Page last updated: 2024-10-15

phosphoserine and Breast Cancer

phosphoserine has been researched along with Breast Cancer in 54 studies

Phosphoserine: The phosphoric acid ester of serine.

Research Excerpts

ExcerptRelevanceReference
"Tamoxifen is a standard endocrine therapy for estrogen receptor positive breast cancer patients."7.85Pharmacological inhibition of Rac1-PAK1 axis restores tamoxifen sensitivity in human resistant breast cancer cells. ( Alonso, DF; Cardama, GA; Comin, MJ; Gomez, DE; Gonzalez, N; Menna, PL; Pifano, M; Segatori, VI, 2017)
"Tamoxifen is a standard endocrine therapy for estrogen receptor positive breast cancer patients."5.46Pharmacological inhibition of Rac1-PAK1 axis restores tamoxifen sensitivity in human resistant breast cancer cells. ( Alonso, DF; Cardama, GA; Comin, MJ; Gomez, DE; Gonzalez, N; Menna, PL; Pifano, M; Segatori, VI, 2017)
"Here, we report the development of the breast cancer cell model MCF7::C1199 having Rac1 enhanced activity with the aim of evaluating the role of Rac1 in acquired endocrine resistance."5.46Pharmacological inhibition of Rac1-PAK1 axis restores tamoxifen sensitivity in human resistant breast cancer cells. ( Alonso, DF; Cardama, GA; Comin, MJ; Gomez, DE; Gonzalez, N; Menna, PL; Pifano, M; Segatori, VI, 2017)
"Herein, using the T47D breast cancer model, we probed mechanisms of cell cycle-dependent PR action."5.40Progesterone receptor-cyclin D1 complexes induce cell cycle-dependent transcriptional programs in breast cancer cells. ( Daniel, AR; Diep, CH; Dressing, GE; Hagan, CR; Knudsen, KE; Knutson, TP; Lange, CA; Schiewer, MJ, 2014)
"Analysis of 65 ErbB2-expressing primary breast cancers reveals a highly significant relationship between Ser1113 phosphorylation and EGFR overexpression (p < 0."5.31Association of ErbB2 Ser1113 phosphorylation with epidermal growth factor receptor co-expression and poor prognosis in human breast cancer. ( Epstein, RJ; Gulliford, T; Huang, G; Ouyang, X; Smith, G; Zhang, H, 2001)
" In this report, we show that cervical cancer HeLa cells and breast cancer MDA MB 231 cells with reduced GRK5 expression display increased sensitivity to the apoptotic effects of paclitaxel (Taxol)."3.91G protein-coupled receptor kinase 5 modifies cancer cell resistance to paclitaxel. ( Alp, D; Benovic, JL; Jacinto, AZ; Lagman, J; Lee, CS; Peng, N; Sayegh, P; So, CH; Sok, V; Sulon, SM, 2019)
"Tamoxifen is a standard endocrine therapy for estrogen receptor positive breast cancer patients."3.85Pharmacological inhibition of Rac1-PAK1 axis restores tamoxifen sensitivity in human resistant breast cancer cells. ( Alonso, DF; Cardama, GA; Comin, MJ; Gomez, DE; Gonzalez, N; Menna, PL; Pifano, M; Segatori, VI, 2017)
"These findings may explain in part the aneuploidy observed in BRCA2-mutated tumors."1.56Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1. ( Beaurepere, R; Boucherit, V; Carreira, A; Duchambon, P; Ehlén, Å; El Marjou, A; Julien, M; Martin, C; Miron, S; Ropars, V; Sessa, G; Theillet, FX; Zinn-Justin, S, 2020)
"Cancer metastasis accounts for the major cause of cancer-related deaths."1.56Phosphorylation of PDHA by AMPK Drives TCA Cycle to Promote Cancer Metastasis. ( Cai, Z; Chilton, FH; D'Agostino, RB; Furdui, CM; Han, F; Hsu, CC; Hsu, FC; Huang, CY; Jin, G; Kucera, GL; Li, CF; Lin, HK; Liu, C; Pan, BS; Parks, JS; Pasche, B; Peng, D; Rezaeian, AH; Tsai, FJ; Wang, CY; Wang, G; Wang, YH; Watabe, K; Wu, SY; Yang, SC; Zhang, A; Zhang, W; Zhang, X, 2020)
"Approximately 70% of breast cancer cells express oestrogen receptor alpha (ERα)."1.46A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells. ( Bando, Y; Chen, YA; Honda, J; Imoto, I; Izumi, K; Katagiri, T; Komatsu, M; Miyoshi, Y; Mizuguchi, K; Ono, M; Sasa, M; Shima, H; Yoshimaru, T, 2017)
"Tamoxifen is a standard endocrine therapy for estrogen receptor positive breast cancer patients."1.46Pharmacological inhibition of Rac1-PAK1 axis restores tamoxifen sensitivity in human resistant breast cancer cells. ( Alonso, DF; Cardama, GA; Comin, MJ; Gomez, DE; Gonzalez, N; Menna, PL; Pifano, M; Segatori, VI, 2017)
"Here, we report the development of the breast cancer cell model MCF7::C1199 having Rac1 enhanced activity with the aim of evaluating the role of Rac1 in acquired endocrine resistance."1.46Pharmacological inhibition of Rac1-PAK1 axis restores tamoxifen sensitivity in human resistant breast cancer cells. ( Alonso, DF; Cardama, GA; Comin, MJ; Gomez, DE; Gonzalez, N; Menna, PL; Pifano, M; Segatori, VI, 2017)
