phosphorylcholine has been researched along with Pneumococcal Infections in 44 studies
Phosphorylcholine: Calcium and magnesium salts used therapeutically in hepatobiliary dysfunction.
phosphocholine : The phosphate of choline; and the parent compound of the phosphocholine family.
Pneumococcal Infections: Infections with bacteria of the species STREPTOCOCCUS PNEUMONIAE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Aging in mice is accompanied by qualitative changes in the antibody repertoire to phosphorylcholine (PC), a natural epitope of certain pneumococci." | 3.68 | Repertoire diversity of antibody response to bacterial antigens in aged mice. III. Phosphorylcholine antibody from young and aged mice differ in structure and protective activity against infection with Streptococcus pneumoniae. ( Cerny, J; Nicoletti, C; Yang, X, 1993) |
| "Phosphorylcholine (PC) is an immunodominant epitope in some pathogens including Streptococcus pneumoniae and it is well-known that PC-specific antibodies (Abs) play a key role in the induction of protective immunity against pneumococcal infection." | 1.37 | Mucosal immune features to phosphorylcholine by nasal Flt3 ligand cDNA-based vaccination. ( Baatarjav, T; Fujihashi, K; Fukui, M; Gilbert, RS; Goto, M; Ito, HO; Kataoka, K; Kawabata, S; Terao, Y; Yamamoto, M, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (22.73) | 18.7374 |
| 1990's | 10 (22.73) | 18.2507 |
| 2000's | 8 (18.18) | 29.6817 |
| 2010's | 15 (34.09) | 24.3611 |
| 2020's | 1 (2.27) | 2.80 |
| Authors | Studies |
|---|---|
| Ohori, J | 1 |
| Iuchi, H | 1 |
| Maseda, Y | 1 |
| Kurono, Y | 1 |
| Kataoka, K | 2 |
| Fukuyama, Y | 1 |
| Briles, DE | 11 |
| Miyake, T | 1 |
| Fujihashi, K | 2 |
| Ngwa, DN | 1 |
| Agrawal, A | 3 |
| Vale, AM | 1 |
| Kapoor, P | 1 |
| Skibinski, GA | 1 |
| Elgavish, A | 1 |
| Mahmoud, TI | 1 |
| Zemlin, C | 1 |
| Zemlin, M | 1 |
| Burrows, PD | 1 |
| Nobrega, A | 1 |
| Kearney, JF | 1 |
| Schroeder, HW | 1 |
| Young, NM | 1 |
| Foote, SJ | 1 |
| Wakarchuk, WW | 1 |
| Zeng, XF | 1 |
| Ma, Y | 1 |
| Yang, L | 1 |
| Zhou, L | 1 |
| Xin, Y | 1 |
| Chang, L | 1 |
| Zhang, JR | 1 |
| Hao, X | 1 |
| Vassal-Stermann, E | 1 |
| Lacroix, M | 1 |
| Gout, E | 1 |
| Laffly, E | 1 |
| Pedersen, CM | 1 |
| Martin, L | 1 |
| Amoroso, A | 1 |
| Schmidt, RR | 1 |
| Zähringer, U | 1 |
| Gaboriaud, C | 1 |
| Di Guilmi, AM | 1 |
| Thielens, NM | 1 |
| Ramos-Sevillano, E | 1 |
| Urzainqui, A | 1 |
| Campuzano, S | 1 |
| Moscoso, M | 1 |
| González-Camacho, F | 1 |
| Domenech, M | 1 |
| Rodríguez de Córdoba, S | 1 |
| Sánchez-Madrid, F | 1 |
| Brown, JS | 1 |
| García, E | 1 |
| Yuste, J | 1 |
| Chuang, YP | 1 |
| Peng, ZR | 1 |
| Tseng, SF | 1 |
| Lin, YC | 1 |
| Sytwu, HK | 1 |
| Hsieh, YC | 1 |
| Gang, TB | 2 |
| Hanley, GA | 1 |
| Zamora-Carreras, H | 1 |
| Maestro, B | 1 |
| Strandberg, E | 1 |
| Ulrich, AS | 1 |
| Sanz, JM | 1 |
| Jiménez, MÁ | 1 |
