phosphotyrosine has been researched along with Breast Cancer in 126 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (1.59) | 18.7374 |
| 1990's | 53 (42.06) | 18.2507 |
| 2000's | 43 (34.13) | 29.6817 |
| 2010's | 24 (19.05) | 24.3611 |
| 2020's | 4 (3.17) | 2.80 |
| Authors | Studies |
|---|---|
| Agazie, YM; Geldenhuys, WJ; Hartman, Z | 1 |
| Chi, Y; Fahmy, B; Fan, M; Li, M; Miranda-Carboni, GA; Narayanan, R; Ponnusamy, S; Wang, W; Wu, J; Wu, ZH; Xue, J | 1 |
| Belle, L; Daly, RJ; Gehling, F; Goodall, GJ; Khew-Goodall, Y; Li, X; Lonic, A; Nguyen, EV; Parton, RG; Schieber, NL | 1 |
| Clark, CA; Curiel, TJ; Drerup, JM; Hu, Y; Jin, VX; Li, R; Li, T; Wu, B; Yang, J; Yuan, B | 1 |
| Condeelis, J; Gil-Henn, H; Halo, T; Koleske, AJ; Machida, K; Mader, CC; Rosenberg, BJ; Wu, YI; Yin, T | 1 |
| Chen, P; Chu, B; He, A; He, W; Hu, J; Hunter, T; Li, P; Li, SSC; Sun, Y; Tian, R; Tian, Y; Xu, R; Yang, P; Zhang, M; Zhou, W | 1 |
| Ali, AY; Parr, C | 1 |
| Chang, WC; Chen, CH; Du, Y; Hsu, JL; Hung, MC; Huo, L; James, BP; Khotskaya, YB; Lam, YC; Lim, SO; Liu, CG; Liu, X; Nakanishi, K; Patel, DJ; Shen, J; Wang, Y; Wu, Y; Xia, W | 1 |
| Ahn, R; Cory, S; Ha, JR; Hallett, M; Hardy, WR; Im, YK; Maric, G; Park, M; Pawson, T; Sabourin, V; Siegel, PM; Ursini-Siegel, J; Zhao, H | 1 |
| Diakonova, M; Oladimeji, P; Rider, L | 1 |
| Ertel, A; Lin, J; Liu, C; Neilson, LM; Peck, AR; Rui, H; Sato, T; Tran, TH | 1 |
| Aceto, N; Alajati, A; Bentires-Alj, M; Bonenfant, D; Duss, S; Sarret, S; Sausgruber, N; Voshol, H | 1 |
| Cheng, L; Chiang, HC; Curiel, TJ; Elledge, R; Han, Y; Hu, Y; Li, R; Li, X; Lin, J; Su, H; Tekmal, RR; Wang, L; Wang, T; Xie, X; Xu, X; Ye, Q; Yuan, B; Yuan, ZM; Zhang, B | 1 |
| Chen, YX; Du, YJ; Gao, CJ; Gu, LC; Li, Y; Liang, N; Ma, R; Ning, SL; Pang, Q; Sun, JP; Wang, HM; Xiao, KH; Xu, YF; Yang, DX; Yang, F; Yao, W; Yu, X; Zhang, LL; Zhang, Y | 1 |
| Ambaye, ND; Cergol, KM; Gunzburg, MJ; Kulkarni, K; Lucas, WA; Panjikar, S; Payne, RJ; Perlmutter, P; Pero, SC; Traore, DA; Watson, GM; Wilce, JA; Wilce, MC | 1 |
| Rapp, UR; Sperl, B; Ulaganathan, VK; Ullrich, A | 1 |
| de la Cueva, A; Kirsch, KH; Kumbrink, J; Sailer, N; Soni, S | 1 |
| Alho, I; Bicho, M; Coelho, C; Costa, L | 1 |
| Cheng, L; Chiang, HC; Curiel, TJ; Elledge, R; Gupta, HB; Gupta, K; Hu, Y; Lathrop, K; Li, R; McHardy, S; Sareddy, GR; Vadlamudi, R; Wang, D; Wang, P; Ye, Q; Yuan, B | 1 |
| Farooq, A; Frangou, C; Guo, J; Li, J; Li, YW; Mussell, AL; Qu, J; Shen, H; Sudol, M; Wilson, KE; Yang, N; Zhang, J; Zhang, Y | 1 |
| Diakonova, M; Hammer, A | 1 |
| Kim, Y; Lu, F; Okada, N; Sun, H; Xiong, X; Zhang, H; Zhu, L | 1 |
| Bernaciak, TM; Fox, EM; Shupnik, MA; Silva, CM; Weaver, AM; Wen, J | 1 |
| Chien, CD; Dakshanamurthy, S; Fereshteh, MP; Kagan, BL; Lahusen, JT; Oh, AS; Riegel, AT; Wellstein, A; Xu, J; Zhang, X | 1 |
| Bast, RC; Heymach, JV; Le, XF; Lu, C; Mao, W; Sood, AK; Thornton, A | 1 |
| Andò, S; Barone, I; Bonofiglio, D; Catalano, S; Giordano, C; Gu, G; Malivindi, R; Qi, H; Rizza, P | 1 |
| Liao, WS; Mandal, PK; McMurray, JS | 1 |
| Brown, SB; Brunton, VG; Cooke, TG; Edwards, J; Elsberger, B; Mallon, EA; Mitchell, TJ; Tan, BA; Tovey, SM | 1 |
| Freydin, B; Hooke, JA; Hyslop, T; Klimowicz, AC; Kovatich, AJ; Liu, C; Magliocco, AM; Nevalainen, MT; Peck, AR; Pequignot, E; Rimm, DL; Rosenberg, AL; Rui, H; Sauter, G; Shriver, CD; Stringer, GA; Tran, TH; Witkiewicz, AK; Yang, N | 1 |
| Al-Ahmadie, H; Azare, J; Berishaj, M; Bromberg, J; Chang, Q; Doane, A; Gerald, W; Hassimi, M; Leslie, K; Lyden, D; Mark, K; Nnoli, J; Stracke, M; Viale, A | 1 |
| Bose, R; Boyer, AP; Collier, TS; Vidavsky, I | 1 |
| Dong, Z; Hardy, WR; Kaplan, A; Ngan, E; Northey, JJ; Pawson, T; Siegel, PM | 1 |
| Cook, L; Diakonova, M; Hammer, A; Li, Q; Mattingly, RR; Oladimeji, P; Rider, L | 1 |
| Auzenne, EJ; Bast, RC; Gao, F; Klostergaard, J; Liao, WS; Lu, Z; Mandal, PK; McMurray, JS; Robertson, FM | 1 |
| Becker, E; Dirks, WG; Drexler, HG; Fähnrich, S; Lis, Y; MacLeod, RA | 1 |
| Kikawa, KD; Kinch, MS; Van Etten, RL; Vidale, DR | 1 |
| Burke, TR; Guo, R; Li, B; Wei, CQ; Yang, D | 1 |
| Chen, X; Pennock, S; Wang, Y; Wang, Z | 1 |
| Kundu, GC; Mahabeleshwar, GH | 1 |
| Ali, S; Campiglio, M; Chughtai, N; Lebrun, JJ; Minoo, P; Stein-Gerlach, M; Ullrich, A | 1 |
| Camp, RL; Dolled-Filhart, M; Kowalski, DP; Rimm, DL; Smith, BL | 1 |
| Li, P; Liu, H; Peach, ML; Roller, PP; Yang, D; Zhang, M | 1 |
| Attems, J; Czerwenka, K; Hudelist, G; Köstler, WJ; Kubista, E; Manavi, M; Müller, R; Singer, CF; Steger, GG; Zielinski, CC | 1 |
| Jacobson, K; Roy, P | 1 |
| Hamaguchi, M; Machida, K; Miyazaki, K; Nimura, Y; Oo, ML; Senga, T; Takenouchi, Y; Watanabe, Y | 1 |
| Hirohashi, S; Kanai, Y; Kokubu, A; Sekine, S; Shibata, T | 1 |
| Druker, BJ; Epstein, RJ; Lim, YP; Ooi, LL; Wong, CY | 1 |
| Benassati, S; Boland, RL; Capiati, DA; Picotto, G; Rossi, AM | 1 |
| Bindu, L; Burke, TR; Fisher, RJ; Liu, H; Shi, ZD; Worthy, KM; Yang, D; Zhang, M | 1 |
| Attems, J; Czerwenka, K; Gschwantler-Kaulich, D; Hoschützky, H; Huber, I; Hudelist, G; Köstler, WJ; Kubista, E; Manavi, M; Müller, R; Singer, CF; Zielinski, CC | 1 |
| Bowden, ET; Mueller, SC; Myoui, A; Onikoyi, E; Slack, R; Yamada, KM; Yoneda, T | 1 |
| Hays, S; Kern, FG; Manuvakhova, M; Qu, Z; Rentz, SS; Thottassery, JV; Westbrook, L | 1 |
| Foulke, JG; Han, W; Tang, CK; Yu, H; Zhang, T | 1 |
| Geng, M; Li, J; Tang, X; Xin, X | 1 |
| Eng, C; Minaguchi, T; Waite, KA | 1 |
| Ahmed, S; Al-Ahmadie, H; Berishaj, M; Bornmann, W; Bromberg, JF; Gao, SP; Gerald, WL; Leslie, K | 1 |
| Lidke, DS; Oliver, JM; Raymond-Stintz, MA; Steinberg, SL; Williams, L; Wilson, BS; Yang, S; Ying, W; Zhang, J | 1 |
| Bartholomeusz, C; Hortobagyi, GN; Kurisu, K; Sudo, T; Ueno, NT; Yamasaki, F; Zhang, D | 1 |
| Boyce, T; Clack, G; Duffield, E; Fennell, M; Green, T; Jacobs, V; Jones, RJ; Kelly, J; Pinto, F; Robertson, J | 1 |
| Agelaki, S; Georgoulias, V; Kallergi, G; Markomanolaki, H; Stournaras, C | 1 |
| Chen, CS; Chen, Y; Choong, LY; Druker, BJ; Hande, MP; Lim, S; Lim, YP; Loh, MC; Man, X; Pan, M; Poonepalli, A; Salto-Tellez, M; Shah, N; Tan, PH; Toy, W; Wong, CY | 1 |
| Jia, L; Sakai, R; Uekita, T | 1 |
| Franco, RS; Lower, EE; Martelo, OJ; Miller, MA | 1 |
| Ding, IY; Kern, FG; Lippman, ME; McLeskey, SW | 1 |
| Antoniotti, S; De Bortoli, M; Hynes, NE; Maggiora, P; Sapei, ML; Taverna, D | 1 |
| Beerli, RR; Graus-Porta, D; Hynes, NE | 1 |
| Bacus, SS; Chace, D; Chin, DM; Cohen, BD; Goetze, A; Green, JM; Hellström, I; Mixan, B; Plowman, GD; Siegall, CB | 1 |
| Aaronson, SA; Alimandi, M; Curia, MC; Di Fiore, PP; Fedi, P; Kraus, MH; Muraro, R; Romano, A | 1 |
| Arnold, SF; Jaffe, H; Notides, AC; Obourn, JD | 1 |
