phosphoserine has been researched along with Alzheimer Disease in 34 studies
Phosphoserine: The phosphoric acid ester of serine.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "L-Phosphoserine is a membrane metabolite that is elevated in Alzheimer's disease brain." | 2.38 | Possible roles of L-phosphoserine in the pathogenesis of Alzheimer's disease. ( Klunk, WE; McClure, RJ; Pettegrew, JW, 1991) |
| "L-Phosphoserine has also been found to be a competitive antagonist at the N-methyl-D-aspartate recognition site and an antagonist of metabotropic receptor-mediated hydrolysis of inositol phospholipids." | 2.38 | Possible roles of L-phosphoserine in the pathogenesis of Alzheimer's disease. ( Klunk, WE; McClure, RJ; Pettegrew, JW, 1991) |
| "While a potential causal factor in Alzheimer's disease (AD), brain insulin resistance has not been demonstrated directly in that disorder." | 1.38 | Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. ( Arnold, SE; Arvanitakis, Z; Bakshi, KP; Bennett, DA; Fuino, RL; Han, LY; Kawaguchi, KR; Kazi, H; Samoyedny, AJ; Schneider, JA; Stucky, A; Talbot, K; Trojanowski, JQ; Wang, HY; Wilson, RS; Wolf, BA, 2012) |
| "The neuropathological hallmarks of Alzheimer's disease and other tauopathies include senile plaques and/or neurofibrillary tangles." | 1.32 | Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration. ( Bing, G; Bronson, R; Huang, HK; Hunter, T; Li, X; Liou, YC; Lu, KP; Ryo, A; Sun, A; Uchida, T; Yu, ZX; Zhou, XZ, 2003) |
| "Alzheimer's disease is characterized by changes in phospholipid metabolism leading to a perturbation in the levels of phosphomonoesters, including L-Phosphoserine (L-PS)." | 1.29 | Molecular membrane interactions of a phospholipid metabolite. Implications for Alzheimer's disease pathophysiology. ( Mason, RP; Pettegrew, JW; Trumbore, MW, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 15 (44.12) | 18.2507 |
| 2000's | 7 (20.59) | 29.6817 |
| 2010's | 11 (32.35) | 24.3611 |
| 2020's | 1 (2.94) | 2.80 |
| Authors | Studies |
|---|---|
| Wittrahm, R | 1 |
| Takalo, M | 1 |
| Marttinen, M | 1 |
| Kuulasmaa, T | 1 |
| Mäkinen, P | 1 |
| Kemppainen, S | 1 |
| Martiskainen, H | 1 |
| Rauramaa, T | 1 |
| Pike, I | 1 |
| Leinonen, V | 1 |
| Natunen, T | 1 |
| Haapasalo, A | 1 |
| Hiltunen, M | 1 |
| Zatsepina, OG | 1 |
| Kechko, OI | 1 |
| Mitkevich, VA | 1 |
| Kozin, SA | 1 |
| Yurinskaya, MM | 1 |
| Vinokurov, MG | 1 |
| Serebryakova, MV | 1 |
| Rezvykh, AP | 1 |
| Evgen'ev, MB | 1 |
| Makarov, AA | 1 |
| Hu, YB | 1 |
| Ren, RJ | 1 |
| Zhang, YF | 1 |
| Huang, Y | 1 |
| Cui, HL | 1 |
| Ma, C | 1 |
| Qiu, WY | 1 |
| Wang, H | 1 |
| Cui, PJ | 1 |
| Chen, HZ | 1 |
| Wang, G | 1 |
| Gu, GJ | 1 |
| Lund, H | 1 |
| Wu, D | 1 |
| Blokzijl, A | 1 |
| Classon, C | 1 |
| von Euler, G | 1 |
| Landegren, U | 1 |
| Sunnemark, D | 1 |
| Kamali-Moghaddam, M | 1 |
| Cavallucci, V | 1 |
| Berretta, N | 1 |
| Nobili, A | 1 |
| Nisticò, R | 1 |
| Mercuri, NB | 1 |
| D'Amelio, M | 1 |
| Kim, B | 1 |
| Figueroa-Romero, C | 1 |
| Pacut, C | 1 |
| Backus, C | 1 |
| Feldman, EL | 1 |
| Ando, K | 1 |
| Oka, M | 1 |
| Ohtake, Y | 1 |
| Hayashishita, M | 1 |