"The inhibitory effects of PP4c on breast cancer cell survival and growth were lost in PEA15 knockdown cells, confirming that PP4c action is mediated, at least in part, through the de-phosphorylation of apoptosis regulator PEA15."1.43The protein phosphatase 4 - PEA15 axis regulates the survival of breast cancer cells. ( Mohammed, HN; Mourtada-Maarabouni, M; Pickard, MR, 2016)
"Our work shows that PP4 regulates breast cancer cell survival and identifies a novel PP4c-PEA15 signalling axis in the control of breast cancer cell survival."1.43The protein phosphatase 4 - PEA15 axis regulates the survival of breast cancer cells. ( Mohammed, HN; Mourtada-Maarabouni, M; Pickard, MR, 2016)
"Herein, using the T47D breast cancer model, we probed mechanisms of cell cycle-dependent PR action."1.40Progesterone receptor-cyclin D1 complexes induce cell cycle-dependent transcriptional programs in breast cancer cells. ( Daniel, AR; Diep, CH; Dressing, GE; Hagan, CR; Knudsen, KE; Knutson, TP; Lange, CA; Schiewer, MJ, 2014)
"Here, we have used human breast cancer T47D cells stably overexpressing PAK1 wild type or PAK1 Y3F mutant in which Tyr(s) 153, 201, and 285 were mutated to phenylalanines to demonstrate that phosphorylation of these three tyrosines are required for maximal PRL-dependent ruffling."1.39Tyrosyl phosphorylated PAK1 regulates breast cancer cell motility in response to prolactin through filamin A. ( Cook, L; Diakonova, M; Hammer, A; Li, Q; Mattingly, RR; Oladimeji, P; Rider, L, 2013)
"We therefore examined Axin1 in breast cancer and report decreased AXIN1 expression and a shift in the ratio of expression of two naturally occurring AXIN1 splice variants."1.38Mechanistic insight into Myc stabilization in breast cancer involving aberrant Axin1 expression. ( Arnold, H; Chen, D; Daniel, CJ; Farrell, AS; Janghorban, M; Laraway, BJ; Lum, L; Scanlan, C; Sears, R; Troxell, M; Zhang, X, 2012)
"In tamoxifen-resistant breast cancer cells, BG alone or in combination with antiestrogen (tamoxifen [TAM]/ICI 182,780 [fulvestrant, Faslodex]) therapy enhances p53 upregulated modulator of apoptosis (PUMA) expression, cytochrome C release and poly (ADP-ribose) polymerase (PARP) cleavage, all indicative of apoptosis."1.38MGMT inhibition restores ERα functional sensitivity to antiestrogen therapy. ( Baidas, S; Baker, CH; Bobustuc, GC; Caparas, ML; Constantino, SM; Isley, B; Jeudy, S; Konduri, SD; Limaye, A; Maddipatla, S; Shah, N; Smith, JS; Srivenugopal, KS, 2012)
"Co-treatment of etoposide and KG-135 markedly elevated the expression and phosphorylation at the serine 15 residue of p53 as well as the cellular levels of Bax and p21(Waf1/Cip1)."1.36Potentiation of etoposide-induced apoptosis in HeLa cells by co-treatment with KG-135, a quality-controlled standardized ginsenoside formulation. ( Cho, SJ; Choi, JS; Kim, HY; Lee, SK; Lee, WH; Park, BD; Park, JH; Surh, YJ, 2010)
"Importantly, Parvin-beta suppressed breast cancer growth in vivo, with associated decreased proliferation."1.35Parvin-beta inhibits breast cancer tumorigenicity and promotes CDK9-mediated peroxisome proliferator-activated receptor gamma 1 phosphorylation. ( Bowser, MJ; Delemos, AS; Hannigan, GE; Johnstone, CN; Liu, Y; Mongroo, PS; Rich, AS; Rustgi, AK; Schupp, M; Tobias, JW, 2008)
"Taken together, treatment of breast cancer cells that overexpress HER2 with the anti-HER2 antibody trastuzumab inhibits CDK2, Rb phosphorylation, E2F activity, NPAT, and histone H4 via PI3K signaling that are needed for both DNA and histone synthesis during progression from G(1) phase to S phase of the cell cycle."1.33Anti-HER2 antibody trastuzumab inhibits CDK2-mediated NPAT and histone H4 expression via the PI3K pathway. ( Bast, RC; Bedrosian, I; Keyomarsi, K; Le, XF; Lee, MH; Lu, Z; Mao, W; Murray, M; Zhao, J, 2006)
"Analysis of 65 ErbB2-expressing primary breast cancers reveals a highly significant relationship between Ser1113 phosphorylation and EGFR overexpression (p < 0."1.31Association of ErbB2 Ser1113 phosphorylation with epidermal growth factor receptor co-expression and poor prognosis in human breast cancer. ( Epstein, RJ; Gulliford, T; Huang, G; Ouyang, X; Smith, G; Zhang, H, 2001)
"Casein kinase II was found to phosphorylate the purified recombinant hER on serine 167 in vitro."1.29Serine 167 is the major estradiol-induced phosphorylation site on the human estrogen receptor. ( Arnold, SF; Jaffe, H; Notides, AC; Obourn, JD, 1994)