| Arnold, SF; Notides, AC | 1 |
| Bacus, SS; Chang, CJ; Hung, MC; Zhang, L | 1 |
| Barbacci, EG; Cooper, BA; Corman, ML; Dee, MF; DiOrio, CI; Doty, JL; Gallaschun, RJ; Moyer, JD; Muzzi, ML; Schnur, RC | 1 |
| Esselman, WJ; Kang, S; Welsch, CW; Wirth, J; Zhai, Y | 1 |
| Heffelfinger, S; Lower, EE; Miller, MA; Westermann, C; Williams, L | 1 |
| Hamburger, AW; Mishra, S | 3 |
| Kaur, G; Sausville, EA; Sebers, S; Seynaeve, CM; Stetler-Stevenson, M; Worland, PJ | 1 |
| Arteaga, CL; Halter, SA; Winnier, AR | 1 |
| Adriaansen-Slot, SS; Rijksen, G; Salden, M; Schraag, B; Staal, GE | 1 |
| Carlton, GW; Culouscou, JM; Green, JM; Plowman, GD; Shoyab, M | 1 |
| Abraham, I; McCroskey, MC; Sampson, KE | 1 |
| Arnold, SF; Notides, AC; Vorojeikina, DP | 1 |
| Fogleman, PB; Schmidt-Ullrich, RK; Valerie, K; Walters, J | 1 |
| Bacus, SS; Chin, D; Stern, DF; Yarden, Y; Zelnick, CR | 1 |
| Abbondanza, C; Auricchio, F; Bilancio, A; Castoria, G; Migliaccio, A; Pagano, M | 1 |
| Dilts, CA; Ethier, SP; Kokeny, KE; Ridings, JW | 1 |
| Bacus, SS; Ben-Baruch, N; Chen, X; Karunagaran, D; Lavi, S; Leitner, O; Levkowitz, G; Ratzkin, BJ; Tzahar, E; Yarden, Y | 1 |
| Fenoglio-Preiser, CM; Heffelfinger, SC; Lower, EE; Miller, MA | 1 |
| Claesson-Welsh, L; Heldin, CH; Margolis, B; Yokote, K | 1 |
| Daly, RJ; Fiddes, RJ; Janes, PW; Sanderson, GM; Sivertsen, SP; Sutherland, RL | 1 |
| Dziubinski, ML; Ethier, SP; Jove, R; Sartor, CI; Yu, CL | 1 |
| Guvakova, MA; Surmacz, E | 2 |
| Anderson, WA; Asseffa, A; Balan, KV; Eckberg, WR; Gyles, P; Han, Z; Hollis, VW; Mohamood, AS; Wyche, JH | 1 |
| Bigner, SH; Bose, S; Giovanella, BC; Hibshoosh, H; Ittmann, M; Li, J; Liaw, D; McCombie, R; Miliaresis, C; Parsons, R; Podsypanina, K; Puc, J; Rodgers, L; Tycko, B; Wang, SI; Wigler, MH; Yen, C | 1 |
| Canbay, E; Goffin, V; Kilic, E; Norman, M; Zachary, I | 1 |
| Carter, D; Flick, MB; Halaban, R; Kacinski, BM; Maher, MG; Perrotta, PL; Sapi, E | 1 |
| Davis, JG; Greene, MI; Kajino, K; Kajino, Y; O'Rourke, DM; Wang, Q; Weber, BL; Zhang, HB; Zhang, HT; Zhang, X; Zhao, HZ | 1 |
| Chen, PB; Contessa, JN; Dent, P; Kavanagh, BD; Mikkelsen, RB; Rorrer, WK; Schmidt-Ullrich, RK; Todd, DG; Valerie, K | 1 |
| Bajou, K; Dejana, E; Desreux, J; Foidart, JM; Lewalle, JM; Mareel, M; Noël, A | 1 |
| Huey, K; Reichart, DB; Resnik, JL; Seely, BL; Webster, NJ | 1 |
| Jackson, JG; White, MF; Yee, D | 1 |
| Horwitz, KB; Lange, CA; Richer, JK; Shen, T | 1 |
| Emilsen, E; Nesland, JM; Suo, Z; Tveit, KM | 1 |
| Bartholomew, PJ; DePasquale, JA; Vinci, JM | 1 |
| Ethier, SP; Ignatoski, KM | 1 |
| Baserga, R; Carturan, S; Catalano, E; Criscuolo, M; D'Ambrosio, C; Huang, Z; Pifferi, M; Rubini, M; Shan, S; Yumet, G | 1 |
| Cornea, A; Costa, ME; Creswick, KE; Hill, DF; Lioubin, MN; Ma, YJ; Ojeda, SR; Plowman, GD | 1 |
| Hart, IR; Marshall, JF; Perry, P; Stone, M; von Schlippe, M; Zhu, AJ | 1 |
| Kaulsay, KK; Lee, KO; Lobie, PE; Mertani, HC | 1 |
| Chambers, AF; Elliott, BE; Hota, C; Tremblay, E; Tuck, AB | 1 |
| Liu, J; Ma, Y; Spence, MJ; Streiff, R; Vestal, RE | 1 |
| Boilly, B; Hondermarck, H; Lemoine, J; Nurcombe, V; Peyrat, J; Smart, CE; Vercoutter-Edouart, A | 1 |
| Freeman, AL; Kain, R; Lindberg, RA; Ogawa, K; Pasquale, EB; Pasqualini, R | 1 |
| Bagheri-Yarmand, R; Kumar, R; Kung, HJ; Mandal, M; Taludker, AH; Vadlamudi, RK; Wang, RA | 1 |
| Calvo, B; Caskey, L; Earp, HS; Ethier, S; Guttridge, K; Harrelson, J; Hynes, N; Kawata, E; Kozlowska, E; Sartor, CI; Zhou, H | 1 |
| Adam, L; Bao, Y; Kumar, R; McPherson, RA; Santen, RJ; Shupnik, M; Song, RX | 1 |
| Bano, M; Dickson, RB; Kidwell, WR; Lippman, ME; Worland, P | 1 |
| Christianson, TA; Clinton, GM; Lin, YJ | 1 |
| Clinton, GM; Li, SW; Lin, YZ | 1 |
| Andrulis, IL; Blackstein, ME; Pawson, T; Wildenhain, Y | 1 |
| Ginsburg, E; Vonderhaar, BK | 1 |
| Aaronson, SA; Arnstein, P; Artrip, J; Di Fiore, PP; DiMarco, E; Kraus, MH; Lonardo, F; Pierce, JH | 1 |
| Weinberg, RA; Yarden, Y | 1 |
| Rijksen, G; Staal, GE; van Oirschot, BA | 1 |
1 trial(s) available for phosphotyrosine and Breast Cancer
| Article | Year |
|---|---|
Her-2/neu and EGFR tyrosine kinase activation predict the efficacy of trastuzumab-based therapy in patients with metastatic breast cancer.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibody Specificity; Breast Neoplasms; Disease Progression; Enzyme Activation; ErbB Receptors; Gene Expression Regulation, Neoplastic; Humans; Immunotherapy; Middle Aged; Neoplasm Metastasis; Peptides; Phosphotyrosine; Prognosis; Receptor, ErbB-2; Survival Rate; Trastuzumab | 2006 |
125 other study(ies) available for phosphotyrosine and Breast Cancer
| Article | Year |
|---|---|
A specific amino acid context in EGFR and HER2 phosphorylation sites enables selective binding to the active site of Src homology phosphatase 2 (SHP2).
Topics: Amino Acid Sequence; Amino Acids; Animals; Breast Neoplasms; Catalytic Domain; Cell Line, Transformed; Epidermal Growth Factor; ErbB Receptors; Humans; Mice; Models, Molecular; Mutagenesis, Site-Directed; Mutation; NIH 3T3 Cells; Peptides; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Receptor, ErbB-2; Signal Transduction; Substrate Specificity | 2020 |
ABL1-dependent OTULIN phosphorylation promotes genotoxic Wnt/β-catenin activation to enhance drug resistance in breast cancers.
Topics: Animals; beta Catenin; Breast Neoplasms; Cell Line, Tumor; Cell Survival; DNA Damage; Drug Resistance, Neoplasm; Endopeptidases; Female; HEK293 Cells; Humans; Mice, Inbred NOD; Mice, SCID; Models, Biological; Neoplasm Metastasis; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins c-abl; Ubiquitination; Wnt Signaling Pathway | 2020 |
Phosphorylation of PKCδ by FER tips the balance from EGFR degradation to recycling.
Topics: Breast Neoplasms; Cell Line, Tumor; Endocytosis; Endosomes; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Mitogens; Phosphorylation; Phosphotyrosine; Protein Kinase C-delta; Protein Stability; Protein Transport; Protein Tyrosine Phosphatases, Non-Receptor; Protein-Tyrosine Kinases; Proteolysis; rab GTP-Binding Proteins; RNA, Messenger; Time Factors; Ubiquitination | 2021 |
Estrogen receptor beta signaling in CD8
Topics: Animals; Breast Neoplasms; CD8-Positive T-Lymphocytes; Equol; Estrogen Receptor beta; Female; HEK293 Cells; Humans; Immune Checkpoint Inhibitors; Immunotherapy, Adoptive; Male; Mice; Mutation; Phosphotyrosine; Signal Transduction; Survival Analysis; Xenograft Model Antitumor Assays | 2021 |
Phosphorylated cortactin recruits Vav2 guanine nucleotide exchange factor to activate Rac3 and promote invadopodial function in invasive breast cancer cells.
