Page last updated: 2024-10-15

phosphoserine and Neoplasms

phosphoserine has been researched along with Neoplasms in 38 studies

Phosphoserine: The phosphoric acid ester of serine.

Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

Research Excerpts

ExcerptRelevanceReference
" Moreover, sustained administration of phosphoserine promoted tumor growth in the malignant ascites and subcutaneous tumor models."4.12Phosphatidylserine released from apoptotic cells in tumor induces M2-like macrophage polarization through the PSR-STAT3-JMJD3 axis. ( Jun, R; Liang, X; Liu, T; Liu, YT; Luo, M; Shao, B; Tong, A; Wang, RB; Wei, XW; Wei, YQ; Yang, JY; Yi, T; Zhao, X, 2022)
"Apoptotic cells and macrophages in tumors were detected by immunohistochemical staining."1.72Phosphatidylserine released from apoptotic cells in tumor induces M2-like macrophage polarization through the PSR-STAT3-JMJD3 axis. ( Jun, R; Liang, X; Liu, T; Liu, YT; Luo, M; Shao, B; Tong, A; Wang, RB; Wei, XW; Wei, YQ; Yang, JY; Yi, T; Zhao, X, 2022)
"Conversely, Tnfr1(-/-)Tag-expressing cancers resist cytokine-induced senescence and grow aggressively, even in TNFR1-expressing hosts."1.39T-helper-1-cell cytokines drive cancer into senescence. ( Alkhaled, M; Aßmann, S; Bauer, J; Berdel, J; Braumüller, H; Braungart, K; Brenner, E; Essmann, F; Fehrenbacher, B; Fend, F; Griessinger, C; Hahn, M; Handgretinger, R; Häring, HU; Kneilling, M; Mehra, T; Meier, F; Mocikat, R; Niessner, H; Pesic, M; Quintanilla-Martinez, L; Ranta, F; Röcken, M; Schaller, M; Schilbach, K; Schulze-Osthoff, K; Ullrich, S; van den Broek, M; Wieder, T; Zender, L, 2013)
"Invasion by cancer cells has been associated with NFAT1 (nuclear factor of activated T cells) activation and expression of the COX-2 (cyclooxygenase 2) gene."1.38Human VRK2 (vaccinia-related kinase 2) modulates tumor cell invasion by hyperactivation of NFAT1 and expression of cyclooxygenase-2. ( Lazo, PA; Vázquez-Cedeira, M, 2012)
"The mechanisms of Src implication in cancer and inflammation are linked to the ability of activated Src to phosphorylate multiple downstream targets that mediate its cellular effector functions."1.36Src kinase-mediated phosphorylation stabilizes inducible nitric-oxide synthase in normal cells and cancer cells. ( Abdel Fattah, E; Eissa, NT; Gorgun, FM; Mazumdar, T; Pandit, L; Tyryshkin, A; Zeng, S, 2010)
"Ebp1 is polyubiquitinated in cancer cells, which is regulated by its phosphorylation."1.35Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor. ( Brat, DJ; Cheng, D; Gu, W; Liu, X; Liu, Z; Oh, SM; Okada, M; Peng, J; Sun, SY; Ye, K; Zhou, W, 2009)
"In MDA-MB-231 cells, a breast cancer cell line showing constitutive phosphorylated ERK1/2, CT phosphorylated c-Raf at Ser(259) via the protein kinase A pathway, resulting in suppression of ERK1/2 phosphorylation."1.34Calcitonin targets extracellular signal-regulated kinase signaling pathway in human cancers. ( Bai, Y; Han, B; Kakudo, K; Nakamura, M; Nishishita, T, 2007)
"In human cancers, specific residues of p53 are mutated at a high frequency."1.31Difference in the centrosome duplication regulatory activity among p53 'hot spot' mutants: potential role of Ser 315 phosphorylation-dependent centrosome binding of p53. ( Fukasawa, K; Horn, HF; Tarapore, P; Tokuyama, Y, 2001)

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-19902 (5.26)18.7374
1990's1 (2.63)18.2507
2000's21 (55.26)29.6817
2010's12 (31.58)24.3611
2020's2 (5.26)2.80

