phosphoserine has been researched along with Hemophilia A in 4 studies
Phosphoserine: The phosphoric acid ester of serine.
Hemophilia A: The classic hemophilia resulting from a deficiency of factor VIII. It is an inherited disorder of blood coagulation characterized by a permanent tendency to hemorrhage.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hemophilia A is a bleeding disorder caused by the deficiency of an important coagulation factor; Factor VIII (FVIII)." | 1.42 | Intravenous administration of Factor VIII-O-Phospho-L-Serine (OPLS) complex reduces immunogenicity and preserves pharmacokinetics of the therapeutic protein. ( Balu-Iyer, SV; Gaitonde, P; Purohit, VS, 2015) |
| "However, approximately 30% of Hemophilia A patients develop neutralizing antibodies (Nabs) against the recombinant protein." | 1.42 | Intravenous administration of Factor VIII-O-Phospho-L-Serine (OPLS) complex reduces immunogenicity and preserves pharmacokinetics of the therapeutic protein. ( Balu-Iyer, SV; Gaitonde, P; Purohit, VS, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fathallah, AM | 1 |
| Ramakrishnan, R | 1 |
| Balu-Iyer, SV | 3 |
| Gaitonde, P | 1 |
| Purohit, VS | 3 |
| Ramani, K | 1 |
| Sarkar, R | 1 |
| Kazazian, HH | 1 |
| Balasubramanian, SV | 1 |
| Miclea, RD | 1 |
4 other studies available for phosphoserine and Hemophilia A
| Article | Year |
|---|---|
O-phospho-l-serine mediates hyporesponsiveness toward FVIII in hemophilia A-murine model by inducing tolerogenic properties in dendritic cells.
Topics: Adjuvants, Immunologic; Animals; Antibodies; CD40 Antigens; Cells, Cultured; Coagulants; Dendritic C | 2014 |
Intravenous administration of Factor VIII-O-Phospho-L-Serine (OPLS) complex reduces immunogenicity and preserves pharmacokinetics of the therapeutic protein.
Topics: Administration, Intravenous; Animals; Area Under Curve; Factor VIII; Half-Life; Hemophilia A; Male; | 2015 |
Lower inhibitor development in hemophilia A mice following administration of recombinant factor VIII-O-phospho-L-serine complex.
Topics: Animals; Factor VIII; Female; Hemophilia A; Humans; Isoantibodies; Male; Mice; Mice, Inbred C57BL; M | 2005 |
O-phospho-L-serine, multi-functional excipient for B domain deleted recombinant factor VIII.
Topics: Animals; Antibodies, Monoclonal; Binding Sites; Coagulants; Disease Models, Animal; Drug Stability; | 2007 |