Topics: Actins; Breast Neoplasms; Cell Line, Tumor; Cortactin; Extracellular Matrix; Guanine Nucleotide Exchange Factors; Humans; Neoplasm Invasiveness; Phosphorylation; Phosphotyrosine; Podosomes; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-vav; Pseudopodia; rac GTP-Binding Proteins | 2017 |
Photoaffinity-engineered protein scaffold for systematically exploring native phosphotyrosine signaling complexes in tumor samples.
Topics: Animals; Benzimidazoles; Biomarkers, Tumor; Breast Neoplasms; Cancer-Associated Fibroblasts; Cell Line, Tumor; Female; Humans; Mammary Tumor Virus, Mouse; Mass Spectrometry; Mice, Transgenic; Phosphorylation; Phosphotyrosine; Piperidines; Protein Binding; Protein Engineering; Proteomics; Receptor, ErbB-2; Receptor, Platelet-Derived Growth Factor beta; Signal Transduction; src Homology Domains; Ultraviolet Rays | 2018 |
Boswellia frereana suppresses HGF-mediated breast cancer cell invasion and migration through inhibition of c-Met signalling.
Topics: Boswellia; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell-Matrix Junctions; Endothelial Cells; Female; Hepatocyte Growth Factor; Humans; Neoplasm Invasiveness; Phosphorylation; Phosphotyrosine; Plant Extracts; Proto-Oncogene Proteins c-met; Signal Transduction; Spheroids, Cellular | 2018 |
EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2.
Topics: Argonaute Proteins; Breast Neoplasms; Cell Hypoxia; Cell Line, Tumor; Cell Survival; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs; Neoplasm Invasiveness; Nucleic Acid Conformation; Phosphorylation; Phosphotyrosine; Prognosis; Protein Binding; Ribonuclease III; RNA Precursors; Survival Analysis | 2013 |
The ShcA PTB domain functions as a biological sensor of phosphotyrosine signaling during breast cancer progression.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Disease Progression; Female; Fibronectins; Humans; Integrin alpha5beta1; Mammary Neoplasms, Experimental; Mice; Mice, Transgenic; Mutation; Neovascularization, Pathologic; Phosphotyrosine; Protein Structure, Tertiary; Receptor Protein-Tyrosine Kinases; Shc Signaling Adaptor Proteins; Signal Transduction; Vascular Endothelial Growth Factor A | 2013 |
PAK1 regulates breast cancer cell invasion through secretion of matrix metalloproteinases in response to prolactin and three-dimensional collagen IV.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Collagen Type IV; Enzyme Activation; Female; Gene Expression Regulation, Neoplastic; Humans; Matrix Metalloproteinases; Mitogen-Activated Protein Kinases; Models, Biological; Mutant Proteins; Neoplasm Invasiveness; NF-kappa B; p21-Activated Kinases; Phosphorylation; Phosphotyrosine; Prolactin; Rats; Transcription, Genetic | 2013 |
Global profiling of prolactin-modulated transcripts in breast cancer in vivo.
Topics: Animals; Biomarkers, Tumor; Breast Neoplasms; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Estradiol; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Ontology; Humans; Janus Kinase 1; Janus Kinase 2; Mice, Nude; Neoplasm Metastasis; Oligonucleotide Array Sequence Analysis; Parathyroid Hormone-Related Protein; Phosphotyrosine; Prolactin; Reproducibility of Results; RNA, Messenger; STAT5 Transcription Factor; Up-Regulation; Xenograft Model Antitumor Assays | 2013 |
Mammary tumor formation and metastasis evoked by a HER2 splice variant.
Topics: Alternative Splicing; Animals; Apoptosis; Biomarkers, Tumor; Breast; Breast Neoplasms; Cell Culture Techniques; Cell Cycle; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Chromatography, Liquid; Epithelial-Mesenchymal Transition; Female; Gene Expression Profiling; Humans; Immunoenzyme Techniques; Lung Neoplasms; Mammary Glands, Human; Mammary Neoplasms, Animal; Mice; Mice, SCID; Oligonucleotide Array Sequence Analysis; Phosphorylation; Phosphotyrosine; Real-Time Polymerase Chain Reaction; Receptor, ErbB-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tandem Mass Spectrometry | 2013 |
A phosphotyrosine switch determines the antitumor activity of ERβ.
Topics: Animals; Breast Neoplasms; Disease-Free Survival; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Gene Knockdown Techniques; Heterografts; Humans; Intracellular Signaling Peptides and Proteins; MCF-7 Cells; Mice; Mice, 129 Strain; Mutant Proteins; Nuclear Proteins; Phosphotyrosine; Prognosis; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-abl; Recombinant Proteins; Signal Transduction; Transcriptional Activation; Tumor Suppressor Proteins | 2014 |
The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes.
Topics: Amino Acid Motifs; Amino Acid Sequence; beta-Transducin Repeat-Containing Proteins; Breast Neoplasms; Catalytic Domain; Cell Line, Tumor; Crystallography, X-Ray; Female; Humans; Hydrophobic and Hydrophilic Interactions; Kinetics; Lysine; Lysosomes; Models, Biological; Molecular Sequence Data; Neoplasm Staging; Peptides; Phosphorylation; Phosphotyrosine; Proteasome Endopeptidase Complex; Protein Tyrosine Phosphatases, Non-Receptor; Proteolysis; Receptor, ErbB-2; Signal Transduction; Structure-Activity Relationship; Substrate Specificity; Ubiquitination | 2014 |
Cyclic Peptides Incorporating Phosphotyrosine Mimetics as Potent and Specific Inhibitors of the Grb7 Breast Cancer Target.
Topics: Antineoplastic Agents; Binding Sites; Breast Neoplasms; Crystallography, X-Ray; Female; GRB7 Adaptor Protein; Humans; Malonates; Molecular Targeted Therapy; Peptides, Cyclic; Peptidomimetics; Phosphates; Phosphotyrosine; Protein Conformation; src Homology Domains | 2015 |
Germline variant FGFR4 p.G388R exposes a membrane-proximal STAT3 binding site.
Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Binding Sites; Breast Neoplasms; Cell Line; Cell Membrane; Disease Models, Animal; Disease Progression; Exons; Female; Gene Knock-In Techniques; Germ-Line Mutation; Humans; Lung Neoplasms; Male; Mice; Mice, Transgenic; Molecular Sequence Data; Phosphorylation; Phosphotyrosine; Polymorphism, Single Nucleotide; Receptor, Fibroblast Growth Factor, Type 4; Signal Transduction; STAT3 Transcription Factor | 2015 |
A truncated phosphorylated p130Cas substrate domain is sufficient to drive breast cancer growth and metastasis formation in vivo.
Topics: Amino Acid Motifs; Animals; Breast Neoplasms; Cell Line, Tumor; Crk-Associated Substrate Protein; CSK Tyrosine-Protein Kinase; Disease Progression; Female; Genes, Reporter; Heterografts; Humans; MCF-7 Cells; Mice; Mice, Inbred NOD; Mice, SCID; Mice, Transgenic; Neoplasm Metastasis; Neoplasm Proteins; Peptide Fragments; Phosphorylation; Phosphotyrosine; Protein Domains; Protein Processing, Post-Translational; Recombinant Fusion Proteins; src-Family Kinases | 2016 |
Low Molecular Weight Protein Tyrosine Phosphatase Slow Isoform Knockdown in MDA-MB-435 Cells Decreases RAW 264.7 Osteoclastic Differentiation.
Topics: Adenocarcinoma; Animals; Bone Neoplasms; Breast Neoplasms; Cell Differentiation; Cell Line, Tumor; Culture Media, Conditioned; Interleukin-6; Interleukin-8; Mice; Neoplasm Proteins; Osteoclasts; Phosphorylation; Phosphotyrosine; Protein Isoforms; Protein Processing, Post-Translational; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; RANK Ligand; RAW 264.7 Cells; RNA Interference; RNA, Small Interfering; src-Family Kinases | 2016 |
Tyrosine phosphorylation regulates ERβ ubiquitination, protein turnover, and inhibition of breast cancer.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Proliferation; Cell Survival; Estrogen Receptor beta; Female; HEK293 Cells; Humans; Ki-67 Antigen; Ligands; MCF-7 Cells; Mice; Mice, Nude; Neoplasm Transplantation; p300-CBP Transcription Factors; Phosphorylation; Phosphotyrosine; Proteasome Endopeptidase Complex; Tyrosine; Ubiquitination | 2016 |
Phosphorylation of Tyr188 in the WW domain of YAP1 plays an essential role in YAP1-induced cellular transformation.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Breast Neoplasms; Cell Line, Tumor; Cell Transformation, Neoplastic; Humans; Immunoprecipitation; Mass Spectrometry; Morphogenesis; Oncogenes; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Domains; Protein Processing, Post-Translational; Transcription Factors; YAP-Signaling Proteins | 2016 |
Prolactin-induced PAK1 tyrosyl phosphorylation promotes FAK dephosphorylation, breast cancer cell motility, invasion and metastasis.
Topics: Animals; Breast Neoplasms; Cell Movement; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Female; Focal Adhesion Protein-Tyrosine Kinases; Gene Silencing; Humans; Mice; Models, Biological; Neoplasm Invasiveness; Neoplasm Metastasis; p21-Activated Kinases; Phosphorylation; Phosphotyrosine; Prolactin; Protein Tyrosine Phosphatase, Non-Receptor Type 12 | 2016 |
Acid sphingomyelinase is required for cell surface presentation of Met receptor tyrosine kinase in cancer cells.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Membrane; Cholesterol; Enzyme Activation; Female; Humans; Integrin beta3; Ligands; Melanoma; Membrane Glycoproteins; Neoplasms; Phosphotyrosine; Proto-Oncogene Proteins c-met; Qa-SNARE Proteins; Receptor, IGF Type 1; Signal Transduction; Sphingomyelin Phosphodiesterase; trans-Golgi Network; Viral Envelope Proteins | 2016 |
Signal transducer and activator of transcription 5b, c-Src, and epidermal growth factor receptor signaling play integral roles in estrogen-stimulated proliferation of estrogen receptor-positive breast cancer cells.
