phosphorylcholine has been researched along with Infantile Respiratory Distress Syndrome in 106 studies
Phosphorylcholine: Calcium and magnesium salts used therapeutically in hepatobiliary dysfunction.
phosphocholine : The phosphate of choline; and the parent compound of the phosphocholine family.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Further research needs to be performed to determine the optimal dosing and timing of these agents, as well as comparative trials studying efficacy." | 3.78 | Exogenous surfactant use in neonates. ( Ishisaka, DY, 1996) |
| " Ongoing trials may identify whether prophylactic or rescue administration of the surfactant preparation is the preferred approach and whether different dosage regimens or different administration techniques impart greater therapeutic efficacy." | 3.77 | Colfosceril palmitate. A review of the therapeutic efficacy and clinical tolerability of a synthetic surfactant preparation (Exosurf Neonatal) in neonatal respiratory distress syndrome. ( Dechant, KL; Faulds, D, 1991) |
| " We conclude that after giving two doses of Exosurf, further doses might best be delayed until after two days, and that further clinical evaluation of dosage regimens is required." | 2.67 | Turnover of exogenous artificial surfactant. ( Ashton, MR; Austin, NC; Hall, MA; Normand, IC; Postle, AD; Smith, DE, 1992) |
| " We conclude that beneficial effects of surfactant on pulmonary mechanics were not apparent 2 hours after dosing but were evident 24 hours after dosing and persisted for the first 7 to 14 days of life." | 2.67 | Pulmonary mechanics and energetics in preterm infants who had respiratory distress syndrome treated with synthetic surfactant. ( Abbasi, S; Bhutani, VK; Gerdes, JS; Long, WA, 1992) |
| "Pulmonary hemorrhage was present in 55% of 159 infants undergoing autopsy; the incidence was not different in infants treated with surfactant or air placebo." | 2.67 | Pulmonary hemorrhage in premature infants after treatment with synthetic surfactant: an autopsy evaluation. The American Exosurf Neonatal Study Group I, and the Canadian Exosurf Neonatal Study Group. ( Derleth, D; Finer, N; Long, W; McMurray, B; Mullett, M; Peliowski, A; Sankaran, K; van Houten, J; Walker, D; Wold, D, 1992) |
| " Many investigators using different surfactants, dosing schedules, and pulmonary function methodologies to evaluate lung mechanics have reported that the improvement in compliance after surfactant treatment usually follows the clinical improvement in gas exchange." | 2.38 | Delayed compliance increase in infants with respiratory distress syndrome following synthetic surfactant. ( Ariagno, RL; Armsby, DH; Baldwin, R; Bellon, G; Carlisle, K; Long, W; Rector, D; Stevenson, DK, 1992) |
| "The effect of surfactant administration for respiratory distress syndrome (RDS) on indomethacin (INDO) pharmacodynamics and dosing requirements for patent ductus arteriosus (PDA) closure and renal toxicity was evaluated." | 1.36 | Indomethacin pharmacodynamics are altered by surfactant: a possible challenge to current indomethacin dosing guidelines created before surfactant availability. ( Carlos, RQ; Davonzo, C; Dimaguila, MA; Gal, P; McPherson, C; Ransom, JL; Smith, M; Wimmer, JE, 2010) |
| "Pulmonary hemorrhage was defined by an onset of bright red blood from the endotracheal tube in quantities that resulted in increased ventilatory support and a new infiltrate on a chest radiograph." | 1.29 | Pulmonary hemorrhage risk in infants with a clinically diagnosed patent ductus arteriosus: a retrospective cohort study. ( Buck, R; Garland, J; Weinberg, M, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (1.89) | 18.7374 |
| 1990's | 88 (83.02) | 18.2507 |
| 2000's | 13 (12.26) | 29.6817 |
| 2010's | 3 (2.83) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, L | 1 |
| Cao, HY | 1 |
| Zhao, S | 1 |
| Yuan, LJ | 1 |
| Han, D | 1 |
| Jiang, H | 1 |
| Wu, S | 1 |
| Wu, HM | 1 |
| Lal, MK | 1 |
| Sinha, SK | 1 |
| Moya, F | 1 |
| McPherson, C | 1 |