Research

Studies (54)

TimeframeStudies, this research(%)All Research%
pre-19901 (1.85)18.7374
1990's5 (9.26)18.2507
2000's18 (33.33)29.6817
2010's23 (42.59)24.3611
2020's7 (12.96)2.80

Authors

AuthorsStudies
Zhu, H1
Su, Z1
Ning, J1
Zhou, L1
Tan, L1
Sayed, S1
Song, J1
Wang, Z1
Li, H1
Sun, Q1
Liu, S1
Sha, O1
Leng, F1
Chen, X1
Lu, D1
Oviya, RP1
Thangaretnam, KP1
Ramachandran, B1
Ramanathan, P1
Jayavelu, S1
Gopal, G1
Rajkumar, T1
Ehlén, Å1
Martin, C1
Miron, S1
Julien, M1
Theillet, FX1
Ropars, V1
Sessa, G1
Beaurepere, R1
Boucherit, V1
Duchambon, P1
El Marjou, A1
Zinn-Justin, S1
Carreira, A1
Chen, K1
Jiao, X1
Di Rocco, A1
Shen, D1
Xu, S1
Ertel, A1
Yu, Z1
Di Sante, G1
Wang, M1
Li, Z1
Pestell, TG1
Casimiro, MC1
Skordalakes, E1
Achilefu, S1
Pestell, RG1
Kim, JJ1
Lee, SY1
Choi, JH1
Woo, HG1
Xhemalce, B1
Miller, KM1
Dimri, S1
Malhotra, R1
Shet, T1
Mokal, S1
Gupta, S1
De, A1
Cai, Z1
Li, CF1
Han, F1
Liu, C1
Zhang, A1
Hsu, CC1
Peng, D1
Zhang, X2
Jin, G1
Rezaeian, AH1
Wang, G1
Zhang, W1
Pan, BS1
Wang, CY1
Wang, YH1
Wu, SY1
Yang, SC1
Hsu, FC1
D'Agostino, RB1
Furdui, CM1
Kucera, GL1
Parks, JS1
Chilton, FH1
Huang, CY1
Tsai, FJ1
Pasche, B1
Watabe, K1
Lin, HK1
Yoshimaru, T1
Ono, M1
Bando, Y1
Chen, YA1
Mizuguchi, K1
Shima, H1
Komatsu, M1
Imoto, I1
Izumi, K1
Honda, J1
Miyoshi, Y1
Sasa, M1
Katagiri, T1
Lagman, J1
Sayegh, P1
Lee, CS1
Sulon, SM1
Jacinto, AZ1
Sok, V1
Peng, N1
Alp, D1
Benovic, JL1
So, CH1
Liu, RM1
Tian, XY1
Huang, XT1
Zhou, H1
Wei, C1
Cao, Y2
Yang, X1
Zheng, Z1
Guan, K1
Wang, Q2
Tai, Y1
Zhang, Y1
Ma, S1
Ge, X1
Xu, C1
Li, J1
Yan, H1
Ling, Y1
Song, T1
Zhu, L1
Zhang, B1
Xu, Q1
Hu, C1
Bian, XW1
He, X1
Zhong, H1
Dressing, GE1
Knutson, TP1
Schiewer, MJ1
Daniel, AR1
Hagan, CR1
Diep, CH1
Knudsen, KE1
Lange, CA2
Li, D1
Yallowitz, A1
Ozog, L1
Marchenko, N1
Lee, MS1
Kim, S1
Kim, BG1
Won, C1
Nam, SH1
Kang, S1
Kim, HJ1
Kang, M1
Ryu, J1
Song, HE1
Lee, D1
Ye, SK1
Jeon, NL1
Kim, TY1
Cho, NH1
Lee, JW1
Abdel-Fatah, TM1
Middleton, FK1
Arora, A1
Agarwal, D1
Chen, T1
Moseley, PM1
Perry, C1
Doherty, R1
Chan, S1
Green, AR1
Rakha, E1
Ball, G1
Ellis, IO1
Curtin, NJ1
Madhusudan, S1
Hicks, MJ1
Hu, Q1
Macrae, E1
DeWille, J1
Sau, A1
Lau, R1
Cabrita, MA1
Nolan, E1
Crooks, PA1
Visvader, JE1
Pratt, MA1
Mohammed, HN1
Pickard, MR1
Mourtada-Maarabouni, M1
Bhattacharya, R1
Mukherjee, N1
Dasgupta, H1
Islam, MS1
Alam, N1
Roy, A1
Das, P1
Roychoudhury, S1
Panda, CK1
Gonzalez, N1
Cardama, GA1
Comin, MJ1
Segatori, VI1
Pifano, M1
Alonso, DF1
Gomez, DE1
Menna, PL1
Vanneste, M1
Hanoux, V1
Bouakka, M1
Bonnamy, PJ1
Neubauer, H1
Clare, SE1
Wozny, W1
Schwall, GP1
Poznanovic, S1
Stegmann, W1
Vogel, U1
Sotlar, K1
Wallwiener, D1
Kurek, R1
Fehm, T1
Cahill, MA1
Li, C1
Liang, YY1
Feng, XH1
Tsai, SY1
Tsai, MJ1
O'Malley, BW1
Hong, X1
Liu, Y2