Topics: Breast Neoplasms; Cell Count; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Drug Resistance, Neoplasm; ErbB Receptors; Estradiol; Estrogen Receptor alpha; Gene Expression Regulation, Neoplastic; Genes, Neoplasm; Humans; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins pp60(c-src); Signal Transduction; STAT5 Transcription Factor; Tamoxifen; Transcription, Genetic | 2008 |
Tyrosine phosphorylation of the nuclear receptor coactivator AIB1/SRC-3 is enhanced by Abl kinase and is required for its activity in cancer cells.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Epidermal Growth Factor; Female; Fusion Proteins, bcr-abl; Histone Acetyltransferases; Humans; Insulin-Like Growth Factor I; Mice; Nuclear Receptor Coactivator 3; Phosphorylation; Phosphotyrosine; Promoter Regions, Genetic; Protein Binding; Protein Interaction Mapping; Protein-Tyrosine Kinases; Trans-Activators; Transcription Factors | 2008 |
Specific blockade of VEGF and HER2 pathways results in greater growth inhibition of breast cancer xenografts that overexpress HER2.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Endothelial Cells; Female; Humans; Ligands; Mice; Mice, Nude; Neovascularization, Pathologic; Pericytes; Phosphotyrosine; Placenta Growth Factor; Pregnancy Proteins; Receptor, ErbB-2; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Trastuzumab; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays | 2008 |
Rapid estradiol/ERalpha signaling enhances aromatase enzymatic activity in breast cancer cells.
Topics: Amino Acid Sequence; Aromatase; Breast Neoplasms; Cell Line, Tumor; Enzyme Activation; ErbB Receptors; Estradiol; Estrogen Receptor alpha; Female; Humans; Models, Biological; Molecular Sequence Data; Multiprotein Complexes; Phosphorylation; Phosphotyrosine; Protein Binding; Receptors, Growth Factor; Signal Transduction; src-Family Kinases | 2009 |
Synthesis of phosphatase-stable, cell-permeable peptidomimetic prodrugs that target the SH2 domain of Stat3.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Dimerization; Female; Heterocyclic Compounds, 3-Ring; Humans; Phosphorylation; Phosphotyrosine; Prodrugs; Pyrrolidines; src Homology Domains; STAT3 Transcription Factor | 2009 |
Is expression or activation of Src kinase associated with cancer-specific survival in ER-, PR- and HER2-negative breast cancer patients?
Topics: Breast Neoplasms; Enzyme Activation; Female; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Middle Aged; Models, Biological; Phosphotyrosine; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; src-Family Kinases | 2009 |
Loss of nuclear localized and tyrosine phosphorylated Stat5 in breast cancer predicts poor clinical outcome and increased risk of antiestrogen therapy failure.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Intraductal, Noninfiltrating; Cohort Studies; Disease Progression; Disease-Free Survival; Drug Resistance, Neoplasm; Estrogen Receptor Modulators; Female; Humans; Lymphatic Metastasis; Middle Aged; Neoplasm Proteins; Nuclear Proteins; Phosphorylation; Phosphotyrosine; Prognosis; Protein Processing, Post-Translational; STAT5 Transcription Factor; Survival Analysis; Treatment Failure; Tumor Suppressor Proteins; Young Adult | 2011 |
Stat3 mediates expression of autotaxin in breast cancer.
Topics: Breast Neoplasms; Cell Line, Tumor; Cluster Analysis; Female; Gene Expression Regulation, Neoplastic; Genes, Neoplasm; Humans; Lymph Nodes; Neoplasm Metastasis; Phosphoric Diester Hydrolases; Phosphorylation; Phosphotyrosine; STAT3 Transcription Factor | 2011 |
Quantitative proteomics with siRNA screening identifies novel mechanisms of trastuzumab resistance in HER2 amplified breast cancers.
Topics: Antibodies, Monoclonal, Humanized; Antigens, CD; Antigens, Neoplasm; Breast Neoplasms; Cell Adhesion Molecules; Cell Line, Tumor; Cyclin-Dependent Kinases; Drug Resistance, Neoplasm; Female; Humans; Isotope Labeling; Neoplasm Proteins; Paxillin; Phosphatidylinositol 3-Kinase; Phosphorylation; Phosphotyrosine; Proteomics; Proto-Oncogene Proteins c-akt; Receptor, ErbB-2; RNA Interference; RNA, Small Interfering; Signal Transduction; Trastuzumab | 2013 |
Distinct phosphotyrosine-dependent functions of the ShcA adaptor protein are required for transforming growth factor β (TGFβ)-induced breast cancer cell migration, invasion, and metastasis.
Topics: Amino Acid Motifs; Animals; Breast Neoplasms; Cell Movement; Cell Survival; Female; Humans; Lung Neoplasms; Mammary Neoplasms, Animal; Mice; Neoplasm Invasiveness; Neoplasm Metastasis; Phosphorylation; Phosphotyrosine; Receptor, ErbB-2; RNA, Small Interfering; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Transforming Growth Factor beta1 | 2013 |
Tyrosyl phosphorylated PAK1 regulates breast cancer cell motility in response to prolactin through filamin A.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Movement; Clone Cells; Contractile Proteins; Female; Filamins; Green Fluorescent Proteins; Humans; Janus Kinase 2; Microfilament Proteins; Models, Biological; Mutant Proteins; p21-Activated Kinases; Phosphorylation; Phosphoserine; Phosphotyrosine; Prolactin | 2013 |
A phosphopeptide mimetic prodrug targeting the SH2 domain of Stat3 inhibits tumor growth and angiogenesis.
Topics: Animals; Biomimetics; Breast Neoplasms; Female; Humans; Mice; Mice, Nude; Neovascularization, Pathologic; Phosphopeptides; Phosphorylation; Phosphotyrosine; Prodrugs; src Homology Domains; STAT3 Transcription Factor; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2012 |
Expression and functional analysis of the anaplastic lymphoma kinase (ALK) gene in tumor cell lines.
Topics: Anaplastic Lymphoma Kinase; Animals; Antibodies, Monoclonal; Blotting, Western; Breast Neoplasms; Chromosomes, Human, Pair 2; Chromosomes, Human, Pair 5; Gene Expression; Glioblastoma; Humans; Immunosorbent Techniques; Lymphoma; Melanoma; Mice; Neuroblastoma; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor Protein-Tyrosine Kinases; Retinoblastoma; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sarcoma, Ewing; Sensitivity and Specificity; Translocation, Genetic; Tumor Cells, Cultured | 2002 |
Regulation of the EphA2 kinase by the low molecular weight tyrosine phosphatase induces transformation.
Topics: Breast Neoplasms; Cell Line, Transformed; Cells, Cultured; Chelating Agents; Dose-Response Relationship, Drug; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Epithelial Cells; Gene Expression Regulation, Enzymologic; Humans; Immunoblotting; Isoenzymes; Oligonucleotides, Antisense; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Receptor, EphA2; Signal Transduction; Time Factors; Transfection; Tumor Cells, Cultured; Tyrosine; Vanadates | 2002 |
Development of a phosphatase-stable phosphotyrosyl mimetic suitably protected for the synthesis of high-affinity Grb2 SH2 domain-binding ligands.
Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Breast Neoplasms; Cell Membrane Permeability; Enzyme-Linked Immunosorbent Assay; Female; GRB2 Adaptor Protein; Humans; Indicators and Reagents; Ligands; Molecular Mimicry; Phosphoric Monoester Hydrolases; Phosphotyrosine; Proteins; Receptor, ErbB-2; src Homology Domains; Tumor Cells, Cultured | 2002 |
Internalization of inactive EGF receptor into endosomes and the subsequent activation of endosome-associated EGF receptors. Epidermal growth factor.
Topics: Animals; Breast Neoplasms; Cell Line; Dogs; Endosomes; ErbB Receptors; Fluorescent Antibody Technique, Indirect; Humans; Kidney; Membrane Proteins; Mice; Monensin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Quinazolines; Signal Transduction; Tumor Cells, Cultured; Tyrphostins | 2002 |
Syk, a protein-tyrosine kinase, suppresses the cell motility and nuclear factor kappa B-mediated secretion of urokinase type plasminogen activator by inhibiting the phosphatidylinositol 3'-kinase activity in breast cancer cells.
Topics: Breast Neoplasms; Cell Division; Cell Movement; Enzyme Precursors; Female; Humans; Intracellular Signaling Peptides and Proteins; Kinetics; Neoplasm Metastasis; NF-kappa B; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Recombinant Proteins; Syk Kinase; Transfection; Tumor Cells, Cultured; Urokinase-Type Plasminogen Activator | 2003 |
The adaptor function of SHP-2 downstream of the prolactin receptor is required for the recruitment of p29, a substrate of SHP-2.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Breast Neoplasms; GRB2 Adaptor Protein; Humans; Intracellular Signaling Peptides and Proteins; Janus Kinase 2; Lymphoma; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Rats; Receptors, Prolactin; Signal Transduction; Substrate Specificity; Tumor Cells, Cultured; Tyrosine | 2003 |
Tissue microarray analysis of signal transducers and activators of transcription 3 (Stat3) and phospho-Stat3 (Tyr705) in node-negative breast cancer shows nuclear localization is associated with a better prognosis.
Topics: Acute-Phase Proteins; Biomarkers; Breast Neoplasms; Cell Nucleus; DNA-Binding Proteins; Female; Humans; Immunohistochemistry; Lymphatic Metastasis; Multivariate Analysis; Phosphorylation; Phosphotyrosine; Prognosis; Proportional Hazards Models; STAT3 Transcription Factor; Survival Analysis; Time Factors; Trans-Activators | 2003 |
Concise and enantioselective synthesis of Fmoc-Pmp(But)2-OH and design of potent Pmp-containing Grb2-SH2 domain antagonists.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Amino Acids; Animals; Breast Neoplasms; Fluorenes; GRB2 Adaptor Protein; Inhibitory Concentration 50; Mice; Molecular Mimicry; Molecular Sequence Data; Peptides, Cyclic; Phenylalanine; Phosphotyrosine; Proteins; Receptor, ErbB-2; src Homology Domains; Stereoisomerism; Tumor Cells, Cultured | 2003 |
Her-2/neu-triggered intracellular tyrosine kinase activation: in vivo relevance of ligand-independent activation mechanisms and impact upon the efficacy of trastuzumab-based treatment.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Biomarkers, Tumor; Breast Neoplasms; Carcinoma, Ductal, Breast; Enzyme Activation; Female; Gene Expression Regulation, Neoplastic; Humans; Immunoglobulin G; Ligands; Middle Aged; Phosphorylation; Phosphotyrosine; Prognosis; Protein-Tyrosine Kinases; Receptor, ErbB-2; Receptors, Progesterone; Survival Rate; Trastuzumab; Treatment Outcome | 2003 |
Overexpression of profilin reduces the migration of invasive breast cancer cells.