| Gal, P | 1 |
| Ransom, JL | 1 |
| Carlos, RQ | 1 |
| Dimaguila, MA | 1 |
| Smith, M | 1 |
| Davonzo, C | 1 |
| Wimmer, JE | 1 |
| Bahadue, FL | 1 |
| Soll, R | 1 |
| St John, EB | 1 |
| Carlo, WA | 1 |
| Bevilacqua, G | 1 |
| Parmigiani, S | 1 |
| Bhutani, VK | 3 |
| Bowen, FW | 1 |
| Sivieri, EM | 1 |
| Todorov, R | 1 |
| Iordanova, A | 1 |
| Georgiev, GA | 1 |
| Petkova, Kh | 1 |
| Stoimenova, E | 1 |
| Georgieva, R | 1 |
| Khristova, E | 1 |
| Vasiliev, Kh | 1 |
| Lalchev, Z | 1 |
| Halliday, HL | 2 |
| Walther, FJ | 2 |
| Mullett, M | 2 |
| Schumacher, R | 4 |
| Sundell, H | 2 |
| Easa, D | 3 |
| Long, W | 22 |
| Sell, M | 2 |
| Cotton, R | 3 |
| Hirata, T | 1 |
| Guthrie, R | 2 |
| LeBlanc, M | 2 |
| Mammel, M | 2 |
| Gerdes, J | 4 |
| Gerdes, M | 1 |
| Beaumont, E | 1 |
| Cook, L | 2 |
| Dhanireddy, R | 1 |
| Kopleman, A | 1 |
| Jarret, R | 1 |
| Kraybill, EN | 1 |
| Bose, CL | 1 |
| Corbet, AJ | 2 |
| Garcia-Prats, J | 2 |
| Asbill, D | 1 |
| Edwards, K | 2 |
| Courtney, SE | 1 |
| McMillan, D | 2 |
| Walter, D | 2 |
| Thompson, T | 2 |
| Sauve, R | 2 |
| Conway, B | 1 |
| Bard, H | 5 |
| Corbet, A | 5 |
| Casiro, O | 2 |
| Bingham, W | 2 |
| MacMurray, B | 3 |
| Whitfield, M | 2 |
| Saigal, S | 2 |
| Vincer, M | 2 |
| Robertson, C | 2 |
| Sankaran, K | 3 |
| Gong, A | 2 |
| Anday, E | 2 |
| Boros, S | 1 |
| Bucciarelli, R | 2 |
| Burchfield, D | 1 |
| Zucker, J | 1 |
| Derleth, D | 2 |
| Stevenson, D | 2 |
| Pauly, T | 2 |
| Smyth, J | 2 |
| Allen, A | 1 |
| Peliowski, A | 2 |
| Volberg, F | 2 |
| Shukla, A | 1 |
| Chernick, V | 2 |
| Finer, N | 2 |
| Schiff, D | 1 |
| Watts, J | 2 |
| Krzeski, R | 1 |
| Avila, E | 1 |
| Puri, A | 1 |
| Rosenberg, A | 1 |
| Hamdan, AH | 2 |
| Shaw, NJ | 2 |
| Saliba, E | 1 |
| Nashashibi, M | 1 |
| Vaillant, MC | 1 |
| Nasr, C | 1 |
| Laugier, J | 1 |
| Seppänen, M | 1 |
| Kääpä, P | 1 |
| Kero, P | 1 |
| Patel, CA | 1 |
| Klein, JM | 1 |
| Cleary, JP | 1 |
| Bernstein, G | 1 |
| Mannino, FL | 1 |
| Heldt, GP | 1 |
| Leach, CL | 1 |
| Holm, B | 1 |
| Morin, FC | 1 |
| Fuhrman, BP | 1 |
| Papo, MC | 1 |
| Steinhorn, D | 1 |
| Hernan, LJ | 1 |
| Choukroun, ML | 1 |
| Llanas, B | 1 |
| Apere, H | 1 |
| Fayon, M | 1 |
| Galperine, RI | 1 |
| Guenard, H | 1 |
| Demarquez, JL | 1 |
| Billman, D | 1 |
| Nicks, J | 1 |
| Garland, J | 1 |
| Buck, R | 1 |
| Weinberg, M | 1 |
| Tarnow-Mordi, WO | 2 |
| Soll, RF | 4 |
| Lim, NL | 1 |
| Nordin, MM | 1 |
| Cheah, IG | 1 |
| Gore, SM | 1 |
| Robertson, B | 3 |
| Speer, CP | 2 |
| Morley, C | 1 |
| Tarnow-Mordi, W | 1 |
| Moya, FR | 1 |
| Hoffman, DR | 1 |
| Zhao, B | 1 |
| Johnston, JM | 1 |
| Stenson, BJ | 1 |
| Glover, RM | 1 |
| Parry, GJ | 1 |
| Wilkie, RA | 1 |
| Laing, IA | 1 |
| Rollins, M | 1 |
| Jenkins, J | 1 |
| Tubman, R | 1 |
| Corkey, C | 1 |
| Wilson, D | 1 |
| Sehgal, SS | 1 |
| Ewing, CK | 1 |
| Richards, T | 1 |
| Taeusch, HW | 1 |
| Wach, R | 1 |
| Darlow, B | 1 |
| Bourchier, D | 1 |
| Broadbent, R | 1 |
| Knight, D | 1 |
| Selby, R | 1 |
| Chan, JO | 1 |
| Moglia, BA | 1 |
| Reeves, IV | 1 |
| Kim, AH | 1 |
| Darrow, KA | 1 |
| Seaton, JF | 1 |
| Marks, KH | 1 |
| Sangstad, OD | 1 |
| Horbar, JD | 1 |
| Wright, LL | 1 |
| Wright, EC | 1 |
| Fanaroff, AA | 1 |
| Korones, SB | 1 |
| Shankaran, S | 1 |
| Oh, W | 1 |
| Fletcher, BD | 1 |
| Bauer, CR | 1 |
| Phibbs, CS | 1 |
| Phibbs, RH | 1 |
| Wakeley, A | 1 |
| Schlueter, MA | 2 |
| Sniderman, S | 1 |
| Tooley, WH | 2 |
| Bratlid, D | 1 |
| Farstad, T | 1 |
| Abbasi, S | 2 |
| Gerdes, JS | 2 |
| Alba, J | 1 |
| Agarwal, R | 1 |
| Hegyi, T | 1 |
| Hiatt, IM | 1 |
| Pennefather, PM | 1 |
| Tin, W | 1 |
| Clarke, MP | 1 |
| Fritz, S | 1 |
| Strong, NP | 1 |
| Ishisaka, DY | 1 |
| Lenoir, S | 1 |
| Grandjean, H | 1 |
| Claris, O | 1 |
| Hascoët, JM | 1 |
| Hudak, ML | 3 |
| Farrell, EE | 1 |
| Rosenberg, AA | 2 |
| Jung, AL | 2 |
| Auten, RL | 2 |
| Durand, DJ | 2 |
| Horgan, MJ | 1 |
| Buckwald, S | 1 |
| Belcastro, MR | 2 |
| Donohue, PK | 2 |
| Carrion, V | 1 |
| Maniscalco, WW | 1 |
| Balsan, MJ | 1 |
| Torres, BA | 1 |
