phosphorylcholine has been researched along with Pregnancy in 38 studies
Phosphorylcholine: Calcium and magnesium salts used therapeutically in hepatobiliary dysfunction.
phosphocholine : The phosphate of choline; and the parent compound of the phosphocholine family.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study demonstrates that prenatal choline deficiency has profound effects by delaying neurodevelopment as evidenced by structural and metabolic MRI assessments." | 7.83 | Perinatal choline deficiency delays brain development and alters metabolite concentrations in the young pig. ( Dilger, RN; Getty, CM; Mudd, AT; Sutton, BP, 2016) |
| "Treatment of rats with choline during brain development results in long-lasting enhancement of spatial memory whereas choline deficiency has the opposite effect." | 7.71 | Choline deficiency induces apoptosis in primary cultures of fetal neurons. ( Fernandes, A; Mar, MH; Meeker, RB; Yen, CL; Zeisel, SH, 2001) |
| "Miltefosine was originally formulated and registered as a topical treatment for cutaneous cancers." | 6.43 | Development of miltefosine as an oral treatment for leishmaniasis. ( Engel, J; Sindermann, H, 2006) |
| "Choline is an important nutrient that is actively transported from mother to fetus across the placenta and from mother to infant across the mammary gland." | 5.29 | Pregnancy and lactation are associated with diminished concentrations of choline and its metabolites in rat liver. ( da Costa, KA; Mar, MH; Zeisel, SH; Zhou, Z, 1995) |
| "Future issues that need to be addressed for miltefosine are efficacy against non-Indian visceral leishmaniasis, efficacy in HIV-coinfected patients, efficacy against the many forms of cutaneous and mucosal disease, effectiveness under clinical practice conditions, generation of drug resistance and the need to provide a second antileishmanial agent to protect against this disastrous event, and the ability to maintain reproductive contraceptive practices under routine clinical conditions." | 4.83 | Miltefosine: issues to be addressed in the future. ( Berman, J; Bryceson, AD; Croft, S; Engel, J; Gutteridge, W; Karbwang, J; Sindermann, H; Soto, J; Sundar, S; Urbina, JA, 2006) |
| "This study demonstrates that prenatal choline deficiency has profound effects by delaying neurodevelopment as evidenced by structural and metabolic MRI assessments." | 3.83 | Perinatal choline deficiency delays brain development and alters metabolite concentrations in the young pig. ( Dilger, RN; Getty, CM; Mudd, AT; Sutton, BP, 2016) |
| "Treatment of rats with choline during brain development results in long-lasting enhancement of spatial memory whereas choline deficiency has the opposite effect." | 3.71 | Choline deficiency induces apoptosis in primary cultures of fetal neurons. ( Fernandes, A; Mar, MH; Meeker, RB; Yen, CL; Zeisel, SH, 2001) |
| "Choline supplementation of pregnant rats between d 12 and 17 of pregnancy permanently enhances the spatial memory of offspring; however, the mechanism is unknown." | 3.69 | Choline distribution and metabolism in pregnant rats and fetuses are influenced by the choline content of the maternal diet. ( Garner, SC; Mar, MH; Zeisel, SH, 1995) |