Topics: Actins; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Contractile Proteins; Epidermal Growth Factor; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Green Fluorescent Proteins; Humans; Luminescent Proteins; Microfilament Proteins; Phosphoproteins; Phosphotyrosine; Profilins; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Transfection | 2004 |
Tyrosine phosphorylation of NOS3 in a breast cancer cell line and Src-transformed cells.
Topics: Animals; Breast Neoplasms; Cell Line, Transformed; Cell Line, Tumor; COS Cells; Female; Humans; Mutation; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Oncogene Protein pp60(v-src); Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins pp60(c-src); Pyrazoles; Pyrimidines; Transfection | 2004 |
Cytoplasmic p120ctn regulates the invasive phenotypes of E-cadherin-deficient breast cancer.
Topics: Base Sequence; Breast Neoplasms; Cadherins; Carcinoma, Lobular; Catenins; Cell Adhesion Molecules; Cell Division; Cell Movement; Delta Catenin; Female; Humans; Immunohistochemistry; Neoplasm Invasiveness; Oligodeoxyribonucleotides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Plasmids; RNA, Small Interfering; Transfection | 2004 |
Selective tyrosine hyperphosphorylation of cytoskeletal and stress proteins in primary human breast cancers: implications for adjuvant use of kinase-inhibitory drugs.
Topics: Animals; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Chemotherapy, Adjuvant; Chromatography; Cytoskeleton; Electrophoresis, Gel, Two-Dimensional; Heat-Shock Proteins; Humans; Immunoblotting; Ligands; Male; Mass Spectrometry; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; Neoplasms; Phosphoproteins; Phosphorylation; Phosphotyrosine; Signal Transduction; Tyrosine | 2004 |
Inhibition of serum-stimulated mitogen activated protein kinase by 1alpha,25(OH)2-vitamin D3 in MCF-7 breast cancer cells.
Topics: Breast Neoplasms; Calcitriol; Cell Line, Tumor; Cell Membrane; Cell Nucleus; Cell Proliferation; Enzyme Activation; Enzyme Inhibitors; Humans; Mitogen-Activated Protein Kinases; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Transport; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins pp60(c-src); Pyrazoles; Pyrimidines; Receptors, Calcitriol; Serum; Signal Transduction | 2004 |
Synthesis of a C-terminally biotinylated macrocyclic peptide mimetic exhibiting high Grb2 SH2 domain-binding affinity.
Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Biotinylation; Breast Neoplasms; Cyclization; Female; GRB2 Adaptor Protein; Humans; Ligands; Models, Molecular; Molecular Mimicry; Peptide Fragments; Phosphotyrosine; Protein Binding; Receptor, ErbB-2; src Homology Domains; Structure-Activity Relationship; Tumor Cells, Cultured | 2005 |
Co-localization of cortactin and phosphotyrosine identifies active invadopodia in human breast cancer cells.
Topics: Breast Neoplasms; Carcinoma; Cell Line, Tumor; Cell Membrane; Cortactin; CSK Tyrosine-Protein Kinase; Down-Regulation; Enzyme Activation; Extracellular Matrix; Female; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Humans; Microscopy, Electron, Transmission; Neoplasm Invasiveness; Peptide Hydrolases; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pseudopodia; src-Family Kinases; Transfection; Up-Regulation | 2006 |
Expression of the SNT-1/FRS2 phosphotyrosine binding domain inhibits activation of MAP kinase and PI3-kinase pathways and antiestrogen resistant growth induced by FGF-1 in human breast carcinoma cells.
Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Breast Neoplasms; Carcinoma; Cell Line, Tumor; Cell Proliferation; Doxycycline; Drug Resistance, Neoplasm; Enzyme Activation; Estrogen Receptor Modulators; Female; Fibroblast Growth Factor 1; Gene Expression Regulation, Neoplastic; Humans; Membrane Proteins; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphotyrosine; Protein Binding; Protein Structure, Tertiary; Signal Transduction | 2006 |
Hypophosphorylation of residue Y1045 leads to defective downregulation of EGFRvIII.
Topics: Amino Acid Sequence; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; ErbB Receptors; Female; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Phosphorylation; Phosphotyrosine | 2006 |
A new marine-derived sulfated polysaccharide from brown alga suppresses tumor metastasis both in vitro and in vivo.
Topics: Breast Neoplasms; Carbohydrate Sequence; Cell Adhesion; Cell Line, Tumor; Cell Movement; Female; Humans; Models, Biological; Molecular Sequence Data; Neoplasm Metastasis; Phaeophyceae; Phosphorylation; Phosphotyrosine; Polysaccharides; Seawater; Wound Healing | 2006 |
Nuclear localization of PTEN is regulated by Ca(2+) through a tyrosil phosphorylation-independent conformational modification in major vault protein.
Topics: Apoptosis; Base Sequence; Breast Neoplasms; Calcium; Cell Cycle; Cell Line, Tumor; Cell Nucleus; DNA Primers; Female; Humans; Membrane Proteins; Phosphorylation; Phosphotyrosine; Plasmids; Protein Conformation; Protein Transport; PTEN Phosphohydrolase; RNA, Neoplasm; RNA, Small Interfering; Transfection; Vault Ribonucleoprotein Particles | 2006 |
Stat3 is tyrosine-phosphorylated through the interleukin-6/glycoprotein 130/Janus kinase pathway in breast cancer.
Topics: Breast Neoplasms; Cell Line, Tumor; Enzyme-Linked Immunosorbent Assay; Female; Gene Expression Regulation, Neoplastic; Glycoproteins; Humans; Immunohistochemistry; Interleukin-6; Janus Kinases; Phosphotyrosine; STAT3 Transcription Factor | 2007 |
Mapping ErbB receptors on breast cancer cell membranes during signal transduction.
Topics: Adaptor Proteins, Signal Transducing; Animals; Breast Neoplasms; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Epidermal Growth Factor; ErbB Receptors; Female; Humans; Neuregulin-1; Phosphatidylinositol 3-Kinases; Phosphotyrosine; Protein Transport; Receptor Protein-Tyrosine Kinases; Receptor, ErbB-2; Receptor, ErbB-3; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; STAT5 Transcription Factor; Transfection | 2007 |
Sensitivity of breast cancer cells to erlotinib depends on cyclin-dependent kinase 2 activity.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p27; Cytoplasm; Drug Resistance, Neoplasm; ErbB Receptors; Erlotinib Hydrochloride; Extracellular Signal-Regulated MAP Kinases; Female; G1 Phase; Genes, Dominant; Humans; Phosphorylation; Phosphotyrosine; Protein Transport; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-2; Transfection | 2007 |
The impact of delay in cryo-fixation on biomarkers of Src tyrosine kinase activity in human breast and bladder cancers.
Topics: Aged; Aged, 80 and over; Biomarkers; Biopsy; Breast Neoplasms; Female; Focal Adhesion Protein-Tyrosine Kinases; Freezing; Humans; Immunoassay; Male; Middle Aged; Paxillin; Phosphorylation; Phosphotyrosine; src-Family Kinases; Time Factors; Tissue Fixation; Urinary Bladder Neoplasms | 2008 |
Activation of FAK/PI3K/Rac1 signaling controls actin reorganization and inhibits cell motility in human cancer cells.
Topics: Actins; Analgesics, Opioid; Androstadienes; Breast Neoplasms; Caseins; Cell Line, Tumor; Cell Membrane; Cell Movement; Enzyme Activation; Female; Focal Adhesion Kinase 1; Humans; Melanoma; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphotyrosine; rac1 GTP-Binding Protein; Receptors, Androgen; Signal Transduction; Wortmannin | 2007 |
Progressive loss of epidermal growth factor receptor in a subpopulation of breast cancers: implications in target-directed therapeutics.
Topics: Animals; Asian People; Breast Neoplasms; Cell Line, Tumor; Disease Progression; Drug Delivery Systems; Drug Resistance, Neoplasm; Enzyme Activation; ErbB Receptors; Female; Gefitinib; Gene Dosage; Humans; Mice; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphotyrosine; Proteomics; Quinazolines; Reproducibility of Results | 2007 |
Hyperphosphorylated cortactin in cancer cells plays an inhibitory role in cell motility.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Movement; Clone Cells; Cortactin; Crk-Associated Substrate Protein; Focal Adhesions; Humans; Models, Biological; Phosphorylation; Phosphotyrosine; Protein Transport; RNA, Small Interfering; Stomach Neoplasms | 2008 |
Enzymatic and immunohistochemical evaluation of tyrosine phosphorylation in breast cancer specimens.
Topics: Breast; Breast Neoplasms; Cell Membrane; Cytosol; Female; Humans; Immunohistochemistry; Lymphatic Metastasis; Paraffin Embedding; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Tyrosine | 1993 |
MDA-MB-134 breast carcinoma cells overexpress fibroblast growth factor (FGF) receptors and are growth-inhibited by FGF ligands.
Topics: Antibodies; Breast Neoplasms; Cell Division; Female; Fibroblast Growth Factors; Humans; Phosphorylation; Phosphotyrosine; Receptors, Fibroblast Growth Factor; RNA, Messenger; RNA, Neoplasm; Tumor Cells, Cultured; Tyrosine | 1994 |
Oestrogen and epidermal growth factor down-regulate erbB-2 oncogene protein expression in breast cancer cells by different mechanisms.
Topics: Breast Neoplasms; Cell Division; Down-Regulation; Epidermal Growth Factor; Estradiol; Gene Expression Regulation, Neoplastic; Genes, erbB-2; Humans; In Vitro Techniques; Phosphotyrosine; Receptor Protein-Tyrosine Kinases; Receptor, ErbB-2; RNA, Messenger; RNA, Neoplasm; Transcription, Genetic; Tumor Cells, Cultured; Tyrosine | 1994 |
Single-chain antibody-mediated intracellular retention of ErbB-2 impairs Neu differentiation factor and epidermal growth factor signaling.