| Miller, RR | 1 |
| Jansen, RD | 2 |
| Graeber, JE | 1 |
| Laskay, KM | 1 |
| Matteson, EJ | 2 |
| Egan, EA | 3 |
| Brody, AS | 2 |
| Martin, DJ | 2 |
| Riddlesberger, MM | 2 |
| Montgomery, P | 2 |
| Rogers, D | 1 |
| Skelton, R | 1 |
| Jeffery, HE | 1 |
| Bassiouny, MR | 1 |
| Remo, C | 1 |
| Cherian, E | 1 |
| Wyble, L | 1 |
| Santeiro, ML | 1 |
| Cummings, NJ | 1 |
| Kimberlin, LV | 1 |
| Asselin, JM | 1 |
| Hamm, CR | 1 |
| Sandberg, KL | 1 |
| Lindstrom, DP | 1 |
| Sjöqvist, BA | 1 |
| Parker, RA | 1 |
| Cotton, RB | 1 |
| Fok, TF | 1 |
| al-Essa, M | 1 |
| Dolovich, M | 1 |
| Rasid, F | 1 |
| Kirpalani, H | 1 |
| Murdoch, E | 2 |
| Kempley, ST | 2 |
| Lloyd, J | 1 |
| Todd, DA | 1 |
| John, E | 1 |
| Sanghvi, KP | 1 |
| Merchant, RH | 1 |
| da Costa, DE | 1 |
| Pai, MG | 1 |
| Al Khusaiby, SM | 1 |
| Rimensberger, PC | 1 |
| Beghetti, M | 1 |
| Hanquinet, S | 1 |
| Berner, M | 1 |
| Kukkonen, AK | 1 |
| Virtanen, M | 1 |
| Järvenpää, AL | 1 |
| Pokela, ML | 1 |
| Ikonen, S | 1 |
| Fellman, V | 1 |
| Suresh, GK | 1 |
| Giannakopoulou, C | 1 |
| Hatzidaki, E | 1 |
| Korakaki, E | 1 |
| Christodoulaki, M | 1 |
| Margari, KM | 1 |
| Mamoulakis, D | 1 |
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| Nakamura, KT | 1 |
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| Ibarra-Pratt, E | 1 |
| Smith, MB | 1 |
| Armsby, DH | 1 |
| Bellon, G | 1 |
| Carlisle, K | 1 |
| Rector, D | 1 |
| Baldwin, R | 1 |
| Stevenson, DK | 1 |
| Ariagno, RL | 1 |
| Rubin, BK | 1 |
| Ramirez, O | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pulse Oximetry With Clinical Observation to Screen for Lung Disease in Neonates[NCT02533583] | 15,000 participants (Anticipated) | Observational | 2015-11-30 | Active, not recruiting | |||
| Lung UltrasouNd Guided Surfactant Therapy in Preterm Infants: an International Multicentric Randomized Control Trial (LUNG Study)[NCT05198375] | 668 participants (Anticipated) | Interventional | 2022-04-05 | Recruiting | |||
| Generic Database: A Survey of Morbidity and Mortality in Very Low Birth Weight Infants[NCT00063063] | 80,000 participants (Anticipated) | Observational | 1987-01-31 | Recruiting | |||
| Efficacy and Safety of Exosurf Neonatal and Survanta for the Treatment of Respiratory Distress Syndrome[NCT01203358] | Phase 2/Phase 3 | 617 participants (Actual) | Interventional | 1991-01-31 | Completed | ||
| Open Lung Maneuvers During High Frequency Oscillatory Ventilation in Extremely Preterm Infants - A Single Center Randomized Controlled Trial[NCT04289324] | 36 participants (Anticipated) | Interventional | 2020-02-25 | Recruiting | |||
| Comparative Trial of Two Strategies of RDS Treatment in Newborns With Birth Weight > 1500 Grams[NCT00277030] | Phase 4 | 110 participants | Interventional | 2006-01-31 | Recruiting | ||
| [NCT01839227] | 87 participants (Actual) | Interventional | 2012-11-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
10 reviews available for phosphorylcholine and Infantile Respiratory Distress Syndrome
| Article | Year |
|---|---|
Effect of exogenous pulmonary surfactants on mortality rate in neonatal respiratory distress syndrome: A network meta-analysis of randomized controlled trials.
Topics: Biological Products; Drug Combinations; Fatty Alcohols; Humans; Phosphatidylglycerols; Phospholipids | 2015 |
Surfactant respiratory therapy using Surfaxin/sinapultide.
Topics: Drug Combinations; Fatty Alcohols; Humans; Infant, Newborn; Peptides; Phosphatidylglycerols; Phospho | 2008 |
Synthetic surfactants: where are we? Evidence from randomized, controlled clinical trials.
Topics: Animals; Biological Products; Bronchopulmonary Dysplasia; Dose-Response Relationship, Drug; Drug Com | 2009 |
Early versus delayed selective surfactant treatment for neonatal respiratory distress syndrome.
Topics: Acute Disease; Acute Lung Injury; Chronic Disease; Drug Combinations; Fatty Alcohols; Humans; Infant | 2012 |
Early versus delayed selective surfactant treatment for neonatal respiratory distress syndrome.
