ubiquitin-Protein Ligases | 1997 |
Mutational activation of pp60(c-src) leads to a tumorigenic phenotype in a preneoplastic Syrian hamster embryo cell line.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Base Sequence; Cell Line; Cell Transformation, Neoplastic; Cricetinae; DNA; Mesocricetus; Mice; Molecular Sequence Data; Mutation; Phenotype; Phosphorylation; Phosphotyrosine; Polymerase Chain Reaction; Precancerous Conditions; Proto-Oncogene Proteins pp60(c-src); Transfection; Tyrosine | 1997 |
Insulin-like growth factor I receptor signaling in transformation by src oncogenes.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Cell Adhesion Molecules; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; DNA-Binding Proteins; Epidermal Growth Factor; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genes, src; Insulin Receptor Substrate Proteins; Mice; Oncogenes; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Receptor, IGF Type 1; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; STAT1 Transcription Factor; Trans-Activators; Transfection | 1997 |
Relationship of p215BRCA1 to tyrosine kinase signaling pathways and the cell cycle in normal and transformed cells.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Antibody Specificity; BRCA1 Protein; Breast Neoplasms; Cell Cycle; Cell Transformation, Neoplastic; Humans; Mice; Molecular Sequence Data; Phenotype; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor Protein-Tyrosine Kinases; Signal Transduction; Subcellular Fractions; Tumor Cells, Cultured; Tyrosine | 1997 |
Regulation of the oncogenic activity of BCR-ABL by a tightly bound substrate protein RIN1.
Topics: Adaptor Proteins, Signal Transducing; Animals; Carrier Proteins; Cell Division; Cell Transformation, Neoplastic; Fusion Proteins, bcr-abl; GRB2 Adaptor Protein; Hematopoiesis; Humans; Intracellular Signaling Peptides and Proteins; Leukemia, Experimental; Macromolecular Substances; Mice; Phosphorylation; Phosphotyrosine; Protein Binding; Proteins; rab GTP-Binding Proteins; Signal Transduction; src Homology Domains; Structure-Activity Relationship; Survival Analysis; Tumor Cells, Cultured | 1997 |
Phosphotyrosine binding domain-dependent upregulation of the platelet-derived growth factor receptor alpha signaling cascade by transforming mutants of Cbl: implications for Cbl's function and oncogenicity.
Topics: 3T3 Cells; Animals; Cell Division; Cell Transformation, Neoplastic; Humans; Mice; Mutation; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Receptor, Platelet-Derived Growth Factor alpha; Receptors, Platelet-Derived Growth Factor; Signal Transduction; src Homology Domains; Ubiquitin-Protein Ligases; Up-Regulation | 1997 |
The role of the Shc phosphotyrosine interaction/phosphotyrosine binding domain and tyrosine phosphorylation sites in polyoma middle T antigen-mediated cell transformation.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Amino Acid Sequence; Animals; Antigens, Polyomavirus Transforming; Binding Sites; Cell Transformation, Neoplastic; GRB2 Adaptor Protein; Mice; Molecular Sequence Data; Phosphorylation; Phosphotyrosine; Proteins; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Tyrosine | 1997 |
Gastrin receptor expression and function during rapid transformation of the enterochromaffin-like cells in an African rodent.
Topics: Animals; Blotting, Western; Cell Transformation, Neoplastic; Enterochromaffin Cells; Female; Gastrins; Gene Expression Regulation, Neoplastic; Histamine H2 Antagonists; Immunohistochemistry; Male; Muridae; Phosphorylation; Phosphoserine; Phosphotyrosine; Polymerase Chain Reaction; Receptors, Cholecystokinin; RNA, Messenger; Stomach Neoplasms; Triazoles | 1997 |
Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors.
Topics: Amino Acid Sequence; Animals; Antigens, CD34; Cell Line; Cell Transformation, Neoplastic; Digestive System; DNA, Complementary; Esophageal Neoplasms; Gastrointestinal Neoplasms; Humans; Intestinal Neoplasms; Ligands; Mice; Mice, Nude; Molecular Sequence Data; Mutation; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins c-kit; Recombinant Proteins; Sequence Deletion; Stem Cell Factor; Stomach Neoplasms; Transfection | 1998 |
Oncogenic activation of the PDGF beta receptor by the transmembrane domain of p185neu*.
