phosphorylcholine has been researched along with Hemolysis in 46 studies
Phosphorylcholine: Calcium and magnesium salts used therapeutically in hepatobiliary dysfunction.
phosphocholine : The phosphate of choline; and the parent compound of the phosphocholine family.
Hemolysis: The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Miltefosine (MFS) is an alkylphosphocholine used for the local treatment of cutaneous metastases of breast cancer and oral therapy of visceral leishmaniasis." | 5.42 | Miltefosine Lipid Nanocapsules for Single Dose Oral Treatment of Schistosomiasis Mansoni: A Preclinical Study. ( Amer, EI; Eissa, MM; El-Azzouni, MZ; El-Khordagui, LK; El-Moslemany, RM; Ramadan, AA, 2015) |
| "Miltefosine was fungicidal for C." | 5.33 | Hexadecylphosphocholine (miltefosine) has broad-spectrum fungicidal activity and is efficacious in a mouse model of cryptococcosis. ( Ellis, DH; Ganendren, R; Handke, R; Obando, D; Sorrell, TC; Widmer, F; Wright, LC, 2006) |
| "Hemolysis is a serious side effect of antitumor alkylphospholipids (APLs) that limits dose levels and is a constraint in their use in therapeutic regimen." | 1.56 | Synthesis and Evaluation of Antitumor Alkylphospholipid Prodrugs. ( Gaillard, B; Lebeau, L; Pons, F; Remy, JS, 2020) |
| "Hemolysis was estimated from hemoglobin concentration in the supernatant." | 1.46 | Triggering of Eryptosis, the Suicidal Erythrocyte Death, by Perifosine. ( Egler, J; Lang, F, 2017) |
| "The toxic effects of miltefosine on the epithelial cells of the gastrointestinal tract and its hemolytic action on erythrocytes have limited its use as an antileishmanial agent." | 1.43 | Miltefosine-loaded lipid nanoparticles: Improving miltefosine stability and reducing its hemolytic potential toward erythtocytes and its cytotoxic effect on macrophages. ( Barioni, MB; da Gama Bitencourt, JJ; de Paula Pinto, C; Guimarães, TH; Ito, AS; Pazin, WM; Santos, MA; Santos, MR; Valduga, CJ, 2016) |
| "Miltefosine (MFS) is an alkylphosphocholine used for the local treatment of cutaneous metastases of breast cancer and oral therapy of visceral leishmaniasis." | 1.42 | Miltefosine Lipid Nanocapsules for Single Dose Oral Treatment of Schistosomiasis Mansoni: A Preclinical Study. ( Amer, EI; Eissa, MM; El-Azzouni, MZ; El-Khordagui, LK; El-Moslemany, RM; Ramadan, AA, 2015) |
| "Miltefosine (MT) is an alkylphospholipid that has been approved for the treatment of breast cancer metastasis and visceral leishmaniasis, although its mechanism of action remains poorly understood." | 1.39 | Interaction of miltefosine with the lipid and protein components of the erythrocyte membrane. ( Alonso, A; Hansen, D; Mendanha, SA; Moreira, RA, 2013) |