Authors

AuthorsStudies
Liang, X1
Luo, M1
Shao, B1
Yang, JY1
Tong, A1
Wang, RB1
Liu, YT1
Jun, R1
Liu, T1
Yi, T1
Zhao, X1
Wei, YQ1
Wei, XW1
Laurien, L1
Nagata, M1
Schünke, H1
Delanghe, T1
Wiederstein, JL1
Kumari, S1
Schwarzer, R1
Corona, T1
Krüger, M1
Bertrand, MJM1
Kondylis, V1
Pasparakis, M1
Wu, D1
Hu, D1
Chen, H2
Shi, G1
Fetahu, IS1
Wu, F1
Rabidou, K1
Fang, R1
Tan, L1
Xu, S1
Liu, H1
Argueta, C1
Zhang, L1
Mao, F1
Yan, G1
Chen, J1
Dong, Z1
Lv, R1
Xu, Y1
Wang, M1
Ye, Y1
Zhang, S1
Duquette, D1
Geng, S1
Yin, C1
Lian, CG1
Murphy, GF1
Adler, GK1
Garg, R1
Lynch, L1
Yang, P1
Li, Y1
Lan, F1
Fan, J1
Shi, Y2
Shi, YG1
Hatzivassiliou, G1
Haling, JR1
Song, K1
Price, S1
Heald, R1
Hewitt, JF1
Zak, M1
Peck, A1
Orr, C1
Merchant, M1
Hoeflich, KP1
Chan, J1
Luoh, SM1
Anderson, DJ1
Ludlam, MJ1
Wiesmann, C1
Ultsch, M1
Friedman, LS1
Malek, S1
Belvin, M1
Rea, K1
Sensi, M1
Anichini, A1
Canevari, S1
Tomassetti, A1
Liu, P1
Begley, M1
Michowski, W1
Inuzuka, H1
Ginzberg, M1
Gao, D1
Tsou, P1
Gan, W1
Papa, A1
Kim, BM1
Wan, L1
Singh, A1
Zhai, B1
Yuan, M1
Wang, Z1
Gygi, SP1
Lee, TH1
Lu, KP3
Toker, A1
Pandolfi, PP2
Asara, JM1
Kirschner, MW1
Sicinski, P1
Cantley, L1
Wei, W1
Lee, MG1
Han, J1
Jeong, SI1
Her, NG1
Lee, JH2
Ha, TK1
Kang, MJ1
Ryu, BK1
Chi, SG1
Jeong, SA1
Kim, K1
Cha, JS1
Khadka, P1
Cho, HS1
Chung, IK1
Fusté, NP1
Fernández-Hernández, R1
Cemeli, T1
Mirantes, C1
Pedraza, N1
Rafel, M1
Torres-Rosell, J1
Colomina, N1
Ferrezuelo, F1
Dolcet, X1
Garí, E1
Liu, Z1
Oh, SM1
Okada, M1
Liu, X2
Cheng, D1
Peng, J1
Brat, DJ1
Sun, SY1
Zhou, W1
Gu, W1
Ye, K1
Park, AY1
Shen, TL1
Chien, S1
Guan, JL1
Lin, HK1
Wang, G1
Chen, Z1
Teruya-Feldstein, J1
Liu, Y1
Chan, CH1
Yang, WL1
Erdjument-Bromage, H1
Nakayama, KI1
Nimer, S1
Tempst, P1
Pasquale, EB1
Tyryshkin, A1
Gorgun, FM1
Abdel Fattah, E1
Mazumdar, T1
Pandit, L1
Zeng, S1
Eissa, NT1
Andersen, JN1
Sathyanarayanan, S1
Di Bacco, A1
Chi, A1
Zhang, T1
Chen, AH1
Dolinski, B1
Kraus, M1
Roberts, B1
Arthur, W1
Klinghoffer, RA1
Gargano, D1
Li, L1
Feldman, I1
Lynch, B1
Rush, J1
Hendrickson, RC1
Blume-Jensen, P1
Paweletz, CP1
Wang, JX1
Zeng, Q1
Chen, L1
Du, JC1
Yan, XL1
Yuan, HF1
Zhai, C1
Zhou, JN1
Jia, YL1
Yue, W1
Pei, XT1
Vázquez-Cedeira, M1
Lazo, PA1
Braumüller, H1
Wieder, T1
Brenner, E1
Aßmann, S1
Hahn, M1
Alkhaled, M1
Schilbach, K1
Essmann, F1
Kneilling, M1
Griessinger, C1
Ranta, F1
Ullrich, S1
Mocikat, R1
Braungart, K1
Mehra, T1
Fehrenbacher, B1
Berdel, J1
Niessner, H1
Meier, F1
van den Broek, M1
Häring, HU1
Handgretinger, R1
Quintanilla-Martinez, L1
Fend, F1
Pesic, M1
Bauer, J1
Zender, L1
Schaller, M1
Schulze-Osthoff, K1
Röcken, M1
SPERTI, S2
LORINIMPINNA, LA1
MORET, V2
SILIPRANDI, N1
Horejsí, Z1
Falck, J1
Bakkenist, CJ1
Kastan, MB1
Lukas, J1
Bartek, J1
Mhawech, P1
Wulf, G1
Finn, G1
Suizu, F1
Perez-Pinera, P1
Menendez-Gonzalez, M1
del Valle, M1
Vega, JA1
Matsumoto, M1
Furihata, M1
Ohtsuki, Y1
Fang, D1
Hawke, D1
Zheng, Y1
Xia, Y1
Meisenhelder, J1
Nika, H1
Mills, GB1
Kobayashi, R1
Hunter, T1
Lu, Z1
Caraglia, M1
Marra, M1
Viscomi, C1
D'Alessandro, AM1
Budillon, A1
Meo, G1
Arra, C1
Barbieri, A1
Rapp, UR1
Baldi, A1
Tassone, P1
Venuta, S1
Abbruzzese, A1
Tagliaferri, P1
Matthew, EM1
Yen, TJ1
Dicker, DT1
Dorsey, JF1
Yang, W1
Navaraj, A1
El-Deiry, WS1
Shouse, GP1
Cai, X1
Nakamura, M1
Han, B1
Nishishita, T1
Bai, Y1
Kakudo, K1
Kang, T1
Wei, Y1
Honaker, Y1
Yamaguchi, H1
Appella, E1
Hung, MC1
Piwnica-Worms, H1
Xia, H1
Nho, R1
Kleidon, J1
Kahm, J1
Henke, CA1
Grunicke, HH1
Maly, K1
Uberall, F1
Schubert, C1
Kindler, E1
Stekar, J1
Brachwitz, H1
Carr, AM1
Bowman, T1
Garcia, R1
Turkson, J1
Jove, R1
Tarapore, P1
Tokuyama, Y1
Horn, HF1
Fukasawa, K1
Wu, JW1
Hu, M1
Chai, J1
Seoane, J1
Huse, M1
Li, C1
Rigotti, DJ1
Kyin, S1
Muir, TW1
Fairman, R1
Massagué, J1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Safety and Efficacy of Saracatinib In Subjects With Lymphangioleiomyomatosis[NCT02737202]Phase 228 participants (Actual)Interventional2016-04-30Terminated
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

