phosphoserine has been researched along with Neoplasms in 38 studies
Phosphoserine: The phosphoric acid ester of serine.
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Excerpt | Relevance | Reference |
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" Moreover, sustained administration of phosphoserine promoted tumor growth in the malignant ascites and subcutaneous tumor models." | 4.12 | Phosphatidylserine released from apoptotic cells in tumor induces M2-like macrophage polarization through the PSR-STAT3-JMJD3 axis. ( Jun, R; Liang, X; Liu, T; Liu, YT; Luo, M; Shao, B; Tong, A; Wang, RB; Wei, XW; Wei, YQ; Yang, JY; Yi, T; Zhao, X, 2022) |
"Apoptotic cells and macrophages in tumors were detected by immunohistochemical staining." | 1.72 | Phosphatidylserine released from apoptotic cells in tumor induces M2-like macrophage polarization through the PSR-STAT3-JMJD3 axis. ( Jun, R; Liang, X; Liu, T; Liu, YT; Luo, M; Shao, B; Tong, A; Wang, RB; Wei, XW; Wei, YQ; Yang, JY; Yi, T; Zhao, X, 2022) |
"Conversely, Tnfr1(-/-)Tag-expressing cancers resist cytokine-induced senescence and grow aggressively, even in TNFR1-expressing hosts." | 1.39 | T-helper-1-cell cytokines drive cancer into senescence. ( Alkhaled, M; Aßmann, S; Bauer, J; Berdel, J; Braumüller, H; Braungart, K; Brenner, E; Essmann, F; Fehrenbacher, B; Fend, F; Griessinger, C; Hahn, M; Handgretinger, R; Häring, HU; Kneilling, M; Mehra, T; Meier, F; Mocikat, R; Niessner, H; Pesic, M; Quintanilla-Martinez, L; Ranta, F; Röcken, M; Schaller, M; Schilbach, K; Schulze-Osthoff, K; Ullrich, S; van den Broek, M; Wieder, T; Zender, L, 2013) |
"Invasion by cancer cells has been associated with NFAT1 (nuclear factor of activated T cells) activation and expression of the COX-2 (cyclooxygenase 2) gene." | 1.38 | Human VRK2 (vaccinia-related kinase 2) modulates tumor cell invasion by hyperactivation of NFAT1 and expression of cyclooxygenase-2. ( Lazo, PA; Vázquez-Cedeira, M, 2012) |
"The mechanisms of Src implication in cancer and inflammation are linked to the ability of activated Src to phosphorylate multiple downstream targets that mediate its cellular effector functions." | 1.36 | Src kinase-mediated phosphorylation stabilizes inducible nitric-oxide synthase in normal cells and cancer cells. ( Abdel Fattah, E; Eissa, NT; Gorgun, FM; Mazumdar, T; Pandit, L; Tyryshkin, A; Zeng, S, 2010) |