Topics: Acute Disease; Acute Lung Injury; Chronic Disease; Drug Combinations; Fatty Alcohols; Humans; Infant | 2012 |
Early versus delayed selective surfactant treatment for neonatal respiratory distress syndrome.
Topics: Acute Disease; Acute Lung Injury; Chronic Disease; Drug Combinations; Fatty Alcohols; Humans; Infant | 2012 |
Early versus delayed selective surfactant treatment for neonatal respiratory distress syndrome.
Topics: Acute Disease; Acute Lung Injury; Chronic Disease; Drug Combinations; Fatty Alcohols; Humans; Infant | 2012 |
Overview of clinical trials comparing natural and synthetic surfactants.
Topics: Biological Products; Drug Combinations; Fatty Alcohols; Humans; Infant, Newborn; Phospholipids; Phos | 1995 |
Artificial versus natural surfactant--can we base clinical practice on a firm scientific footing?
Topics: Biological Products; Clinical Trials as Topic; Drug Combinations; Fatty Alcohols; Humans; Infant, Ne | 1994 |
Exogenous surfactant use in neonates.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Biological Products; Drug Combinations; Fatty Alcohols; Humans; | 1996 |
Natural surfactant extract versus synthetic surfactant for neonatal respiratory distress syndrome.
Topics: Biological Products; Drug Combinations; Fatty Alcohols; Humans; Infant, Newborn; Infant, Premature; | 2000 |
Delayed compliance increase in infants with respiratory distress syndrome following synthetic surfactant.
Topics: Drug Combinations; Fatty Alcohols; Female; Follow-Up Studies; Humans; Infant, Newborn; Lung Complian | 1992 |
Colfosceril palmitate. A review of the therapeutic efficacy and clinical tolerability of a synthetic surfactant preparation (Exosurf Neonatal) in neonatal respiratory distress syndrome.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Animals; Double-Blind Method; Drug Combinations; Fatty Alcohols; | 1991 |
68 trials available for phosphorylcholine and Infantile Respiratory Distress Syndrome
| Article | Year |
|---|---|
Postnatal changes in pulmonary mechanics and energetics of infants with respiratory distress syndrome following surfactant treatment.
Topics: Continuous Positive Airway Pressure; Drug Combinations; Fatty Alcohols; Humans; Infant, Newborn; Inf | 2005 |
One-year follow-up of 66 premature infants weighing 500 to 699 grams treated with a single dose of synthetic surfactant or air placebo at birth: results of a double-blind trial. American Exosurf Neonatal Study Group I.
Topics: Air; Child Development; Double-Blind Method; Drug Combinations; Fatty Alcohols; Female; Follow-Up St | 1995 |
One-year follow-up of 273 infants with birth weights of 700 to 1100 grams after prophylactic treatment of respiratory distress syndrome with synthetic surfactant or air placebo. American Exosurf Neonatal Study Group I.
Topics: Air; Child Development; Chronic Disease; Double-Blind Method; Drug Combinations; Fatty Alcohols; Fem | 1995 |
Health and neurodevelopmental outcome at 1-year adjusted age in 508 infants weighing 700 to 1100 grams who received prophylaxis with one versus three doses of synthetic surfactant. American Exosurf Neonatal Study Groups I and II.
Topics: Child Development; Double-Blind Method; Drug Combinations; Fatty Alcohols; Female; Follow-Up Studies | 1995 |
Double-blind evaluation of developmental and health status to age 2 years of infants weighing 700 to 1350 grams treated prophylactically at birth with a single dose of synthetic surfactant or air placebo.
Topics: Air; Child Development; Double-Blind Method; Drug Combinations; Fatty Alcohols; Female; Follow-Up St | 1995 |
Double-blind 1-year follow-up of 1540 infants with respiratory distress syndrome randomized to rescue treatment with two doses of synthetic surfactant or air in four clinical trials. American and Canadian Exosurf Neonatal Study Groups.
Topics: Air; Birth Weight; Child Development; Double-Blind Method; Drug Combinations; Fatty Alcohols; Female | 1995 |
Double-blind developmental evaluation at 1-year corrected age of 597 premature infants with birth weights from 500 to 1350 grams enrolled in three placebo-controlled trials of prophylactic synthetic surfactant. American Exosurf Neonatal Study Group I.
Topics: Air; Child Development; Double-Blind Method; Drug Combinations; Fatty Alcohols; Female; Follow-Up St | 1995 |
One-year follow-up of 89 infants with birth weights of 500 to 749 grams and respiratory distress syndrome randomized to two rescue doses of synthetic surfactant or air placebo. Canadian Exosurf Neonatal Study Group. Canadian Exosurf Neonatal Follow-Up Gro
Topics: Air; Child Development; Double-Blind Method; Drug Combinations; Fatty Alcohols; Female; Follow-Up St | 1995 |
One-year outcome in 232 premature infants with birth weights of 750 to 1249 grams and respiratory distress syndrome randomized to rescue treatment with two doses of synthetic surfactant or air placebo. Canadian Exosurf Neonatal Study Group.
Topics: Air; Child Development; Double-Blind Method; Drug Combinations; Fatty Alcohols; Female; Follow-Up St | 1995 |
One-year follow-up evaluation of 260 premature infants with respiratory distress syndrome and birth weights of 700 to 1350 grams randomized to two rescue doses of synthetic surfactant or air placebo. American Exosurf Neonatal Study Group I.
