phosphorylcholine has been researched along with Vasospasm, Intracranial in 5 studies
Phosphorylcholine: Calcium and magnesium salts used therapeutically in hepatobiliary dysfunction.
phosphocholine : The phosphate of choline; and the parent compound of the phosphocholine family.
Vasospasm, Intracranial: Constriction of arteries in the SKULL due to sudden, sharp, and often persistent smooth muscle contraction in blood vessels. Intracranial vasospasm results in reduced vessel lumen caliber, restricted blood flow to the brain, and BRAIN ISCHEMIA that may lead to hypoxic-ischemic brain injury (HYPOXIA-ISCHEMIA, BRAIN).
| Excerpt | Relevance | Reference |
|---|---|---|
| " Eicosapentaenoic acid (EPA) inhibits sphingosylphosphorylcholine -Rho-kinase-activated Ca(2+)-sensitization in vitro and in subarachnoid hemorrhage (SAH) models in vivo and has also been shown to inhibit the occurrence of cerebral vasospasm (CIV) after the onset of SAH in a prospective, nonrandomized study." | 5.19 | A prospective, multicenter, randomized study of the efficacy of eicosapentaenoic acid for cerebral vasospasm: the EVAS study. ( Nakagawara, J; Ogasawara, K; Shirao, S; Suzuki, M; Tominaga, T; Yoneda, H, 2014) |
| "Inflammation has an important function in the development of cerebral vasospasm after subarachnoid hemorrhage (SAH); however, the mediators of this inflammatory response have not been clearly identified." | 1.37 | Sphingosylphosphorylcholine is a proinflammatory mediator in cerebral arteries. ( Hunter, I; Mathieson, FA; Nixon, GF; Wirrig, C, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shirao, S | 3 |
| Yoneda, H | 3 |
| Shinoyama, M | 1 |
| Sugimoto, K | 1 |
| Koizumi, H | 1 |
| Ishihara, H | 1 |
| Oka, F | 1 |
| Sadahiro, H | 1 |
| Nomura, S | 1 |
| Fujii, M | 1 |
| Tamechika, M | 1 |
| Kagawa, Y | 1 |
| Owada, Y | 1 |
| Suzuki, M | 3 |
| Fujisawa, H | 1 |
| Kudo, A | 1 |
| Kurokawa, T | 1 |
| Kunitsugu, I | 1 |
| Ogasawara, K | 2 |
| Soma, M | 1 |
| Kobayashi, S | 1 |
| Ogawa, A | 1 |
| Wirrig, C | 1 |
| Hunter, I | 1 |
| Mathieson, FA | 1 |
| Nixon, GF | 1 |
| Nakagawara, J | 1 |
| Tominaga, T | 1 |
| Somlyo, AV | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Eicosapentaenoic Acid Cerebral Vasospasm Therapy Study (EVAS): Effect of Eicosapentaenoic Acid on Cerebral Vasospasm Following Subarachnoid Hemorrhage[NCT00839449] | Phase 4 | 200 participants (Actual) | Interventional | 2004-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for phosphorylcholine and Vasospasm, Intracranial
| Article | Year |
|---|---|
A prospective, multicenter, randomized study of the efficacy of eicosapentaenoic acid for cerebral vasospasm: the EVAS study.
Topics: Aged; Arachidonic Acid; Cardiovascular Agents; Combined Modality Therapy; Eicosapentaenoic Acid; Fem | 2014 |
4 other studies available for phosphorylcholine and Vasospasm, Intracranial
| Article | Year |
|---|---|
A novel trigger for cholesterol-dependent smooth muscle contraction mediated by the sphingosylphosphorylcholine-Rho-kinase pathway in the rat basilar artery: a mechanistic role for lipid rafts.
Topics: Amides; Animals; Antihypertensive Agents; Basilar Artery; beta-Cyclodextrins; Carotid Artery, Intern | 2015 |
Inhibitory effects of eicosapentaenoic acid on chronic cerebral vasospasm after subarachnoid hemorrhage: possible involvement of a sphingosylphosphorylcholine-rho-kinase pathway.
Topics: Animals; Basilar Artery; Benzopyrans; Cerebral Angiography; Cisterna Magna; Disease Models, Animal; | 2008 |
Sphingosylphosphorylcholine is a proinflammatory mediator in cerebral arteries.
Topics: Animals; Blood Platelets; Blotting, Western; Cells, Cultured; Cerebral Arteries; Chemokine CCL2; Ele | 2011 |
New roads leading to Ca2+ sensitization.
Topics: Animals; Calcium Signaling; Cattle; Cerebral Arteries; Heterotrimeric GTP-Binding Proteins; Humans; | 2002 |