| "Miltefosine was originally formulated and registered as a topical treatment for cutaneous cancers." | 2.43 | Development of miltefosine as an oral treatment for leishmaniasis. ( Engel, J; Sindermann, H, 2006) |
| "Diethanolamine (DEA) is a widely used ingredient in many consumer products and in a number of industrial applications." | 1.34 | Diethanolamine alters proliferation and choline metabolism in mouse neural precursor cells. ( da Costa, KA; Guo, Z; Niculescu, MD; Wu, R; Zeisel, SH, 2007) |
| "Choline is an important nutrient that is actively transported from mother to fetus across the placenta and from mother to infant across the mammary gland." | 1.29 | Pregnancy and lactation are associated with diminished concentrations of choline and its metabolites in rat liver. ( da Costa, KA; Mar, MH; Zeisel, SH; Zhou, Z, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (23.68) | 18.7374 |
| 1990's | 8 (21.05) | 18.2507 |
| 2000's | 10 (26.32) | 29.6817 |
| 2010's | 11 (28.95) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Holásková, I | 1 |
| Elliott, M | 1 |
| Brundage, K | 1 |
| Lukomska, E | 1 |
| Schafer, R | 1 |
| Barnett, JB | 1 |
| Rapoport, JL | 1 |
| Parchim, NF | 1 |
| Wang, W | 1 |
| Iriyama, T | 1 |
| Ashimi, OA | 1 |
| Siddiqui, AH | 1 |
| Blackwell, S | 1 |
| Sibai, B | 1 |
| Kellems, RE | 1 |
| Xia, Y | 1 |
| Mudd, AT | 1 |
| Getty, CM | 1 |
| Sutton, BP | 1 |
| Dilger, RN | 1 |
| Grönwall, C | 1 |
| Clancy, RM | 1 |
| Getu, L | 1 |
| Lloyd, KA | 1 |
| Siegel, DL | 1 |
| Reed, JH | 1 |
| Buyon, JP | 1 |
| Silverman, GJ | 1 |
| Lowry, PJ | 1 |
| Kumar, D | 1 |
| Ramesh, V | 1 |
| Verma, S | 1 |
| Ramam, M | 1 |
| Salotra, P | 1 |
| Fischer, LM | 1 |
| da Costa, KA | 3 |
| Galanko, J | 1 |
| Sha, W | 1 |
| Stephenson, B | 1 |
| Vick, J | 1 |
| Zeisel, SH | 6 |
| Mehedint, MG | 1 |
| Craciunescu, CN | 1 |
| Takai, N | 1 |
| Ueda, T | 1 |
| Ishii, T | 1 |
| Kira, N | 1 |
| Nishida, M | 1 |
| Nasu, K | 1 |
| Narahara, H | 1 |
| Wilson, FA | 1 |
| Holtrop, G | 1 |
| Calder, AG | 1 |
| Anderson, SE | 1 |
| Lobley, GE | 1 |
| Rees, WD | 2 |
| McEwen, AM | 1 |
| Burgess, DT | 1 |
| Hanstock, CC | 1 |
| Seres, P | 1 |
| Khalili, P | 1 |
| Newman, SC | 1 |
| Baker, GB | 1 |
| Mitchell, ND | 1 |
| Khudabux-Der, J | 1 |
| Allen, PS | 1 |
| LeMelledo, JM | 1 |
| Ross, RG | 1 |
| Hunter, SK | 1 |
| McCarthy, L | 1 |
| Beuler, J | 1 |
| Hutchison, AK | 1 |
| Wagner, BD | 1 |
| Leonard, S | 1 |
| Stevens, KE | 1 |
| Freedman, R | 1 |
| Amato, M | 1 |
| Petit, K | 1 |
| Fiore, HH | 1 |
| Doyle, CA | 1 |
| Frantz, ID | 1 |
| Nielsen, HC | 1 |
| NEIL, MW | 1 |
| St John, EB | 1 |
| Carlo, WA | 1 |
| Sindermann, H | 2 |
| Engel, J | 2 |
| Berman, J | 1 |
| Bryceson, AD | 1 |
| Croft, S | 1 |
| Gutteridge, W | 1 |
| Karbwang, J | 1 |
| Soto, J | 1 |
| Sundar, S | 1 |
| Urbina, JA | 1 |
| Niculescu, MD | 1 |
| Wu, R | 1 |
| Guo, Z | 1 |
| Maloney, CA | 1 |
| Hay, SM | 1 |
| Heusser, CH | 1 |
| Etlinger, HM | 1 |
| Julius, MH | 2 |
| Weinhold, PA | 1 |
| Feldman, DA | 1 |
| Quade, MM | 1 |
| Miller, JC | 1 |
| Brooks, RL | 1 |
| Post, M | 1 |
| Batenburg, JJ | 1 |
| Van Golde, LM | 1 |