"Ebp1 is polyubiquitinated in cancer cells, which is regulated by its phosphorylation." | 1.35 | Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor. ( Brat, DJ; Cheng, D; Gu, W; Liu, X; Liu, Z; Oh, SM; Okada, M; Peng, J; Sun, SY; Ye, K; Zhou, W, 2009) |
"In MDA-MB-231 cells, a breast cancer cell line showing constitutive phosphorylated ERK1/2, CT phosphorylated c-Raf at Ser(259) via the protein kinase A pathway, resulting in suppression of ERK1/2 phosphorylation." | 1.34 | Calcitonin targets extracellular signal-regulated kinase signaling pathway in human cancers. ( Bai, Y; Han, B; Kakudo, K; Nakamura, M; Nishishita, T, 2007) |
"In human cancers, specific residues of p53 are mutated at a high frequency." | 1.31 | Difference in the centrosome duplication regulatory activity among p53 'hot spot' mutants: potential role of Ser 315 phosphorylation-dependent centrosome binding of p53. ( Fukasawa, K; Horn, HF; Tarapore, P; Tokuyama, Y, 2001) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 2 (5.26) | 18.7374 |
1990's | 1 (2.63) | 18.2507 |
2000's | 21 (55.26) | 29.6817 |
2010's | 12 (31.58) | 24.3611 |
2020's | 2 (5.26) | 2.80 |
Authors | Studies |
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Liang, X | 1 |
Luo, M | 1 |
Shao, B | 1 |
Yang, JY | 1 |
Tong, A | 1 |
Wang, RB | 1 |
Liu, YT | 1 |
Jun, R | 1 |
Liu, T | 1 |
Yi, T | 1 |
Zhao, X | 1 |
Wei, YQ | 1 |
Wei, XW | 1 |
Laurien, L | 1 |
Nagata, M | 1 |
Schünke, H | 1 |
Delanghe, T | 1 |
Wiederstein, JL | 1 |
Kumari, S | 1 |
Schwarzer, R | 1 |
Corona, T | 1 |
Krüger, M | 1 |
Bertrand, MJM | 1 |
Kondylis, V | 1 |
Pasparakis, M | 1 |
Wu, D | 1 |
Hu, D | 1 |
Chen, H | 2 |
Shi, G | 1 |
Fetahu, IS | 1 |
Wu, F | 1 |
Rabidou, K | 1 |
Fang, R | 1 |
Tan, L | 1 |
Xu, S | 1 |
Liu, H | 1 |
Argueta, C | 1 |
Zhang, L | 1 |
Mao, F | 1 |
Yan, G | 1 |
Chen, J | 1 |
Dong, Z | 1 |
Lv, R | 1 |
Xu, Y | 1 |
Wang, M | 1 |
Ye, Y | 1 |
Zhang, S | 1 |
Duquette, D | 1 |
Geng, S | 1 |
Yin, C | 1 |
Lian, CG | 1 |
Murphy, GF | 1 |
Adler, GK | 1 |
Garg, R | 1 |
Lynch, L | 1 |
Yang, P | 1 |
Li, Y | 1 |
Lan, F | 1 |
Fan, J | 1 |
Shi, Y | 2 |
Shi, YG | 1 |
Hatzivassiliou, G | 1 |
Haling, JR | 1 |
Song, K | 1 |
Price, S | 1 |
Heald, R | 1 |
Hewitt, JF | 1 |
Zak, M | 1 |
Peck, A | 1 |
Orr, C | 1 |
Merchant, M | 1 |
Hoeflich, KP | 1 |
Chan, J | 1 |
Luoh, SM | 1 |
Anderson, DJ | 1 |
Ludlam, MJ | 1 |
Wiesmann, C | 1 |
Ultsch, M | 1 |
Friedman, LS | 1 |
Malek, S | 1 |
Belvin, M | 1 |
Rea, K | 1 |
Sensi, M | 1 |
Anichini, A | 1 |
Canevari, S | 1 |
Tomassetti, A | 1 |
Liu, P | 1 |
Begley, M | 1 |