Topics: Amino Acid Sequence; Animals; Cell Transformation, Neoplastic; Cells, Cultured; Mice; Molecular Sequence Data; Oncogenes; Phosphorylation; Phosphotyrosine; Receptor, ErbB-2; Receptors, Platelet-Derived Growth Factor; Recombinant Fusion Proteins; Structure-Activity Relationship | 1998 |
Uncoupling signal transducers from oncogenic MET mutants abrogates cell transformation and inhibits invasive growth.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Carcinoma, Papillary; Carcinoma, Renal Cell; Cell Division; Cell Transformation, Neoplastic; Cloning, Molecular; COS Cells; Humans; Kidney Neoplasms; Kinetics; Mutagenesis, Site-Directed; Neoplasm Invasiveness; Oncogenes; Peptide Fragments; Phosphorylation; Phosphotyrosine; Point Mutation; Polymerase Chain Reaction; Proto-Oncogene Proteins c-met; Recombinant Fusion Proteins; Signal Transduction; Transfection | 1998 |
Dual effect on the RET receptor of MEN 2 mutations affecting specific extracytoplasmic cysteines.
Topics: 3T3 Cells; Amino Acid Substitution; Animals; Cell Transformation, Neoplastic; Cysteine; Dimerization; Disulfides; Drosophila Proteins; Glycosylation; Hirschsprung Disease; Humans; Membrane Proteins; Mice; Models, Biological; Multiple Endocrine Neoplasia Type 2a; PC12 Cells; Phosphotyrosine; Precipitin Tests; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Rats; Receptor Protein-Tyrosine Kinases; Transcriptional Activation | 1998 |
Reduced C-terminal Src kinase (Csk) activities in hepatocellular carcinoma.
Topics: Aged; Animals; Blotting, Western; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; CSK Tyrosine-Protein Kinase; Female; Humans; Liver Cirrhosis; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Middle Aged; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins pp60(c-src); Rats; Rats, Inbred LEC; Rats, Wistar; src-Family Kinases | 1999 |
Epigallocathechin-3 gallate selectively inhibits the PDGF-BB-induced intracellular signaling transduction pathway in vascular smooth muscle cells and inhibits transformation of sis-transfected NIH 3T3 fibroblasts and human glioblastoma cells (A172).
Topics: 3T3 Cells; Animals; Antineoplastic Agents; Aorta; Becaplermin; Brain Neoplasms; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Catechin; Cell Transformation, Neoplastic; Cells, Cultured; Glioblastoma; Humans; Kinetics; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Oncogene Proteins v-sis; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Rats; Rats, Inbred WKY; Recombinant Proteins; Retroviridae Proteins, Oncogenic; Signal Transduction; Tea; Transfection; Tumor Cells, Cultured | 1999 |
H-Ras activation promotes cytoplasmic accumulation and phosphoinositide 3-OH kinase association of beta-catenin in epidermal keratinocytes.
Topics: Adenomatous Polyposis Coli Protein; alpha Catenin; Animals; beta Catenin; Cadherins; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell Membrane; Cell Nucleus; Cell Transformation, Neoplastic; Cytoplasm; Cytoskeletal Proteins; Enzyme Activation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Keratinocytes; Mice; Microinjections; Oncogene Protein p21(ras); Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Binding; Trans-Activators | 1999 |
EB-1, a tyrosine kinase signal transduction gene, is transcriptionally activated in the t(1;19) subset of pre-B ALL, which express oncoprotein E2a-Pbx1.
Topics: Adenomatous Polyposis Coli Protein; Amino Acid Sequence; B-Lymphocytes; Bone Marrow Cells; Cell Line; Cell Transformation, Neoplastic; Cytoskeletal Proteins; Expressed Sequence Tags; Fetus; Gene Expression Regulation, Neoplastic; Homeodomain Proteins; Humans; Molecular Sequence Data; Neoplasm Proteins; Oncogene Proteins, Fusion; Organ Specificity; Phosphotyrosine; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Protein-Tyrosine Kinases; RNA, Messenger; Sequence Homology, Amino Acid; Signal Transduction; Stem Cells; Transcriptional Activation; Translocation, Genetic | 1999 |
Transformation of rat fibroblasts by phospholipase C-gamma1 overexpression is accompanied by tyrosine dephosphorylation of paxillin.