Topics: Antibodies, Monoclonal; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Line; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Gene Expression; Genes, fos; Glycoproteins; Humans; Immunoglobulin Heavy Chains; Immunoglobulin Light Chains; Immunoglobulin Variable Region; Kinetics; Neuregulins; Phosphorylation; Phosphotyrosine; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptor, ErbB-2; Recombinant Proteins; Ribosomal Protein S6 Kinases; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1995 |
HER4 expression correlates with cytotoxicity directed by a heregulin-toxin fusion protein.
Topics: ADP Ribose Transferases; Amino Acid Sequence; Animals; Bacterial Toxins; Base Sequence; Breast Neoplasms; Cell Line; Cell Survival; DNA Primers; ErbB Receptors; Exotoxins; Female; Gene Expression; Glycoproteins; Humans; Immunotoxins; Kidney; Kinetics; Leukemia, T-Cell; Lung Neoplasms; Male; Molecular Sequence Data; Neuregulins; Ovarian Neoplasms; Phosphorylation; Phosphotyrosine; Polymerase Chain Reaction; Prostatic Neoplasms; Pseudomonas aeruginosa; Pseudomonas aeruginosa Exotoxin A; Rats; Receptor, ErbB-4; Recombinant Fusion Proteins; RNA, Messenger; Tumor Cells, Cultured; Tyrosine; Virulence Factors | 1995 |
Cooperative signaling of ErbB3 and ErbB2 in neoplastic transformation and human mammary carcinomas.
Topics: 3T3 Cells; Animals; Base Sequence; Breast Neoplasms; Cell Transformation, Neoplastic; DNA Primers; ErbB Receptors; Gene Expression Regulation, Neoplastic; Genes, erbB; Glycoproteins; Ligands; Mice; Molecular Sequence Data; Neuregulins; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptor Aggregation; Receptor, ErbB-2; Receptor, ErbB-3; RNA, Messenger; Signal Transduction; Tyrosine | 1995 |
Phosphorylation of the human estrogen receptor on tyrosine 537 in vivo and by src family tyrosine kinases in vitro.
Topics: Animals; Breast Neoplasms; Humans; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Multigene Family; Neoplasm Proteins; Nucleopolyhedroviruses; Phosphorylation; Phosphotyrosine; Protein Phosphatase 1; Protein Processing, Post-Translational; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Proto-Oncogene Proteins pp60(c-src); Receptors, Estrogen; Recombinant Proteins; Spodoptera; Tumor Cells, Cultured; Tyrosine | 1995 |
An antiestrogen: a phosphotyrosyl peptide that blocks dimerization of the human estrogen receptor.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Breast Neoplasms; Cell Line; DNA Probes; Estrogen Antagonists; Female; Humans; Molecular Sequence Data; Oligopeptides; Phosphorylation; Phosphotyrosine; Protein Conformation; Receptors, Estrogen; Tumor Cells, Cultured; Tyrosine | 1995 |
Suppressed transformation and induced differentiation of HER-2/neu-overexpressing breast cancer cells by emodin.
Topics: Breast Neoplasms; Cell Differentiation; Cell Division; Cell Line, Transformed; Cell Transformation, Neoplastic; Drug Screening Assays, Antitumor; Emodin; Humans; Phosphorylation; Phosphotyrosine; Proto-Oncogene Mas; Receptor, ErbB-2; Tumor Cells, Cultured; Tyrosine | 1995 |
Inhibition of the oncogene product p185erbB-2 in vitro and in vivo by geldanamycin and dihydrogeldanamycin derivatives.
Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Benzoquinones; Breast Neoplasms; Dose-Response Relationship, Drug; Female; Humans; Lactams, Macrocyclic; Mice; Mice, Nude; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rats; Receptor, ErbB-2; Rifabutin; Structure-Activity Relationship; Transfection; Tumor Cells, Cultured | 1995 |
LAR-PTPase cDNA transfection suppression of tumor growth of neu oncogene-transformed human breast carcinoma cells.
Topics: Animals; Breast Neoplasms; Cell Division; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Genes, erbB-2; Genes, Tumor Suppressor; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Phosphotyrosine; Protein Tyrosine Phosphatases; Receptor, ErbB-2; RNA, Neoplasm; Transfection; Transplantation, Heterologous; Tumor Cells, Cultured; Type C Phospholipases | 1995 |
Increased phosphotyrosine in breast cancer tissue is associated with a worse prognosis.
Topics: Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Lobular; Disease-Free Survival; Female; Humans; Neoplasm Staging; Phosphotyrosine; Predictive Value of Tests; Probability; Prognosis; Receptors, Estrogen; Receptors, Progesterone; Retrospective Studies; Survival Rate; Time Factors | 1995 |
O-phospho-L-tyrosine inhibits cellular growth by activating protein tyrosine phosphatases.
Topics: Breast Neoplasms; Carcinoma, Renal Cell; Cell Death; Cell Division; Doxorubicin; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Etoposide; Humans; Kidney Neoplasms; Neoplasm Proteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; S Phase; Sensitivity and Specificity; Tumor Cells, Cultured; Tyrosine | 1993 |
Exogenous phosphotyrosine modulates epidermal growth factor receptor tyrosine phosphorylation.
Topics: Breast Neoplasms; Cell Division; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Humans; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Tumor Cells, Cultured; Tyrosine; Vanadates | 1993 |
Role of intracellular Ca2+ in the epidermal growth factor induced inhibition of protein tyrosine phosphatase activity in a breast cancer cell line.
Topics: Breast Neoplasms; Calcium; Epidermal Growth Factor; ErbB Receptors; Humans; In Vitro Techniques; Phosphoproteins; Phosphotyrosine; Protein Tyrosine Phosphatases; Tumor Cells, Cultured; Tyrosine | 1993 |
Cell cycle arrest and growth inhibition by the protein kinase antagonist UCN-01 in human breast carcinoma cells.
Topics: Alkaloids; Breast Neoplasms; Carcinoma; Cell Cycle; Cell Division; DNA, Neoplasm; Dose-Response Relationship, Drug; Female; Flow Cytometry; Growth Inhibitors; Humans; In Vitro Techniques; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase Inhibitors; Staurosporine; Time Factors; Tumor Cells, Cultured; Tyrosine | 1993 |
Pretreatment with vitamin A inhibits transforming growth factor alpha stimulation of human mammary carcinoma cells.
Topics: Breast Neoplasms; Cell Division; ErbB Receptors; Female; Gene Expression; Humans; In Vitro Techniques; Phosphotyrosine; RNA, Messenger; Signal Transduction; Transforming Growth Factor alpha; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine; Vitamin A | 1993 |
Standardization of an enzyme-linked immunosorbent assay for the determination of protein tyrosine kinase activity.
Topics: Animals; Breast Neoplasms; Chemistry Techniques, Analytical; Detergents; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Reference Standards; Reproducibility of Results; Serum Albumin, Bovine; Spleen; Tissue Extracts; Trichloroacetic Acid; Tyrosine | 1993 |
Characterization of a breast cancer cell differentiation factor that specifically activates the HER4/p180erbB4 receptor.
Topics: Amino Acid Sequence; Animals; Breast Neoplasms; Carcinoma, Hepatocellular; Cell Differentiation; CHO Cells; Chromatography; Cricetinae; ErbB Receptors; Glycoproteins; Humans; Liver Neoplasms; Molecular Sequence Data; Molecular Weight; Neuregulins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Receptor, ErbB-4; Receptors, Cell Surface; Recombinant Proteins; Tumor Cells, Cultured; Tyrosine | 1993 |
Identification of a 170 kDa membrane kinase with increased activity in KB-V1 multidrug resistant cells.
Topics: Alkaloids; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Calcium; Carbazoles; Carrier Proteins; Clone Cells; Cyclic AMP; Drug Resistance; Electrophoresis, Polyacrylamide Gel; Humans; Indole Alkaloids; Indoles; KB Cells; Melanoma, Experimental; Membrane Glycoproteins; Mice; Neoplasm Proteins; Phosphatidylserines; Phosphorylation; Phosphothreonine; Phosphotyrosine; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Pyrroles; Staurosporine; Transfection; Tumor Cells, Cultured; Tyrosine | 1993 |
Phosphorylation of tyrosine 537 on the human estrogen receptor is required for binding to an estrogen response element.
Topics: Amino Acid Sequence; Animals; Base Sequence; Breast Neoplasms; Chromatography, Affinity; Cytosol; DNA-Binding Proteins; Estradiol; Female; Humans; Macromolecular Substances; Molecular Sequence Data; Molecular Weight; Mutagenesis, Site-Directed; Oligonucleotide Probes; Phosphorylation; Phosphotyrosine; Point Mutation; Protein-Tyrosine Kinases; Receptors, Estrogen; Recombinant Proteins; Spodoptera; Transfection; Tumor Cells, Cultured; Tyrosine; Xenopus | 1995 |
Radiation-induced autophosphorylation of epidermal growth factor receptor in human malignant mammary and squamous epithelial cells.
Topics: Breast Neoplasms; Carcinoma, Squamous Cell; Cell Division; Cell Line; Cobalt Radioisotopes; Confidence Intervals; Dose-Response Relationship, Radiation; Epidermal Growth Factor; ErbB Receptors; Female; Humans; Kinetics; Phosphorylation; Phosphotyrosine; Signal Transduction; Tumor Cells, Cultured; Up-Regulation | 1996 |
Type 1 receptor tyrosine kinases are differentially phosphorylated in mammary carcinoma and differentially associated with steroid receptors.
Topics: Biomarkers, Tumor; Breast Neoplasms; ErbB Receptors; Female; Frozen Sections; Genes, erbB-2; Humans; Immunohistochemistry; Phosphorylation; Phosphotyrosine; Prognosis; Proto-Oncogene Mas; Receptor Protein-Tyrosine Kinases; Receptor, ErbB-2; Receptor, ErbB-4; Receptors, Estrogen; Receptors, Progesterone; Receptors, Steroid; Retrospective Studies | 1996 |
A 67 kDa non-hormone binding estradiol receptor is present in human mammary cancers.
Topics: Adenosine Triphosphate; Adult; Aged; Breast Neoplasms; Carcinoma, Ductal, Breast; Cytosol; Estradiol; Female; Humans; Middle Aged; Molecular Weight; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor Protein-Tyrosine Kinases; Receptors, Estrogen | 1996 |
erbB family receptor expression and growth regulation in a newly isolated human breast cancer cell line.