| "Miltefosine was fungicidal for C." | 1.33 | Hexadecylphosphocholine (miltefosine) has broad-spectrum fungicidal activity and is efficacious in a mouse model of cryptococcosis. ( Ellis, DH; Ganendren, R; Handke, R; Obando, D; Sorrell, TC; Widmer, F; Wright, LC, 2006) |
| "Tritrpticin is a member of the cathelicidin family of antimicrobial peptides." | 1.33 | Structure-function analysis of tritrpticin analogs: potential relationships between antimicrobial activities, model membrane interactions, and their micelle-bound NMR structures. ( Kernaghan, SD; Nguyen, LT; Rekdal, Ø; Schibli, DJ; Vogel, HJ, 2006) |
| "Erucylphosphocholine (ErPC) is a promising candidate for the treatment of human brain tumors." | 1.31 | Structure-activity relationships of alkylphosphocholine derivatives: antineoplastic action on brain tumor cell lines in vitro. ( Eibl, H; Erdlenbruch, B; Hammersen, K; Jendrossek, V; Krügener, R; Kugler, W; Lakomek, M, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (8.70) | 18.7374 |
| 1990's | 8 (17.39) | 18.2507 |
| 2000's | 13 (28.26) | 29.6817 |
| 2010's | 16 (34.78) | 24.3611 |
| 2020's | 5 (10.87) | 2.80 |
| Authors | Studies |
|---|---|
| Kuo, SY | 1 |
| Chen, PC | 1 |
| Huang, KT | 1 |
| Huang, CJ | 1 |
| Sinha, S | 1 |
| Bhattacharjya, S | 1 |
| Lin, H | 1 |
| Wang, Q | 1 |
| Zhong, R | 1 |
| Li, Z | 1 |
| Zhao, W | 1 |
| Chen, Y | 1 |
| Tian, M | 1 |
| Luo, X | 1 |
| Zhang, Q | 1 |
| Fang, RH | 1 |
| Gao, W | 1 |
| Zhang, L | 1 |
| Gaillard, B | 1 |
| Remy, JS | 1 |
| Pons, F | 1 |
| Lebeau, L | 1 |
| Rysin, A | 1 |
| Paal, M | 1 |
| Lokerse, WJM | 1 |
| Wedmann, B | 1 |
| Hossann, M | 1 |
| Vogeser, M | 1 |
| Winter, G | 1 |
| Lindner, LH | 1 |
| Egler, J | 1 |
| Lang, F | 2 |
| Petit, K | 1 |
| Suwalsky, M | 1 |
| Colina, JR | 1 |
| Aguilar, LF | 1 |
| Jemiola-Rzeminska, M | 1 |
| Strzalka, K | 1 |
| Alonso, L | 2 |
| Cardoso, ÉJS | 1 |
| Mendanha, SA | 2 |
| Alonso, A | 3 |
| Moreira, RA | 1 |
| Hansen, D | 1 |
| Munoz, C | 1 |
| Alzoubi, K | 1 |
| Jacobi, J | 1 |
| Abed, M | 1 |
| Yuan, J | 1 |
| Tong, L | 1 |
| Yi, H | 1 |
| Wang, B | 1 |
| Shen, J | 1 |
| Lin, S | 1 |
| Wu, M | 2 |
| Guo, K | 2 |
| Dong, H | 2 |
| Zeng, R | 2 |
| Tu, M | 2 |
| Zhao, J | 2 |
| Speer, A | 1 |
| Sun, J | 1 |
| Danilchanka, O | 1 |
| Meikle, V | 1 |
| Rowland, JL | 1 |
| Walter, K | 1 |
| Buck, BR | 1 |
| Pavlenok, M | 1 |
| Hölscher, C | 1 |
| Ehrt, S | 1 |
| Niederweis, M | 1 |
| Eissa, MM | 1 |
| El-Moslemany, RM | 1 |
| Ramadan, AA | 1 |
| Amer, EI | 1 |
| El-Azzouni, MZ | 1 |
| El-Khordagui, LK | 1 |
| da Gama Bitencourt, JJ | 1 |
| Pazin, WM | 1 |
| Ito, AS | 1 |
| Barioni, MB | 1 |
| de Paula Pinto, C | 1 |
| Santos, MA | 1 |
| Guimarães, TH | 1 |
| Santos, MR | 1 |
| Valduga, CJ | 1 |
| Hoel, TN | 1 |
| Thiara, AS | 1 |
| Videm, V | 1 |
| Fiane, AE | 1 |
| Mollnes, TE | 1 |
| Castellheim, A | 1 |
| Svennevig, JL | 1 |
| Someya, T | 1 |
| Kobayashi, M | 1 |
| Waguri, S | 1 |