Topics: Animals; Cell Adhesion; Cell Size; Cell Transformation, Neoplastic; Cytoskeletal Proteins; Fibroblasts; Fibronectins; Isoenzymes; Paxillin; Phospholipase C gamma; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Binding; Rats; Type C Phospholipases; Tyrosine | 1999 |
Stat3-mediated transformation of NIH-3T3 cells by the constitutively active Q205L Galphao protein.
Topics: 3T3 Cells; Animals; Cell Line, Transformed; Cell Transformation, Neoplastic; CSK Tyrosine-Protein Kinase; DNA-Binding Proteins; Enzyme Activation; Genes, Reporter; GTP-Binding Protein alpha Subunits; Heterotrimeric GTP-Binding Proteins; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Neurites; Neuronal Plasticity; Neurons; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Signal Transduction; src-Family Kinases; STAT3 Transcription Factor; Trans-Activators; Transfection | 2000 |
ZNF198-FGFR1 transforming activity depends on a novel proline-rich ZNF198 oligomerization domain.
Topics: Animals; Binding Sites; Carrier Proteins; Cell Transformation, Neoplastic; DNA-Binding Proteins; Enzyme Activation; Hematopoietic Stem Cells; Lymphoma, T-Cell; Macromolecular Substances; Mice; Phosphorylation; Phosphotyrosine; Proline; Receptor Protein-Tyrosine Kinases; Receptor, Fibroblast Growth Factor, Type 1; Receptors, Fibroblast Growth Factor; Recombinant Fusion Proteins; Structure-Activity Relationship; Transcription Factors; Tumor Cells, Cultured | 2000 |
The src homology 2 domain of Bcr/Abl is required for efficient induction of chronic myeloid leukemia-like disease in mice but not for lymphoid leukemogenesis or activation of phosphatidylinositol 3-kinase.
Topics: Animals; Bone Marrow Cells; Cell Line; Cell Transformation, Neoplastic; Disease Models, Animal; Enzyme Activation; Female; Fusion Proteins, bcr-abl; Interleukin-3; Leukemia, B-Cell; Leukemia, Experimental; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Mice; Mice, Inbred BALB C; Myeloid Cells; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotyrosine; Point Mutation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Binding; Signal Transduction; src Homology Domains; Stem Cells | 2001 |
A switch from p130Cas/Crk to Gab1/Crk signaling correlates with anchorage independent growth and JNK activation in cells transformed by the Met receptor oncoprotein.
Topics: 3T3 Cells; Actins; Adaptor Proteins, Signal Transducing; Animals; Cell Adhesion; Cell Division; Cell Size; Cell Transformation, Neoplastic; Crk-Associated Substrate Protein; Cytoskeletal Proteins; Enzyme Activation; Fibronectins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mice; Mitogen-Activated Protein Kinase Kinases; Mutation; Oncogene Proteins; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Binding; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; Proto-Oncogene Proteins c-met; Retinoblastoma-Like Protein p130; Signal Transduction; Stress Fibers; Wound Healing | 2000 |
Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation.
Topics: 3T3 Cells; Alanine; Animals; Baculoviridae; Cell Line; Cell Nucleus; Cell Transformation, Neoplastic; Cytokines; Cytosol; Dimerization; DNA; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Design; Gene Expression Regulation; Growth Substances; Insecta; Luciferases; Mice; Models, Biological; Mutation; Peptides; Phosphopeptides; Phosphotyrosine; Plasmids; Protein Binding; Protein Structure, Tertiary; Signal Transduction; src Homology Domains; STAT3 Transcription Factor; Time Factors; Trans-Activators; Transcription, Genetic; Transfection | 2001 |
Evidence for the epidermal growth factor receptor as a target for lung cancer prevention.
Topics: Antineoplastic Agents; Blotting, Western; Carcinogens; Cell Transformation, Neoplastic; Cyclin D1; DNA Primers; ErbB Receptors; Gene Expression Regulation; Humans; Lung Neoplasms; Mitosis; Nitrosamines; Phosphotyrosine; Reverse Transcriptase Polymerase Chain Reaction; Transfection; Tretinoin | 2002 |
Differential expression and signaling of CBL and CBL-B in BCR/ABL transformed cells.