Topics: Air; Child Development; Double-Blind Method; Drug Combinations; Fatty Alcohols; Female; Follow-Up St | 1995 |
Outcome at 1-year adjusted age of 957 infants weighing more than 1250 grams with respiratory distress syndrome randomized to receive synthetic surfactant or air placebo. American and Canadian Exosurf Neonatal Study Groups.
Topics: Air; Child Development; Chronic Disease; Double-Blind Method; Drug Combinations; Fatty Alcohols; Fem | 1995 |
Double-blind, randomized, placebo-controlled Canadian multicenter trial of two doses of synthetic surfactant or air placebo in 224 infants weighing 500 to 749 grams with respiratory distress syndrome. Canadian Exosurf Neonatal Study Group.
Topics: Air; Double-Blind Method; Drug Combinations; Fatty Alcohols; Female; Humans; Infant, Low Birth Weigh | 1995 |
Effects of two rescue doses of synthetic surfactant in 344 infants with respiratory distress syndrome weighing 750 to 1249 grams: a double-blind, placebo-controlled multicenter Canadian trial. Canadian Exosurf Neonatal Study Group.
Topics: Air; Double-Blind Method; Drug Combinations; Fatty Alcohols; Female; Humans; Infant, Newborn; Lung D | 1995 |
Double-blind, randomized trial of one versus three prophylactic doses of synthetic surfactant in 826 neonates weighing 700 to 1100 grams: effects on mortality rate. American Exosurf Neonatal Study Groups I and IIa.
Topics: Bronchopulmonary Dysplasia; Cause of Death; Double-Blind Method; Drug Administration Schedule; Drug | 1995 |
Instillation rate effects of Exosurf on cerebral and cardiovascular haemodynamics in preterm neonates.
Topics: Blood Flow Velocity; Blood Pressure; Brain; Cerebrovascular Circulation; Drug Administration Schedul | 1994 |
Improved oxygenation during synchronized intermittent mandatory ventilation in neonates with respiratory distress syndrome: a randomized, crossover study.
Topics: Carbon Dioxide; Combined Modality Therapy; Cross-Over Studies; Drug Combinations; Fatty Alcohols; Hu | 1995 |
Partial liquid ventilation in premature lambs with respiratory distress syndrome: efficacy and compatibility with exogenous surfactant.
Topics: Animals; Animals, Newborn; Biological Products; Combined Modality Therapy; Drug Combinations; Emulsi | 1995 |
Pulmonary mechanics in ventilated preterm infants with respiratory distress syndrome after exogenous surfactant administration: a comparison between two surfactant preparations.
Topics: Airway Resistance; Biological Products; Combined Modality Therapy; Drug Combinations; Fatty Alcohols | 1994 |
Exosurf rescue surfactant improves high ventilation-perfusion mismatch in respiratory distress syndrome.
Topics: Airway Resistance; Blood Gas Analysis; Blood Pressure; Dose-Response Relationship, Drug; Double-Blin | 1994 |
Surfactant therapy in respiratory distress syndrome--the first local experience.
Topics: Cause of Death; Combined Modality Therapy; Drug Combinations; Fatty Alcohols; Female; Humans; Infant | 1994 |
OSIRIS trial.
Topics: Adrenal Cortex Hormones; Drug Administration Schedule; Drug Combinations; Fatty Alcohols; Humans; In | 1993 |
OSIRIS trial.
Topics: Brain Diseases; Drug Administration Schedule; Drug Combinations; Fatty Alcohols; Humans; Infant, New | 1993 |
OSIRIS trial.
Topics: Drug Administration Schedule; Drug Combinations; Fatty Alcohols; Humans; Infant Mortality; Infant, N | 1993 |
OSIRIS trial.
Topics: Diagnostic Errors; Drug Combinations; Fatty Alcohols; Humans; Infant, Newborn; Male; Phosphorylcholi | 1993 |
Static respiratory compliance in the newborn. III: Early changes after exogenous surfactant treatment.
Topics: Animals; Biological Products; Drug Combinations; Fatty Alcohols; Female; Humans; Infant, Newborn; In | 1994 |
Comparison of clinical responses to natural and synthetic surfactants.
Topics: Arteries; Biological Products; Cerebral Hemorrhage; Drug Combinations; Fatty Alcohols; Humans; Infan | 1993 |
Modified bovine surfactant (Survanta) versus a protein-free surfactant (Exosurf) in the treatment of respiratory distress syndrome in preterm infants: a pilot study.
Topics: Biological Products; Drug Combinations; Fatty Alcohols; Female; Humans; Infant, Newborn; Infant, Pre | 1994 |
Respiratory distress syndrome in New Zealand: evidence from the OSIRIS trial of exogenous surfactant (Exosurf).
Topics: Birth Weight; Cerebral Hemorrhage; Cohort Studies; Cost of Illness; Drug Combinations; Fatty Alcohol | 1994 |
Cardiorespiratory and stress hormone responses during first dose surfactant administration in neonates with RDS.
Topics: Biological Products; Blood Pressure; Catecholamines; Drug Combinations; Fatty Alcohols; Hemodynamics | 1994 |
A multicenter randomized trial comparing two surfactants for the treatment of neonatal respiratory distress syndrome. National Institute of Child Health and Human Development Neonatal Research Network.
Topics: Biological Products; Drug Combinations; Fatty Alcohols; Female; Humans; Infant, Newborn; Male; Phosp | 1993 |
Cost effects of surfactant therapy for neonatal respiratory distress syndrome.
Topics: Costs and Cost Analysis; Drug Combinations; Fatty Alcohols; Female; Hospital Costs; Hospital Mortali | 1993 |
[Natural and synthetic surfactant in the treatment of neonatal respiratory distress syndrome].