| Ushiyama, T | 1 |
| Nagaoka, E | 1 |
| Hijikata, W | 1 |
| Shinshi, T | 1 |
| Arai, H | 1 |
| Takatani, S | 1 |
| Yu, HY | 1 |
| Huang, KC | 1 |
| Yip, BS | 1 |
| Tu, CH | 1 |
| Chen, HL | 1 |
| Cheng, HT | 1 |
| Cheng, JW | 1 |
| Subasinghage, AP | 1 |
| O'Flynn, D | 1 |
| Conlon, JM | 1 |
| Hewage, CM | 1 |
| Jacobs, S | 1 |
| De Somer, F | 1 |
| Vandenplas, G | 1 |
| Van Belleghem, Y | 1 |
| Taeymans, Y | 1 |
| Van Nooten, G | 1 |
| Jendrossek, V | 1 |
| Hammersen, K | 1 |
| Erdlenbruch, B | 1 |
| Kugler, W | 1 |
| Krügener, R | 1 |
| Eibl, H | 3 |
| Lakomek, M | 1 |
| Agresta, M | 1 |
| D'Arrigo, P | 1 |
| Fasoli, E | 1 |
| Losi, D | 1 |
| Pedrocchi-Fantoni, G | 1 |
| Riva, S | 1 |
| Servi, S | 1 |
| Tessaro, D | 1 |
| Ochi, S | 1 |
| Oda, M | 1 |
| Matsuda, H | 1 |
| Ikari, S | 1 |
| Sakurai, J | 1 |
| Mravljak, J | 1 |
| Zeisig, R | 2 |
| Pecar, S | 1 |
| Widmer, F | 1 |
| Wright, LC | 1 |
| Obando, D | 1 |
| Handke, R | 1 |
| Ganendren, R | 1 |
| Ellis, DH | 1 |
| Sorrell, TC | 1 |
| Drechsler, A | 1 |
| Potrich, C | 1 |
| Sabo, JK | 1 |
| Frisanco, M | 1 |
| Guella, G | 1 |
| Dalla Serra, M | 1 |
| Anderluh, G | 1 |
| Separovic, F | 1 |
| Norton, RS | 1 |
| Schibli, DJ | 1 |
| Nguyen, LT | 1 |
| Kernaghan, SD | 1 |
| Rekdal, Ø | 1 |
| Vogel, HJ | 1 |
| Calogeropoulou, T | 1 |
| Angelou, P | 1 |
| Detsi, A | 1 |
| Fragiadaki, I | 1 |
| Scoulica, E | 1 |
| Carotenuto, A | 1 |
| Malfi, S | 1 |
| Saviello, MR | 1 |
| Campiglia, P | 1 |
| Gomez-Monterrey, I | 1 |
| Mangoni, ML | 1 |
| Gaddi, LM | 1 |
| Novellino, E | 1 |
| Grieco, P | 1 |
| Nuhn, P | 1 |
| Kertscher, P | 1 |
| Dobner, B | 1 |
| Braune, KD | 1 |
| Kluge, S | 1 |
| Nazarov, PG | 1 |
| Berestovaia, LK | 1 |
| Findlay, RD | 1 |
| Taeusch, HW | 1 |
| David-Cu, R | 1 |
| Walther, FJ | 1 |
| Bock, TK | 1 |
| Müller, BW | 1 |
| Gillespie, SH | 1 |
| McWhinney, PH | 1 |
| Patel, S | 1 |
| Raynes, JG | 1 |
| McAdam, KP | 1 |
| Whiley, RA | 1 |
| Hardie, JM | 1 |
| Lundberg, BB | 1 |
| Lewis, AL | 1 |
| Cumming, ZL | 1 |
| Goreish, HH | 1 |
| Kirkwood, LC | 1 |
| Tolhurst, LA | 1 |
| Stratford, PW | 1 |
| Walker, N | 1 |
| Holley, J | 1 |
| Naylor, CE | 1 |
| Flores-Díaz, M | 1 |
| Alape-Girón, A | 1 |
| Carter, G | 1 |
| Carr, FJ | 1 |
| Thelestam, M | 1 |
| Keyte, M | 1 |
| Moss, DS | 1 |
| Basak, AK | 1 |
| Miller, J | 1 |
| Titball, RW | 1 |
| Kaufmann-Kolle, P | 1 |
| Unger, C | 2 |
| Kötting, J | 1 |
| Marschner, NW | 1 |
| Neumüller, W | 1 |
| Fichtner, I | 1 |
| Arndt, D | 1 |
| Jungmann, S | 1 |
| Tschopp, J | 1 |
| Schäfer, S | 1 |
| Masson, D | 1 |
| Peitsch, MC | 1 |
| Heusser, C | 1 |
| Strasberg, PM | 1 |
| Callahan, JW | 1 |
| Baine, WB | 1 |
1 trial available for phosphorylcholine and Hemolysis
| Article | Year |
|---|---|
Active or passive bio-coating: does it matters in extracorporeal circulation?