Michowski, W | 1 |
Inuzuka, H | 1 |
Ginzberg, M | 1 |
Gao, D | 1 |
Tsou, P | 1 |
Gan, W | 1 |
Papa, A | 1 |
Kim, BM | 1 |
Wan, L | 1 |
Singh, A | 1 |
Zhai, B | 1 |
Yuan, M | 1 |
Wang, Z | 1 |
Gygi, SP | 1 |
Lee, TH | 1 |
Lu, KP | 3 |
Toker, A | 1 |
Pandolfi, PP | 2 |
Asara, JM | 1 |
Kirschner, MW | 1 |
Sicinski, P | 1 |
Cantley, L | 1 |
Wei, W | 1 |
Lee, MG | 1 |
Han, J | 1 |
Jeong, SI | 1 |
Her, NG | 1 |
Lee, JH | 2 |
Ha, TK | 1 |
Kang, MJ | 1 |
Ryu, BK | 1 |
Chi, SG | 1 |
Jeong, SA | 1 |
Kim, K | 1 |
Cha, JS | 1 |
Khadka, P | 1 |
Cho, HS | 1 |
Chung, IK | 1 |
Fusté, NP | 1 |
Fernández-Hernández, R | 1 |
Cemeli, T | 1 |
Mirantes, C | 1 |
Pedraza, N | 1 |
Rafel, M | 1 |
Torres-Rosell, J | 1 |
Colomina, N | 1 |
Ferrezuelo, F | 1 |
Dolcet, X | 1 |
Garí, E | 1 |
Liu, Z | 1 |
Oh, SM | 1 |
Okada, M | 1 |
Liu, X | 2 |
Cheng, D | 1 |
Peng, J | 1 |
Brat, DJ | 1 |
Sun, SY | 1 |
Zhou, W | 1 |
Gu, W | 1 |
Ye, K | 1 |
Park, AY | 1 |
Shen, TL | 1 |
Chien, S | 1 |
Guan, JL | 1 |
Lin, HK | 1 |
Wang, G | 1 |
Chen, Z | 1 |
Teruya-Feldstein, J | 1 |
Liu, Y | 1 |
Chan, CH | 1 |
Yang, WL | 1 |
Erdjument-Bromage, H | 1 |
Nakayama, KI | 1 |
Nimer, S | 1 |
Tempst, P | 1 |
Pasquale, EB | 1 |
Tyryshkin, A | 1 |
Gorgun, FM | 1 |
Abdel Fattah, E | 1 |
Mazumdar, T | 1 |
Pandit, L | 1 |
Zeng, S | 1 |
Eissa, NT | 1 |
Andersen, JN | 1 |
Sathyanarayanan, S | 1 |
Di Bacco, A | 1 |
Chi, A | 1 |
Zhang, T | 1 |
Chen, AH | 1 |
Dolinski, B | 1 |
Kraus, M | 1 |
Roberts, B | 1 |
Arthur, W | 1 |
Klinghoffer, RA | 1 |
Gargano, D | 1 |
Li, L | 1 |
Feldman, I | 1 |
Lynch, B | 1 |
Rush, J | 1 |
Hendrickson, RC | 1 |
Blume-Jensen, P | 1 |
Paweletz, CP | 1 |
Wang, JX | 1 |
Zeng, Q | 1 |
Chen, L | 1 |
Du, JC | 1 |
Yan, XL | 1 |
Yuan, HF | 1 |
Zhai, C | 1 |
Zhou, JN | 1 |
Jia, YL | 1 |
Yue, W | 1 |
Pei, XT | 1 |
Vázquez-Cedeira, M | 1 |
Lazo, PA | 1 |
Braumüller, H | 1 |
Wieder, T | 1 |
Brenner, E | 1 |
Aßmann, S | 1 |
Hahn, M | 1 |
Alkhaled, M | 1 |
Schilbach, K | 1 |
Essmann, F | 1 |
Kneilling, M | 1 |
Griessinger, C | 1 |
Ranta, F | 1 |
Ullrich, S | 1 |
Mocikat, R | 1 |
Braungart, K | 1 |
Mehra, T | 1 |
Fehrenbacher, B | 1 |
Berdel, J | 1 |
Niessner, H | 1 |
Meier, F | 1 |
van den Broek, M | 1 |
Häring, HU | 1 |
Handgretinger, R | 1 |
Quintanilla-Martinez, L | 1 |
Fend, F | 1 |
Pesic, M | 1 |
Bauer, J | 1 |
Zender, L | 1 |
Schaller, M | 1 |
Schulze-Osthoff, K | 1 |
Röcken, M | 1 |
SPERTI, S | 2 |
LORINIMPINNA, LA | 1 |
MORET, V | 2 |
SILIPRANDI, N | 1 |
Horejsí, Z | 1 |