Hu, G1
Zhao, D1
Shen, J1
Shen, F1
Cao, X1
Law, M1
Corsino, P1
Parker, NT1
Law, BK1
Lee, WH1
Choi, JS1
Kim, HY1
Park, JH1
Park, BD1
Cho, SJ1
Lee, SK1
Surh, YJ1
Andersen, JN1
Sathyanarayanan, S1
Di Bacco, A1
Chi, A1
Zhang, T1
Chen, AH1
Dolinski, B1
Kraus, M1
Roberts, B1
Arthur, W1
Klinghoffer, RA1
Gargano, D1
Li, L1
Feldman, I1
Lynch, B1
Rush, J1
Hendrickson, RC1
Blume-Jensen, P1
Paweletz, CP1
Woolley, AG1
Algie, M1
Samuel, W1
Harfoot, R1
Wiles, A1
Hung, NA1
Tan, PH1
Hains, P1
Valova, VA1
Huschtscha, L1
Royds, JA1
Perez, D1
Yoon, HS1
Cohen, SB1
Robinson, PJ1
Bay, BH1
Lasham, A1
Braithwaite, AW1
Farrell, AS1
Daniel, CJ1
Arnold, H1
Scanlan, C1
Laraway, BJ1
Janghorban, M1
Lum, L1
Chen, D1
Troxell, M1
Sears, R1
Khan, JA1
Amazit, L1
Bellance, C1
Guiochon-Mantel, A1
Lombès, M1
Loosfelt, H1
Bobustuc, GC1
Smith, JS1
Maddipatla, S1
Jeudy, S1
Limaye, A1
Isley, B1
Caparas, ML1
Constantino, SM1
Shah, N1
Baker, CH1
Srivenugopal, KS1
Baidas, S1
Konduri, SD1
Mao, L1
Dauchy, RT1
Blask, DE1
Slakey, LM1
Xiang, S1
Yuan, L1
Dauchy, EM1
Shan, B1
Brainard, GC1
Hanifin, JP1
Frasch, T1
Duplessis, TT1
Hill, SM1
Hammer, A1
Rider, L1
Oladimeji, P1
Cook, L1
Li, Q1
Mattingly, RR1
Diakonova, M1
Hofseth, LJ1
Saito, S1
Hussain, SP1
Espey, MG1
Miranda, KM1
Araki, Y1
Jhappan, C1
Higashimoto, Y1
He, P1
Linke, SP1
Quezado, MM1
Zurer, I1
Rotter, V1
Wink, DA1
Appella, E1
Harris, CC1
Shen, WH1
Yin, Y1
Broussard, SR1
McCusker, RH1
Freund, GG1
Dantzer, R1
Kelley, KW1
Murphy, L1
Cherlet, T1
Adeyinka, A1
Niu, Y1
Snell, L1
Watson, P1
Wesierska-Gadek, J1
Gueorguieva, M1
Horky, M1
Gburcik, V1
Bot, N1
Maggiolini, M1
Picard, D1
Yamashita, H1
Nishio, M1
Kobayashi, S1
Ando, Y1
Sugiura, H1
Zhang, Z1
Hamaguchi, M1
Mita, K1
Fujii, Y1
Iwase, H1
Le, XF1
Bedrosian, I1
Mao, W1
Murray, M1
Lu, Z1
Keyomarsi, K1
Lee, MH1
Zhao, J1
Bast, RC1
Sarwar, N1
Kim, JS1
Jiang, J1
Peston, D1
Sinnett, HD1
Madden, P1
Gee, JM1
Nicholson, RI1
Lykkesfeldt, AE1
Shousha, S1
Coombes, RC1
Ali, S1
Rodrik, V1
Gomes, E1
Hui, L1
Rockwell, P1
Foster, DA1
Sekine, Y1
Ikeda, O1
Hayakawa, Y1
Tsuji, S1
Imoto, S1
Aoki, N1
Sugiyama, K1
Matsuda, T1
Johnstone, CN1
Mongroo, PS1
Rich, AS1
Schupp, M1
Bowser, MJ1
Delemos, AS1
Tobias, JW1
Hannigan, GE1
Rustgi, AK1
Arnold, SF1
Obourn, JD1
Jaffe, H1
Notides, AC1
Geier, A1
Hemi, R1
Haimsohn, M1
Beery, R1
Karasik, A1
Craig, AL2
Burch, L1
Vojtesek, B1
Mikutowska, J1
Thompson, A1
Hupp, TR2
Blaydes, JP1
Burch, LR1
Thompson, AM1
Shen, T1
Horwitz, KB1
Ouyang, X1
Gulliford, T1
Zhang, H1
Smith, G1
Huang, G1
Epstein, RJ1
Clark, DE1
Poteet-Smith, CE1
Smith, JA1
Lannigan, DA1
Métivier, R1
Gay, FA1
Hübner, MR1
Flouriot, G1
Salbert, G1
Gannon, F1
Kah, O1
Pakdel, F1
Lin, YZ1
Li, SW1
Clinton, GM1
Schütze, S1
Scheurich, P1
Pfizenmaier, K1
Krönke, M1