Topics: Aged; Cardiopulmonary Bypass; Coated Materials, Biocompatible; Complement Activation; Coronary Arter | 2011 |
45 other studies available for phosphorylcholine and Hemolysis
| Article | Year |
|---|---|
Bio-inspired zwitterionic polymeric chelating assembly for treatment of copper-induced cytotoxicity and hemolysis.
Topics: Chelating Agents; Copper; Hemolysis; Humans; Methacrylates; Micelles; Phosphorylcholine; Polymers; P | 2021 |
NMR Structure and Localization of the Host Defense Peptide ThanatinM21F in Zwitterionic Dodecylphosphocholine Micelle: Implications in Antimicrobial and Hemolytic Activity.
Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antimicrobial Cationic Peptides; Hemolysis; M | 2022 |
Biomimetic phosphorylcholine strategy to improve the hemocompatibility of pH-responsive micelles containing tertiary amino groups.
Topics: Antibiotics, Antineoplastic; Biomimetic Materials; Doxorubicin; Drug Liberation; Erythrocytes; Hemol | 2019 |
A Biomimetic Nanoparticle to "Lure and Kill" Phospholipase A2.
Topics: Animals; Biomimetic Materials; Erythrocyte Membrane; Hemolysis; Human Umbilical Vein Endothelial Cel | 2020 |
Synthesis and Evaluation of Antitumor Alkylphospholipid Prodrugs.
Topics: Administration, Intravenous; Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitum | 2020 |
Evaluation of release and pharmacokinetics of hexadecylphosphocholine (miltefosine) in phosphatidyldiglycerol-based thermosensitive liposomes.
Topics: Animals; Antineoplastic Agents; Calorimetry, Differential Scanning; Chromatography, Liquid; Hemolysi | 2021 |
Triggering of Eryptosis, the Suicidal Erythrocyte Death, by Perifosine.
Topics: Aniline Compounds; Calcium; Cell Size; Ceramides; Eryptosis; Erythrocyte Membrane; Erythrocytes; Flo | 2017 |
In vitro effects of the antitumor drug miltefosine on human erythrocytes and molecular models of its membrane.
Topics: Antineoplastic Agents; Calorimetry, Differential Scanning; Dimyristoylphosphatidylcholine; Erythrocy | 2019 |
Interactions of miltefosine with erythrocyte membrane proteins compared to those of ionic surfactants.
Topics: Animals; Antiprotozoal Agents; Bis-Trimethylammonium Compounds; Cattle; Dose-Response Relationship, | 2019 |
Interaction of miltefosine with the lipid and protein components of the erythrocyte membrane.
Topics: Antineoplastic Agents; Antiprotozoal Agents; Erythrocyte Membrane; Hemolysis; Humans; Membrane Lipid | 2013 |
Effect of miltefosine on erythrocytes.
Topics: Anti-Infective Agents; Antineoplastic Agents; Cell Death; Cell Size; Cells, Cultured; Erythrocytes; | 2013 |
Synthesis and one-pot tethering of hydroxyl-capped phosphorylcholine onto cellulose membrane for improving hemocompatibility and antibiofouling property.
Topics: Adsorption; Animals; Bacterial Adhesion; Biofouling; Cattle; Cellulose; Escherichia coli; Fibrinogen | 2013 |
In vitro drug release and biological evaluation of biomimetic polymeric micelles self-assembled from amphiphilic deoxycholic acid-phosphorylcholine-chitosan conjugate.
Topics: Animals; Biomimetic Materials; Cell Survival; Chitosan; Deoxycholic Acid; Drug Carriers; Erythrocyte | 2014 |
Self-assemblied nanocomplexes based on biomimetic amphiphilic chitosan derivatives for protein delivery.
