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phosphorylcholine and Keratitis, Acanthamoeba

phosphorylcholine has been researched along with Keratitis, Acanthamoeba in 16 studies

Phosphorylcholine: Calcium and magnesium salts used therapeutically in hepatobiliary dysfunction.
phosphocholine : The phosphate of choline; and the parent compound of the phosphocholine family.

Research Excerpts

ExcerptRelevanceReference
"The purpose of this study was to report a retrospective case series of anterior scleral and limbal inflammatory necrosis after adjuvant miltefosine for recalcitrant Acanthamoeba keratitis (AK)."8.12Anterior Scleral and Limbal Inflammatory Necrosis After Adjuvant Miltefosine for Recalcitrant Acanthamoeba Keratitis. ( Berdahl, J; de la Presa, M; Holland, EJ; Ibach, M, 2022)
"To report a case series of patients with treatment-resistant Acanthamoeba keratitis (AK) using oral miltefosine, often as salvage therapy."8.02Oral Miltefosine as Salvage Therapy for Refractory Acanthamoeba Keratitis. ( Appenheimer, AB; Chodosh, J; Hou, JH; Kang, JJ; Morrill, AM; Rapuano, CJ; Saeed, HN; Thulasi, P; Tu, EY; Vyas, N; Zegans, ME; Zuckerman, R, 2021)
"This case shows resolution of recalcitrant Acanthamoeba keratitis with oral miltefosine in an immunocompetent patient."7.91Oral Miltefosine as Adjunctive Treatment for Recalcitrant Acanthamoeba Keratitis. ( Dewan, N; Holland, SP; Iovieno, A; Ming, W; Yeung, SN, 2019)
"In this study, a series of compounds - miltefosine, polyhexamethylene biguanide, chlorhexidine and propamidine isethionate - and combinations of the latter three agents with miltefosine were prepared and used in a rat model for the topical treatment of Acanthamoeba keratitis."7.80Miltefosine and polyhexamethylene biguanide: a new drug combination for the treatment of Acanthamoeba keratitis. ( Arici, MK; Dursun, A; Obwaller, A; Polat, ZA; Vural, A; Walochnik, J, 2014)
"Miltefosine treatment yielded much higher cure scores than propamidine isetionate plus polyhexanide."5.38Efficacy of miltefosine for topical treatment of Acanthamoeba keratitis in Syrian hamsters. ( Obwaller, A; Polat, ZA; Vural, A; Walochnik, J, 2012)
"The treatment of Acanthamoeba keratitis has now been possible since the first successful therapy developed in the mid 1980s with a combination of propamidine 0."4.82Treatment of Acanthamoeba keratitis. ( Seal, D, 2003)
"The purpose of this study was to report a retrospective case series of anterior scleral and limbal inflammatory necrosis after adjuvant miltefosine for recalcitrant Acanthamoeba keratitis (AK)."4.12Anterior Scleral and Limbal Inflammatory Necrosis After Adjuvant Miltefosine for Recalcitrant Acanthamoeba Keratitis. ( Berdahl, J; de la Presa, M; Holland, EJ; Ibach, M, 2022)
"To report a case series of patients with treatment-resistant Acanthamoeba keratitis (AK) using oral miltefosine, often as salvage therapy."4.02Oral Miltefosine as Salvage Therapy for Refractory Acanthamoeba Keratitis. ( Appenheimer, AB; Chodosh, J; Hou, JH; Kang, JJ; Morrill, AM; Rapuano, CJ; Saeed, HN; Thulasi, P; Tu, EY; Vyas, N; Zegans, ME; Zuckerman, R, 2021)
"This case shows resolution of recalcitrant Acanthamoeba keratitis with oral miltefosine in an immunocompetent patient."3.91Oral Miltefosine as Adjunctive Treatment for Recalcitrant Acanthamoeba Keratitis. ( Dewan, N; Holland, SP; Iovieno, A; Ming, W; Yeung, SN, 2019)
"In this study, a series of compounds - miltefosine, polyhexamethylene biguanide, chlorhexidine and propamidine isethionate - and combinations of the latter three agents with miltefosine were prepared and used in a rat model for the topical treatment of Acanthamoeba keratitis."3.80Miltefosine and polyhexamethylene biguanide: a new drug combination for the treatment of Acanthamoeba keratitis. ( Arici, MK; Dursun, A; Obwaller, A; Polat, ZA; Vural, A; Walochnik, J, 2014)
"Acanthamoeba keratitis is a corneal disease associated predominantly with contact lens wear."2.42[Treatment of Acanthamoeba keratitis: possibilities, problems, and new approaches]. ( Aspöck, H; Duchêne, M; Eibl, H; Walochnik, J, 2003)
"Miltefosine treatment yielded much higher cure scores than propamidine isetionate plus polyhexanide."1.38Efficacy of miltefosine for topical treatment of Acanthamoeba keratitis in Syrian hamsters. ( Obwaller, A; Polat, ZA; Vural, A; Walochnik, J, 2012)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (25.00)29.6817
2010's5 (31.25)24.3611
2020's7 (43.75)2.80