Topics: Biological Products; Drug Combinations; Fatty Alcohols; Humans; Infant, Newborn; Infant, Premature, | 1994 |
Long-term pulmonary consequences of respiratory distress syndrome in preterm infants treated with exogenous surfactant.
Topics: Drug Combinations; Fatty Alcohols; Female; Follow-Up Studies; Humans; Infant, Newborn; Infant, Prema | 1993 |
A multicenter, randomized trial comparing synthetic surfactant with modified bovine surfactant extract in the treatment of neonatal respiratory distress syndrome. Vermont-Oxford Neonatal Network.
Topics: Biological Products; Chronic Disease; Drug Combinations; Fatty Alcohols; Female; Humans; Infant, Low | 1996 |
Retinopathy of prematurity in a controlled trial of prophylactic surfactant treatment.
Topics: Drug Combinations; England; Fatty Alcohols; Female; Follow-Up Studies; Humans; Incidence; Infant, Ne | 1996 |
Exogenous surfactant use in neonates.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Biological Products; Drug Combinations; Fatty Alcohols; Humans; | 1996 |
A multicenter randomized, masked comparison trial of natural versus synthetic surfactant for the treatment of respiratory distress syndrome.
Topics: Bronchopulmonary Dysplasia; Cross-Over Studies; Drug Combinations; Fatty Alcohols; Humans; Incidence | 1996 |
Factors affecting the neonatal response to artificial surfactant.
Topics: Administration, Inhalation; Analysis of Variance; Chi-Square Distribution; Drug Combinations; Evalua | 1996 |
Comparison of the changes in the a/A oxygen ratio after administration of two surfactants for the treatment of neonatal respiratory distress syndrome.
Topics: Algorithms; Biological Products; Blood Gas Analysis; Drug Combinations; Fatty Alcohols; Humans; Hypo | 1997 |
A multicenter randomized masked comparison trial of synthetic surfactant versus calf lung surfactant extract in the prevention of neonatal respiratory distress syndrome.
Topics: Age Factors; Bronchopulmonary Dysplasia; Cerebral Hemorrhage; Data Interpretation, Statistical; Drug | 1997 |
Surfactant replacement therapy improves ventilation inhomogeneity in infants with respiratory distress syndrome.
Topics: Analysis of Variance; Biological Products; Breath Tests; Double-Blind Method; Drug Combinations; Fat | 1997 |
Collaborative trial of prenatal thyrotropin-releasing hormone and corticosteroids for prevention of respiratory distress syndrome. Collaborative Santiago Surfactant Group.
Topics: Adrenal Cortex Hormones; Adult; Betamethasone; Dose-Response Relationship, Drug; Double-Blind Method | 1998 |
Changes in pulmonary artery pressure during the acute phase of respiratory distress syndrome treated with three different types of surfactant.
Topics: Acceleration; Biological Products; Birth Weight; Blood Pressure; Cardiac Output; Drug Combinations; | 1998 |
Randomized trial examining cerebral haemodynamics following artificial or animal surfactant.
Topics: Biological Products; Cerebral Arteries; Cerebrovascular Circulation; Drug Combinations; Fatty Alcoho | 1998 |
Serial phospholipid analysis in preterm infants: comparison of Exosurf and Survanta.
Topics: Analysis of Variance; Biological Products; Chi-Square Distribution; Chromatography, Thin Layer; Drug | 1999 |
Single dose surfactant rescue therapy in neonatal respiratory distress syndrome.
Topics: Biological Products; Drug Combinations; Fatty Alcohols; Female; Humans; Infant, Newborn; Lipids; Mal | 1998 |
Comparative trial of artificial and natural surfactants in the treatment of respiratory distress syndrome of prematurity: experiences in a developing country.
Topics: Biological Products; Blood Gas Analysis; Developing Countries; Drug Combinations; Fatty Alcohols; Fe | 1999 |
Randomized trial comparing natural and synthetic surfactant: increased infection rate after natural surfactant?
Topics: Biological Products; C-Reactive Protein; Drug Combinations; Fatty Alcohols; Female; Humans; Infant, | 2000 |
The effects of synthetic and natural surfactant on fluid balance in acute respiratory distress syndrome.
Topics: Biological Products; Birth Weight; Diuresis; Drug Combinations; Fatty Alcohols; Gestational Age; Hum | 2000 |
Comparative randomized study: administration of natural and synthetic surfactant to premature newborns with respiratory distress syndrome.
Topics: Drug Combinations; Fatty Alcohols; Humans; Infant, Newborn; Infant, Premature; Phosphorylcholine; Po | 2002 |
Early or selective surfactant (colfosceril palmitate, Exosurf) for intubated babies at 26 to 29 weeks gestation. A European double-blind trial with sequential analysis. European Exosurf Study Group.
Topics: Brain Diseases; Cysts; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Fatty A | 1992 |
Early versus delayed neonatal administration of a synthetic surfactant--the judgment of OSIRIS. The OSIRIS Collaborative Group (open study of infants at high risk of or with respiratory insufficiency--the role of surfactant.
Topics: Drug Administration Schedule; Drug Combinations; Fatty Alcohols; Humans; Infant; Infant, Newborn; Ox | 1992 |
Surfactant for babies.
Topics: Drug Administration Schedule; Drug Combinations; Fatty Alcohols; Humans; Infant, Newborn; Phosphoryl | 1992 |
Exosurf treatment investigational new drug phase: effect of an individualized third dose in infants with respiratory distress syndrome.