5 reviews available for phosphoserine and Neoplasms

ArticleYear
Pinning down cell signaling, cancer and Alzheimer's disease.
    Trends in biochemical sciences, 2004, Volume: 29, Issue:4

    Topics: Alzheimer Disease; CDC2-CDC28 Kinases; Cell Cycle; Cyclin-Dependent Kinase 2; Humans; Models, Biolog

2004
14-3-3 proteins--an update.
    Cell research, 2005, Volume: 15, Issue:4

    Topics: 14-3-3 Proteins; Animals; Biomarkers, Tumor; Cell Cycle; Cell Differentiation; Cell Proliferation; C

2005
Phosphorylation-specific prolyl isomerization: is there an underlying theme?
    Nature cell biology, 2005, Volume: 7, Issue:5

    Topics: Alzheimer Disease; Cell Proliferation; Humans; Isomerism; Neoplasms; NIMA-Interacting Peptidylprolyl

2005
Posttranslational phosphorylation of mutant p53 protein in tumor development.
    Medical molecular morphology, 2006, Volume: 39, Issue:2

    Topics: Humans; Mutant Proteins; Neoplasms; Phosphorylation; Phosphoserine; Protein Processing, Post-Transla

2006
STATs in oncogenesis.
    Oncogene, 2000, May-15, Volume: 19, Issue:21

    Topics: Animals; Cell Transformation, Neoplastic; DNA-Binding Proteins; Gene Expression Regulation, Neoplast

2000

Other Studies

33 other studies available for phosphoserine and Neoplasms

ArticleYear
Phosphatidylserine released from apoptotic cells in tumor induces M2-like macrophage polarization through the PSR-STAT3-JMJD3 axis.
    Cancer communications (London, England), 2022, Volume: 42, Issue:3

    Topics: Animals; Apoptosis; Ascites; Jumonji Domain-Containing Histone Demethylases; Macrophages; Mice; Neop

2022
Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation.
    Nature communications, 2020, 04-08, Volume: 11, Issue:1

    Topics: Alanine Transaminase; Animals; Apoptosis; Bone Marrow Cells; Colitis; Genotype; Hepatitis; Inflammat

2020
Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer.
    Nature, 2018, Volume: 559, Issue:7715