| Shimizu, S | 1 |
| Hisanaga, S | 1 |
| Iijima, KM | 1 |
| Iijima, K | 1 |
| Gatt, A | 1 |
| Iijima-Ando, K | 1 |
| Sofola, O | 1 |
| Kerr, F | 1 |
| Rogers, I | 1 |
| Killick, R | 1 |
| Augustin, H | 1 |
| Gandy, C | 1 |
| Allen, MJ | 1 |
| Hardy, J | 1 |
| Lovestone, S | 1 |
| Partridge, L | 1 |
| Barone, E | 1 |
| Di Domenico, F | 1 |
| Cenini, G | 1 |
| Sultana, R | 1 |
| Cini, C | 1 |
| Preziosi, P | 1 |
| Perluigi, M | 1 |
| Mancuso, C | 1 |
| Butterfield, DA | 1 |
| Talbot, K | 1 |
| Wang, HY | 1 |
| Kazi, H | 1 |
| Han, LY | 1 |
| Bakshi, KP | 1 |
| Stucky, A | 1 |
| Fuino, RL | 1 |
| Kawaguchi, KR | 1 |
| Samoyedny, AJ | 1 |
| Wilson, RS | 1 |
| Arvanitakis, Z | 1 |
| Schneider, JA | 1 |
| Wolf, BA | 1 |
| Bennett, DA | 1 |
| Trojanowski, JQ | 2 |
| Arnold, SE | 1 |
| Meek, AR | 1 |
| Simms, GA | 1 |
| Weaver, DF | 1 |
| Liou, YC | 1 |
| Sun, A | 1 |
| Ryo, A | 1 |
| Zhou, XZ | 1 |
| Yu, ZX | 1 |
| Huang, HK | 1 |
| Uchida, T | 1 |
| Bronson, R | 1 |
| Bing, G | 1 |
| Li, X | 1 |
| Hunter, T | 1 |
| Lu, KP | 3 |
| Ksiezak-Reding, H | 1 |
| Pyo, HK | 1 |
| Feinstein, B | 1 |
| Pasinetti, GM | 1 |
| Wulf, G | 1 |
| Finn, G | 1 |
| Suizu, F | 1 |
| Singer, D | 1 |
| Lehmann, J | 1 |
| Hanisch, K | 1 |
| Härtig, W | 1 |
| Hoffmann, R | 2 |
| Yang, SD | 2 |
| Yu, JS | 2 |
| Liu, WK | 1 |
| Yen, SH | 1 |
| Fabian, H | 1 |
| Otvos, L | 2 |
| Szendrei, GI | 1 |
| Lang, E | 1 |
| Mantsch, HH | 1 |
| Drewes, G | 1 |
| Trinczek, B | 1 |
| Illenberger, S | 1 |
| Biernat, J | 2 |
| Schmitt-Ulms, G | 1 |
| Meyer, HE | 2 |
| Mandelkow, EM | 2 |
| Mandelkow, E | 2 |
| Shiah, SG | 1 |
| Huang, JJ | 1 |
| Paudel, HK | 1 |
| Lew, J | 1 |
| Ali, Z | 1 |
| Wang, JH | 1 |
| Brion, JP | 1 |
| Smith, C | 1 |
| Couck, AM | 1 |
| Gallo, JM | 1 |
| Anderton, BH | 1 |
| Bramblett, GT | 1 |
| Goedert, M | 3 |
| Jakes, R | 2 |
| Merrick, SE | 1 |
| Lee, VM | 3 |
| Mason, RP | 1 |
| Trumbore, MW | 1 |
| Pettegrew, JW | 3 |
| Hasegawa, M | 1 |
| Crowther, RA | 1 |
| Ihara, Y | 2 |
| Shiurba, RA | 1 |
| Ishiguro, K | 1 |
| Takahashi, M | 1 |
| Sato, K | 1 |
| Spooner, ET | 1 |
| Mercken, M | 1 |
| Yoshida, R | 1 |
| Wheelock, TR | 1 |
| Yanagawa, H | 1 |
| Imahori, K | 1 |
| Nixon, RA | 1 |
| Leight, S | 1 |
| Varga, I | 1 |
| Gu, Y | 1 |
| Hamajima, N | 1 |
| Vijayan, S | 1 |
| El-Akkad, E | 1 |
| Grundke-Iqbal, I | 1 |
| Iqbal, K | 1 |
| Klunk, WE | 2 |
| McClure, RJ | 2 |
| Uéda, K | 1 |
| Masliah, E | 1 |
| Saitoh, T | 1 |
| Bakalis, SL | 1 |
| Scoble, H | 1 |
| Kosik, KS | 1 |
| Steiner, B | 1 |
| Gustke, N | 1 |
| Schmidt, B | 1 |
| Mieskes, G | 1 |
| Söling, HD | 1 |
| Drechsel, D | 1 |
| Kirschner, MW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Open Label, Single Site, 48 Week, Randomised Controlled Trial Evaluating the Safety and Efficacy of Exenatide Once-weekly in the Treatment of Patients With Multiple System Atrophy[NCT04431713] | Phase 2 | 50 participants (Anticipated) | Interventional | 2020-09-16 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for phosphoserine and Alzheimer Disease
| Article | Year |
|---|---|
Pinning down cell signaling, cancer and Alzheimer's disease.