Topics: Animals; Biomimetic Materials; Cattle; Chitosan; Deoxycholic Acid; Drug Carriers; Drug Liberation; H | 2015 |
Surface hydrolysis of sphingomyelin by the outer membrane protein Rv0888 supports replication of Mycobacterium tuberculosis in macrophages.
Topics: Bacterial Outer Membrane Proteins; Cells, Cultured; Ceramides; Erythrocyte Membrane; Hemolysis; Host | 2015 |
Miltefosine Lipid Nanocapsules for Single Dose Oral Treatment of Schistosomiasis Mansoni: A Preclinical Study.
Topics: Administration, Oral; Animals; Antiprotozoal Agents; Drug Evaluation, Preclinical; Hemolysis; Liver; | 2015 |
Hemolytic potential of miltefosine is dependent on cell concentration: Implications for in vitro cell cytotoxicity assays and pharmacokinetic data.
Topics: Erythrocyte Membrane; Hemolysis; Humans; In Vitro Techniques; Phosphorylcholine | 2016 |
Miltefosine-loaded lipid nanoparticles: Improving miltefosine stability and reducing its hemolytic potential toward erythtocytes and its cytotoxic effect on macrophages.
Topics: Animals; Antiprotozoal Agents; Cell Death; Cells, Cultured; Drug Carriers; Drug Stability; Erythrocy | 2016 |
In vitro evaluation of PHISIO-coated sets for pediatric cardiac surgery.
Topics: Biomarkers; Blood Coagulation; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Child; Coated Ma | 2009 |
Development of a disposable maglev centrifugal blood pump intended for one-month support in bridge-to-bridge applications: in vitro and initial in vivo evaluation.
Topics: Animals; Animals, Newborn; Autopsy; Biomarkers; Cattle; Centrifugation; Coated Materials, Biocompati | 2009 |
Rational design of tryptophan-rich antimicrobial peptides with enhanced antimicrobial activities and specificities.
Topics: Amino Acid Sequence; Anti-Infective Agents; Antimicrobial Cationic Peptides; Calorimetry; Circular D | 2010 |
Conformational and membrane interaction studies of the antimicrobial peptide alyteserin-1c and its analogue [E4K]alyteserin-1c.
Topics: Anti-Infective Agents; Antimicrobial Cationic Peptides; Bacteria; Chlorides; Cyclic N-Oxides; Hemoly | 2011 |
Structure-activity relationships of alkylphosphocholine derivatives: antineoplastic action on brain tumor cell lines in vitro.
Topics: Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Cycle; Cell Division; Cell Survival | 2002 |
Synthesis and antiproliferative activity of alkylphosphocholines.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line; HeLa Cells; Hemolysis; Humans; Inhibitory | 2003 |
Clostridium perfringens alpha-toxin activates the sphingomyelin metabolism system in sheep erythrocytes.
Topics: 4-Aminobenzoic Acid; ADP Ribose Transferases; Amidohydrolases; Animals; Bacterial Toxins; Botulinum | 2004 |
Synthesis and biological evaluation of spin-labeled alkylphospholipid analogs.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cyclic N-Oxides; Drug Screening Assays, Antitumor; Hemolysi | 2005 |
Hexadecylphosphocholine (miltefosine) has broad-spectrum fungicidal activity and is efficacious in a mouse model of cryptococcosis.
Topics: Acyltransferases; Animals; Antifungal Agents; Cryptococcosis; Disease Models, Animal; Enzyme Inhibit | 2006 |
Structure and activity of the N-terminal region of the eukaryotic cytolysin equinatoxin II.
Topics: Amino Acid Sequence; Animals; Cell Membrane; Cnidarian Venoms; Eukaryotic Cells; Hemolysis; Humans; | 2006 |
Structure-function analysis of tritrpticin analogs: potential relationships between antimicrobial activities, model membrane interactions, and their micelle-bound NMR structures.
