phosphorylcholine has been researched along with Leucocythaemia in 14 studies
Phosphorylcholine: Calcium and magnesium salts used therapeutically in hepatobiliary dysfunction.
phosphocholine : The phosphate of choline; and the parent compound of the phosphocholine family.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The primary objective of this phase I study was to determine the maximum tolerated dose (MTD) of UCN-01 given in combination with perifosine in patients with advanced acute leukemias and myelodysplastic syndrome." | 9.17 | Phase I study of UCN-01 and perifosine in patients with relapsed and refractory acute leukemias and high-risk myelodysplastic syndrome. ( Baer, MR; Bauer, KS; Carroll, M; Fleckinger, S; Gojo, I; Luger, S; Norsworthy, KJ; Perl, A; Sausville, EA; Tidwell, M, 2013) |
| "Interactions between histone deacetylase inhibitors (HDACIs) and the alkyl-lysophospholipid perifosine were examined in human leukemia cells." | 7.73 | Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species. ( Bauer, C; Dai, Y; Dent, P; Grant, S; Payne, SG; Rahmani, M; Reese, E; Spiegel, S, 2005) |
| "The primary objective of this phase I study was to determine the maximum tolerated dose (MTD) of UCN-01 given in combination with perifosine in patients with advanced acute leukemias and myelodysplastic syndrome." | 5.17 | Phase I study of UCN-01 and perifosine in patients with relapsed and refractory acute leukemias and high-risk myelodysplastic syndrome. ( Baer, MR; Bauer, KS; Carroll, M; Fleckinger, S; Gojo, I; Luger, S; Norsworthy, KJ; Perl, A; Sausville, EA; Tidwell, M, 2013) |
| "Interactions between histone deacetylase inhibitors (HDACIs) and the alkyl-lysophospholipid perifosine were examined in human leukemia cells." | 3.73 | Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species. ( Bauer, C; Dai, Y; Dent, P; Grant, S; Payne, SG; Rahmani, M; Reese, E; Spiegel, S, 2005) |
| "D-19391 was added to the SK-BR-3 breast cancer cell line and HePC to the Molt-4 leukemia cell line in concentrations of, respectively, 18." | 1.30 | Cellular uptake and retention measurements of alkylphosphocholines in the SK-BR-3 breast cancer and Molt-4 leukemia cell line using capillary gas chromatography. ( Brochez, V; De Potter, CR; Diniz, JA; Van den Eeckhout, EG; Van Heuverswyn, D, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (57.14) | 18.2507 |
| 2000's | 1 (7.14) | 29.6817 |
| 2010's | 5 (35.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gojo, I | 1 |
| Perl, A | 1 |
| Luger, S | 1 |
| Baer, MR | 1 |
| Norsworthy, KJ | 1 |
| Bauer, KS | 1 |
| Tidwell, M | 1 |
| Fleckinger, S | 1 |
| Carroll, M | 1 |
| Sausville, EA | 1 |
| Voltan, R | 2 |
| Celeghini, C | 2 |
| Melloni, E | 1 |
| Secchiero, P | 1 |
| Zauli, G | 2 |
| Rimondi, E | 1 |
| Gattei, V | 1 |
| Wang, Y | 1 |
| Chen, L | 1 |
| Ding, Y | 1 |
| Yan, W | 1 |
| Thomé, CH | 1 |
| dos Santos, GA | 1 |
| Ferreira, GA | 1 |
| Scheucher, PS | 1 |
| Izumi, C | 1 |
| Leopoldino, AM | 1 |
| Simão, AM | 1 |
| Ciancaglini, P | 1 |
| de Oliveira, KT | 1 |
| Chin, A | 1 |
| Hanash, SM | 1 |
| Falcão, RP | 1 |
| Rego, EM | 1 |
| Greene, LJ | 1 |
| Faça, VM | 1 |
| Rahmani, M | 1 |
| Reese, E | 1 |
| Dai, Y | 1 |
| Bauer, C | 1 |
| Payne, SG | 1 |
| Dent, P | 1 |
| Spiegel, S | 1 |
| Grant, S | 1 |
| Berkovic, D | 3 |
| Berkovic, K | 1 |
| Fleer, EA | 4 |
| Eibl, H | 3 |
| Unger, C | 3 |
| Adebodun, F | 1 |
| Post, JF | 1 |
| Goeckenjan, M | 1 |
| Lüders, S | 1 |
| Hiddemann, W | 2 |
| Haase, D | 1 |
| Konstantinov, SM | 1 |
| Topashka-Ancheva, M | 1 |
| Benner, A | 1 |
| Berger, MR | 1 |
| Brochez, V | 1 |
| Van Heuverswyn, D | 1 |
| Diniz, JA | 1 |
| De Potter, CR | 1 |
| Van den Eeckhout, EG | 1 |