Topics: Base Sequence; Blotting, Western; Breast; Breast Neoplasms; Cell Division; Cell Line; DNA Primers; ErbB Receptors; Female; Gene Expression; Genes, erbB-2; Humans; Kinetics; Molecular Sequence Data; Phosphoproteins; Phosphotyrosine; Pleural Effusion; Polymerase Chain Reaction; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Receptor, ErbB-2; Receptor, ErbB-3; RNA, Messenger; Tumor Cells, Cultured; Vanadates | 1996 |
An immunological approach reveals biological differences between the two NDF/heregulin receptors, ErbB-3 and ErbB-4.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Base Sequence; Breast Neoplasms; Cell Differentiation; CHO Cells; Clone Cells; Cricetinae; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA Primers; Epidermal Growth Factor; ErbB Receptors; Female; Glycoproteins; Humans; Hybridomas; Immunohistochemistry; Intercellular Adhesion Molecule-1; Macromolecular Substances; Mammals; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Neuregulins; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins; Receptor, ErbB-3; Receptor, ErbB-4; Restriction Mapping; Transfection; Tumor Cells, Cultured | 1996 |
Plasma membrane phosphotyrosine, Her2-NEU, and epidermal growth factor receptor in human breast cancer. A comparative study.
Topics: Breast Neoplasms; Cell Nucleus; Cytoplasm; Epidermal Growth Factor; Epithelium; ErbB Receptors; Female; Fixatives; Formaldehyde; Gene Expression Regulation, Neoplastic; Humans; Membrane Proteins; Middle Aged; Neoplasm Staging; Oncogenes; Paraffin Embedding; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor Protein-Tyrosine Kinases; Receptor, ErbB-2; Tissue Fixation; Tumor Cells, Cultured | 1996 |
Grb7 is a downstream signaling component of platelet-derived growth factor alpha- and beta-receptors.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Amino Acid Sequence; Animals; Breast Neoplasms; Endothelium, Vascular; GRB7 Adaptor Protein; Humans; Molecular Sequence Data; Peptides; Phosphopeptides; Phosphotyrosine; Protein Binding; Proteins; Receptor, Platelet-Derived Growth Factor alpha; Receptor, Platelet-Derived Growth Factor beta; Receptors, Platelet-Derived Growth Factor; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; src Homology Domains; Swine; Tumor Cells, Cultured | 1996 |
Heregulin (HRG)-induced mitogenic signaling and cytotoxic activity of a HRG/PE40 ligand toxin in human breast cancer cells.
Topics: Adaptor Proteins, Signal Transducing; ADP Ribose Transferases; Bacterial Toxins; Base Sequence; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Cell Cycle; Cell Division; Cell Line; Cell Survival; Cloning, Molecular; DNA Primers; ErbB Receptors; Exotoxins; Female; Glycoproteins; GRB2 Adaptor Protein; Humans; Immunotoxins; Kinetics; Molecular Sequence Data; Neuregulin-1; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Proteins; Proto-Oncogene Proteins; Pseudomonas aeruginosa Exotoxin A; Receptor, ErbB-2; Receptor, ErbB-3; Receptor, ErbB-4; Recombinant Proteins; Restriction Mapping; Signal Transduction; src Homology Domains; Tumor Cells, Cultured; Virulence Factors | 1995 |
Role of epidermal growth factor receptor and STAT-3 activation in autonomous proliferation of SUM-102PT human breast cancer cells.
Topics: Adenocarcinoma; Breast Neoplasms; Cell Division; DNA-Binding Proteins; Epidermal Growth Factor; ErbB Receptors; Female; Humans; Middle Aged; Phosphotyrosine; Receptor Protein-Tyrosine Kinases; Receptors, Estrogen; RNA, Neoplasm; Signal Transduction; STAT3 Transcription Factor; Trans-Activators; Tumor Cells, Cultured | 1997 |
Overexpressed IGF-I receptors reduce estrogen growth requirements, enhance survival, and promote E-cadherin-mediated cell-cell adhesion in human breast cancer cells.
Topics: Breast Neoplasms; Cadherins; Cell Adhesion; Cell Aggregation; Cell Division; Cell Survival; Collagen; Drug Combinations; Estradiol; Extracellular Matrix; Fluorescent Antibody Technique; Humans; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Laminin; Neoplasm Invasiveness; Phosphoproteins; Phosphorylation; Phosphotyrosine; Proteins; Proteoglycans; Receptor, IGF Type 1; Transfection; Tumor Cells, Cultured | 1997 |
Estrogen receptor, growth factor receptor and protooncogene protein activities and possible signal transduction crosstalk in estrogen dependent and independent breast cancer cell lines.
Topics: Actins; Breast Neoplasms; Carcinoma; ErbB Receptors; Estrogens; Humans; Mitogen-Activated Protein Kinase Kinases; Phosphotyrosine; Protein Kinases; Proto-Oncogene Proteins; Receptors, Estrogen; Receptors, Growth Factor; Second Messenger Systems; Signal Transduction; Tumor Cells, Cultured | 1997 |
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer.
Topics: Amino Acid Sequence; Brain Neoplasms; Breast Neoplasms; Chromosome Mapping; Chromosomes, Human, Pair 10; Female; Frameshift Mutation; Genes, Tumor Suppressor; Glioblastoma; Humans; Male; Microfilament Proteins; Molecular Sequence Data; Mutation; Neoplasm Transplantation; Neoplasms; Phosphoric Monoester Hydrolases; Phosphotyrosine; Prostatic Neoplasms; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; PTEN Phosphohydrolase; Sequence Deletion; Sequence Homology, Amino Acid; Tensins; Transplantation, Heterologous; Tumor Cells, Cultured; Tumor Suppressor Proteins | 1997 |
Prolactin stimulates the JAK2 and focal adhesion kinase pathways in human breast carcinoma T47-D cells.
Topics: Breast Neoplasms; Cell Adhesion Molecules; Cytoskeletal Proteins; Female; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Janus Kinase 2; Kinetics; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Prolactin; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Recombinant Proteins; Tumor Cells, Cultured | 1997 |
Recognition of activated CSF-1 receptor in breast carcinomas by a tyrosine 723 phosphospecific antibody.
Topics: Amino Acid Sequence; Animals; Antibodies; Antibody Specificity; Breast Neoplasms; Carcinoma in Situ; Cells, Cultured; Cross Reactions; Epitopes; Fibroblasts; Genes, fms; Humans; Immunohistochemistry; Macrophages; Mice; Mice, Inbred BALB C; Phosphopeptides; Phosphorylation; Phosphotyrosine; Proto-Oncogene Mas; Receptor, Macrophage Colony-Stimulating Factor; Tumor Cells, Cultured | 1997 |
Relationship of p215BRCA1 to tyrosine kinase signaling pathways and the cell cycle in normal and transformed cells.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Antibody Specificity; BRCA1 Protein; Breast Neoplasms; Cell Cycle; Cell Transformation, Neoplastic; Humans; Mice; Molecular Sequence Data; Phenotype; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor Protein-Tyrosine Kinases; Signal Transduction; Subcellular Fractions; Tumor Cells, Cultured; Tyrosine | 1997 |
Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation.
Topics: Breast Neoplasms; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma, Squamous Cell; Cell Division; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Humans; Inositol 1,4,5-Trisphosphate; Isoenzymes; Nitriles; Phospholipase C gamma; Phosphotyrosine; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Quinazolines; Radiation, Ionizing; Receptor Protein-Tyrosine Kinases; Signal Transduction; Tumor Cells, Cultured; Type C Phospholipases; Tyrphostins | 1997 |
Alteration of interendothelial adherens junctions following tumor cell-endothelial cell interaction in vitro.
Topics: Adenocarcinoma; alpha Catenin; beta Catenin; Breast Neoplasms; Cadherins; Cell Adhesion; Cytoskeletal Proteins; Desmoplakins; Endothelium, Vascular; Female; gamma Catenin; Humans; Intercellular Junctions; Microscopy, Electron, Scanning; Phosphorylation; Phosphotyrosine; Protein Binding; Trans-Activators; Tumor Cells, Cultured; Vinculin | 1997 |
Elevated insulin-like growth factor I receptor autophosphorylation and kinase activity in human breast cancer.
Topics: Breast; Breast Neoplasms; Humans; Ligands; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Receptor Protein-Tyrosine Kinases; Receptor, Insulin; Receptors, Somatomedin | 1998 |
Insulin receptor substrate-1 is the predominant signaling molecule activated by insulin-like growth factor-I, insulin, and interleukin-4 in estrogen receptor-positive human breast cancer cells.
Topics: Androstadienes; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Female; Flavonoids; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Interleukin-4; Intracellular Signaling Peptides and Proteins; Kinetics; Mitogen-Activated Protein Kinase Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase Inhibitors; Protein Kinases; Receptor, Insulin; Receptors, Estrogen; Signal Transduction; Tumor Cells, Cultured; Wortmannin | 1998 |
Convergence of progesterone and epidermal growth factor signaling in breast cancer. Potentiation of mitogen-activated protein kinase pathways.
Topics: Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle; Cell Line; Epidermal Growth Factor; Female; Humans; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; p38 Mitogen-Activated Protein Kinases; Phosphotyrosine; Progesterone; Promegestone; Receptor Cross-Talk; Receptors, Growth Factor; Signal Transduction; Up-Regulation | 1998 |
Type 1 protein tyrosine kinases in benign and malignant breast lesions.
Topics: Adult; Aged; Breast; Breast Neoplasms; Carcinoma; ErbB Receptors; Female; Fibroadenoma; Humans; Immunohistochemistry; Middle Aged; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptor, ErbB-2; Receptor, ErbB-3; Receptor, ErbB-4; Tumor Cells, Cultured | 1998 |
Decreased tyrosine phosphorylation of focal adhesion kinase after estradiol treatment of MCF-7 human breast carcinoma cells.
Topics: Breast Neoplasms; Cell Adhesion; Cell Adhesion Molecules; Cytoskeletal Proteins; Dimethyl Sulfoxide; Estradiol; Female; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Estrogen; Tamoxifen; Tumor Cells, Cultured; Tyrosine | 1998 |
Constitutive activation of pp125fak in newly isolated human breast cancer cell lines.