Topics: Amino Acid Substitution; Anti-Infective Agents; Escherichia coli; Fluoresceins; Hemolysis; Humans; I | 2006 |
Design and synthesis of potent antileishmanial cycloalkylidene-substituted ether phospholipid derivatives.
Topics: Animals; Cells, Cultured; Cycloparaffins; Drug Design; Ethers; Hemolysis; Humans; Leishmania; Leishm | 2008 |
A different molecular mechanism underlying antimicrobial and hemolytic actions of temporins A and L.
Topics: Amino Acid Sequence; Anti-Bacterial Agents; Antimicrobial Cationic Peptides; Circular Dichroism; Ery | 2008 |
[Synthesis and biological activity of some lysing and fusogenically active phosphocholine derivatives].
Topics: Cell Fusion; Chemical Phenomena; Chemistry; Choline; Hemolysis; Humans; In Vitro Techniques; Phospho | 1982 |
[Inhibition effect of C-reactive protein on the hemolytic activity of streptolysin O. Comparison of conformational variants].
Topics: Bacterial Proteins; C-Reactive Protein; Hemolysis; Humans; Phosphorylcholine; Polysaccharides, Bacte | 1995 |
Lysis of red blood cells and alveolar epithelial toxicity by therapeutic pulmonary surfactants.
Topics: Animals; Biological Products; Drug Combinations; Epithelial Cells; Epithelium; Fatty Alcohols; Hemol | 1995 |
A novel assay to determine the hemolytic activity of drugs incorporated in colloidal carrier systems.
Topics: Colloids; Drug Carriers; Erythrocytes; Hemoglobins; Hemolysis; Humans; In Vitro Techniques; Phosphor | 1994 |
Species of alpha-hemolytic streptococci possessing a C-polysaccharide phosphorylcholine-containing antigen.
Topics: Antigens, Bacterial; Hemolysis; Phosphorylcholine; Streptococcus; Teichoic Acids | 1993 |
Ether lipids enhance the cytotoxic effect of teniposide and paclitaxel in liposomes against leukaemic cells in culture.
Topics: Antineoplastic Agents, Phytogenic; Drug Antagonism; Drug Synergism; Hemolysis; HL-60 Cells; Humans; | 1997 |
Crosslinkable coatings from phosphorylcholine-based polymers.
Topics: Bacterial Adhesion; Coated Materials, Biocompatible; Cross-Linking Reagents; Escherichia coli; Hemol | 2001 |
Identification of residues in the carboxy-terminal domain of Clostridium perfringens alpha-toxin (phospholipase C) which are required for its biological activities.
Topics: Amino Acid Substitution; Aspartic Acid; Bacterial Toxins; Calcium-Binding Proteins; Clostridium perf | 2000 |
Hexadecylphosphocholine in liposomal dispersions.
Topics: Antineoplastic Agents; Hemolysis; Lipid Bilayers; Liposomes; Phosphorylcholine | 1992 |
Hexadecylphosphocholine and octadecyl-methyl-glycero-3-phosphocholine: a comparison of hemolytic activity, serum binding and tissue distribution.
Topics: Animals; Antineoplastic Agents; Female; Hemolysis; Phospholipid Ethers; Phosphorylcholine; Rats; Rat | 1992 |
Antitumor effects of alkylphosphocholines in different murine tumor models: use of liposomal preparations.
Topics: Animals; Antineoplastic Agents; Hemolysis; Humans; Leukemia P388; Liposomes; Mammary Neoplasms, Expe | 1991 |
Phosphorylcholine acts as a Ca2+-dependent receptor molecule for lymphocyte perforin.
Topics: Animals; Calcium; Choline; Chromatography, Affinity; Erythrocytes; Hemolysis; Membrane Glycoproteins | 1989 |
Lysosphingolipids and mitochondrial function. II. Deleterious effects of sphingosylphosphorylcholine.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Calcium; Choline; Erythrocytes; Hemolysi | 1988 |
Cytolytic and phospholipase C activity in Legionella species.
Topics: Animals; Cytotoxins; Dogs; Egg Yolk; Erythrocytes; Guinea Pigs; Hemolysis; Humans; Legionella; Phosp | 1985 |