| Hergott, CB | 1 |
| Roche, AM | 1 |
| Naidu, NA | 1 |
| Mesaros, C | 1 |
| Blair, IA | 1 |
| Weiser, JN | 2 |
| Gutiérrez-Fernández, J | 1 |
| Saleh, M | 1 |
| Alcorlo, M | 1 |
| Gómez-Mejía, A | 1 |
| Pantoja-Uceda, D | 1 |
| Treviño, MA | 1 |
| Voß, F | 1 |
| Abdullah, MR | 1 |
| Galán-Bartual, S | 1 |
| Seinen, J | 1 |
| Sánchez-Murcia, PA | 1 |
| Gago, F | 1 |
| Bruix, M | 1 |
| Hammerschmidt, S | 1 |
| Hermoso, JA | 1 |
| Thornton, JA | 1 |
| Durick-Eder, K | 1 |
| Tuomanen, EI | 3 |
| Baatarjav, T | 1 |
| Gilbert, RS | 1 |
| Terao, Y | 1 |
| Fukui, M | 1 |
| Goto, M | 1 |
| Kawabata, S | 1 |
| Yamamoto, M | 1 |
| Ito, HO | 1 |
| Hammond, DJ | 1 |
| Singh, SK | 1 |
| Ferguson, DA | 1 |
| Mishra, VK | 1 |
| Harris, SL | 2 |
| Dagtas, AS | 1 |
| Diamond, B | 4 |
| Koppel, EA | 1 |
| Wieland, CW | 1 |
| van den Berg, VC | 1 |
| Litjens, M | 1 |
| Florquin, S | 1 |
| van Kooyk, Y | 1 |
| van der Poll, T | 1 |
| Geijtenbeek, TB | 1 |
| Daniels, CC | 1 |
| Briles, TC | 1 |
| Mirza, S | 1 |
| Håkansson, AP | 1 |
| Fillon, S | 1 |
| Soulis, K | 1 |
| Rajasekaran, S | 1 |
| Benedict-Hamilton, H | 1 |
| Radin, JN | 1 |
| Orihuela, CJ | 1 |
| El Kasmi, KC | 1 |
| Murti, G | 1 |
| Kaushal, D | 1 |
| Gaber, MW | 1 |
| Weber, JR | 1 |
| Murray, PJ | 1 |
| Forman, C | 6 |
| Hudak, S | 3 |
| Claflin, JL | 4 |
| McDaniel, LS | 1 |
| Benjamin, WH | 1 |
| McNamara, MK | 1 |
| Ward, RE | 1 |
| Kohler, H | 1 |
| Szu, SC | 1 |
| Clarke, S | 1 |
| Robbins, JB | 1 |
| Wallick, S | 1 |
| Yother, J | 1 |
| Gray, BM | 1 |
| Nahm, M | 1 |
| Schroer, K | 1 |
| Davie, J | 1 |
| Baker, P | 1 |
| Kearney, J | 1 |
| Barletta, R | 1 |
| Mold, C | 2 |
| Nakayama, S | 1 |
| Holzer, TJ | 1 |
| Gewurz, H | 1 |
| Du Clos, TW | 2 |
| Limpanasithikul, W | 1 |
| Ray, S | 1 |
| Fischer, RT | 2 |
| Longo, DL | 2 |
| Kenny, JJ | 2 |
| Lim, PL | 2 |
| Choy, WF | 2 |
| Chan, ST | 1 |
| Leung, DT | 1 |
| Ng, SS | 1 |
| Nicoletti, C | 2 |
| Yang, X | 1 |
| Cerny, J | 1 |
| Guo, WX | 1 |
| Burger, AM | 1 |
| Sieckmann, DG | 1 |
| Ekdahl, K | 1 |
| Braconier, JH | 1 |
| Svanborg, C | 1 |
| Trolle, S | 1 |
| Chachaty, E | 1 |
| Kassis-Chikhani, N | 1 |
| Wang, C | 1 |
| Fattal, E | 1 |
| Couvreur, P | 1 |
| Alonso, J | 1 |
| Andremont, A | 1 |
| Gosink, KK | 1 |
| Mann, ER | 1 |
| Guglielmo, C | 1 |
| Masure, HR | 1 |
| Park, MK | 1 |
| Nahm, MH | 1 |
| Rodic-Polic, B | 1 |
| Crain, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The SILVA Study: Survival in an International Phase III Prospective Randomized LD Small Cell Lung Cancer Vaccination Study With Adjuvant BEC2 and BCG[NCT00037713] | Phase 3 | 515 participants (Actual) | Interventional | 1998-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for phosphorylcholine and Pneumococcal Infections
| Article | Year |
|---|---|
Dendritic cell-targeting DNA-based nasal adjuvants for protective mucosal immunity to Streptococcus pneumoniae.
