phosphoserine has been researched along with Seizures in 7 studies
Phosphoserine: The phosphoric acid ester of serine.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The potential anticonvulsant effect of group III metabotropic glutamate receptor (mGluR) agonist (R,S)-4-phosphonophenylglycine ((R,S)-PPG) against seizures induced in immature 12-day-old rats by bilateral intracerebroventricular (icv) infusion of DL-homocysteic acid (DL-HCA, 600 nmol/side) was examined in the present study." | 7.72 | Seizures induced by homocysteic acid in immature rats are prevented by group III metabotropic glutamate receptoragonist (R,S)-4-phosphonophenylglycine. ( Folbergrová, J; Haugvicová, R; Mares, P, 2003) |
| "Recently, several groups reported that seizures increase mammalian target of rapamycin (mTOR) kinase activity, and such increased activity in genetic models can contribute to spontaneous seizures." | 5.39 | Spatiotemporal characterization of mTOR kinase activity following kainic acid induced status epilepticus and analysis of rat brain response to chronic rapamycin treatment. ( Blazejczyk, M; Caban, B; Jaworski, J; Kazmierska, P; Konopacki, J; Macias, M; Rodo, A; Skalecka, A; Tarkowski, B, 2013) |
| "Generalized clonic-tonic seizures were completely suppressed and cortical energy metabolite changes which normally accompany these seizures were either normalized (glucose and glycogen decreases) or markedly ameliorated (an accumulation of lactate)." | 5.32 | Seizures induced by homocysteic acid in immature rats are prevented by group III metabotropic glutamate receptoragonist (R,S)-4-phosphonophenylglycine. ( Folbergrová, J; Haugvicová, R; Mares, P, 2003) |
| "The potential anticonvulsant effect of group III metabotropic glutamate receptor (mGluR) agonist (R,S)-4-phosphonophenylglycine ((R,S)-PPG) against seizures induced in immature 12-day-old rats by bilateral intracerebroventricular (icv) infusion of DL-homocysteic acid (DL-HCA, 600 nmol/side) was examined in the present study." | 3.72 | Seizures induced by homocysteic acid in immature rats are prevented by group III metabotropic glutamate receptoragonist (R,S)-4-phosphonophenylglycine. ( Folbergrová, J; Haugvicová, R; Mares, P, 2003) |
| "The metabotropic Group III agonist, (1S,3R,4S)-1-aminocyclopentane-1,2,4-tricarboxylic acid (ACPT-1), selective for the mGlu(4alpha) receptor, suppresses sound-induced seizures in DBA/2 mice following its intracerebroventricular (i." | 3.71 | Anticonvulsant activity of a mGlu(4alpha) receptor selective agonist, (1S,3R,4S)-1-aminocyclopentane-1,2,4-tricarboxylic acid. ( Chapman, AG; Meldrum, BS; Talebi, A; Yip, PK, 2001) |
| " We have used intracerebroventricular administration to test a novel group III agonist, (R,S)-4-phosphonophenylglycine (PPG), that is preferential for mglu(8), against sound-induced seizures in DBA/2 mice." | 3.70 | Anticonvulsant activity of a metabotropic glutamate receptor 8 preferential agonist, (R,S)-4-phosphonophenylglycine. ( Chapman, AG; Meldrum, BS; Nanan, K; Yip, P, 1999) |
| "Recently, several groups reported that seizures increase mammalian target of rapamycin (mTOR) kinase activity, and such increased activity in genetic models can contribute to spontaneous seizures." | 1.39 | Spatiotemporal characterization of mTOR kinase activity following kainic acid induced status epilepticus and analysis of rat brain response to chronic rapamycin treatment. ( Blazejczyk, M; Caban, B; Jaworski, J; Kazmierska, P; Konopacki, J; Macias, M; Rodo, A; Skalecka, A; Tarkowski, B, 2013) |
