phosphorylcholine has been researched along with Medulloblastoma in 2 studies
Phosphorylcholine: Calcium and magnesium salts used therapeutically in hepatobiliary dysfunction.
phosphocholine : The phosphate of choline; and the parent compound of the phosphocholine family.
Medulloblastoma: A malignant neoplasm that may be classified either as a glioma or as a primitive neuroectodermal tumor of childhood (see NEUROECTODERMAL TUMOR, PRIMITIVE). The tumor occurs most frequently in the first decade of life with the most typical location being the cerebellar vermis. Histologic features include a high degree of cellularity, frequent mitotic figures, and a tendency for the cells to organize into sheets or form rosettes. Medulloblastoma have a high propensity to spread throughout the craniospinal intradural axis. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2060-1)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Perifosine treatment led to the rapid induction of cell death in medulloblastoma cell lines, with pronounced suppression of phosphorylated AKT in a time-dependent and concentration-dependent manner." | 5.35 | The alkylphospholipid perifosine induces apoptosis and p21-mediated cell cycle arrest in medulloblastoma. ( Broaddus, WC; Fillmore, HL; Kadian, R; Kumar, A; Tye, GW; Van Meter, TE, 2009) |
| "Perifosine treatment led to the rapid induction of cell death in medulloblastoma cell lines, with pronounced suppression of phosphorylated AKT in a time-dependent and concentration-dependent manner." | 1.35 | The alkylphospholipid perifosine induces apoptosis and p21-mediated cell cycle arrest in medulloblastoma. ( Broaddus, WC; Fillmore, HL; Kadian, R; Kumar, A; Tye, GW; Van Meter, TE, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Becher, OJ | 1 |
| Millard, NE | 1 |
| Modak, S | 1 |
| Kushner, BH | 1 |
| Haque, S | 1 |
| Spasojevic, I | 1 |
| Trippett, TM | 1 |
| Gilheeney, SW | 1 |
| Khakoo, Y | 1 |
| Lyden, DC | 1 |
| De Braganca, KC | 1 |
| Kolesar, JM | 1 |
| Huse, JT | 1 |
| Kramer, K | 1 |
| Cheung, NV | 1 |
| Dunkel, IJ | 1 |
| Kumar, A | 1 |
| Fillmore, HL | 1 |
| Kadian, R | 1 |
| Broaddus, WC | 1 |
| Tye, GW | 1 |
| Van Meter, TE | 1 |
1 trial available for phosphorylcholine and Medulloblastoma
| Article | Year |
|---|---|
A phase I study of single-agent perifosine for recurrent or refractory pediatric CNS and solid tumors.
Topics: Adolescent; Antineoplastic Agents; Central Nervous System Neoplasms; Child; Child, Preschool; Drug A | 2017 |
1 other study available for phosphorylcholine and Medulloblastoma
| Article | Year |
|---|---|
The alkylphospholipid perifosine induces apoptosis and p21-mediated cell cycle arrest in medulloblastoma.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Survival; Ce | 2009 |