    Topics: 5-Methylcytosine; Adenylate Kinase; Animals; Diabetes Mellitus; Dioxygenases; DNA; DNA Methylation;

2018
Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers.
    Nature, 2013, Sep-12, Volume: 501, Issue:7466

    Topics: Allosteric Regulation; Azetidines; Cell Survival; Clinical Trials as Topic; Crystallography, X-Ray;

2013
EGFR/MEK/ERK/CDK5-dependent integrin-independent FAK phosphorylated on serine 732 contributes to microtubule depolymerization and mitosis in tumor cells.
    Cell death & disease, 2013, Oct-03, Volume: 4

    Topics: Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclin-Dependent Kinase 5; Epidermal Growth Fac

2013
Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus.
    Nature, 2014, Apr-24, Volume: 508, Issue:7497

    Topics: Animals; Apoptosis; Cell Cycle; Cell Proliferation; Cyclin A2; Cyclin-Dependent Kinase 2; Embryonic

2014
XAF1 directs apoptotic switch of p53 signaling through activation of HIPK2 and ZNF313.
    Proceedings of the National Academy of Sciences of the United States of America, 2014, Oct-28, Volume: 111, Issue:43

    Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Protein

2014
Akt-mediated phosphorylation increases the binding affinity of hTERT for importin α to promote nuclear translocation.
    Journal of cell science, 2015, Jun-15, Volume: 128, Issue:12

    Topics: Active Transport, Cell Nucleus; alpha Karyopherins; Amino Acid Sequence; Blotting, Western; Cell Nuc

2015
Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin.
    Nature communications, 2016, 05-16, Volume: 7

    Topics: Animals; Cell Line, Tumor; Cell Membrane; Cyclin D1; Cyclin-Dependent Kinase 4; Cytoplasm; Down-Regu

2016
Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor.
    Molecular biology of the cell, 2009, Volume: 20, Issue:3

    Topics: Adaptor Proteins, Signal Transducing; Cell Proliferation; E2F1 Transcription Factor; HeLa Cells; Hum

2009
Role of focal adhesion kinase Ser-732 phosphorylation in centrosome function during mitosis.
    The Journal of biological chemistry, 2009, Apr-03, Volume: 284, Issue:14

    Topics: Animals; Cells, Cultured; Centrosome; Cytoplasm; Dyneins; Focal Adhesion Protein-Tyrosine Kinases; G

2009
Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB.
    Nature cell biology, 2009, Volume: 11, Issue:4

    Topics: 14-3-3 Proteins; Amino Acid Sequence; Animals; Cell Movement; Conserved Sequence; Cytosol; Enzyme Ac

2009
Journal club. A biologist is gratified to find reconciliation for a conflicted receptor.
    Nature, 2009, Sep-10, Volume: 461, Issue:7261

    Topics: Enzyme Activation; Ephrin-A1; Ligands; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms; Phosph

2009
Src kinase-mediated phosphorylation stabilizes inducible nitric-oxide synthase in normal cells and cancer cells.
    The Journal of biological chemistry, 2010, Jan-01, Volume: 285, Issue:1

    Topics: Animals; Cell Line, Tumor; Disease Models, Animal; Enzyme Activation; Enzyme Stability; Epidermal Gr

2010
Pathway-based identification of biomarkers for targeted therapeutics: personalized oncology with PI3K pathway inhibitors.
    Science translational medicine, 2010, Aug-04, Volume: 2, Issue:43

    Topics: Adaptor Proteins, Signal Transducing; Animals; Basophils; Biomarkers, Tumor; Breast Neoplasms; Cell

2010
SPINDLIN1 promotes cancer cell proliferation through activation of WNT/TCF-4 signaling.
    Molecular cancer research : MCR, 2012, Volume: 10, Issue:3

    Topics: Aurora Kinases; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Cell Cycle Proteins; Ce

2012
Human VRK2 (vaccinia-related kinase 2) modulates tumor cell invasion by hyperactivation of NFAT1 and expression of cyclooxygenase-2.
    The Journal of biological chemistry, 2012, Dec-14, Volume: 287, Issue:51

    Topics: Animals; Binding Sites; Cell Line, Tumor; Cyclooxygenase 2; DNA-Binding Proteins; Gene Expression Re

2012
T-helper-1-cell cytokines drive cancer into senescence.
    Nature, 2013, Feb-21, Volume: 494, Issue:7437

    Topics: Animals; Antigens, Polyomavirus Transforming; Cell Cycle; Cell Proliferation; Cellular Senescence; C

2013
PHOSPHORYLSERINE SEQUENCES IN PHOSPHOPROTEINS FROM EHRLICH ASCITES CELLS.
    Biochimica et biophysica acta, 1964, Mar-16, Volume: 82

