Page last updated: 2024-10-15

phosphoserine and Obesity

phosphoserine has been researched along with Obesity in 13 studies

Phosphoserine: The phosphoric acid ester of serine.

Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).

Research Excerpts

ExcerptRelevanceReference
"Obesity is accompanied by impaired fasting glycerol release, lower HSL protein expression, and serine phosphorylation."3.74Hormone-sensitive lipase serine phosphorylation and glycerol exchange across skeletal muscle in lean and obese subjects: effect of beta-adrenergic stimulation. ( Blaak, EE; Goossens, GH; Jocken, JW; Kiens, B; Roepstorff, C; Saris, WH; van Baak, M; van der Baan, P, 2008)
"Obesity is defined as an abnormal accumulation of adipose tissue, which is one of the major metabolic organs that regulate energy homeostasis."2.72Regulatory roles of G-protein coupled receptors in adipose tissue metabolism and their therapeutic potential. ( Han, J; Im, H; Im, S; Kim, K; Lee, YH; Park, JH, 2021)
"Obesity is accompanied by impaired fasting glycerol release, lower HSL protein expression, and serine phosphorylation."1.35Hormone-sensitive lipase serine phosphorylation and glycerol exchange across skeletal muscle in lean and obese subjects: effect of beta-adrenergic stimulation. ( Blaak, EE; Goossens, GH; Jocken, JW; Kiens, B; Roepstorff, C; Saris, WH; van Baak, M; van der Baan, P, 2008)
"Obesity is associated with insulin resistance and a state of abnormal inflammatory response."1.34Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance. ( Araújo, EP; Carvalheira, JB; Carvalho-Filho, MA; Curi, R; Hirabara, SM; Prada, PO; Saad, MJ; Schenka, AA; Tsukumo, DM; Vassallo, J; Velloso, LA, 2007)
"We conclude that obesity is associated with increased intramyocellular ceramide content."1.32Ceramide content is increased in skeletal muscle from obese insulin-resistant humans. ( Adams, JM; Berria, R; DeFronzo, RA; Mandarino, LJ; Pratipanawatr, T; Sullards, MC; Wang, E, 2004)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (7.69)18.2507
2000's7 (53.85)29.6817
2010's4 (30.77)24.3611
2020's1 (7.69)2.80

Authors

AuthorsStudies
Bukosza, EN1
Kaucsár, T1
Godó, M1
Lajtár, E1
Tod, P1
Koncsos, G1
Varga, ZV1
Baranyai, T1
Nguyen, MT1
Schachner, H1
Sőti, C1
Ferdinandy, P1
Giricz, Z1
Szénási, G1
Hamar, P1
Im, H1
Park, JH1
Im, S1
Han, J1
Kim, K1
Lee, YH1
Kim, B1
Figueroa-Romero, C1
Pacut, C1
Backus, C1
Feldman, EL1
Choi, JH2
Banks, AS2
Estall, JL1
Kajimura, S1
Boström, P1
Laznik, D2
Ruas, JL1
Chalmers, MJ2
Kamenecka, TM2
Blüher, M1
Griffin, PR2
Spiegelman, BM2
Busby, SA1
Kumar, N1
Kuruvilla, DS1
Shin, Y1
He, Y1
Bruning, JB1
Marciano, DP1
Cameron, MD1
Jurczak, MJ1
Schürer, SC1
Vidović, D1
Shulman, GI1
Jiang, G1
Dallas-Yang, Q1
Li, Z1
Szalkowski, D1
Liu, F1
Shen, X1
Wu, M1
Zhou, G1
Doebber, T1
Berger, J1
Moller, DE1
Zhang, BB1
Carvalheira, JB2
Ribeiro, EB1
Araújo, EP2
Guimarães, RB1
Telles, MM1
Torsoni, M1
Gontijo, JA1
Velloso, LA2
Saad, MJ2
Adams, JM1
Pratipanawatr, T1
Berria, R1
Wang, E1
DeFronzo, RA1
Sullards, MC1
Mandarino, LJ1
Gao, Z1
Zhang, X1
Zuberi, A1
Hwang, D1
Quon, MJ1
Lefevre, M1
Ye, J1
Tsukumo, DM1
Carvalho-Filho, MA1
Prada, PO1
Hirabara, SM1
Schenka, AA1
Vassallo, J1
Curi, R1
Hosooka, T1
Noguchi, T1
Kotani, K1
Nakamura, T1
Sakaue, H1
Inoue, H1
Ogawa, W1
Tobimatsu, K1
Takazawa, K1
Sakai, M1
Matsuki, Y1
Hiramatsu, R1
Yasuda, T1
Lazar, MA1
Yamanashi, Y1
Kasuga, M1
Jocken, JW1
Roepstorff, C1
Goossens, GH1
van der Baan, P1
van Baak, M1
Saris, WH1
Kiens, B1
Blaak, EE1
Dunaif, A1
Xia, J1
Book, CB1
Schenker, E1
Tang, Z1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Muscle Insulin Resistance In Aging[NCT02230839]200 participants (Anticipated)Interventional2014-06-30Active, not recruiting
Regulation of Lipolysis by Insulin in Skeletal Muscle and Adipose Tissue in Type 2 Diabetes[NCT01680133]20 participants (Actual)Observational2007-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for phosphoserine and Obesity