Topics: Adaptor Proteins, Signal Transducing; Animals; Carrier Proteins; Cell Line, Transformed; Cell Movement; Cell Transformation, Neoplastic; Down-Regulation; Fusion Proteins, bcr-abl; Gene Expression Regulation, Neoplastic; Genes, abl; Humans; Hydrogen Peroxide; Mice; Nuclear Proteins; Oncogene Protein v-cbl; Oncogene Proteins; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Proto-Oncogene Proteins c-pim-1; Proto-Oncogene Proteins c-vav; Retroviridae Proteins, Oncogenic; RNA, Messenger; Signal Transduction; Transfection; Ubiquitin-Protein Ligases | 2002 |
Repair by Src kinase of function-impaired RET with multiple endocrine neoplasia type 2A mutation with substitutions of tyrosines in the COOH-terminal kinase domain for phenylalanine.
Topics: 3T3 Cells; Amino Acid Substitution; Animals; Catalysis; Cell Transformation, Neoplastic; Drosophila Proteins; Humans; Mice; Multiple Endocrine Neoplasia Type 2a; Mutagenesis; Phenylalanine; Phosphorylation; Phosphotyrosine; Polymerase Chain Reaction; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; src-Family Kinases; Transfection; Tyrosine | 2002 |
Transformation of Ba/F3 cells and Rat-1 cells by ETV6/ARG.
Topics: Animals; Cell Adhesion; Cell Division; Cell Transformation, Neoplastic; Colony-Forming Units Assay; DNA-Binding Proteins; ETS Translocation Variant 6 Protein; Fibroblasts; Fusion Proteins, bcr-abl; Genes, abl; Humans; Interleukin-3; Leukemia, Myeloid; Oncogene Proteins; Phosphorylation; Phosphotyrosine; Plasmids; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-ets; Rats; Recombinant Proteins; Repressor Proteins; Tumor Cells, Cultured; Tyrosine | 2002 |
Sequence and expression of caveolin, a protein component of caveolae plasma membrane domains phosphorylated on tyrosine in Rous sarcoma virus-transformed fibroblasts.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Base Sequence; Caveolin 1; Caveolins; Cell Membrane; Cell Transformation, Neoplastic; Chickens; Fibroblasts; Fluorescent Antibody Technique; Gene Expression; Gizzard, Avian; Membrane Proteins; Mice; Molecular Sequence Data; Muscle, Smooth; Oligodeoxyribonucleotides; Peptide Fragments; Phosphorylation; Phosphotyrosine; Polymerase Chain Reaction; Protein Conformation; Protein Structure, Secondary; Transfection; Tyrosine | 1992 |
The SH2- and SH3-containing Nck protein transforms mammalian fibroblasts in the absence of elevated phosphotyrosine levels.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Line; Cell Transformation, Neoplastic; Fibroblasts; Humans; Immunoblotting; Ligands; Mice; Mice, Inbred BALB C; Oncogene Protein pp60(v-src); Oncogene Protein v-crk; Oncogene Proteins; Phosphotyrosine; Rats; Retroviridae Proteins, Oncogenic; Sulfhydryl Compounds; Tyrosine; Vanadates | 1992 |
Ornithine decarboxylase activity is critical for cell transformation.
Topics: 3T3 Cells; Animals; Avian Sarcoma Viruses; Base Sequence; Cell Division; Cell Transformation, Neoplastic; DNA; Eflornithine; Gene Expression; Genes, src; Humans; Mice; Molecular Sequence Data; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Phosphotyrosine; Proto-Oncogene Mas; Rats; RNA, Antisense; Transfection; Tyrosine | 1992 |
Point mutations in the abl SH2 domain coordinately impair phosphotyrosine binding in vitro and transforming activity in vivo.
