phosphorylcholine has been researched along with Neuroblastoma in 15 studies
Phosphorylcholine: Calcium and magnesium salts used therapeutically in hepatobiliary dysfunction.
phosphocholine : The phosphate of choline; and the parent compound of the phosphocholine family.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Perifosine is an alkylphospholipid analog that inhibits or modulates signaling through signal transduction pathways such as Akt, which is enhanced in neuroblastoma (NB) by activation of tyrosine kinase receptors." | 9.24 | Phase I study of perifosine monotherapy in patients with recurrent or refractory neuroblastoma. ( Chin, M; Kato, K; Kawamoto, H; Kosaka, Y; Matsumoto, K; Mugishima, H; Shichino, H, 2017) |
| "Perifosine, an Akt inhibitor, has been shown to be effective in controlling neuroblastoma tumor growth." | 7.85 | Proteome and Acetylome Analysis Identifies Novel Pathways and Targets Regulated by Perifosine in Neuroblastoma. ( Dong, Y; Gu, X; Hua, Z; Li, Z; Liu, Z; Thiele, CJ; Tian, W; Zhan, Y; Zhang, X, 2017) |
| "Perifosine-treated mice bearing xenograft NB tumors had longer survival than untreated mice (untreated vs treated, median survival: AS, 13 days, 95% confidence interval [CI] = 11 to 16 days vs not reached, P = ." | 5.36 | In vitro and in vivo inhibition of neuroblastoma tumor cell growth by AKT inhibitor perifosine. ( Li, Z; Liewehr, DJ; Steinberg, SM; Tan, F; Thiele, CJ, 2010) |
| "Perifosine is an alkylphospholipid analog that inhibits or modulates signaling through signal transduction pathways such as Akt, which is enhanced in neuroblastoma (NB) by activation of tyrosine kinase receptors." | 5.24 | Phase I study of perifosine monotherapy in patients with recurrent or refractory neuroblastoma. ( Chin, M; Kato, K; Kawamoto, H; Kosaka, Y; Matsumoto, K; Mugishima, H; Shichino, H, 2017) |
| "Perifosine, an Akt inhibitor, has been shown to be effective in controlling neuroblastoma tumor growth." | 3.85 | Proteome and Acetylome Analysis Identifies Novel Pathways and Targets Regulated by Perifosine in Neuroblastoma. ( Dong, Y; Gu, X; Hua, Z; Li, Z; Liu, Z; Thiele, CJ; Tian, W; Zhan, Y; Zhang, X, 2017) |
| "The cell numbers of three mouse neuroblastoma cell lines were decreased upon incubation with lysosphingolipids in the following order of effectiveness: lysosulfatide (lysoCS) greater than psychosine (Ps) greater than sphingosylphosphocholine (SPC)." | 3.68 | Effects of various lysosphingolipids on cell growth, morphology and lipid composition in three neuroblastoma cell lines. ( Hara, A; Sugiyama, E; Taketomi, T; Uemura, K, 1990) |
| "Perifosine-treated mice bearing xenograft NB tumors had longer survival than untreated mice (untreated vs treated, median survival: AS, 13 days, 95% confidence interval [CI] = 11 to 16 days vs not reached, P = ." | 1.36 | In vitro and in vivo inhibition of neuroblastoma tumor cell growth by AKT inhibitor perifosine. ( Li, Z; Liewehr, DJ; Steinberg, SM; Tan, F; Thiele, CJ, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (26.67) | 18.2507 |
| 2000's | 1 (6.67) | 29.6817 |
| 2010's | 10 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Matsumoto, K | 1 |
| Shichino, H | 1 |
| Kawamoto, H | 1 |
| Kosaka, Y | 1 |
| Chin, M | 1 |
| Kato, K | 1 |
| Mugishima, H | 1 |
| Becher, OJ | 2 |
| Millard, NE | 1 |
| Modak, S | 2 |
| Kushner, BH | 2 |
| Haque, S | 1 |
| Spasojevic, I | 1 |
| Trippett, TM | 1 |
| Gilheeney, SW | 1 |
| Khakoo, Y | 1 |
| Lyden, DC | 1 |
| De Braganca, KC | 1 |
| Kolesar, JM | 1 |
| Huse, JT | 1 |
| Kramer, K | 2 |
| Cheung, NV | 2 |
| Dunkel, IJ | 2 |
| Yu, T | 1 |
| Li, L | 1 |
| Liu, W | 1 |
| Ya, B | 1 |
| Cheng, H | 1 |
| Xin, Q | 1 |
| Durbas, M | 1 |
| Horwacik, I | 1 |
| Boratyn, E | 1 |
| Kamycka, E | 1 |
| Rokita, H | 1 |
| Basu, EM | 1 |
| Roberts, SS | 1 |
| Wang, N | 1 |
| Jin, X | 1 |
| Guo, D | 1 |
| Tong, G | 1 |
| Zhu, X | 1 |
| Gu, X | 1 |
| Hua, Z | 1 |
| Dong, Y | 1 |
| Zhan, Y | 1 |
| Zhang, X | 1 |
| Tian, W | 1 |
| Liu, Z | 1 |
| Thiele, CJ | 3 |
| Li, Z | 3 |
| Brodeur, GM | 1 |
| Tan, F | 1 |
| Liewehr, DJ | 1 |
| Steinberg, SM | 1 |
| Oh, DY | 1 |
| Nakamura, K | 1 |
| Sugiyama, E | 2 |
| Uemura, K | 2 |
| Hara, A | 2 |
| Taketomi, T | 2 |
| Bhakoo, KK | 1 |
| Williams, SR | 1 |
| Florian, CL | 1 |
| Land, H | 1 |
| Noble, MD | 1 |
| Hunt, AN | 1 |
| Burdge, GC | 1 |
| Antony, P | 1 |
| Kanfer, JN | 1 |
| Freysz, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase I Study of Single Agent Perifosine for Recurrent Pediatric Solid Tumors[NCT00776867] | Phase 1 | 38 participants (Anticipated) | Interventional | 2008-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for phosphorylcholine and Neuroblastoma
| Article | Year |
|---|---|
Phase I study of perifosine monotherapy in patients with recurrent or refractory neuroblastoma.