Topics: Alzheimer Disease; CDC2-CDC28 Kinases; Cell Cycle; Cyclin-Dependent Kinase 2; Humans; Models, Biolog | 2004 |
Phosphorylation-specific prolyl isomerization: is there an underlying theme?
Topics: Alzheimer Disease; Cell Proliferation; Humans; Isomerism; Neoplasms; NIMA-Interacting Peptidylprolyl | 2005 |
Possible roles of L-phosphoserine in the pathogenesis of Alzheimer's disease.
Topics: Alzheimer Disease; Aminobutyrates; Animals; Humans; Phosphoserine; Receptors, N-Methyl-D-Aspartate | 1991 |
31 other studies available for phosphoserine and Alzheimer Disease
| Article | Year |
|---|---|
MECP2 Increases the Pro-Inflammatory Response of Microglial Cells and Phosphorylation at Serine 423 Regulates Neuronal Gene Expression upon Neuroinflammation.
Topics: Alzheimer Disease; Animals; Brain; Brain-Derived Neurotrophic Factor; Cell Adhesion Molecules, Neuro | 2021 |
Amyloid-β with isomerized Asp7 cytotoxicity is coupled to protein phosphorylation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Apoptosis; Aspartic Acid; Cell Line, Tumor; Cell Survival; | 2018 |
Rho-associated coiled-coil kinase 1 activation mediates amyloid precursor protein site-specific Ser655 phosphorylation and triggers amyloid pathology.
Topics: Alzheimer Disease; Amides; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cells, Cu | 2019 |
Role of individual MARK isoforms in phosphorylation of tau at Ser²⁶² in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Antibody Specificity; Antigens, Bacterial; Bact | 2013 |
Calcineurin inhibition rescues early synaptic plasticity deficits in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; CA1 Region, Hippocampal; Calcineurin Inhibitors; Caspase 3; Dendrites; D | 2013 |
Insulin Resistance Prevents AMPK-induced Tau Dephosphorylation through Akt-mediated Increase in AMPKSer-485 Phosphorylation.
Topics: Adenylate Kinase; Alzheimer Disease; Animals; Cell Line; Diabetes Complications; Diet, High-Fat; Hum | 2015 |
Tau phosphorylation at Alzheimer's disease-related Ser356 contributes to tau stabilization when PAR-1/MARK activity is elevated.
Topics: Alzheimer Disease; Amino Acid Substitution; Animals; Disease Models, Animal; Drosophila melanogaster | 2016 |
Tau Ser262 phosphorylation is critical for Abeta42-induced tau toxicity in a transgenic Drosophila model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetically Modified; Brain; Checkpoint | 2010 |
Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset Drosophila model of Alzheimer's disease.
Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Disease Models, Animal; Drosophil | 2010 |
Biliverdin reductase--a protein levels and activity in the brains of subjects with Alzheimer disease and mild cognitive impairment.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Cognition; Enzyme Activation; Female; Humans; Mal | 2011 |
Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Apolipoprotein E4; Brain; Cerebellar Cortex; Cognition D | 2012 |
Searching for an endogenous anti-Alzheimer molecule: identifying small molecules in the brain that slow Alzheimer disease progression by inhibition of ß-amyloid aggregation.
Topics: 3-Hydroxyanthranilic Acid; Alzheimer Disease; Amyloid beta-Peptides; Computer Simulation; In Vitro T | 2013 |
Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration.
Topics: Aging; Alzheimer Disease; Amino Acid Motifs; Animals; Behavior, Animal; Gene Deletion; Gene Expressi | 2003 |
Akt/PKB kinase phosphorylates separately Thr212 and Ser214 of tau protein in vitro.