Topics: Amino Acid Sequence; Binding Sites; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cloning, Molecular; DNA Mutational Analysis; Humans; Immunoblotting; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oncogene Proteins v-abl; Phosphotyrosine; Retroviridae; Tyrosine | 1992 |
Expression of a protein tyrosine phosphatase in normal and v-src-transformed mouse 3T3 fibroblasts.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Cell Line, Transformed; Cell Transformation, Neoplastic; Cell Transformation, Viral; Endoplasmic Reticulum; Gene Expression; Mice; Molecular Sequence Data; Oncogene Protein pp60(v-src); Phosphotyrosine; Protein Tyrosine Phosphatases; Transfection; Tyrosine | 1992 |
Cloning and characterization of a thermolabile v-src gene for use in reversible transformation of mammalian cells.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Avian Sarcoma Viruses; Base Sequence; Cell Differentiation; Cell Line, Transformed; Cell Transformation, Neoplastic; Chick Embryo; Cloning, Molecular; DNA-Binding Proteins; Early Growth Response Protein 1; Fibroblasts; Gene Expression Regulation, Viral; Genes, src; Immediate-Early Proteins; Mice; Molecular Sequence Data; Muscles; Oligodeoxyribonucleotides; Oncogene Protein pp60(v-src); Phosphorylation; Phosphotyrosine; Polymerase Chain Reaction; Temperature; Transcription Factors; Transcription, Genetic; Tyrosine; Viral Proteins; Zinc Fingers | 1992 |
Glycoprotein tyrosine phosphorylation in Rous sarcoma virus-transformed chicken embryo fibroblasts.
Topics: Animals; Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Cells, Cultured; Chick Embryo; Fibroblasts; Glycoproteins; Kinetics; Mutation; Phosphorylation; Phosphotyrosine; Tyrosine | 1990 |
Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases.
Topics: Animals; Cell Line, Transformed; Cell Transformation, Neoplastic; Fusion Proteins, gag-onc; GTPase-Activating Proteins; Immunosorbent Techniques; Mice; Mitosis; Molecular Weight; Oncogene Protein p21(ras); Oncogene Protein pp60(v-src); Oncogenes; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; ras GTPase-Activating Proteins; Rats; Retroviridae; Tyrosine | 1990 |
Serum independence of transcription from the promoter of an avian retrovirus in v-src-transformed cells is a primary, intracellular effect of increased tyrosine phosphorylation.
Topics: Animals; Avian Sarcoma Viruses; Cell Line; Cell Transformation, Neoplastic; Cycloheximide; Kinetics; Oncogene Protein pp60(v-src); Oncogenes; Phosphorylation; Phosphotyrosine; Promoter Regions, Genetic; Protein-Tyrosine Kinases; Temperature; Transfection; Tyrosine; Vanadates | 1990 |
Tyrosine phosphorylation is a signal for the trafficking of pp85, an 85-kDa phosphorylated polypeptide associated with phosphatidylinositol kinase activity.
Topics: 1-Phosphatidylinositol 4-Kinase; Animals; Antigens, Polyomavirus Transforming; Cell Line; Cell Membrane; Cell Transformation, Neoplastic; Cells, Cultured; Cytosol; Mice; Molecular Weight; Neoplasm Proteins; Phosphoproteins; Phosphorylation; Phosphotransferases; Phosphotyrosine; Polyomavirus; Tyrosine | 1990 |
Mutagenic analysis of the v-crk oncogene: requirement for SH2 and SH3 domains and correlation between increased cellular phosphotyrosine and transformation.
Topics: Animals; Avian Sarcoma Viruses; Base Sequence; Cell Adhesion; Cell Division; Cell Transformation, Neoplastic; Chick Embryo; Fibroblasts; Molecular Sequence Data; Mutation; Oligonucleotide Probes; Oncogene Protein v-crk; Oncogenes; Phosphoproteins; Phosphotyrosine; Plasmids; Restriction Mapping; Retroviridae Proteins, Oncogenic; Tyrosine | 1990 |
Temperature-sensitive mutants of Abelson murine leukemia virus deficient in protein tyrosine kinase activity.
Topics: Abelson murine leukemia virus; Amino Acid Sequence; Amino Acids; Animals; Cell Line; Cell Transformation, Neoplastic; Kinetics; Leukemia Virus, Murine; Mice; Molecular Sequence Data; Mutation; Phosphorylation; Phosphotyrosine; Plasmids; Protein-Tyrosine Kinases; Temperature; Tyrosine | 1990 |
A small v-sis/platelet-derived growth factor (PDGF) B-protein domain in which subtle conformational changes abrogate PDGF receptor interaction and transforming activity.