Authors

AuthorsStudies
de la Presa, M1
Ibach, M1
Berdahl, J1
Holland, EJ1
Avdagic, E1
Chew, HF1
Veldman, P1
Tu, EY3
Jafri, M1
Doshi, R1
Boggild, AK1
Reidy, JJ2
Farooq, AV2
Thulasi, P2
Saeed, HN1
Rapuano, CJ1
Hou, JH1
Appenheimer, AB1
Chodosh, J1
Kang, JJ1
Morrill, AM1
Vyas, N1
Zegans, ME1
Zuckerman, R1
Si, Z1
Veldman, PB1
Kaur, A1
Sahu, SK1
Matoba, A1
Weikert, MP1
Kim, S1
Bagga, B1
Joseph, J1
Garg, P1
Chandran, K1
Jayabhasker, P1
Manjulatha, K1
Sharma, S1
Dewan, N1
Ming, W1
Holland, SP1
Yeung, SN1
Iovieno, A1
Polat, ZA2
Walochnik, J4
Obwaller, A3
Vural, A2
Dursun, A1
Arici, MK1
Mrva, M1
Garajová, M1
Lukáč, M1
Ondriska, F1
Seal, D1
Duchêne, M2
Eibl, H2
Aspöck, H2
Vasseneix, C1
Gargala, G1
François, A1
Hellot, MF1
Duclos, C1
Muraine, M1
Benichou, J1
Ballet, JJ1
Brasseur, G1
Favennec, L1
Seifert, K1
Hottkowitz, T1
Wiedermann, G1

Reviews

2 reviews available for phosphorylcholine and Keratitis, Acanthamoeba

ArticleYear
Treatment of Acanthamoeba keratitis.
    Expert review of anti-infective therapy, 2003, Volume: 1, Issue:2

    Topics: Acanthamoeba Keratitis; Amebicides; Anti-Bacterial Agents; Anti-Infective Agents, Local; Antiprotozo

2003
[Treatment of Acanthamoeba keratitis: possibilities, problems, and new approaches].
    Wiener klinische Wochenschrift, 2003, Volume: 115 Suppl 3

    Topics: Acanthamoeba Keratitis; Antiprotozoal Agents; Benzamidines; Biguanides; Contact Lens Solutions; Cont

2003

Other Studies

14 other studies available for phosphorylcholine and Keratitis, Acanthamoeba

ArticleYear
Anterior Scleral and Limbal Inflammatory Necrosis After Adjuvant Miltefosine for Recalcitrant Acanthamoeba Keratitis.
    Cornea, 2022, Jun-01, Volume: 41, Issue:6

    Topics: Acanthamoeba Keratitis; Adjuvants, Immunologic; Adult; Humans; Inflammation; Necrosis; Phosphorylcho