Other Studies

54 other studies available for phosphoserine and Breast Cancer

ArticleYear
Transmembrane protein 97 exhibits oncogenic properties via enhancing LRP6-mediated Wnt signaling in breast cancer.
    Cell death & disease, 2021, 10-06, Volume: 12, Issue:10

    Topics: Animals; beta Catenin; Breast Neoplasms; Casein Kinase I; Cell Line, Tumor; Cell Movement; Cell Prol

2021
Mitochondrial ribosomal small subunit (MRPS) MRPS23 protein-protein interaction reveals phosphorylation by CDK11-p58 affecting cell proliferation and knockdown of MRPS23 sensitizes breast cancer cells to CDK1 inhibitors.
    Molecular biology reports, 2022, Volume: 49, Issue:10

    Topics: Apoptosis; Apoptosis Regulatory Proteins; Breast Neoplasms; CDC2 Protein Kinase; Cell Line, Tumor; C

2022
Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1.
    Nature communications, 2020, 04-14, Volume: 11, Issue:1

    Topics: Aneuploidy; BRCA2 Protein; Breast Neoplasms; Cell Cycle Proteins; Chromosome Segregation; Chromosome

2020
Endogenous Cyclin D1 Promotes the Rate of Onset and Magnitude of Mitogenic Signaling via Akt1 Ser473 Phosphorylation.
    Cell reports, 2020, 09-15, Volume: 32, Issue:11

    Topics: 3T3 Cells; Animals; Breast Neoplasms; Cell Membrane; Cyclin D1; Cyclin-Dependent Kinases; Female; Ge

2020
PCAF-Mediated Histone Acetylation Promotes Replication Fork Degradation by MRE11 and EXO1 in BRCA-Deficient Cells.
    Molecular cell, 2020, 10-15, Volume: 80, Issue:2

    Topics: Acetylation; Amino Acid Sequence; Ataxia Telangiectasia Mutated Proteins; BRCA1 Protein; BRCA2 Prote

2020
Noncanonical pS727 post translational modification dictates major STAT3 activation and downstream functions in breast cancer.
    Experimental cell research, 2020, 11-15, Volume: 396, Issue:2

    Topics: Animals; Anthelmintics; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Humans; Mice

2020
Phosphorylation of PDHA by AMPK Drives TCA Cycle to Promote Cancer Metastasis.
    Molecular cell, 2020, 10-15, Volume: 80, Issue:2

    Topics: AMP-Activated Protein Kinases; Animals; Breast Neoplasms; Catalytic Domain; Cell Line, Tumor; Cell S

2020
A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells.
    Nature communications, 2017, 05-30, Volume: 8

    Topics: A Kinase Anchor Proteins; Amino Acid Sequence; Breast Neoplasms; Cell Line, Tumor; Cyclic AMP-Depend

2017
G protein-coupled receptor kinase 5 modifies cancer cell resistance to paclitaxel.
    Molecular and cellular biochemistry, 2019, Volume: 461, Issue:1-2

    Topics: Acetylation; Apoptosis; Biocatalysis; Breast Neoplasms; Docetaxel; Drug Resistance, Neoplasm; Female

2019
Transfer of Ser7 phosphorylated CENP-A from centromere to midbody during mitosis in MCF-7 cells.
    Folia biologica, 2013, Volume: 59, Issue:3

    Topics: Adenocarcinoma; Autoantigens; Biological Transport; Breast Neoplasms; Centromere; Centromere Protein