Topics: Animals; Antibodies, Monoclonal; Cell Transformation, Neoplastic; Codon; DNA Mutational Analysis; Epitopes; Mice; Oncogene Proteins v-sis; Phosphotyrosine; Platelet-Derived Growth Factor; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Retroviridae Proteins, Oncogenic; Tyrosine | 1990 |
Phosphorylation and activation of epidermal growth factor receptors in cells transformed by the src oncogene.
Topics: Animals; Blotting, Western; Cell Line; Cell Transformation, Neoplastic; Epidermal Growth Factor; ErbB Receptors; Humans; In Vitro Techniques; Oncogene Protein pp60(v-src); Peptide Mapping; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Signal Transduction; Transfection; Type C Phospholipases; Tyrosine | 1991 |
The noncatalytic src homology region 2 segment of abl tyrosine kinase binds to tyrosine-phosphorylated cellular proteins with high affinity.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cloning, Molecular; Escherichia coli; Genes, abl; Genes, src; Mice; Phosphotyrosine; Protein Binding; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-abl; Proto-Oncogene Proteins pp60(c-src); Restriction Mapping; Sequence Homology, Nucleic Acid; Tyrosine | 1991 |
SH2 mutants of c-src that are host dependent for transformation are trans-dominant inhibitors of mouse cell transformation by activated c-src.
Topics: Animals; Blotting, Northern; Cell Line; Cell Transformation, Neoplastic; Chick Embryo; Gene Expression Regulation; Genes, src; Mice; Mutagenesis, Site-Directed; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); RNA; Species Specificity; Transfection; Tyrosine | 1990 |
Identification of domains of the v-crk oncogene product sufficient for association with phosphotyrosine-containing proteins.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cloning, Molecular; DNA Mutational Analysis; Oncogene Protein pp60(v-src); Oncogene Protein v-crk; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Rats; Retroviridae Proteins, Oncogenic; Structure-Activity Relationship; Tyrosine; Viral Fusion Proteins | 1991 |
Constitutively activated neu oncoprotein tyrosine kinase interferes with growth factor-induced signals for gene activation.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; ErbB Receptors; Gene Expression; Genes, ras; Humans; Phosphotyrosine; Poly A; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogenes; Receptor, ErbB-2; RNA; RNA, Messenger; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 1991 |
Tyrosine phosphorylation of a common 57-kDa protein in growth factor-stimulated and -transformed cells.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Granulocyte-Macrophage Colony-Stimulating Factor; Growth Substances; Kinetics; Macrophage Colony-Stimulating Factor; Mice; Molecular Weight; Phosphates; Phosphoproteins; Phosphorylation; Phosphotyrosine; Recombinant Proteins; Tyrosine | 1991 |
Thymic tumorigenesis induced by overexpression of p56lck.
Topics: Animals; Antigens, Differentiation, T-Lymphocyte; CD4 Antigens; CD8 Antigens; Cell Line; Cell Transformation, Neoplastic; Cloning, Molecular; Gene Expression Regulation, Neoplastic; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Mice; Mice, Transgenic; Oncogenes; Phosphotyrosine; Protein-Tyrosine Kinases; T-Lymphocyte Subsets; Thymoma; Thymus Neoplasms; Tyrosine | 1991 |
BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cell Line; Cell Transformation, Neoplastic; Exons; Fusion Proteins, bcr-abl; Genes, abl; Genetic Variation; Humans; Insecta; Molecular Sequence Data; Oncogene Proteins; Oncogenes; Phosphotyrosine; Plasmids; Protein Biosynthesis; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcr; Regulatory Sequences, Nucleic Acid; Transcription, Genetic; Transfection; Tyrosine | 1991 |
Dissociation of platelet-derived growth factor (PDGF) receptor autophosphorylation from other PDGF-mediated second messenger events.