Falck, J | 1 |
Bakkenist, CJ | 1 |
Kastan, MB | 1 |
Lukas, J | 1 |
Bartek, J | 1 |
Mhawech, P | 1 |
Wulf, G | 1 |
Finn, G | 1 |
Suizu, F | 1 |
Perez-Pinera, P | 1 |
Menendez-Gonzalez, M | 1 |
del Valle, M | 1 |
Vega, JA | 1 |
Matsumoto, M | 1 |
Furihata, M | 1 |
Ohtsuki, Y | 1 |
Fang, D | 1 |
Hawke, D | 1 |
Zheng, Y | 1 |
Xia, Y | 1 |
Meisenhelder, J | 1 |
Nika, H | 1 |
Mills, GB | 1 |
Kobayashi, R | 1 |
Hunter, T | 1 |
Lu, Z | 1 |
Caraglia, M | 1 |
Marra, M | 1 |
Viscomi, C | 1 |
D'Alessandro, AM | 1 |
Budillon, A | 1 |
Meo, G | 1 |
Arra, C | 1 |
Barbieri, A | 1 |
Rapp, UR | 1 |
Baldi, A | 1 |
Tassone, P | 1 |
Venuta, S | 1 |
Abbruzzese, A | 1 |
Tagliaferri, P | 1 |
Matthew, EM | 1 |
Yen, TJ | 1 |
Dicker, DT | 1 |
Dorsey, JF | 1 |
Yang, W | 1 |
Navaraj, A | 1 |
El-Deiry, WS | 1 |
Shouse, GP | 1 |
Cai, X | 1 |
Nakamura, M | 1 |
Han, B | 1 |
Nishishita, T | 1 |
Bai, Y | 1 |
Kakudo, K | 1 |
Kang, T | 1 |
Wei, Y | 1 |
Honaker, Y | 1 |
Yamaguchi, H | 1 |
Appella, E | 1 |
Hung, MC | 1 |
Piwnica-Worms, H | 1 |
Xia, H | 1 |
Nho, R | 1 |
Kleidon, J | 1 |
Kahm, J | 1 |
Henke, CA | 1 |
Grunicke, HH | 1 |
Maly, K | 1 |
Uberall, F | 1 |
Schubert, C | 1 |
Kindler, E | 1 |
Stekar, J | 1 |
Brachwitz, H | 1 |
Carr, AM | 1 |
Bowman, T | 1 |
Garcia, R | 1 |
Turkson, J | 1 |
Jove, R | 1 |
Tarapore, P | 1 |
Tokuyama, Y | 1 |
Horn, HF | 1 |
Fukasawa, K | 1 |
Wu, JW | 1 |
Hu, M | 1 |
Chai, J | 1 |
Seoane, J | 1 |
Huse, M | 1 |
Li, C | 1 |
Rigotti, DJ | 1 |
Kyin, S | 1 |
Muir, TW | 1 |
Fairman, R | 1 |
Massagué, J | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Safety and Efficacy of Saracatinib In Subjects With Lymphangioleiomyomatosis[NCT02737202] | Phase 2 | 28 participants (Actual) | Interventional | 2016-04-30 | Terminated | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
5 reviews available for phosphoserine and Neoplasms
Article | Year |
---|---|
Pinning down cell signaling, cancer and Alzheimer's disease.
Topics: Alzheimer Disease; CDC2-CDC28 Kinases; Cell Cycle; Cyclin-Dependent Kinase 2; Humans; Models, Biolog | 2004 |
14-3-3 proteins--an update.
Topics: 14-3-3 Proteins; Animals; Biomarkers, Tumor; Cell Cycle; Cell Differentiation; Cell Proliferation; C | 2005 |
Phosphorylation-specific prolyl isomerization: is there an underlying theme?
Topics: Alzheimer Disease; Cell Proliferation; Humans; Isomerism; Neoplasms; NIMA-Interacting Peptidylprolyl | 2005 |
Posttranslational phosphorylation of mutant p53 protein in tumor development.