Topics: Drug Administration Schedule; Drug Combinations; Drugs, Investigational; Fatty Alcohols; Humans; Inf | 1992 |
Mucus rheology and transport in neonatal respiratory distress syndrome and the effect of surfactant therapy.
Topics: Drug Combinations; Elasticity; Fatty Alcohols; Humans; Infant, Newborn; Infant, Premature; Mucocilia | 1992 |
Turnover of exogenous artificial surfactant.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Birth Weight; Chromatography, High Pressure Liquid; Drug Combina | 1992 |
Colfosceril palmitate. A review of the therapeutic efficacy and clinical tolerability of a synthetic surfactant preparation (Exosurf Neonatal) in neonatal respiratory distress syndrome.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Animals; Double-Blind Method; Drug Combinations; Fatty Alcohols; | 1991 |
Pulmonary mechanics and energetics in preterm infants who had respiratory distress syndrome treated with synthetic surfactant.
Topics: Drug Combinations; Fatty Alcohols; Humans; Infant, Newborn; Infant, Premature; Phosphorylcholine; Po | 1992 |
Controlled trial of a single dose of synthetic surfactant at birth in premature infants weighing 500 to 699 grams. The American Exosurf Neonatal Study Group I.
Topics: Bronchopulmonary Dysplasia; Cerebral Hemorrhage; Double-Blind Method; Drug Combinations; Ductus Arte | 1992 |
Energy expenditure during synthetic surfactant replacement therapy for neonatal respiratory distress syndrome.
Topics: Calorimetry, Indirect; Drug Combinations; Energy Metabolism; Fatty Alcohols; Humans; Infant, Low Bir | 1992 |
Elastase activity and surfactant protein concentration in tracheal aspirates from neonates receiving synthetic surfactant.
Topics: Drug Combinations; Fatty Alcohols; Humans; Infant, Low Birth Weight; Infant, Newborn; Infant, Premat | 1992 |
Pulmonary hemorrhage in premature infants after treatment with synthetic surfactant: an autopsy evaluation. The American Exosurf Neonatal Study Group I, and the Canadian Exosurf Neonatal Study Group.
Topics: Autopsy; Double-Blind Method; Drug Combinations; Fatty Alcohols; Hemorrhage; Humans; Incidence; Infa | 1992 |
A controlled trial of synthetic surfactant in infants weighing 1250 g or more with respiratory distress syndrome. The American Exosurf Neonatal Study Group I, and the Canadian Exosurf Neonatal Study Group.
Topics: Birth Weight; Bronchopulmonary Dysplasia; Child; Drug Combinations; Fatty Alcohols; Female; Follow-U | 1991 |
Reduced mortality in small premature infants treated at birth with a single dose of synthetic surfactant.
Topics: Bronchopulmonary Dysplasia; Drug Combinations; Fatty Alcohols; Follow-Up Studies; Humans; Incidence; | 1991 |
Decreased mortality rate among small premature infants treated at birth with a single dose of synthetic surfactant: a multicenter controlled trial. American Exosurf Pediatric Study Group 1.
Topics: Bronchopulmonary Dysplasia; Drug Combinations; Fatty Alcohols; Female; Humans; Infant, Newborn; Infa | 1991 |
Cerebral blood flow velocity after surfactant instillation in preterm infants.
Topics: Blood Flow Velocity; Cerebral Hemorrhage; Cerebrovascular Circulation; Drug Combinations; Fatty Alco | 1991 |
Effects of two rescue doses of a synthetic surfactant on mortality rate and survival without bronchopulmonary dysplasia in 700- to 1350-gram infants with respiratory distress syndrome. The American Exosurf Neonatal Study Group I.
Topics: Bronchopulmonary Dysplasia; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Fa | 1991 |
Improved outcome at 28 days of age for very low birth weight infants treated with a single dose of a synthetic surfactant.
Topics: Bronchopulmonary Dysplasia; Cause of Death; Double-Blind Method; Drug Combinations; Fatty Alcohols; | 1990 |
30 other studies available for phosphorylcholine and Infantile Respiratory Distress Syndrome
| Article | Year |
|---|---|
Indomethacin pharmacodynamics are altered by surfactant: a possible challenge to current indomethacin dosing guidelines created before surfactant availability.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Biological Products; Coho | 2010 |
Respiratory distress syndrome in VLBW infants: changes in management and outcomes observed by the NICHD Neonatal Research Network.
Topics: Adrenal Cortex Hormones; Drug Combinations; Fatty Alcohols; Female; Humans; Infant, Newborn; Infant, | 2003 |
An observational study of surfactant treatment in infants of 23-30 weeks' gestation: comparison of prophylaxis and early rescue.
Topics: Biological Products; Drug Administration Schedule; Drug Combinations; Fatty Alcohols; Gestational Ag | 2003 |
[Biophysical models in investigations of exogenous surfactant activities on the surface tension and their theurapeutic effectiveness].
Topics: Animals; Biological Products; Biophysical Phenomena; Biophysics; Drug Combinations; Fatty Alcohols; | 2007 |
Changes in pulmonary artery pressure in infants with respiratory distress syndrome following treatment with Exosurf.
Topics: Acute Disease; Blood Pressure; Drug Combinations; Echocardiography, Doppler; Fatty Alcohols; Humans; | 1995 |
Acute effects of synthetic surfactant replacement on pulmonary blood flow in neonatal respiratory distress syndrome.