| Smith, BT | 1 |
| Quan, ZS | 1 |
| Quintáns, J | 1 |
| Possmayer, F | 1 |
| Casola, PG | 1 |
| Chan, F | 1 |
| MacDonald, P | 1 |
| Ormseth, MA | 1 |
| Wong, T | 1 |
| Harding, PG | 1 |
| Tokmakjian, S | 1 |
| McDonald, LJ | 1 |
| Robin, NI | 1 |
| Siegel, L | 1 |
| Garner, SC | 1 |
| Mar, MH | 3 |
| Zhou, Z | 1 |
| Irino, T | 1 |
| Matsushita, M | 1 |
| Sakagishi, Y | 1 |
| Komoda, T | 1 |
| Balestrieri, C | 1 |
| Camussi, G | 1 |
| Giovane, A | 1 |
| Iorio, EL | 1 |
| Quagliuolo, L | 1 |
| Servillo, L | 1 |
| Holmes, HC | 1 |
| Snodgrass, GJ | 1 |
| Iles, RA | 1 |
| Husain, AN | 1 |
| Siddiqui, NH | 1 |
| Stocker, JT | 1 |
| Yen, CL | 1 |
| Meeker, RB | 1 |
| Fernandes, A | 1 |
| Xu, KY | 1 |
| Xiong, Y | 1 |
| Du, YC | 1 |
| Patrick, AD | 1 |
| Young, E | 1 |
| Kleijer, WJ | 1 |
| Niermeijer, MF | 1 |
| Cosenza, H | 1 |
| Augustin, AA | 1 |
| McGregor, JA | 1 |
| Lawellin, D | 1 |
| Franco-Buff, A | 1 |
| Todd, JK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Supplemental Choline and Neurodevelopment in Humans[NCT00678925] | 150 participants (Actual) | Interventional | 2004-12-31 | Completed | |||
| Double-blind Trial of Phosphatidylcholine During Pregnancy and Infant Serum Choline Levels[NCT00332124] | Phase 1 | 351 participants (Actual) | Interventional | 2006-06-30 | Completed | ||
| Generic Database: A Survey of Morbidity and Mortality in Very Low Birth Weight Infants[NCT00063063] | 80,000 participants (Anticipated) | Observational | 1987-01-31 | Recruiting | |||
| Pharmacokinetics of Miltefosine in Children and Adults: Implications for the Treatment of Cutaneous Leishmaniasis in Colombia.[NCT01462500] | Phase 4 | 60 participants (Actual) | Interventional | 2011-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for phosphorylcholine and Pregnancy
| Article | Year |
|---|---|
The placenta is simply a neuroendocrine parasite.
Topics: Animals; Female; Humans; Immune System; Neurokinin B; Neurosecretory Systems; Phosphorylcholine; Pla | 2008 |
Development of miltefosine as an oral treatment for leishmaniasis.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Antineoplastic Agents; Antiprotozoal Age | 2006 |
Miltefosine: issues to be addressed in the future.
Topics: Abnormalities, Drug-Induced; Antiprotozoal Agents; Drug Resistance; Female; Forecasting; HIV Infecti | 2006 |
Idiotypes as variable region markers: analogies between receptors on phosphorylcholine-specific T and B lymphocytes.
Topics: Animals; Animals, Newborn; Autoantibodies; B-Lymphocytes; Binding Sites, Antibody; Choline; Female; | 1977 |
3 trials available for phosphorylcholine and Pregnancy
| Article | Year |
|---|---|
Choline intake and genetic polymorphisms influence choline metabolite concentrations in human breast milk and plasma.
Topics: Adult; Betaine; Choline; Diet; Diet Records; Dietary Supplements; Female; Genotype; Humans; Lactatio | 2010 |
Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Attention; Brain; Child, Preschool; Choline; DNA Mutational | 2013 |
Collaborative trial of prenatal thyrotropin-releasing hormone and corticosteroids for prevention of respiratory distress syndrome. Collaborative Santiago Surfactant Group.