Topics: Humans; Mutant Proteins; Neoplasms; Phosphorylation; Phosphoserine; Protein Processing, Post-Transla | 2006 |
STATs in oncogenesis.
Topics: Animals; Cell Transformation, Neoplastic; DNA-Binding Proteins; Gene Expression Regulation, Neoplast | 2000 |
33 other studies available for phosphoserine and Neoplasms
Article | Year |
---|---|
Phosphatidylserine released from apoptotic cells in tumor induces M2-like macrophage polarization through the PSR-STAT3-JMJD3 axis.
Topics: Animals; Apoptosis; Ascites; Jumonji Domain-Containing Histone Demethylases; Macrophages; Mice; Neop | 2022 |
Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation.
Topics: Alanine Transaminase; Animals; Apoptosis; Bone Marrow Cells; Colitis; Genotype; Hepatitis; Inflammat | 2020 |
Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer.
Topics: 5-Methylcytosine; Adenylate Kinase; Animals; Diabetes Mellitus; Dioxygenases; DNA; DNA Methylation; | 2018 |
Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers.
Topics: Allosteric Regulation; Azetidines; Cell Survival; Clinical Trials as Topic; Crystallography, X-Ray; | 2013 |
EGFR/MEK/ERK/CDK5-dependent integrin-independent FAK phosphorylated on serine 732 contributes to microtubule depolymerization and mitosis in tumor cells.
Topics: Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclin-Dependent Kinase 5; Epidermal Growth Fac | 2013 |
Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus.
Topics: Animals; Apoptosis; Cell Cycle; Cell Proliferation; Cyclin A2; Cyclin-Dependent Kinase 2; Embryonic | 2014 |
XAF1 directs apoptotic switch of p53 signaling through activation of HIPK2 and ZNF313.
Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Protein | 2014 |
Akt-mediated phosphorylation increases the binding affinity of hTERT for importin α to promote nuclear translocation.
Topics: Active Transport, Cell Nucleus; alpha Karyopherins; Amino Acid Sequence; Blotting, Western; Cell Nuc | 2015 |
Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin.
Topics: Animals; Cell Line, Tumor; Cell Membrane; Cyclin D1; Cyclin-Dependent Kinase 4; Cytoplasm; Down-Regu | 2016 |
Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor.
Topics: Adaptor Proteins, Signal Transducing; Cell Proliferation; E2F1 Transcription Factor; HeLa Cells; Hum | 2009 |
Role of focal adhesion kinase Ser-732 phosphorylation in centrosome function during mitosis.
Topics: Animals; Cells, Cultured; Centrosome; Cytoplasm; Dyneins; Focal Adhesion Protein-Tyrosine Kinases; G | 2009 |
Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB.
Topics: 14-3-3 Proteins; Amino Acid Sequence; Animals; Cell Movement; Conserved Sequence; Cytosol; Enzyme Ac | 2009 |
Journal club. A biologist is gratified to find reconciliation for a conflicted receptor.
Topics: Enzyme Activation; Ephrin-A1; Ligands; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms; Phosph | 2009 |
Src kinase-mediated phosphorylation stabilizes inducible nitric-oxide synthase in normal cells and cancer cells.
Topics: Animals; Cell Line, Tumor; Disease Models, Animal; Enzyme Activation; Enzyme Stability; Epidermal Gr | 2010 |
Pathway-based identification of biomarkers for targeted therapeutics: personalized oncology with PI3K pathway inhibitors.
Topics: Adaptor Proteins, Signal Transducing; Animals; Basophils; Biomarkers, Tumor; Breast Neoplasms; Cell | 2010 |
SPINDLIN1 promotes cancer cell proliferation through activation of WNT/TCF-4 signaling.
Topics: Aurora Kinases; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Cell Cycle Proteins; Ce | 2012 |
Human VRK2 (vaccinia-related kinase 2) modulates tumor cell invasion by hyperactivation of NFAT1 and expression of cyclooxygenase-2.
