phosphoserine has been researched along with Parkinson Disease in 15 studies
Phosphoserine: The phosphoric acid ester of serine.
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In contrast to Parkinson's disease (PD) where the pathological α-syn aggregates are almost exclusively neuronal, the α-syn inclusions in MSA are principally observed in oligodendrocytes (OLs) where they form glial cytoplasmic inclusions (GCIs)." | 1.56 | Overexpression of α-Synuclein by Oligodendrocytes in Transgenic Mice Does Not Recapitulate the Fibrillar Aggregation Seen in Multiple System Atrophy. ( Bezard, E; De Giorgi, F; Doudnikoff, E; Faggiani, E; He, X; Ichas, F; Laferrière, F; Meissner, WG; Zinghirino, F, 2020) |
| "Alpha-synuclein (aSyn) is implicated in Parkinson's disease and several other neurodegenerative disorders." | 1.39 | Assessing the subcellular dynamics of alpha-synuclein using photoactivation microscopy. ( Gonçalves, S; Outeiro, TF, 2013) |
| "It is thought that Parkinson's disease involves apoptosis, and NGF prevents apoptosis in an in vivo model system." | 1.31 | Nerve growth factor prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced cell death via the Akt pathway by suppressing caspase-3-like activity using PC12 cells: relevance to therapeutical application for Parkinson's disease. ( Chiba, H; Shimoke, K, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 8 (53.33) | 24.3611 |
| 2020's | 4 (26.67) | 2.80 |
| Authors | Studies |
|---|---|
| Kumari, R | 1 |
| Kumar, R | 1 |
| Kumar, S | 1 |
| Singh, AK | 1 |
| Hanpude, P | 1 |
| Jangir, D | 1 |
| Maiti, TK | 1 |
| Hong, CT | 1 |
| Chen, KY | 1 |
| Wang, W | 1 |
| Chiu, JY | 1 |
| Wu, D | 1 |
| Chao, TY | 1 |
| Hu, CJ | 1 |
| Chau, KD | 1 |
| Bamodu, OA | 1 |
| Laferrière, F | 1 |
| He, X | 1 |
| Zinghirino, F | 1 |
| Doudnikoff, E | 1 |
| Faggiani, E | 1 |
| Meissner, WG | 1 |
| Bezard, E | 1 |
| De Giorgi, F | 1 |
| Ichas, F | 1 |
| Zhang, S | 2 |
| Liu, YQ | 1 |
| Jia, C | 1 |
| Lim, YJ | 1 |
| Feng, G | 1 |
| Xu, E | 1 |
| Long, H | 1 |
| Kimura, Y | 2 |
| Tao, Y | 1 |
| Zhao, C | 1 |
| Wang, C | 1 |
| Liu, Z | 2 |
| Hu, JJ | 1 |
| Ma, MR | 1 |
| Jiang, L | 1 |
| Li, D | 1 |
| Wang, R | 1 |
| Dawson, VL | 1 |
| Dawson, TM | 1 |
| Li, YM | 1 |
| Mao, X | 1 |
| Liu, C | 1 |
| Chen, J | 1 |
| Ren, Y | 1 |
| Gui, C | 1 |
| Zhao, M | 1 |
| Wu, X | 1 |
| Mao, K | 1 |
| Li, W | 1 |
| Zou, F | 1 |
| Koyano, F | 1 |
| Okatsu, K | 1 |
| Kosako, H | 1 |
| Tamura, Y | 1 |
| Go, E | 1 |
| Kimura, M | 1 |
| Tsuchiya, H | 1 |
| Yoshihara, H | 1 |
| Hirokawa, T | 1 |
| Endo, T | 1 |
| Fon, EA | 1 |
| Trempe, JF | 1 |
| Saeki, Y | 1 |
| Tanaka, K | 1 |
| Matsuda, N | 1 |
| Landeck, N | 1 |
| Hall, H | 1 |
| Ardah, MT | 1 |
| Majbour, NK | 1 |
| El-Agnaf, OM | 1 |
| Halliday, G | 1 |
| Kirik, D | 1 |
| Covy, JP | 1 |
| Yuan, W | 1 |
| Waxman, EA | 1 |
| Hurtig, HI | 1 |
| Van Deerlin, VM | 1 |
| Giasson, BI | 1 |
| Austin, PJ | 1 |
| Betts, MJ | 1 |
| Broadstock, M | 1 |
| O'Neill, MJ | 1 |
| Mitchell, SN | 1 |
| Duty, S | 1 |
| Li, X | 2 |
| Wang, QJ | 1 |
| Pan, N | 1 |
| Lee, S | 1 |
| Zhao, Y | 1 |
| Chait, BT | 1 |
| Yue, Z | 2 |
| Kondapalli, C | 1 |
| Kazlauskaite, A | 1 |
| Zhang, N | 1 |
| Woodroof, HI | 1 |
| Campbell, DG | 1 |
| Gourlay, R | 1 |
| Burchell, L | 1 |
| Walden, H | 1 |
| Macartney, TJ | 1 |
| Deak, M | 1 |
| Knebel, A | 1 |
| Alessi, DR | 1 |
| Muqit, MM | 1 |
| Sheng, Z | 1 |
| Bustos, D | 1 |
| Kleinheinz, T | 1 |
| Le Pichon, CE | 1 |
| Dominguez, SL | 1 |
| Solanoy, HO | 1 |
| Drummond, J | 1 |
| Zhang, X | 1 |
| Ding, X | 1 |
| Cai, F | 1 |
| Song, Q | 1 |
| van der Brug, MP | 1 |
| Burdick, DJ | 1 |
| Gunzner-Toste, J | 1 |
| Chen, H | 1 |
| Liu, X | 1 |
| Estrada, AA | 1 |
| Sweeney, ZK | 1 |
| Scearce-Levie, K | 1 |
| Moffat, JG | 1 |
| Kirkpatrick, DS | 1 |
| Zhu, H | 1 |
| Gonçalves, S | 1 |
| Outeiro, TF | 1 |
| Vogelsberg-Ragaglia, V | 1 |
| Bruce, J | 1 |
| Richter-Landsberg, C | 1 |
| Zhang, B | 1 |
| Hong, M | 1 |
| Trojanowski, JQ | 1 |
| Lee, VM | 1 |
| Shimoke, K | 1 |
| Chiba, H | 1 |
15 other studies available for phosphoserine and Parkinson Disease
| Article | Year |
|---|---|
Amyloid aggregates of the deubiquitinase OTUB1 are neurotoxic, suggesting that they contribute to the development of Parkinson's disease.