2013
Elevated expression of TANK-binding kinase 1 enhances tamoxifen resistance in breast cancer.
    Proceedings of the National Academy of Sciences of the United States of America, 2014, Feb-04, Volume: 111, Issue:5

    Topics: Breast Neoplasms; Cell Line, Tumor; Cyclin D1; Drug Resistance, Neoplasm; Estrogen Receptor alpha; F

2014
Progesterone receptor-cyclin D1 complexes induce cell cycle-dependent transcriptional programs in breast cancer cells.
    Molecular endocrinology (Baltimore, Md.), 2014, Volume: 28, Issue:4

    Topics: Animals; Breast Neoplasms; Cell Cycle; Cell Extracts; Cell Line, Tumor; Chlorocebus aethiops; COS Ce

2014
A gain-of-function mutant p53-HSF1 feed forward circuit governs adaptation of cancer cells to proteotoxic stress.
    Cell death & disease, 2014, Apr-24, Volume: 5

    Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Nucleus; DNA-Binding Proteins; ErbB Receptors; Fem

2014
Snail1 induced in breast cancer cells in 3D collagen I gel environment suppresses cortactin and impairs effective invadopodia formation.
    Biochimica et biophysica acta, 2014, Volume: 1843, Issue:9

    Topics: Actins; Animals; Breast Neoplasms; Cattle; Cell Line, Tumor; Cell Membrane; Cell Movement; Cell Nucl

2014
Untangling the ATR-CHEK1 network for prognostication, prediction and therapeutic target validation in breast cancer.
    Molecular oncology, 2015, Volume: 9, Issue:3

    Topics: Ataxia Telangiectasia Mutated Proteins; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Chec

2015
Mitogen-activated protein kinase signaling controls basal and oncostatin M-mediated JUNB gene expression.
    Molecular and cellular biochemistry, 2015, Volume: 403, Issue:1-2

    Topics: Breast Neoplasms; Butadienes; Cell Line, Tumor; Extracellular Space; Female; Gene Expression Regulat

2015
Persistent Activation of NF-κB in BRCA1-Deficient Mammary Progenitors Drives Aberrant Proliferation and Accumulation of DNA Damage.
    Cell stem cell, 2016, 07-07, Volume: 19, Issue:1

    Topics: Animals; Ataxia Telangiectasia Mutated Proteins; BRCA1 Protein; Breast; Breast Neoplasms; Cell Line,

2016
The protein phosphatase 4 - PEA15 axis regulates the survival of breast cancer cells.
    Cellular signalling, 2016, Volume: 28, Issue:9

    Topics: Apoptosis; Apoptosis Regulatory Proteins; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Pr

2016
Frequent alterations of SLIT2-ROBO1-CDC42 signalling pathway in breast cancer: clinicopathological correlation.
    Journal of genetics, 2016, Volume: 95, Issue:3

    Topics: Adult; Aged; Breast Neoplasms; cdc42 GTP-Binding Protein; Disease Progression; DNA Methylation; Fema

2016
Pharmacological inhibition of Rac1-PAK1 axis restores tamoxifen sensitivity in human resistant breast cancer cells.
    Cellular signalling, 2017, Volume: 30

    Topics: Breast Neoplasms; Drug Resistance, Neoplasm; Estrogens; Female; Humans; MCF-7 Cells; Models, Biologi

2017
Hyaluronate synthase-2 overexpression alters estrogen dependence and induces histone deacetylase inhibitor-like effects on ER-driven genes in MCF7 breast tumor cells.
    Molecular and cellular endocrinology, 2017, 03-15, Volume: 444

    Topics: Acetylation; Breast Neoplasms; E1A-Associated p300 Protein; Estrogen Receptor alpha; Estrogens; Fema

2017
Breast cancer proteomics reveals correlation between estrogen receptor status and differential phosphorylation of PGRMC1.
    Breast cancer research : BCR, 2008, Volume: 10, Issue:5

    Topics: Amino Acid Substitution; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Intraductal, Noninf

2008
Essential phosphatases and a phospho-degron are critical for regulation of SRC-3/AIB1 coactivator function and turnover.
    Molecular cell, 2008, Sep-26, Volume: 31, Issue:6

    Topics: Breast Neoplasms; Gene Expression Regulation; Genome; HeLa Cells; Humans; Nuclear Receptor Coactivat

2008
EBAG9 inducing hyporesponsiveness of T cells promotes tumor growth and metastasis in 4T1 murine mammary carcinoma.
    Cancer science, 2009, Volume: 100, Issue:5

    Topics: Animals; Antigens, Neoplasm; Breast Neoplasms; Cell Line, Tumor; Female; Gene Expression Regulation,

2009
Identification of a small molecule inhibitor of serine 276 phosphorylation of the p65 subunit of NF-kappaB using in silico molecular docking.
    Cancer letters, 2010, May-28, Volume: 291, Issue:2

    Topics: Antineoplastic Agents; Breast Neoplasms; Carcinoma, Hepatocellular; Cell Line, Tumor; Cyclic AMP Res