Topics: Adjuvants, Immunologic; Administration, Intranasal; Animals; Antibodies, Bacterial; Antigens, Bacter | 2017 |
Structure-Function Relationships of C-Reactive Protein in Bacterial Infection.
Topics: Animals; Bacterial Infections; C-Reactive Protein; Host-Pathogen Interactions; Humans; Phosphorylcho | 2019 |
Review of phosphocholine substituents on bacterial pathogen glycans: synthesis, structures and interactions with host proteins.
Topics: C-Reactive Protein; Host-Pathogen Interactions; Humans; Molecular Structure; Phosphorylcholine; Pneu | 2013 |
Pneumococcal pathogenesis: "innate invasion" yet organ-specific damage.
Topics: Humans; Immunity, Innate; Organ Specificity; Phosphorylcholine; Platelet Membrane Glycoproteins; Pne | 2010 |
40 other studies available for phosphorylcholine and Pneumococcal Infections
| Article | Year |
|---|---|
Phosphorylcholine intranasal immunization with a 13-valent pneumococcal conjugate vaccine can boost immune response against Streptococcus pneumoniae.
Topics: Administration, Intranasal; Animals; Female; Immunity; Immunization, Secondary; Mice; Mice, Inbred B | 2020 |
The link between antibodies to OxLDL and natural protection against pneumococci depends on D(H) gene conservation.
Topics: Amino Acid Sequence; Animals; Antibodies; Antibody Formation; Complementarity Determining Regions; C | 2013 |
A C-terminal truncated mutation of licC attenuates the virulence of Streptococcus pneumoniae.
Topics: Animals; Bacterial Adhesion; Cell Line; Choline-Phosphate Cytidylyltransferase; Disease Models, Anim | 2014 |
Human L-ficolin recognizes phosphocholine moieties of pneumococcal teichoic acid.
Topics: Acetylation; Cell Wall; Complement Activation; Complement C3b; Complement C4b; Fibrinogen; Ficolins; | 2014 |
Pleiotropic effects of cell wall amidase LytA on Streptococcus pneumoniae sensitivity to the host immune response.
Topics: Animals; Bacterial Capsules; Bacterial Proteins; Cell Wall; Complement Activation; Complement C3; Co | 2015 |
Impact of the glpQ2 gene on virulence in a Streptococcus pneumoniae serotype 19A sequence type 320 strain.
Topics: Amino Acid Sequence; Animals; Autolysis; Bacterial Adhesion; Bacterial Proteins; Cell Line; Epitheli | 2015 |
C-reactive protein protects mice against pneumococcal infection via both phosphocholine-dependent and phosphocholine-independent mechanisms.
Topics: Animals; Bacterial Load; C-Reactive Protein; Disease Models, Animal; Male; Mice, Inbred C57BL; Mutan | 2015 |
Micelle-Triggered β-Hairpin to α-Helix Transition in a 14-Residue Peptide from a Choline-Binding Repeat of the Pneumococcal Autolysin LytA.
Topics: Amino Acid Sequence; Bacterial Proteins; Binding Sites; Choline; Circular Dichroism; Humans; Micelle | 2015 |
Bacterial exploitation of phosphorylcholine mimicry suppresses inflammation to promote airway infection.
Topics: Animals; Bacterial Proteins; Carrier Proteins; Carrier State; Cell Wall; Haemophilus Infections; Hae | 2015 |
Modular Architecture and Unique Teichoic Acid Recognition Features of Choline-Binding Protein L (CbpL) Contributing to Pneumococcal Pathogenesis.