Topics: Actin Cytoskeleton; alpha-Synuclein; Amyloid; Animals; Apoptosis; Cell Death; Cell Line, Tumor; Comp | 2020 |
Insulin Resistance Promotes Parkinson's Disease through Aberrant Expression of α-Synuclein, Mitochondrial Dysfunction, and Deregulation of the Polo-Like Kinase 2 Signaling.
Topics: alpha-Synuclein; Animals; Diabetes Mellitus, Type 2; Disease Progression; Dopaminergic Neurons; Geno | 2020 |
Overexpression of α-Synuclein by Oligodendrocytes in Transgenic Mice Does Not Recapitulate the Fibrillar Aggregation Seen in Multiple System Atrophy.
Topics: alpha-Synuclein; Amyloid; Animals; Brain; Cells, Cultured; Humans; Mice, Inbred C57BL; Mice, Transge | 2020 |
Mechanistic basis for receptor-mediated pathological α-synuclein fibril cell-to-cell transmission in Parkinson's disease.
Topics: alpha-Synuclein; Amyloid; Amyloid beta-Protein Precursor; Animals; Antigens, CD; Cell Line, Tumor; E | 2021 |
Phosphorylation of Parkin at serine 131 by p38 MAPK promotes mitochondrial dysfunction and neuronal death in mutant A53T α-synuclein model of Parkinson's disease.
Topics: alpha-Synuclein; Animals; Apoptosis; Cell Line; Disease Models, Animal; Dopaminergic Neurons; Enzyme | 2018 |
Ubiquitin is phosphorylated by PINK1 to activate parkin.
Topics: Animals; Enzyme Activation; Fibroblasts; HeLa Cells; Humans; Membrane Potential, Mitochondrial; Mice | 2014 |
A novel multiplex assay for simultaneous quantification of total and S129 phosphorylated human alpha-synuclein.
Topics: alpha-Synuclein; Animals; Biological Assay; Brain; Disease Progression; HEK293 Cells; Humans; Lewy B | 2016 |
Clinical and pathological characteristics of patients with leucine-rich repeat kinase-2 mutations.
Topics: Aged; alpha-Synuclein; Amino Acid Sequence; Cohort Studies; DNA Mutational Analysis; Female; Genes, | 2009 |
Symptomatic and neuroprotective effects following activation of nigral group III metabotropic glutamate receptors in rodent models of Parkinson's disease.
Topics: Aminobutyrates; Animals; Aspartic Acid; Disease Models, Animal; Excitatory Amino Acid Agonists; Glut | 2010 |
Phosphorylation-dependent 14-3-3 binding to LRRK2 is impaired by common mutations of familial Parkinson's disease.
Topics: 14-3-3 Proteins; Amino Acid Substitution; Animals; Brain; Cells, Cultured; Cyclic AMP-Dependent Prot | 2011 |
PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65.
Topics: Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Enzyme Activation; HEK293 Cells; Humans; Insect | 2012 |
Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations.
Topics: Animals; Binding Sites; Brain; Guanosine Triphosphate; HEK293 Cells; Humans; Leucine-Rich Repeat Ser | 2012 |
Assessing the subcellular dynamics of alpha-synuclein using photoactivation microscopy.
Topics: alpha-Synuclein; Cell Nucleus; Cell Survival; G-Protein-Coupled Receptor Kinase 5; Green Fluorescent | 2013 |
Distinct FTDP-17 missense mutations in tau produce tau aggregates and other pathological phenotypes in transfected CHO cells.
Topics: Animals; CHO Cells; Cricetinae; Dementia; Electrophoresis, Polyacrylamide Gel; Fluorescent Antibody | 2000 |
Nerve growth factor prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced cell death via the Akt pathway by suppressing caspase-3-like activity using PC12 cells: relevance to therapeutical application for Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amino Acid Chloromethyl Ketones; Amino Acid Substituti | 2001 |