    Topics: Animals; Ascites; Biochemical Phenomena; Biochemistry; Carcinoma; Carcinoma, Ehrlich Tumor; Electrop

1964
Phosphorylserine sequences in phosphoproteins from Ehrlich ascites cells.
    Biochimica et biophysica acta, 1962, Jul-30, Volume: 62

    Topics: Ascites; Base Sequence; Biochemistry; Diploidy; Neoplasms; Phosphoproteins; Phosphoserine; Proteins;

1962
Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation.
    Oncogene, 2004, Apr-15, Volume: 23, Issue:17

    Topics: Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Binding Sites; Cell Cycle Proteins; C

2004
Hypertonicity activates GSK3beta in tumor cells.
    Molecular and cellular biochemistry, 2006, Volume: 291, Issue:1-2

    Topics: Enzyme Activation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; HeLa Cells; Humans;

2006
Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity.
    The Journal of biological chemistry, 2007, Apr-13, Volume: 282, Issue:15

    Topics: 14-3-3 Proteins; Amino Acid Sequence; Animals; beta Catenin; Cell Line; Cell Nucleus; Cricetinae; Cr

2007
The farnesyltransferase inhibitor R115777 (ZARNESTRA) enhances the pro-apoptotic activity of interferon-alpha through the inhibition of multiple survival pathways.
    International journal of cancer, 2007, Nov-15, Volume: 121, Issue:10

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Farnesyltranstransferase

2007
Replication stress, defective S-phase checkpoint and increased death in Plk2-deficient human cancer cells.
    Cell cycle (Georgetown, Tex.), 2007, Oct-15, Volume: 6, Issue:20

    Topics: Cell Line, Tumor; Checkpoint Kinase 1; DNA; DNA Replication; Gene Expression Regulation, Enzymologic

2007
Serine 15 phosphorylation of p53 directs its interaction with B56gamma and the tumor suppressor activity of B56gamma-specific protein phosphatase 2A.
    Molecular and cellular biology, 2008, Volume: 28, Issue:1

    Topics: Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; D

2008
Calcitonin targets extracellular signal-regulated kinase signaling pathway in human cancers.
    Journal of molecular endocrinology, 2007, Volume: 39, Issue:6

    Topics: Adenylyl Cyclases; Animals; Calcitonin; Cell Line, Tumor; Cyclic AMP; Cyclic AMP-Dependent Protein K

2007
GSK-3 beta targets Cdc25A for ubiquitin-mediated proteolysis, and GSK-3 beta inactivation correlates with Cdc25A overproduction in human cancers.
    Cancer cell, 2008, Volume: 13, Issue:1

    Topics: Animals; beta-Transducin Repeat-Containing Proteins; cdc25 Phosphatases; Cell Cycle; Cell Line, Tumo

2008
Polymerized collagen inhibits fibroblast proliferation via a mechanism involving the formation of a beta1 integrin-protein phosphatase 2A-tuberous sclerosis complex 2 complex that suppresses S6K1 activity.
    The Journal of biological chemistry, 2008, Jul-18, Volume: 283, Issue:29

    Topics: Cell Adhesion; Cell Line; Cell Proliferation; Collagen; Enzyme Activation; Fibroblasts; Humans; Inte

2008
Cellular signalling as a target in cancer chemotherapy. Phospholipid analogues as inhibitors of mitogenic signal transduction.
    Advances in enzyme regulation, 1996, Volume: 36

    Topics: Antineoplastic Agents; Calcium; Enzyme Inhibitors; Inositol 1,4,5-Trisphosphate; Molecular Structure

1996
Cell cycle. Piecing together the p53 puzzle.
    Science (New York, N.Y.), 2000, Mar-10, Volume: 287, Issue:5459

    Topics: Animals; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Checkpoint Kinase 2; DNA Damag

2000
Difference in the centrosome duplication regulatory activity among p53 'hot spot' mutants: potential role of Ser 315 phosphorylation-dependent centrosome binding of p53.
    Oncogene, 2001, Oct-18, Volume: 20, Issue:47

    Topics: Aneuploidy; Animals; Cell Line; Centrosome; Cyclin-Dependent Kinases; Gene Deletion; Mice; Mutation;

2001
Crystal structure of a phosphorylated Smad2. Recognition of phosphoserine by the MH2 domain and insights on Smad function in TGF-beta signaling.
    Molecular cell, 2001, Volume: 8, Issue:6

    Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Binding Sites; Crystallography, X-Ray; DNA-Binding

2001