Topics: Alzheimer Disease; Amino Acid Sequence; Biomarkers; Cloning, Molecular; Consensus Sequence; Escheric | 2003 |
Neighbored phosphorylation sites as PHF-tau specific markers in Alzheimer's disease.
Topics: Alzheimer Disease; Amino Acid Sequence; Animals; Binding Sites; Biomarkers; Cattle; Epitopes; Humans | 2006 |
Synergistic control mechanism for abnormal site phosphorylation of Alzheimer's diseased brain tau by kinase FA/GSK-3 alpha.
Topics: Alzheimer Disease; Amino Acid Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Glycogen Synth | 1993 |
Tyrosine- versus serine-phosphorylation leads to conformational changes in a synthetic tau peptide.
Topics: Alzheimer Disease; Amino Acid Sequence; Antibodies, Monoclonal; Genes, Synthetic; Humans; Immunodomi | 1994 |
Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262.
Topics: Alzheimer Disease; Amino Acid Sequence; Animals; Brain; Chromatography, Ion Exchange; Cloning, Molec | 1995 |
Protein kinase FA/glycogen synthase kinase-3 alpha after heparin potentiation phosphorylates tau on sites abnormally phosphorylated in Alzheimer's disease brain.
Topics: Alzheimer Disease; Amino Acid Sequence; Animals; Brain; Calcium-Calmodulin-Dependent Protein Kinases | 1994 |
Brain proline-directed protein kinase phosphorylates tau on sites that are abnormally phosphorylated in tau associated with Alzheimer's paired helical filaments.
Topics: Alzheimer Disease; Amino Acid Sequence; Animals; Brain; Calcium-Calmodulin-Dependent Protein Kinases | 1993 |
Developmental changes in tau phosphorylation: fetal tau is transiently phosphorylated in a manner similar to paired helical filament-tau characteristic of Alzheimer's disease.
Topics: Adult; Alzheimer Disease; Amino Acid Sequence; Animals; Blotting, Western; Brain; Electrophoresis, P | 1993 |
Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding.
Topics: Adult; Alzheimer Disease; Amino Acid Sequence; Animals; Brain; Cerebral Cortex; CHO Cells; Cricetina | 1993 |
Molecular membrane interactions of a phospholipid metabolite. Implications for Alzheimer's disease pathophysiology.
Topics: Alzheimer Disease; Calorimetry, Differential Scanning; Cholesterol; Dimyristoylphosphatidylcholine; | 1996 |
Characterization of mAb AP422, a novel phosphorylation-dependent monoclonal antibody against tau protein.
Topics: Alzheimer Disease; Amino Acid Sequence; Animals; Antibodies, Monoclonal; Antibody Specificity; Brain | 1996 |
Immunocytochemistry of tau phosphoserine 413 and tau protein kinase I in Alzheimer pathology.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amino Acid Sequence; Antibody Specificity; Brain; | 1996 |
Unique Alzheimer's disease paired helical filament specific epitopes involve double phosphorylation at specific sites.
Topics: Adult; Alzheimer Disease; Amino Acid Sequence; Animals; Antibodies, Monoclonal; Binding Sites; Blott | 1997 |
Neurofibrillary tangle-associated collapsin response mediator protein-2 (CRMP-2) is highly phosphorylated on Thr-509, Ser-518, and Ser-522.
Topics: Alzheimer Disease; Amino Acid Sequence; Animals; Animals, Newborn; Antibodies, Monoclonal; Antibody | 2000 |
A pool of beta-tubulin is hyperphosphorylated at serine residues in Alzheimer disease brain.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amino Acid Sequence; Blotting, Western; Brain; Humans; M | 2001 |
L-phosphoserine, a metabolite elevated in Alzheimer's disease, interacts with specific L-glutamate receptor subtypes.
Topics: 2-Amino-5-phosphonovalerate; Alzheimer Disease; Animals; Dizocilpine Maleate; Dose-Response Relation | 1991 |
Alz-50 recognizes a phosphorylated epitope of tau protein.
Topics: Acid Phosphatase; Alzheimer Disease; Amino Acid Sequence; Antibodies, Monoclonal; Blotting, Western; | 1990 |
Phosphorylation of microtubule-associated protein tau: identification of the site for Ca2(+)-calmodulin dependent kinase and relationship with tau phosphorylation in Alzheimer tangles.
Topics: Alzheimer Disease; Amino Acid Sequence; Animals; Calmodulin; Cattle; Cloning, Molecular; DNA Mutatio | 1990 |