phosphoserine has been researched along with Idiopathic Parkinson Disease in 15 studies
Phosphoserine: The phosphoric acid ester of serine.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In contrast to Parkinson's disease (PD) where the pathological α-syn aggregates are almost exclusively neuronal, the α-syn inclusions in MSA are principally observed in oligodendrocytes (OLs) where they form glial cytoplasmic inclusions (GCIs)." | 1.56 | Overexpression of α-Synuclein by Oligodendrocytes in Transgenic Mice Does Not Recapitulate the Fibrillar Aggregation Seen in Multiple System Atrophy. ( Bezard, E; De Giorgi, F; Doudnikoff, E; Faggiani, E; He, X; Ichas, F; Laferrière, F; Meissner, WG; Zinghirino, F, 2020) |
| "Alpha-synuclein (aSyn) is implicated in Parkinson's disease and several other neurodegenerative disorders." | 1.39 | Assessing the subcellular dynamics of alpha-synuclein using photoactivation microscopy. ( Gonçalves, S; Outeiro, TF, 2013) |
| "It is thought that Parkinson's disease involves apoptosis, and NGF prevents apoptosis in an in vivo model system." | 1.31 | Nerve growth factor prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced cell death via the Akt pathway by suppressing caspase-3-like activity using PC12 cells: relevance to therapeutical application for Parkinson's disease. ( Chiba, H; Shimoke, K, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 8 (53.33) | 24.3611 |
| 2020's | 4 (26.67) | 2.80 |
| Authors | Studies |
|---|---|
| Kumari, R | 1 |
| Kumar, R | 1 |
| Kumar, S | 1 |
| Singh, AK | 1 |
| Hanpude, P | 1 |
| Jangir, D | 1 |
| Maiti, TK | 1 |
| Hong, CT | 1 |
| Chen, KY | 1 |
| Wang, W | 1 |
| Chiu, JY | 1 |
| Wu, D | 1 |
| Chao, TY | 1 |
| Hu, CJ | 1 |
| Chau, KD | 1 |
| Bamodu, OA | 1 |
| Laferrière, F | 1 |
| He, X | 1 |
| Zinghirino, F | 1 |
| Doudnikoff, E | 1 |
| Faggiani, E | 1 |
| Meissner, WG | 1 |
| Bezard, E | 1 |
| De Giorgi, F | 1 |
| Ichas, F | 1 |
| Zhang, S | 2 |
| Liu, YQ | 1 |
| Jia, C | 1 |
| Lim, YJ | 1 |
| Feng, G | 1 |
| Xu, E | 1 |
| Long, H | 1 |
| Kimura, Y | 2 |
| Tao, Y | 1 |
| Zhao, C | 1 |
| Wang, C | 1 |
| Liu, Z | 2 |
| Hu, JJ | 1 |
| Ma, MR | 1 |
| Jiang, L | 1 |
| Li, D | 1 |
| Wang, R | 1 |
| Dawson, VL | 1 |
| Dawson, TM | 1 |
| Li, YM | 1 |
| Mao, X | 1 |
| Liu, C | 1 |
| Chen, J | 1 |
| Ren, Y | 1 |
| Gui, C | 1 |
| Zhao, M | 1 |
| Wu, X | 1 |
| Mao, K | 1 |
| Li, W | 1 |
| Zou, F | 1 |
| Koyano, F | 1 |
| Okatsu, K | 1 |
| Kosako, H | 1 |
| Tamura, Y | 1 |
| Go, E | 1 |
| Kimura, M | 1 |
| Tsuchiya, H | 1 |
| Yoshihara, H | 1 |
| Hirokawa, T | 1 |
| Endo, T | 1 |
| Fon, EA | 1 |
| Trempe, JF | 1 |
| Saeki, Y | 1 |
| Tanaka, K | 1 |
| Matsuda, N | 1 |
| Landeck, N | 1 |
| Hall, H | 1 |
| Ardah, MT | 1 |
| Majbour, NK | 1 |
| El-Agnaf, OM | 1 |
| Halliday, G | 1 |
| Kirik, D | 1 |
| Covy, JP | 1 |
| Yuan, W | 1 |
| Waxman, EA | 1 |
| Hurtig, HI | 1 |
| Van Deerlin, VM | 1 |
| Giasson, BI | 1 |
| Austin, PJ | 1 |
| Betts, MJ | 1 |
| Broadstock, M | 1 |
| O'Neill, MJ | 1 |
| Mitchell, SN | 1 |
| Duty, S | 1 |
| Li, X | 2 |
| Wang, QJ | 1 |
| Pan, N | 1 |
| Lee, S | 1 |
| Zhao, Y | 1 |
| Chait, BT | 1 |
| Yue, Z | 2 |
| Kondapalli, C | 1 |
| Kazlauskaite, A | 1 |
| Zhang, N | 1 |
| Woodroof, HI | 1 |
| Campbell, DG | 1 |
| Gourlay, R | 1 |
| Burchell, L | 1 |
| Walden, H | 1 |
| Macartney, TJ | 1 |
| Deak, M | 1 |
| Knebel, A | 1 |
| Alessi, DR | 1 |
| Muqit, MM | 1 |
| Sheng, Z | 1 |
| Bustos, D | 1 |
| Kleinheinz, T | 1 |
| Le Pichon, CE | 1 |
| Dominguez, SL | 1 |
| Solanoy, HO | 1 |
| Drummond, J | 1 |
| Zhang, X | 1 |
| Ding, X | 1 |
| Cai, F | 1 |
| Song, Q | 1 |
| van der Brug, MP | 1 |
| Burdick, DJ | 1 |
| Gunzner-Toste, J | 1 |
| Chen, H | 1 |
| Liu, X | 1 |
| Estrada, AA | 1 |
| Sweeney, ZK | 1 |
| Scearce-Levie, K | 1 |
| Moffat, JG | 1 |
| Kirkpatrick, DS | 1 |
| Zhu, H | 1 |
| Gonçalves, S | 1 |
| Outeiro, TF | 1 |
| Vogelsberg-Ragaglia, V | 1 |
| Bruce, J | 1 |
| Richter-Landsberg, C | 1 |
| Zhang, B | 1 |
| Hong, M | 1 |
| Trojanowski, JQ | 1 |
| Lee, VM | 1 |
| Shimoke, K | 1 |
| Chiba, H | 1 |
15 other studies available for phosphoserine and Idiopathic Parkinson Disease
| Article | Year |
|---|---|
Amyloid aggregates of the deubiquitinase OTUB1 are neurotoxic, suggesting that they contribute to the development of Parkinson's disease.