Topics: Adrenal Cortex Hormones; Adult; Betamethasone; Dose-Response Relationship, Drug; Double-Blind Method | 1998 |
31 other studies available for phosphorylcholine and Pregnancy
| Article | Year |
|---|---|
Long-term Immunotoxic Effects of Oral Prenatal and Neonatal Atrazine Exposure.
Topics: Animals; Animals, Newborn; Antibodies, Bacterial; Atrazine; Cells, Cultured; Cytokines; Female; Herb | 2019 |
Prevention of schizophrenia: an impossible dream?
Topics: Attention; Brain; Choline; Female; Humans; Male; Neural Inhibition; Nootropic Agents; Phosphorylchol | 2013 |
Neurokinin 3 receptor and phosphocholine transferase: missing factors for pathogenesis of C-reactive protein in preeclampsia.
Topics: Animals; Biomarkers; C-Reactive Protein; Choline-Phosphate Cytidylyltransferase; Disease Models, Ani | 2015 |
Perinatal choline deficiency delays brain development and alters metabolite concentrations in the young pig.
Topics: Animals; Animals, Newborn; Brain; Choline; Choline Deficiency; Diet; Diffusion Tensor Imaging; Disea | 2016 |
Modulation of natural IgM autoantibodies to oxidative stress-related neo-epitopes on apoptotic cells in newborns of mothers with anti-Ro autoimmunity.
Topics: Adult; Antibodies, Anti-Idiotypic; Apoptosis; Autoantibodies; Autoantigens; Cohort Studies; Enzyme-L | 2016 |
Post-kala-azar dermal leishmaniasis (PKDL) developing after treatment of visceral leishmaniasis with amphotericin B and miltefosine.
Topics: Adult; Amphotericin B; Antimony Sodium Gluconate; Antiprotozoal Agents; Biopsy; Female; Humans; Leis | 2009 |
Maternal dietary choline deficiency alters angiogenesis in fetal mouse hippocampus.
Topics: Angiogenesis Inducing Agents; Animals; Blood Vessels; Cell Count; Cell Proliferation; Cells, Culture | 2010 |
Erucylphosphocholine induces growth inhibition, cell cycle arrest, and apoptosis in human choriocarcinoma cells.
Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Choriocarcinoma; Female; | 2011 |
Effects of methyl-deficient diets on methionine and homocysteine metabolism in the pregnant rat.
Topics: Animals; Choline; Cysteine; Diet; Female; Fetus; Folic Acid; Homocysteine; Kinetics; Litter Size; Li | 2012 |
Increased glutamate levels in the medial prefrontal cortex in patients with postpartum depression.
Topics: Adult; Aspartic Acid; Case-Control Studies; Creatine; Depression, Postpartum; Female; Glutamic Acid; | 2012 |
Effect of exogenous surfactant on the development of surfactant synthesis in premature rabbit lung.
Topics: Animals; Biological Products; Carbon Radioisotopes; Choline; Drug Combinations; Fatty Alcohols; Fema | 2003 |
The occurrence of phosphorylcholine and phosphorylethanolamine in goat placenta.
Topics: Amino Alcohols; Animals; Ethanolamines; Female; Goats; Lecithins; Phosphatidylcholines; Phosphorylch | 1961 |
Respiratory distress syndrome in VLBW infants: changes in management and outcomes observed by the NICHD Neonatal Research Network.
Topics: Adrenal Cortex Hormones; Drug Combinations; Fatty Alcohols; Female; Humans; Infant, Newborn; Infant, | 2003 |
Diethanolamine alters proliferation and choline metabolism in mouse neural precursor cells.
Topics: Animals; Apoptosis; Brain; Bromodeoxyuridine; Carbon Radioisotopes; Cell Proliferation; Cells, Cultu | 2007 |
Folate deficiency during pregnancy impacts on methyl metabolism without affecting global DNA methylation in the rat fetus.
Topics: Amino Acids; Animals; Choline; Diet; DNA Methylation; Female; Fetus; Folic Acid; Folic Acid Deficien | 2007 |
Thymus-independent induction and antigen-dependent recovery of idiotype-specific suppression.