Topics: Blood Flow Velocity; Drug Combinations; Fatty Alcohols; Female; Humans; Infant, Newborn; Male; Phosp | 1994 |
Outcome of infants with birth weights less than 1000 g with respiratory distress syndrome treated with high-frequency ventilation and surfactant replacement therapy.
Topics: Biological Products; Combined Modality Therapy; Drug Combinations; Fatty Alcohols; High-Frequency Ve | 1995 |
Pulmonary hemorrhage risk in infants with a clinically diagnosed patent ductus arteriosus: a retrospective cohort study.
Topics: Cohort Studies; Drug Combinations; Ductus Arteriosus, Patent; Fatty Alcohols; Female; Hemorrhage; Hu | 1994 |
Platelet-activating factor in surfactant preparations.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Animals; Biological Products; Drug Combinations; Fat | 1993 |
[Natural or synthetic surfactant in the treatment of neonatal respiratory distress syndrome].
Topics: Biological Products; Drug Combinations; Fatty Alcohols; Female; Humans; Infant, Newborn; Male; Phosp | 1994 |
Efficacy of surfactant therapy in infants managed with CPAP.
Topics: Combined Modality Therapy; Drug Combinations; Fatty Alcohols; Female; Humans; Infant, Newborn; Male; | 1995 |
[Outcome of blood gas parameters during the first 24 years after Exosurf administration].
Topics: Analysis of Variance; Blood Gas Analysis; Cohort Studies; Drug Combinations; Fatty Alcohols; Humans; | 1996 |
Changes in pulmonary artery pressure in infants with respiratory distress syndrome after treatment with Exosurf.
Topics: Drug Combinations; Fatty Alcohols; Humans; Infant, Newborn; Infant, Premature; Phosphorylcholine; Po | 1996 |
Costs and outcomes associated with colfosceril versus beractant for the treatment of neonatal respiratory distress syndrome.
Topics: Biological Products; Drug Combinations; Drug Costs; Fatty Alcohols; Humans; Infant, Newborn; Phospho | 1997 |
Nebulisation of surfactants in an animal model of neonatal respiratory distress.
Topics: Aerosols; Animals; Biological Products; Carbon Dioxide; Disease Models, Animal; Drug Combinations; F | 1998 |
First intention high-frequency oscillation with early lung volume optimization improves pulmonary outcome in very low birth weight infants with respiratory distress syndrome.
Topics: Drug Combinations; Fatty Alcohols; Female; High-Frequency Ventilation; Humans; Infant, Newborn; Infa | 2000 |
Randomized trial comparing natural and synthetic surfactant: increased infection rate after natural surfactant?
Topics: Biological Products; Drug Combinations; Fatty Alcohols; Humans; Infant, Newborn; Infant, Premature; | 2000 |
Current surfactant use in premature infants.
Topics: Drug Combinations; Fatty Alcohols; Humans; Infant; Infant, Newborn; Infant, Premature, Diseases; Pho | 2001 |
[Exosurf-Neonatal: the synthetic surfactant. Introductory symposium, 20 June 1992].
Topics: Drug Combinations; Fatty Alcohols; Humans; Infant, Newborn; Phosphorylcholine; Polyethylene Glycols; | 1992 |
Effect of intra-amniotic administration of Exosurf in preterm rabbit fetuses.
Topics: Amnion; Animals; Animals, Newborn; Drug Combinations; Fatty Alcohols; Fetus; Gestational Age; Humans | 1992 |
Criteria for use of colfosceril (Exosurf) in neonates.
Topics: Apnea; Drug Combinations; Fatty Alcohols; Hemorrhage; Humans; Infant, Newborn; Intubation, Intratrac | 1992 |
A controlled clinical comparison of four different surfactant preparations in surfactant-deficient preterm lambs.
Topics: Animals; Animals, Newborn; Biological Products; Drug Combinations; Fatty Alcohols; Humans; Infant, N | 1992 |
Prediction of the acute response to surfactant therapy by pulmonary function testing.
Topics: Airway Resistance; Drug Combinations; Fatty Alcohols; Humans; Infant, Newborn; Lung Compliance; Phos | 1992 |
Surfactant replacement therapy: issues related to currently available preparations.
Topics: Biological Products; Drug Combinations; Fatty Alcohols; Humans; Infant, Newborn; Infant, Premature; | 1992 |
Comparing surfactant products.
Topics: Biological Products; Drug Combinations; Fatty Alcohols; Humans; Infant, Newborn; Phosphorylcholine; | 1991 |
Synthetic vs human surfactants in the treatment of respiratory distress syndrome: radiographic findings.
Topics: Bronchopulmonary Dysplasia; Drug Combinations; Fatty Alcohols; Humans; Infant, Newborn; Phosphorylch | 1991 |
Colfosceril palmitate (Exosurf)--artificial surfactant for immature lungs.
Topics: Drug Combinations; Fatty Alcohols; Humans; Infant, Newborn; Phosphorylcholine; Polyethylene Glycols; | 1991 |
From the Food and Drug Administration.
Topics: Chronic Disease; Diet Fads; Dietary Fiber; Drug Combinations; Esophageal Stenosis; Fatty Alcohols; F | 1990 |
Lung function in prematurely delivered rabbits treated with a synthetic surfactant.
Topics: Animals; Drug Combinations; Fatty Alcohols; Infant, Newborn; Lung; Lung Compliance; Lung Volume Meas | 1987 |
Effects of a protein-free, synthetic surfactant on survival and pulmonary function in preterm lambs.
Topics: Animals; Animals, Newborn; Drug Combinations; Fatty Alcohols; Fetal Organ Maturity; Humans; Infant, | 1985 |