2022
Resolution of
    Ocular immunology and inflammation, 2021, Feb-17, Volume: 29, Issue:2

    Topics: Acanthamoeba; Acanthamoeba Keratitis; Administration, Oral; Adult; Antiprotozoal Agents; Cornea; DNA

2021
Oral Miltefosine as Salvage Therapy for Refractory Acanthamoeba Keratitis.
    American journal of ophthalmology, 2021, Volume: 223

    Topics: Acanthamoeba Keratitis; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Antiprotoz

2021
Severe Inflammatory Response in a Patient on Oral Miltefosine for Acanthamoeba Keratitis.
    Ocular immunology and inflammation, 2022, 05-19, Volume: 30, Issue:4

    Topics: Acanthamoeba; Acanthamoeba Keratitis; Humans; Phosphorylcholine

2022
Comment on "Oral Miltefosine as Salvage Therapy for Refractory Acanthamoeba Keratitis".
    American journal of ophthalmology, 2021, Volume: 232

    Topics: Acanthamoeba; Acanthamoeba Keratitis; Humans; Phosphorylcholine; Salvage Therapy

2021
Reply to Comment on "Oral Miltefosine as Salvage Therapy for Recalcitrant Acanthamoeba Keratitis".
    American journal of ophthalmology, 2021, Volume: 232

    Topics: Acanthamoeba; Acanthamoeba Keratitis; Humans; Phosphorylcholine; Salvage Therapy

2021
Corneal Manifestations of Miltefosine Toxicity in Acanthamoeba Keratitis.
    Ophthalmology, 2021, Volume: 128, Issue:9

    Topics: Acanthamoeba Keratitis; Anti-Allergic Agents; Antiprotozoal Agents; Corneal Stroma; Drug Substitutio

2021
Efficacy of Topical Miltefosine in Patients with Acanthamoeba Keratitis: A Pilot Study.
    Ophthalmology, 2019, Volume: 126, Issue:5

    Topics: Acanthamoeba; Acanthamoeba Keratitis; Adult; Animals; Antiprotozoal Agents; Cornea; Eye Infections,

2019
Oral Miltefosine as Adjunctive Treatment for Recalcitrant Acanthamoeba Keratitis.
    Cornea, 2019, Volume: 38, Issue:7

    Topics: Acanthamoeba Keratitis; Administration, Oral; Adult; Antiprotozoal Agents; Chemotherapy, Adjuvant; C

2019
Miltefosine and polyhexamethylene biguanide: a new drug combination for the treatment of Acanthamoeba keratitis.
    Clinical & experimental ophthalmology, 2014, Volume: 42, Issue:2

    Topics: Acanthamoeba; Acanthamoeba Keratitis; Animals; Antiprotozoal Agents; Biguanides; Cell Line; Cell Pro

2014
Weak cytotoxic activity of miltefosine against clinical isolates of Acanthamoeba spp.
    The Journal of parasitology, 2011, Volume: 97, Issue:3

    Topics: Acanthamoeba; Acanthamoeba castellanii; Acanthamoeba Keratitis; Antiprotozoal Agents; Cornea; Dose-R

2011
Efficacy of miltefosine for topical treatment of Acanthamoeba keratitis in Syrian hamsters.
    Parasitology research, 2012, Volume: 110, Issue:2

    Topics: Acanthamoeba; Acanthamoeba Keratitis; Administration, Topical; Animals; Antiprotozoal Agents; Benzam

2012
A keratitis rat model for evaluation of anti-Acanthamoeba polyphaga agents.
    Cornea, 2006, Volume: 25, Issue:5

    Topics: Acanthamoeba; Acanthamoeba Keratitis; Administration, Topical; Animals; Antiprotozoal Agents; Benzam

2006
Cytotoxic activities of alkylphosphocholines against clinical isolates of Acanthamoeba spp.
    Antimicrobial agents and chemotherapy, 2002, Volume: 46, Issue:3

    Topics: Acanthamoeba; Acanthamoeba Keratitis; Alkanes; Amebicides; Animals; Cell Survival; Hexokinase; Human

2002