| "Generalized clonic-tonic seizures were completely suppressed and cortical energy metabolite changes which normally accompany these seizures were either normalized (glucose and glycogen decreases) or markedly ameliorated (an accumulation of lactate)." | 1.32 | Seizures induced by homocysteic acid in immature rats are prevented by group III metabotropic glutamate receptoragonist (R,S)-4-phosphonophenylglycine. ( Folbergrová, J; Haugvicová, R; Mares, P, 2003) |
| "ACPT-1 also protects against clonic seizures induced in DBA/2 mice by the Group I agonist, (RS)-3,5-dihydroxyphenylglycine (3,5-DHPG) (ED(50) 0." | 1.31 | Anticonvulsant activity of a mGlu(4alpha) receptor selective agonist, (1S,3R,4S)-1-aminocyclopentane-1,2,4-tricarboxylic acid. ( Chapman, AG; Meldrum, BS; Talebi, A; Yip, PK, 2001) |
| "Tonic and clonic seizures are abolished at 15 min (ED(50s) 0." | 1.30 | Anticonvulsant activity of a metabotropic glutamate receptor 8 preferential agonist, (R,S)-4-phosphonophenylglycine. ( Chapman, AG; Meldrum, BS; Nanan, K; Yip, P, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, Y | 1 |
| Yuan, J | 1 |
| Yu, X | 1 |
| Liu, X | 1 |
| Tan, C | 1 |
| Chen, Y | 1 |
| Xu, T | 1 |
| Macias, M | 1 |
| Blazejczyk, M | 1 |
| Kazmierska, P | 1 |
| Caban, B | 1 |
| Skalecka, A | 1 |
| Tarkowski, B | 1 |
| Rodo, A | 1 |
| Konopacki, J | 1 |
| Jaworski, J | 1 |
| Folbergrová, J | 1 |
| Haugvicová, R | 1 |
| Mares, P | 1 |
| Tizzano, JP | 1 |
| Griffey, KI | 1 |
| Schoepp, DD | 1 |
| Chapman, AG | 2 |
| Nanan, K | 1 |
| Yip, P | 1 |
| Meldrum, BS | 3 |
| Yip, PK | 2 |
| Rattray, M | 1 |
| Talebi, A | 1 |
7 other studies available for phosphoserine and Seizures
| Article | Year |
|---|---|
Vezatin regulates seizures by controlling AMPAR-mediated synaptic activity.
Topics: Animals; Carrier Proteins; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Epilepsy; E | 2021 |
Spatiotemporal characterization of mTOR kinase activity following kainic acid induced status epilepticus and analysis of rat brain response to chronic rapamycin treatment.
Topics: Animals; Astrocytes; Brain; Cell Death; Cell Nucleus; Hippocampus; Kainic Acid; Male; Neurons; Phosp | 2013 |
Seizures induced by homocysteic acid in immature rats are prevented by group III metabotropic glutamate receptoragonist (R,S)-4-phosphonophenylglycine.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation | 2003 |
Receptor subtypes linked to metabotropic glutamate receptor agonist-mediated limbic seizures in mice.
Topics: Amino Acids, Dicarboxylic; Aminobutyrates; Animals; Cycloleucine; Dose-Response Relationship, Drug; | 1995 |
Anticonvulsant activity of a metabotropic glutamate receptor 8 preferential agonist, (R,S)-4-phosphonophenylglycine.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Female; Glycine; Inferior Colliculi; Inj | 1999 |
Elevated levels of group-III metabotropic glutamate receptors in the inferior colliculus of genetically epilepsy-prone rats following intracollicular administration of L-serine-O-phosphate.
Topics: Animals; Behavior, Animal; Epilepsy; Female; Genetic Predisposition to Disease; Inferior Colliculi; | 2001 |
Anticonvulsant activity of a mGlu(4alpha) receptor selective agonist, (1S,3R,4S)-1-aminocyclopentane-1,2,4-tricarboxylic acid.
Topics: Acoustic Stimulation; Alanine; Aminobutyrates; Animals; Anticonvulsants; Behavior, Animal; Cyclopent | 2001 |