2010
Potentiation of etoposide-induced apoptosis in HeLa cells by co-treatment with KG-135, a quality-controlled standardized ginsenoside formulation.
    Cancer letters, 2010, Aug-01, Volume: 294, Issue:1

    Topics: Androstadienes; Apoptosis; bcl-2-Associated X Protein; Breast Neoplasms; Carcinoma, Hepatocellular;

2010
Pathway-based identification of biomarkers for targeted therapeutics: personalized oncology with PI3K pathway inhibitors.
    Science translational medicine, 2010, Aug-04, Volume: 2, Issue:43

    Topics: Adaptor Proteins, Signal Transducing; Animals; Basophils; Biomarkers, Tumor; Breast Neoplasms; Cell

2010
Prognostic association of YB-1 expression in breast cancers: a matter of antibody.
    PloS one, 2011, Volume: 6, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Antibodies, Neoplasm; Breast Neoplasms; Cell Nucleus; Cohort Studies

2011
Mechanistic insight into Myc stabilization in breast cancer involving aberrant Axin1 expression.
    Proceedings of the National Academy of Sciences of the United States of America, 2012, Feb-21, Volume: 109, Issue:8

    Topics: Alternative Splicing; Animals; Axin Protein; Breast Neoplasms; Cell Line, Tumor; Female; Gene Expres

2012
p38 and p42/44 MAPKs differentially regulate progesterone receptor A and B isoform stabilization.
    Molecular endocrinology (Baltimore, Md.), 2011, Volume: 25, Issue:10

    Topics: Breast Neoplasms; Cell Line, Tumor; Endometrial Neoplasms; Female; Gonanes; Humans; Ligands; MAP Kin

2011
MGMT inhibition restores ERα functional sensitivity to antiestrogen therapy.
    Molecular medicine (Cambridge, Mass.), 2012, Sep-07, Volume: 18

    Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumo

2012
Circadian gating of epithelial-to-mesenchymal transition in breast cancer cells via melatonin-regulation of GSK3β.
    Molecular endocrinology (Baltimore, Md.), 2012, Volume: 26, Issue:11

    Topics: Animals; beta Catenin; Breast Neoplasms; Cell Line, Tumor; Circadian Rhythm; Enzyme Activation; Epit

2012
Tyrosyl phosphorylated PAK1 regulates breast cancer cell motility in response to prolactin through filamin A.
    Molecular endocrinology (Baltimore, Md.), 2013, Volume: 27, Issue:3

    Topics: Breast Neoplasms; Cell Line, Tumor; Cell Movement; Clone Cells; Contractile Proteins; Female; Filami

2013
Nitric oxide-induced cellular stress and p53 activation in chronic inflammation.
    Proceedings of the National Academy of Sciences of the United States of America, 2003, Jan-07, Volume: 100, Issue:1

    Topics: Animals; Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Breast Neoplasms; Cell Cycle

2003
Tumor necrosis factor alpha inhibits cyclin A expression and retinoblastoma hyperphosphorylation triggered by insulin-like growth factor-I induction of new E2F-1 synthesis.
    The Journal of biological chemistry, 2004, Feb-27, Volume: 279, Issue:9

    Topics: Adenocarcinoma; Breast Neoplasms; CDC2-CDC28 Kinases; Cell Cycle; Cell Cycle Proteins; Cyclin A; Cyc

2004
Phospho-serine-118 estrogen receptor-alpha detection in human breast tumors in vivo.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Feb-15, Volume: 10, Issue:4

    Topics: Biomarkers, Tumor; Biopsy; Blotting, Western; Breast Neoplasms; Cell Differentiation; Cell Line, Tum

2004
Roscovitine-induced up-regulation of p53AIP1 protein precedes the onset of apoptosis in human MCF-7 breast cancer cells.
    Molecular cancer therapeutics, 2005, Volume: 4, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Breast Neoplasms; Caspase 3; Caspas

2005
SPBP is a phosphoserine-specific repressor of estrogen receptor alpha.
    Molecular and cellular biology, 2005, Volume: 25, Issue:9

    Topics: Amino Acid Sequence; Breast Neoplasms; Cell Line; Cell Proliferation; Estrogen Receptor alpha; Femal

2005
Phosphorylation of estrogen receptor alpha serine 167 is predictive of response to endocrine therapy and increases postrelapse survival in metastatic breast cancer.
    Breast cancer research : BCR, 2005, Volume: 7, Issue:5

    Topics: Amino Acid Sequence; Animals; Antineoplastic Agents, Hormonal; Breast Neoplasms; Chlorocebus aethiop

2005
Anti-HER2 antibody trastuzumab inhibits CDK2-mediated NPAT and histone H4 expression via the PI3K pathway.
    Cell cycle (Georgetown, Tex.), 2006, Volume: 5, Issue:15

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Breast Neoplasms;