Topics: 1-Phosphatidylinositol 4-Kinase; Animals; Calcium; Cell Division; Cell Line; Cell Transformation, Neoplastic; Chemokine CCL2; Chemotactic Factors; Cyclic AMP; DNA; Gene Expression; Genes, ras; GTP-Binding Proteins; Mice; Phosphorylation; Phosphotransferases; Phosphotyrosine; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-myc; rap GTP-Binding Proteins; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Type C Phospholipases; Tyrosine | 1991 |
Oncogenic potential of erbB-2 in human mammary epithelial cells.
Topics: Animals; Breast; Breast Neoplasms; Cell Line; Cell Transformation, Neoplastic; DNA; Epithelium; Gene Expression; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogenes; Receptor, ErbB-2; Transfection; Tyrosine | 1991 |
Comparison of three methods for detecting tyrosine-phosphorylated proteins.
Topics: Animals; Antigen-Antibody Complex; Autoradiography; Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Cells, Cultured; Chick Embryo; Chromatography, Affinity; Fibroblasts; Glycoproteins; Immunoblotting; Methionine; Phosphates; Phosphoproteins; Phosphorus Radioisotopes; Phosphotyrosine; Radioisotope Dilution Technique; Sulfur Radioisotopes; Tyrosine | 1991 |
Transformation of cells by an inhibitor of phosphatases acting on phosphotyrosine in proteins.
Topics: Animals; Cell Count; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Deoxyglucose; Kinetics; Mice; Moloney murine sarcoma virus; Phosphatidylinositols; Phosphoproteins; Phosphoric Monoester Hydrolases; Phosphotyrosine; Rats; Tyrosine; Vanadates; Vanadium; Zinc | 1985 |
Protein phosphorylation at tyrosine residues in v-abl transformed mouse lymphocytes and fibroblasts.
Topics: Abelson murine leukemia virus; Animals; Cell Transformation, Neoplastic; Chemical Precipitation; Fibroblasts; Lymphocytes; Mice; Mice, Inbred BALB C; Molecular Weight; Oncogene Proteins, Viral; Oncogenes; Phosphopeptides; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Tyrosine | 1986 |
Immunological detection of proteins phosphorylated at tyrosine in cells stimulated by growth factors or transformed by retroviral-oncogene-coded tyrosine kinases.
Topics: Animals; Antibodies; Cell Line; Cell Transformation, Neoplastic; ErbB Receptors; Growth Substances; Mice; Mice, Inbred BALB C; Molecular Weight; Oncogene Protein pp60(v-src); Oncogene Proteins, Viral; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rabbits; Rats; Rats, Inbred F344; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Retroviridae Proteins; Tyrosine | 1986 |
Isolation of antibodies for phosphotyrosine by immunization with a v-abl oncogene-encoded protein.
Topics: Animals; Antibodies; Cell Transformation, Neoplastic; Chromatography, Affinity; Immunization; Oncogene Proteins, Viral; Phosphotyrosine; Tyrosine | 1985 |
gp140v-fms molecules expressed at the surface of cells transformed by the McDonough strain of feline sarcoma virus are phosphorylated in tyrosine and serine.
Topics: Animals; Cats; Cell Transformation, Neoplastic; Genes; Genes, Viral; Oncogene Protein gp140(v-fms); Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Kinase C; Retroviridae; Retroviridae Proteins; Serine; Tyrosine; Vanadates; Vanadium | 1986 |
Isolation of temperature-sensitive tyrosine kinase mutants of v-abl oncogene by screening with antibodies for phosphotyrosine.
Topics: Amino Acid Sequence; Animals; Antibodies; Cell Transformation, Neoplastic; Cells, Cultured; DNA Restriction Enzymes; Escherichia coli; Genes; Mice; Mutation; Oncogenes; Phosphotyrosine; Plasmids; Protein-Tyrosine Kinases; Temperature; Tyrosine | 1987 |
Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity.