Topics: Animals; Antibody-Producing Cells; Antigens, T-Independent; Epitopes; Female; Hemocyanins; Hemolytic | 1983 |
Evidence for a regulatory role of CTP : choline phosphate cytidylyltransferase in the synthesis of phosphatidylcholine in fetal lung following premature birth.
Topics: Animals; Animals, Newborn; Choline; Choline-Phosphate Cytidylyltransferase; Cytidine Diphosphate Cho | 1981 |
The rate-limiting reaction in phosphatidylcholine synthesis by alveolar type II cells isolated from fetal rat lung.
Topics: Animals; Choline; Cytidine Diphosphate Choline; Female; Fetus; Kinetics; Lung; Phosphatidylcholines; | 1984 |
Alteration of clonal profile. III. T15 ontogenetic advantages are not sufficient for establishing idiotypic dominance in adoptive transfer.
Topics: Animals; Clone Cells; Female; Fetus; Genes, Dominant; Immunization, Passive; Immunoglobulin Idiotype | 1981 |
Hormonal induction of pulmonary maturation in the rabbit fetus: effects of maternal treatment with estradiol-17 beta on th endogenous levels of cholinephosphate, CDP-choline and phosphatidylcholine.
Topics: Animals; Choline; Cytidine Diphosphate Choline; Estradiol; Female; Fetus; Lung; Maternal-Fetal Excha | 1981 |
New method for determining lecithin and sphingomyelin in amniotic fluid.
Topics: Amniotic Fluid; Chromatography, Ion Exchange; Female; Fetal Organ Maturity; Humans; Hydrolysis; Lung | 1981 |
Choline distribution and metabolism in pregnant rats and fetuses are influenced by the choline content of the maternal diet.
Topics: Administration, Oral; Animals; Betaine; Brain; Carbon Radioisotopes; Choline; Chromatography, High P | 1995 |
Pregnancy and lactation are associated with diminished concentrations of choline and its metabolites in rat liver.
Topics: Animals; Betaine; Choline; Choline Deficiency; Female; Lactation; Liver; Male; Maternal-Fetal Exchan | 1995 |
Phosphorylcholine as a unique substrate for human intestinal alkaline phosphatase.
Topics: Alkaline Phosphatase; Bone and Bones; Female; Humans; Hydrogen-Ion Concentration; Intestines; Liver; | 1994 |
Measurement of platelet-activating factor acetylhydrolase activity by quantitative high-performance liquid chromatography determination of coumarin-derivatized 1-O-alkyl-2-sn-lysoglyceryl-3-phosphorylcholine.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Chromatography, High Pressure Liquid; Coumarins; Fem | 1996 |
The choline content of human breast milk expressed during the first few weeks of lactation.
Topics: Choline; Female; Glycerylphosphorylcholine; Humans; Infant Nutritional Physiological Phenomena; Infa | 1996 |
Pathology of arrested acinar development in postsurfactant bronchopulmonary dysplasia.
Topics: Biological Products; Body Weight; Bronchopulmonary Dysplasia; Drug Combinations; Fatty Alcohols; Fem | 1998 |
Choline deficiency induces apoptosis in primary cultures of fetal neurons.
Topics: Animals; Apoptosis; Cell Membrane; Cells, Cultured; Ceramides; Cerebral Cortex; Choline; Choline Def | 2001 |
Argipressin(4-8) upregulate CTP: phosphocholine cytidylyltransferase in rat hippocampal neurons.
Topics: Animals; Arginine Vasopressin; Carbon Radioisotopes; Cells, Cultured; Choline-Phosphate Cytidylyltra | 2002 |
Prenatal diagnosis of Niemann-Pick disease type A using chromogenic substrate.
Topics: Amniotic Fluid; Choline; Female; Fibroblasts; Humans; Niemann-Pick Diseases; Phosphorylcholine; Preg | 1977 |
Phospholipase C activity in microorganisms associated with reproductive tract infection.
Topics: Bacteria, Aerobic; Bacteria, Anaerobic; Bacterial Infections; Chorioamnionitis; Endometritis; Female | 1991 |