2006
Phosphorylation of ERalpha at serine 118 in primary breast cancer and in tamoxifen-resistant tumours is indicative of a complex role for ERalpha phosphorylation in breast cancer progression.
    Endocrine-related cancer, 2006, Volume: 13, Issue:3

    Topics: Biomarkers, Tumor; Breast Neoplasms; Disease Progression; Drug Resistance, Neoplasm; Estrogen Recept

2006
Myc stabilization in response to estrogen and phospholipase D in MCF-7 breast cancer cells.
    FEBS letters, 2006, Oct-16, Volume: 580, Issue:24

    Topics: Breast Neoplasms; Cell Line, Tumor; Estradiol; Estrogens; Gene Expression Regulation, Neoplastic; Gl

2006
DUSP22/LMW-DSP2 regulates estrogen receptor-alpha-mediated signaling through dephosphorylation of Ser-118.
    Oncogene, 2007, Sep-06, Volume: 26, Issue:41

    Topics: Breast Neoplasms; Dual-Specificity Phosphatases; Estradiol; Estrogen Receptor alpha; Female; HeLa Ce

2007
Parvin-beta inhibits breast cancer tumorigenicity and promotes CDK9-mediated peroxisome proliferator-activated receptor gamma 1 phosphorylation.
    Molecular and cellular biology, 2008, Volume: 28, Issue:2

    Topics: Actinin; Animals; Breast Neoplasms; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cell

2008
Serine 167 is the major estradiol-induced phosphorylation site on the human estrogen receptor.
    Molecular endocrinology (Baltimore, Md.), 1994, Volume: 8, Issue:9

    Topics: Animals; Breast Neoplasms; Casein Kinase II; Cells, Cultured; Estradiol; Moths; Neoplasms, Hormone-D

1994
Phosphorylation of A 27-kDa protein correlates with survival of protein-synthesis-inhibited MCF-7 cells.
    In vitro cellular & developmental biology. Animal, 1997, Volume: 33, Issue:2

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Aurintricarboxylic Acid; Breast Neoplasms; Carcinoma; Cell S

1997
Novel phosphorylation sites of human tumour suppressor protein p53 at Ser20 and Thr18 that disrupt the binding of mdm2 (mouse double minute 2) protein are modified in human cancers.
    The Biochemical journal, 1999, Aug-15, Volume: 342 ( Pt 1)

    Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Antibody Specificity; Breast Neoplasms; Cell L

1999
Dephosphorylation of p53 at Ser20 after cellular exposure to low levels of non-ionizing radiation.
    Oncogene, 1999, Nov-04, Volume: 18, Issue:46

    Topics: Antibodies, Monoclonal; Breast Neoplasms; Epitopes; Female; Humans; Nuclear Proteins; Phosphorylatio

1999
Phosphorylation of human progesterone receptors at serine-294 by mitogen-activated protein kinase signals their degradation by the 26S proteasome.
    Proceedings of the National Academy of Sciences of the United States of America, 2000, Feb-01, Volume: 97, Issue:3

    Topics: Acetylcysteine; Breast Neoplasms; Consensus Sequence; Cysteine Endopeptidases; Down-Regulation; Enzy

2000
Association of ErbB2 Ser1113 phosphorylation with epidermal growth factor receptor co-expression and poor prognosis in human breast cancer.
    Molecular and cellular biochemistry, 2001, Volume: 218, Issue:1-2

    Topics: Animals; Antibodies, Monoclonal; Becaplermin; Breast Neoplasms; Cells, Cultured; Colforsin; Epiderma

2001
Rsk2 allosterically activates estrogen receptor alpha by docking to the hormone-binding domain.
    The EMBO journal, 2001, Jul-02, Volume: 20, Issue:13

    Topics: Allosteric Regulation; Amino Acid Substitution; Animals; Binding Sites; Breast Neoplasms; Cell Line;

2001
Formation of an hER alpha-COUP-TFI complex enhances hER alpha AF-1 through Ser118 phosphorylation by MAPK.
    The EMBO journal, 2002, Jul-01, Volume: 21, Issue:13

    Topics: Adenocarcinoma; Breast Neoplasms; COUP Transcription Factor I; DNA; DNA-Binding Proteins; Enzyme Inh

2002
Insulin and epidermal growth factor stimulate phosphorylation of p185HER-2 in the breast carcinoma cell line, BT474.
    Molecular and cellular endocrinology, 1990, Mar-05, Volume: 69, Issue:2-3

    Topics: Blood; Breast Neoplasms; Epidermal Growth Factor; ErbB Receptors; Humans; Insulin; Phosphorylation;

1990
Tumor necrosis factor signal transduction. Tissue-specific serine phosphorylation of a 26-kDa cytosolic protein.
    The Journal of biological chemistry, 1989, Feb-25, Volume: 264, Issue:6

    Topics: Breast Neoplasms; Cell Differentiation; Cell Division; Cytosol; Electrophoresis, Polyacrylamide Gel;

1989