Topics: Adolescent; Adult; Child; Child, Preschool; Drug Resistance, Neoplasm; Female; Follow-Up Studies; Hu | 2017 |
A phase I study of single-agent perifosine for recurrent or refractory pediatric CNS and solid tumors.
Topics: Adolescent; Antineoplastic Agents; Central Nervous System Neoplasms; Child; Child, Preschool; Drug A | 2017 |
A phase I/Ib trial targeting the Pi3k/Akt pathway using perifosine: Long-term progression-free survival of patients with resistant neuroblastoma.
Topics: Adolescent; Adult; Antineoplastic Agents; Child; Child, Preschool; Disease-Free Survival; Female; Hu | 2017 |
12 other studies available for phosphorylcholine and Neuroblastoma
| Article | Year |
|---|---|
Silencing of NADPH Oxidase 4 Attenuates Hypoxia Resistance in Neuroblastoma Cells SH-SY5Y by Inhibiting PI3K/Akt-Dependent Glycolysis.
Topics: Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Gene Silencing; Glycolysis; Humans; | 2019 |
GD2 ganglioside specific antibody treatment downregulates PI3K/Akt/mTOR signaling network in human neuroblastoma cell lines.
Topics: Antibodies, Monoclonal; Apoptosis; Cell Line, Tumor; Drug Synergism; Gangliosides; Gene Expression R | 2015 |
Iron Chelation Nanoparticles with Delayed Saturation as an Effective Therapy for Parkinson Disease.
Topics: Animals; Behavior, Animal; Blood-Brain Barrier; Brain; Cell Survival; Disease Models, Animal; Humans | 2017 |
Proteome and Acetylome Analysis Identifies Novel Pathways and Targets Regulated by Perifosine in Neuroblastoma.
Topics: Acetylation; Amino Acids; Antineoplastic Agents; Cell Line, Tumor; Chromatography, Liquid; Humans; L | 2017 |
Getting into the AKT.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Surv | 2010 |
In vitro and in vivo inhibition of neuroblastoma tumor cell growth by AKT inhibitor perifosine.
Topics: Analysis of Variance; Animals; Antineoplastic Agents; Apoptosis; Caspase 3; Caspase 7; Cell Line, Tu | 2010 |
Perifosine-induced inhibition of Akt attenuates brain-derived neurotrophic factor/TrkB-induced chemoresistance in neuroblastoma in vivo.
Topics: Brain Neoplasms; Brain-Derived Neurotrophic Factor; Cell Line, Tumor; Drug Resistance, Neoplasm; Eto | 2011 |
Metabolism and neurite promoting effect of exogenous sphingosylphosphocholine in cultured murine neuroblastoma cells.
Topics: Animals; Cell Differentiation; Mice; Neurites; Neuroblastoma; Phosphorylcholine; Protein Kinase C; S | 1993 |
Immortalization and transformation are associated with specific alterations in choline metabolism.
Topics: Animals; Antigens, Viral, Tumor; Cell Division; Cell Line, Transformed; Choline; Glioblastoma; Human | 1996 |
Chromatin-associated phosphatidylcholine synthesis.
Topics: Carbon Radioisotopes; Cell Nucleus; Choline; Chromatin; Cytidine Diphosphate Choline; Humans; Neurob | 1998 |
Phosphatidylcholine metabolism in nuclei of phorbol ester-activated LA-N-1 neuroblastoma cells.
Topics: Carbon Radioisotopes; Cell Nucleus; Choline; Choline Kinase; Cytidine Diphosphate Choline; Humans; K | 2000 |
Effects of various lysosphingolipids on cell growth, morphology and lipid composition in three neuroblastoma cell lines.
Topics: Animals; Cell Division; Cell Line; Choline; Gangliosides; Kinetics; Lipid Metabolism; Mice; Neurobla | 1990 |