Topics: Breast; Breast Neoplasms; Cell Adhesion Molecules; Cells, Cultured; Enzyme Activation; Epithelial Cells; Female; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Tumor Cells, Cultured | 1999 |
Characterization of an antibody that can detect an activated IGF-I receptor in human cancers.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Antibody Specificity; Binding, Competitive; Biomarkers, Tumor; Breast Neoplasms; Cell Line; Colonic Neoplasms; Cross Reactions; Epitopes; Humans; Ligands; Mice; Molecular Sequence Data; Mutation; Phosphorylation; Phosphotyrosine; Precipitin Tests; Receptor, IGF Type 1; Receptor, Insulin; Transfection | 1999 |
The activated insulin-like growth factor I receptor induces depolarization in breast epithelial cells characterized by actin filament disassembly and tyrosine dephosphorylation of FAK, Cas, and paxillin.
Topics: Actins; Breast Neoplasms; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; Cell Size; Crk-Associated Substrate Protein; Cytoplasm; Cytoskeletal Proteins; Cytoskeleton; Epithelial Cells; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Insulin-Like Growth Factor I; Membrane Potentials; Paxillin; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proteins; Receptor, IGF Type 1; Retinoblastoma-Like Protein p130; Signal Transduction; Tumor Cells, Cultured | 1999 |
Neuregulins signaling via a glial erbB-2-erbB-4 receptor complex contribute to the neuroendocrine control of mammalian sexual development.
Topics: Animals; Astrocytes; Breast Neoplasms; Cerebral Cortex; Cerebral Ventricles; Dinoprostone; ErbB Receptors; Estradiol; Female; Gene Expression Regulation, Developmental; Genes, erbB-1; Humans; Hypothalamus; Neuregulins; Oligodeoxyribonucleotides, Antisense; Oncogene Proteins v-erbB; Ovariectomy; Phosphorylation; Phosphotyrosine; Pregnancy; Progesterone; Rats; Rats, Sprague-Dawley; Receptor, ErbB-2; Receptor, ErbB-4; Reverse Transcriptase Polymerase Chain Reaction; Sexual Maturation; Signal Transduction; Transfection; Tumor Cells, Cultured | 1999 |
Functional interaction between E-cadherin and alphav-containing integrins in carcinoma cells.
Topics: Actins; Antibodies, Monoclonal; Antigens, CD; beta Catenin; Breast Neoplasms; Cadherins; Carcinoma; Cell Adhesion; Cell Movement; Chemotaxis; Cytoskeletal Proteins; Detergents; Female; Genes, Dominant; H-2 Antigens; Humans; Integrin alphaV; Neoplasm Proteins; Phosphotyrosine; Recombinant Fusion Proteins; Solubility; Spheroids, Cellular; Subcellular Fractions; Trans-Activators; Tumor Cells, Cultured; Vitronectin | 2000 |
Autocrine human growth hormone enhancement of human mammary carcinoma cell spreading is Jak2 dependent.
Topics: Actins; Autocrine Communication; Breast Neoplasms; Carcinoma; Cell Adhesion; Enzyme Inhibitors; Female; Growth Hormone; Hormone Antagonists; Human Growth Hormone; Humans; Janus Kinase 2; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Somatotropin; Recombinant Proteins; Tissue Distribution; Tumor Cells, Cultured; Tyrosine; Tyrphostins | 2000 |
Osteopontin-induced, integrin-dependent migration of human mammary epithelial cells involves activation of the hepatocyte growth factor receptor (Met).
Topics: Blotting, Northern; Blotting, Western; Breast; Breast Neoplasms; Cell Movement; Cells, Cultured; Epithelial Cells; Female; Gene Expression; Humans; Integrins; Osteopontin; Phosphoproteins; Phosphotyrosine; Precipitin Tests; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-met; Recombinant Proteins; RNA, Messenger; Sialoglycoproteins | 2000 |
Oncostatin M suppresses EGF-mediated protein tyrosine phosphorylation in breast cancer cells.
Topics: Breast Neoplasms; Carcinoma, Ductal, Breast; Cell Division; Culture Media; Cytokines; Epidermal Growth Factor; ErbB Receptors; Female; Humans; Inflammation Mediators; Oncostatin M; Peptides; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Time Factors; Tumor Cells, Cultured; Tyrosine | 2000 |
The mitogenic signaling pathway for fibroblast growth factor-2 involves the tyrosine phosphorylation of cyclin D2 in MCF-7 human breast cancer cells.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Blotting, Western; Breast Neoplasms; Cyclin D2; Cyclins; Enzyme Activation; Fibroblast Growth Factor 2; Humans; Membrane Proteins; Mitogen-Activated Protein Kinases; Mitogens; Molecular Sequence Data; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins pp60(c-src); Receptors, Fibroblast Growth Factor; Signal Transduction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tumor Cells, Cultured | 2000 |
The ephrin-A1 ligand and its receptor, EphA2, are expressed during tumor neovascularization.
Topics: Animals; Blotting, Western; Breast Neoplasms; Capillaries; Cells, Cultured; Collagen; Drug Combinations; Endothelium, Vascular; Ephrin-A1; Female; Fluorescent Antibody Technique; Gene Expression Regulation, Neoplastic; Humans; Hyperplasia; Laminin; Ligands; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms; Neovascularization, Pathologic; Phosphotyrosine; Proteins; Proteoglycans; Receptor Protein-Tyrosine Kinases; Receptor, EphA2; Sarcoma, Kaposi; Signal Transduction; Transplantation, Heterologous; Tumor Cells, Cultured | 2000 |
Etk/Bmx tyrosine kinase activates Pak1 and regulates tumorigenicity of breast cancer cells.
Topics: Animals; Apoptosis; Breast Neoplasms; Cell Division; Enzyme Activation; Female; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Humans; Kinetics; Mammary Glands, Animal; Mice; Mice, Nude; Organ Specificity; p21-Activated Kinases; Phosphorylation; Phosphotyrosine; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Transfection; Transplantation, Heterologous; Tumor Cells, Cultured | 2001 |
Her4 mediates ligand-dependent antiproliferative and differentiation responses in human breast cancer cells.
Topics: Breast Neoplasms; Cell Differentiation; Cell Division; Cell Size; Epidermal Growth Factor; ErbB Receptors; Female; Flow Cytometry; Heparin-binding EGF-like Growth Factor; Humans; Immunoblotting; Intercellular Signaling Peptides and Proteins; Ligands; Neuregulin-1; Phosphorylation; Phosphotyrosine; Receptor, ErbB-2; Receptor, ErbB-4; RNA, Messenger; Signal Transduction; Tumor Cells, Cultured | 2001 |
Linkage of rapid estrogen action to MAPK activation by ERalpha-Shc association and Shc pathway activation.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Binding Sites; Breast Neoplasms; COS Cells; DNA-Binding Proteins; Enzyme Inhibitors; Estradiol; Estrogen Receptor alpha; ets-Domain Protein Elk-1; Flavonoids; Humans; Mitogen-Activated Protein Kinases; Mutation; Phosphorylation; Phosphotyrosine; Proteins; Proto-Oncogene Proteins; Receptors, Estrogen; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Transcription Factors; Tumor Cells, Cultured | 2002 |
Receptor-induced phosphorylation by mammary-derived growth factor 1 in mammary epithelial cell lines.
Topics: Blotting, Western; Breast; Breast Neoplasms; Cell Line; Cross-Linking Reagents; Epithelial Cells; Epithelium; ErbB Receptors; Growth Substances; Humans; Intercellular Signaling Peptides and Proteins; Neoplasm Proteins; Phosphorylation; Phosphotyrosine; Receptors, Cell Surface; Receptors, Growth Factor; Tumor Cells, Cultured; Tyrosine | 1992 |
Disulfide-linked and noncovalent dimers of p185HER-2 in human breast carcinoma cells.
Topics: Alkylating Agents; Antibodies; Breast Neoplasms; Disulfides; Humans; Iodoacetates; Iodoacetic Acid; Oncogene Proteins, Viral; Phosphorylation; Phosphotyrosine; Precipitin Tests; Receptor, ErbB-2; Tumor Cells, Cultured; Tyrosine | 1992 |
Insulin and epidermal growth factor stimulate phosphorylation of p185HER-2 in the breast carcinoma cell line, BT474.
Topics: Blood; Breast Neoplasms; Epidermal Growth Factor; ErbB Receptors; Humans; Insulin; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Proto-Oncogene Mas; Proto-Oncogene Proteins; Receptor, ErbB-2; Tumor Cells, Cultured; Tyrosine | 1990 |
p185neu is phosphorylated on tyrosine in human primary breast tumors which overexpress neu/erbB-2.
Topics: Antibodies; Breast Neoplasms; Gene Expression; Humans; Immunoblotting; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins; Receptor, ErbB-2; Tumor Cells, Cultured; Tyrosine | 1990 |
Stimulation of growth of human breast cancer cells (T47D) by platelet derived growth factor.
Topics: Annexins; Antibodies; Breast Neoplasms; Calcium-Binding Proteins; Cell Division; Humans; Immunoglobulin Fab Fragments; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1991 |
Oncogenic potential of erbB-2 in human mammary epithelial cells.
Topics: Animals; Breast; Breast Neoplasms; Cell Line; Cell Transformation, Neoplastic; DNA; Epithelium; Gene Expression; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogenes; Receptor, ErbB-2; Transfection; Tyrosine | 1991 |
Experimental approaches to hypothetical hormones: detection of a candidate ligand of the neu protooncogene.
Topics: Animals; Breast Neoplasms; Cell Line; Cell Line, Transformed; Cell Membrane; Culture Media; Fibroblasts; Genes, ras; Hematopoietic Stem Cells; Humans; Mitogens; Mitosis; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rats; Receptor, ErbB-2; Receptors, Cell Surface; Transfection; Tumor Cells, Cultured; Tyrosine | 1989 |
A nonradioactive dot-blot assay for protein tyrosine kinase activity.
Topics: Adenosine Triphosphate; Antibodies; Breast Neoplasms; Cell Extracts; Humans; Immunoblotting; Immunohistochemistry; Immunosuppressive Agents; Intercellular Signaling Peptides and Proteins; Kinetics; Membranes, Artificial; Peptides; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Tyrosine | 1989 |