Topics: Actin Cytoskeleton; alpha-Synuclein; Amyloid; Animals; Apoptosis; Cell Death; Cell Line, Tumor; Comp | 2020 |
Insulin Resistance Promotes Parkinson's Disease through Aberrant Expression of α-Synuclein, Mitochondrial Dysfunction, and Deregulation of the Polo-Like Kinase 2 Signaling.
Topics: alpha-Synuclein; Animals; Diabetes Mellitus, Type 2; Disease Progression; Dopaminergic Neurons; Geno | 2020 |
Overexpression of α-Synuclein by Oligodendrocytes in Transgenic Mice Does Not Recapitulate the Fibrillar Aggregation Seen in Multiple System Atrophy.
Topics: alpha-Synuclein; Amyloid; Animals; Brain; Cells, Cultured; Humans; Mice, Inbred C57BL; Mice, Transge | 2020 |
Mechanistic basis for receptor-mediated pathological α-synuclein fibril cell-to-cell transmission in Parkinson's disease.
Topics: alpha-Synuclein; Amyloid; Amyloid beta-Protein Precursor; Animals; Antigens, CD; Cell Line, Tumor; E | 2021 |
Phosphorylation of Parkin at serine 131 by p38 MAPK promotes mitochondrial dysfunction and neuronal death in mutant A53T α-synuclein model of Parkinson's disease.
Topics: alpha-Synuclein; Animals; Apoptosis; Cell Line; Disease Models, Animal; Dopaminergic Neurons; Enzyme | 2018 |
Ubiquitin is phosphorylated by PINK1 to activate parkin.
Topics: Animals; Enzyme Activation; Fibroblasts; HeLa Cells; Humans; Membrane Potential, Mitochondrial; Mice | 2014 |
A novel multiplex assay for simultaneous quantification of total and S129 phosphorylated human alpha-synuclein.
Topics: alpha-Synuclein; Animals; Biological Assay; Brain; Disease Progression; HEK293 Cells; Humans; Lewy B | 2016 |
Clinical and pathological characteristics of patients with leucine-rich repeat kinase-2 mutations.
Topics: Aged; alpha-Synuclein; Amino Acid Sequence; Cohort Studies; DNA Mutational Analysis; Female; Genes, | 2009 |
Symptomatic and neuroprotective effects following activation of nigral group III metabotropic glutamate receptors in rodent models of Parkinson's disease.
Topics: Aminobutyrates; Animals; Aspartic Acid; Disease Models, Animal; Excitatory Amino Acid Agonists; Glut | 2010 |
Phosphorylation-dependent 14-3-3 binding to LRRK2 is impaired by common mutations of familial Parkinson's disease.
Topics: 14-3-3 Proteins; Amino Acid Substitution; Animals; Brain; Cells, Cultured; Cyclic AMP-Dependent Prot | 2011 |
PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65.
Topics: Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Enzyme Activation; HEK293 Cells; Humans; Insect | 2012 |
Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations.
Topics: Animals; Binding Sites; Brain; Guanosine Triphosphate; HEK293 Cells; Humans; Leucine-Rich Repeat Ser | 2012 |
Assessing the subcellular dynamics of alpha-synuclein using photoactivation microscopy.
Topics: alpha-Synuclein; Cell Nucleus; Cell Survival; G-Protein-Coupled Receptor Kinase 5; Green Fluorescent | 2013 |
Distinct FTDP-17 missense mutations in tau produce tau aggregates and other pathological phenotypes in transfected CHO cells.
Topics: Animals; CHO Cells; Cricetinae; Dementia; Electrophoresis, Polyacrylamide Gel; Fluorescent Antibody | 2000 |
Nerve growth factor prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced cell death via the Akt pathway by suppressing caspase-3-like activity using PC12 cells: relevance to therapeutical application for Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amino Acid Chloromethyl Ketones; Amino Acid Substituti | 2001 |