Topics: Animals; Binding Sites; Cell Line, Tumor; Cyclooxygenase 2; DNA-Binding Proteins; Gene Expression Re | 2012 |
T-helper-1-cell cytokines drive cancer into senescence.
Topics: Animals; Antigens, Polyomavirus Transforming; Cell Cycle; Cell Proliferation; Cellular Senescence; C | 2013 |
PHOSPHORYLSERINE SEQUENCES IN PHOSPHOPROTEINS FROM EHRLICH ASCITES CELLS.
Topics: Animals; Ascites; Biochemical Phenomena; Biochemistry; Carcinoma; Carcinoma, Ehrlich Tumor; Electrop | 1964 |
Phosphorylserine sequences in phosphoproteins from Ehrlich ascites cells.
Topics: Ascites; Base Sequence; Biochemistry; Diploidy; Neoplasms; Phosphoproteins; Phosphoserine; Proteins; | 1962 |
Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation.
Topics: Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Binding Sites; Cell Cycle Proteins; C | 2004 |
Hypertonicity activates GSK3beta in tumor cells.
Topics: Enzyme Activation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; HeLa Cells; Humans; | 2006 |
Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity.
Topics: 14-3-3 Proteins; Amino Acid Sequence; Animals; beta Catenin; Cell Line; Cell Nucleus; Cricetinae; Cr | 2007 |
The farnesyltransferase inhibitor R115777 (ZARNESTRA) enhances the pro-apoptotic activity of interferon-alpha through the inhibition of multiple survival pathways.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Farnesyltranstransferase | 2007 |
Replication stress, defective S-phase checkpoint and increased death in Plk2-deficient human cancer cells.
Topics: Cell Line, Tumor; Checkpoint Kinase 1; DNA; DNA Replication; Gene Expression Regulation, Enzymologic | 2007 |
Serine 15 phosphorylation of p53 directs its interaction with B56gamma and the tumor suppressor activity of B56gamma-specific protein phosphatase 2A.
Topics: Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; D | 2008 |
Calcitonin targets extracellular signal-regulated kinase signaling pathway in human cancers.
Topics: Adenylyl Cyclases; Animals; Calcitonin; Cell Line, Tumor; Cyclic AMP; Cyclic AMP-Dependent Protein K | 2007 |
GSK-3 beta targets Cdc25A for ubiquitin-mediated proteolysis, and GSK-3 beta inactivation correlates with Cdc25A overproduction in human cancers.
Topics: Animals; beta-Transducin Repeat-Containing Proteins; cdc25 Phosphatases; Cell Cycle; Cell Line, Tumo | 2008 |
Polymerized collagen inhibits fibroblast proliferation via a mechanism involving the formation of a beta1 integrin-protein phosphatase 2A-tuberous sclerosis complex 2 complex that suppresses S6K1 activity.
Topics: Cell Adhesion; Cell Line; Cell Proliferation; Collagen; Enzyme Activation; Fibroblasts; Humans; Inte | 2008 |
Cellular signalling as a target in cancer chemotherapy. Phospholipid analogues as inhibitors of mitogenic signal transduction.
Topics: Antineoplastic Agents; Calcium; Enzyme Inhibitors; Inositol 1,4,5-Trisphosphate; Molecular Structure | 1996 |
Cell cycle. Piecing together the p53 puzzle.
Topics: Animals; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Checkpoint Kinase 2; DNA Damag | 2000 |
Difference in the centrosome duplication regulatory activity among p53 'hot spot' mutants: potential role of Ser 315 phosphorylation-dependent centrosome binding of p53.
Topics: Aneuploidy; Animals; Cell Line; Centrosome; Cyclin-Dependent Kinases; Gene Deletion; Mice; Mutation; | 2001 |
Crystal structure of a phosphorylated Smad2. Recognition of phosphoserine by the MH2 domain and insights on Smad function in TGF-beta signaling.
Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Binding Sites; Crystallography, X-Ray; DNA-Binding | 2001 |