Topics: Animals; Binding Sites; Calcium; Carrier Proteins; Cell Wall; Choline; Crystallography, X-Ray; Femal | 2016 |
Mucosal immune features to phosphorylcholine by nasal Flt3 ligand cDNA-based vaccination.
Topics: Administration, Intranasal; Administration, Mucosal; Animals; Antibodies, Bacterial; Bacterial Vacci | 2011 |
The phosphocholine-binding pocket on C-reactive protein is necessary for initial protection of mice against pneumococcal infection.
Topics: Animals; Bacteremia; Binding Sites; C-Reactive Protein; CHO Cells; Cricetinae; Humans; Male; Mice; M | 2012 |
Regulating the isotypic and idiotypic profile of an anti-PC antibody response: lessons from peptide mimics.
Topics: Amino Acid Sequence; Animals; Antibodies, Bacterial; Female; Immunization; Immunoglobulin G; Immunog | 2002 |
Specific ICAM-3 grabbing nonintegrin-related 1 (SIGNR1) expressed by marginal zone macrophages is essential for defense against pulmonary Streptococcus pneumoniae infection.
Topics: Animals; Cell Adhesion Molecules; Fluorescent Antibody Technique; Immunoglobulin M; Lectins, C-Type; | 2005 |
Capsule does not block antibody binding to PspA, a surface virulence protein of Streptococcus pneumoniae.
Topics: Antibodies, Bacterial; Bacterial Capsules; Bacterial Proteins; Fluorescent Antibody Technique, Indir | 2006 |
Platelet-activating factor receptor and innate immunity: uptake of gram-positive bacterial cell wall into host cells and cell-specific pathophysiology.
Topics: Animals; Cell Wall; Endothelium, Vascular; Gram-Positive Bacteria; Immunity, Innate; Mice; Mice, Mut | 2006 |
The effects of idiotype on the ability of IgG1 anti-phosphorylcholine antibodies to protect mice from fatal infection with Streptococcus pneumoniae.
Topics: Animals; Antibodies, Anti-Idiotypic; Choline; Immunization, Passive; Immunoglobulin G; Immunoglobuli | 1984 |
The effects of subclass on the ability of anti-phosphocholine antibodies to protect mice from fatal infection with Streptococcus pneumoniae.
Topics: Animals; Immunoglobulin G; Immunoglobulin Isotypes; Mice; Mice, Inbred CBA; Phosphorylcholine; Pneum | 1984 |
Blood clearance by anti-phosphocholine antibodies as a mechanism of protection in experimental pneumococcal bacteremia.
Topics: Animals; Antibodies, Bacterial; Blood Bactericidal Activity; Choline; Dose-Response Relationship, Im | 1984 |
Monoclonal idiotope vaccine against Streptococcus pneumoniae infection.
Topics: Animals; Antibodies, Monoclonal; Bacterial Vaccines; Immunoglobulin Idiotypes; Mice; Mice, Inbred BA | 1984 |
Protection against pneumococcal infection in mice conferred by phosphocholine-binding antibodies: specificity of the phosphocholine binding and relation to several types.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Antibody Specificity; Chemical Phenomena; Chem | 1983 |
Resistance to Streptococcus pneumoniae is induced by a phosphocholine-protein conjugate.
Topics: Animals; Antigens; Antigens, Bacterial; Cell Wall; Choline; Hemocyanins; Immunity, Active; Immunoglo | 1983 |
Protection of mice from infection with Streptococcus pneumoniae by anti-phosphocholine antibody.
Topics: Animals; Antibodies, Bacterial; Antibodies, Monoclonal; Antigen-Antibody Reactions; Choline; Female; | 1982 |
Anti-phosphorylcholine antibodies of the T15 idiotype are optimally protective against Streptococcus pneumoniae.
Topics: Animals; Antibodies, Monoclonal; Choline; Immunoglobulin Idiotypes; Immunoglobulin M; Male; Mice; Mi | 1982 |
Antiphosphocholine antibodies found in normal mouse serum are protective against intravenous infection with type 3 streptococcus pneumoniae.