| Kötting, J | 1 |
| Neumüller, W | 1 |
| Hochhuth, C | 1 |
| Doenecke, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 1 Study of UCN-01 in Combination With Perifosine in Patients With Relapsed and Refractory Acute Leukemias and High Risk MDS[NCT00301938] | Phase 1 | 30 participants (Actual) | Interventional | 2005-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for phosphorylcholine and Leucocythaemia
| Article | Year |
|---|---|
Phase I study of UCN-01 and perifosine in patients with relapsed and refractory acute leukemias and high-risk myelodysplastic syndrome.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocol | 2013 |
13 other studies available for phosphorylcholine and Leucocythaemia
| Article | Year |
|---|---|
Perifosine plus nutlin-3 combination shows a synergistic anti-leukaemic activity.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Death; Drug Screening Assays, Antitumor; Humans | 2010 |
Perifosine selectively induces cell cycle block and modulates retinoblastoma and E2F1 protein levels in p53 mutated leukemic cell lines.
Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Survival; Drug Screening Assays, Antitumor; E2F1 Trans | 2011 |
Oxidized phospholipid based pH sensitive micelles for delivery of anthracyclines to resistant leukemia cells in vitro.
Topics: Animals; Antibiotics, Antineoplastic; Cell Line, Tumor; Cell Survival; Chemistry, Pharmaceutical; Do | 2012 |
Linker for activation of T-cell family member2 (LAT2) a lipid raft adaptor protein for AKT signaling, is an early mediator of alkylphospholipid anti-leukemic activity.
Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals | 2012 |
Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-2-Associated X Protein; Butyrates; Ce | 2005 |
Inhibition of calcium-dependent protein kinase C by hexadecylphosphocholine and 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine do not correlate with inhibition of proliferation of HL60 and K562 cell lines.
Topics: Antineoplastic Agents; Cell Division; Cell Membrane; Cytosol; Diglycerides; Dose-Response Relationsh | 1994 |
31P NMR characterization of cellular metabolism during dexamethasone induced apoptosis in human leukemic cell lines.
Topics: Adenosine Triphosphate; Apoptosis; Dexamethasone; Ethanolamines; Humans; Hydrogen-Ion Concentration; | 1994 |
Hexadecylphosphocholine inhibits phosphatidylinositol and phosphatidylcholine phospholipase C in human leukemia cells.
Topics: Antineoplastic Agents; Cell Membrane; Cells, Cultured; Chromatography, Thin Layer; Enzyme Activation | 1996 |
Induction of resistance in the human leukemia cell line HL60 towards hexadecylphosphocholine and other ether phospholipid analogues.
Topics: Antigens, Surface; Antineoplastic Agents; Cholesterol; Chromosomes; Drug Resistance, Neoplasm; Flow | 1996 |
Alkylphosphocholines: Effects on human leukemic cell lines and normal bone marrow cells.
Topics: Alkylation; Animals; Antineoplastic Agents; Apoptosis; Bone Marrow Cells; Cell Cycle; Cell Division; | 1998 |
Cellular uptake and retention measurements of alkylphosphocholines in the SK-BR-3 breast cancer and Molt-4 leukemia cell line using capillary gas chromatography.
Topics: Antineoplastic Agents; Breast Neoplasms; Chromatography, Gas; Humans; Leukemia; Phosphorylcholine; R | 1999 |
Antitumoral activity of alkylphosphocholines and analogues in human leukemia cell lines.
Topics: Antineoplastic Agents; Humans; Leukemia; Phosphorylcholine; Tumor Cells, Cultured | 1992 |
Early effects of hexadecylphosphocholine on gene expression in leukemia cell lines.
Topics: Antineoplastic Agents; Humans; Leukemia; Phosphorylcholine; Transcription, Genetic; Tumor Cells, Cul | 1992 |