Topics: 1-Phosphatidylinositol 4-Kinase; Animals; Antigens, Polyomavirus Transforming; Antigens, Viral, Tumor; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Gene Expression Regulation; Mice; Mice, Inbred BALB C; Oncogene Protein gp140(v-fms); Oncogene Proteins v-sis; Oncogene Proteins, Viral; Oncogenes; Phosphatidylinositols; Phosphoproteins; Phosphorylation; Phosphotransferases; Phosphotyrosine; Platelet-Derived Growth Factor; Polyomavirus; Protein-Tyrosine Kinases; Retroviridae Proteins; Simian virus 40; Substrate Specificity; Tyrosine | 1987 |
Tyrosine phosphorylations in vivo associated with v-fms transformation.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Glycoproteins; Immunologic Techniques; Mice; Mink; Oncogene Protein pp60(v-src); Oncogene Proteins, Viral; Oncogenes; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Recombinant Fusion Proteins; Retroviridae Proteins; Structure-Activity Relationship; Tyrosine | 1988 |
Vanadate-treated baby hamster kidney fibroblasts show cytoskeleton and adhesion patterns similar to their Rous sarcoma virus-transformed counterparts.
Topics: Actin Cytoskeleton; Animals; Avian Sarcoma Viruses; Cell Line; Cell Line, Transformed; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cricetinae; Cytoskeleton; Fibroblasts; Kidney; Phenotype; Phosphoproteins; Phosphotyrosine; Tyrosine; Vanadates | 1988 |
A mutation in v-src that removes a single conserved residue in the SH-2 domain of pp60v-src restricts transformation in a host-dependent manner.
Topics: Alleles; Animals; Avian Sarcoma Viruses; Base Sequence; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Chick Embryo; DNA, Viral; L Cells; Molecular Sequence Data; Mutation; Oncogene Protein pp60(v-src); Oncogenes; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Retroviridae Proteins; Substrate Specificity; Tyrosine | 1989 |
Platelet-derived growth factor induces phosphorylation of a 64-kDa nuclear protein.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Nuclear Proteins; Phosphates; Phosphoproteins; Phosphorus Radioisotopes; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Subcellular Fractions; Sulfur Radioisotopes; Tyrosine | 1989 |
Mechanism of reversion of Rous sarcoma virus transformation by herbimycin A: reduction of total phosphotyrosine levels due to reduced kinase activity and increased turnover of p60v-src1.
Topics: Amino Acids; Animals; Avian Sarcoma Viruses; Benzoquinones; Cell Line; Cell Transformation, Neoplastic; Herbicides; Kinetics; Lactams, Macrocyclic; Oncogene Protein pp60(v-src); Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Retroviridae Proteins; Rifabutin; Thermodynamics; Tyrosine | 1989 |
Oncogenic activation of p185neu stimulates tyrosine phosphorylation in vivo.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Gene Expression Regulation; Mutation; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogenes; Receptor, ErbB-2; Transfection; Tyrosine | 1988 |
Novel tyrosine phosphorylations accompany the activation of pp60c-src during chemical carcinogenesis.
Topics: Animals; Blotting, Western; Cell Line; Cell Transformation, Neoplastic; Cricetinae; Mesocricetus; Molecular Weight; Peptide Mapping; Phosphoproteins; Phosphotyrosine; Proto-Oncogene Proteins; Proto-Oncogene Proteins pp60(c-src); Subcellular Fractions; Tyrosine | 1989 |
Evidence that a phosphotyrosine-containing 120,000 Da protein from Rous sarcoma virus-infected cells is phosphorylated by pp60v-src.
Topics: Animals; Avian Sarcoma Viruses; Cell Line; Cell Transformation, Neoplastic; Clone Cells; Electrophoresis, Polyacrylamide Gel; Molecular Weight; Oncogene Protein pp60(v-src); Peptide Mapping; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Retroviridae Proteins; Tyrosine | 1989 |
Tyrosine phosphorylation of a 22-kDa protein is correlated with transformation by Rous sarcoma virus.
Topics: Animals; Antibodies, Monoclonal; Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Chick Embryo; Fibroblasts; Molecular Weight; Mutation; Myristic Acid; Myristic Acids; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins pp60(c-src); Tyrosine | 1989 |
Ultrastructure and gold-immunolabelling of cell-substratum adhesions (podosomes) in RSV-transformed BHK cells.
Topics: Animals; Avian Sarcoma Viruses; Calcium-Binding Proteins; Cell Adhesion; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cytoskeletal Proteins; Gelsolin; Gold; Immunohistochemistry; Microfilament Proteins; Microscopy, Electron; Oncogene Protein pp60(v-src); Phosphotyrosine; Rosette Formation; Tyrosine; Vinculin | 1989 |