Topics: Animals; Antibodies; Antibody Formation; Antibody Specificity; Choline; Crosses, Genetic; Female; Hy | 1981 |
C-reactive protein is protective against Streptococcus pneumoniae infection in mice.
Topics: Animals; Animals, Newborn; Antigens; C-Reactive Protein; Female; Humans; Immune Tolerance; Mice; Mic | 1981 |
Cross-reactive antibodies have both protective and pathogenic potential.
Topics: Amino Acid Sequence; Animals; Antibodies, Bispecific; Base Sequence; Female; Hemocyanins; Immunoglob | 1995 |
A novel phosphocholine antigen protects both normal and X-linked immune deficient mice against Streptococcus pneumoniae. Comparison of the 6-O-phosphocholine hydroxyhexanoate-conjugate with other phosphocholine-containing vaccines.
Topics: Animals; Antigens; Azo Compounds; Caproates; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Hemo | 1995 |
Transgene-encoded antiphosphorylcholine (T15+) antibodies protect CBA/N (xid) mice against infection with Streptococcus pneumoniae but not Trichinella spiralis.
Topics: Animals; Antibodies; Female; Immunization; Mice; Mice, Inbred BALB C; Mice, Inbred CBA; Mice, Transg | 1994 |
Repertoire diversity of antibody response to bacterial antigens in aged mice. III. Phosphorylcholine antibody from young and aged mice differ in structure and protective activity against infection with Streptococcus pneumoniae.
Topics: Aging; Animals; Antibodies, Bacterial; Antibodies, Monoclonal; Antibody Affinity; Antigens, Bacteria | 1993 |
Antibody protection in aging: influence of idiotypic repertoire and antibody binding activity to a bacterial antigen.
Topics: Aging; Animals; Animals, Newborn; Antibodies, Bacterial; Antibodies, Monoclonal; Antigen-Antibody Re | 1995 |
Sequence changes at the V-D junction of the VH1 heavy chain of anti-phosphocholine antibodies alter binding to and protection against Streptococcus pneumoniae.
Topics: Amino Acid Sequence; Animals; Antibodies, Antiphospholipid; Antibody Affinity; Bacterial Adhesion; B | 1997 |
Impaired antibody response to pneumococcal capsular polysaccharides and phosphorylcholine in adult patients with a history of bacteremic pneumococcal infection.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antibodies, Bacterial; Bacteremia; Bacterial Vaccines; C | 1997 |
Phase variation in colony opacity by Streptococcus pneumoniae.
Topics: Animals; Bacterial Capsules; Choline; Flow Cytometry; Fluorescent Antibody Technique; Humans; Mice; | 1998 |
Intranasal immunization with protein-linked phosphorylcholine protects mice against a lethal intranasal challenge with streptococcus pneumoniae.
Topics: Administration, Intranasal; Animals; Female; Immunity, Mucosal; Immunization; Immunoglobulin A; Immu | 2000 |
Role of novel choline binding proteins in virulence of Streptococcus pneumoniae.
Topics: Animals; Bacterial Adhesion; Bacterial Proteins; Carrier Proteins; Cells, Cultured; Cloning, Molecul | 2000 |
Peptide mimic of phosphorylcholine, a dominant epitope found on Streptococcus pneumoniae.
Topics: Amino Acid Sequence; Animals; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal; Cattle; Cross Reac | 2000 |
Protection from Streptococcus pneumoniae infection by C-reactive protein and natural antibody requires complement but not Fc gamma receptors.
Topics: Animals; Antibodies, Bacterial; C-Reactive Protein; Complement Pathway, Classical; Complement System | 2002 |
Mouse antibody to phosphocholine can protect mice from infection with mouse-virulent human isolates of Streptococcus pneumoniae.
Topics: Animals; Antibodies, Monoclonal; Female; Humans; Mice; Mice, Inbred BALB C; Mice, Inbred CBA; Phosph | 1992 |
A thymus-independent (type 1) phosphorylcholine antigen isolated from Trichinella spiralis protects mice against pneumococcal infection.
Topics: Animals; Antibodies, Helminth; Antigens, Helminth; Choline; Immunization; Mice; Mice, Inbred CBA; Ph | 1990 |