ArticleYear
Regulatory roles of G-protein coupled receptors in adipose tissue metabolism and their therapeutic potential.
    Archives of pharmacal research, 2021, Volume: 44, Issue:2

    Topics: Adipose Tissue; Adipose Tissue, Brown; Animals; Energy Metabolism; Humans; Metabolic Diseases; Obesi

2021

Other Studies

12 other studies available for phosphoserine and Obesity

ArticleYear
Glomerular Collagen Deposition and Lipocalin-2 Expression Are Early Signs of Renal Injury in Prediabetic Obese Rats.
    International journal of molecular sciences, 2019, 08-30, Volume: 20, Issue:17

    Topics: Adipose Tissue; Animals; Biomarkers; Body Weight; Collagen; Diet, High-Fat; Fibrosis; Gene Expressio

2019
Insulin Resistance Prevents AMPK-induced Tau Dephosphorylation through Akt-mediated Increase in AMPKSer-485 Phosphorylation.
    The Journal of biological chemistry, 2015, Jul-31, Volume: 290, Issue:31

    Topics: Adenylate Kinase; Alzheimer Disease; Animals; Cell Line; Diabetes Complications; Diet, High-Fat; Hum

2015
Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5.
    Nature, 2010, Jul-22, Volume: 466, Issue:7305

    Topics: Adipose Tissue; Amino Acid Sequence; Animals; Cell Line; Cyclin-Dependent Kinase 5; Diabetes Mellitu

2010
Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation.
    Nature, 2011, Sep-04, Volume: 477, Issue:7365

    Topics: 3T3-L1 Cells; Adipocytes; Adipose Tissue, White; Animals; Biphenyl Compounds; Body Fluids; Chloroceb

2011
Potentiation of insulin signaling in tissues of Zucker obese rats after acute and long-term treatment with PPARgamma agonists.
    Diabetes, 2002, Volume: 51, Issue:8

    Topics: Adipose Tissue; Animals; Fatty Acids, Nonesterified; Female; Insulin; Insulin Receptor Substrate Pro

2002
Selective impairment of insulin signalling in the hypothalamus of obese Zucker rats.
    Diabetologia, 2003, Volume: 46, Issue:12

    Topics: Animals; Blood Glucose; Body Weight; Hypothalamus; Injections, Intraventricular; Insulin; Insulin Re

2003
Ceramide content is increased in skeletal muscle from obese insulin-resistant humans.
    Diabetes, 2004, Volume: 53, Issue:1

    Topics: Adult; Blood Glucose; Ceramides; Fatty Acids, Nonesterified; Female; Glucose Clamp Technique; Humans

2004
Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytes.
    Molecular endocrinology (Baltimore, Md.), 2004, Volume: 18, Issue:8

    Topics: Adipocytes; Adipose Tissue; Animal Feed; Animals; Cell Line; Enzyme Activation; Enzyme Inhibitors; F

2004
Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance.
    Diabetes, 2007, Volume: 56, Issue:8

    Topics: Adipose Tissue; Animal Feed; Animals; Blood Glucose; Body Weight; Cell Shape; Dietary Fats; Enzyme A

2007
Dok1 mediates high-fat diet-induced adipocyte hypertrophy and obesity through modulation of PPAR-gamma phosphorylation.
    Nature medicine, 2008, Volume: 14, Issue:2

    Topics: Adipocytes; Adipogenesis; Adipose Tissue, White; Adiposity; Animals; Diet; DNA-Binding Proteins; Ext

2008
Hormone-sensitive lipase serine phosphorylation and glycerol exchange across skeletal muscle in lean and obese subjects: effect of beta-adrenergic stimulation.
    Diabetes, 2008, Volume: 57, Issue:7

    Topics: Adrenergic beta-Agonists; Adult; Blood Pressure; Body Mass Index; Glycerol; Humans; Isoproterenol; K

2008
Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome.
    The Journal of clinical investigation, 1995, Volume: 96, Issue:2

    Topics: Adult; Blood Glucose; Cells, Cultured; Diabetes Mellitus, Type 2; Female; Fibroblasts; Humans; Insul

1995