phosphorylcholine has been researched along with Glioma in 27 studies
Phosphorylcholine: Calcium and magnesium salts used therapeutically in hepatobiliary dysfunction.
phosphocholine : The phosphate of choline; and the parent compound of the phosphocholine family.
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
| Excerpt | Relevance | Reference |
|---|---|---|
| "ErPC (40 mg/kg) was given to C6 glioma-bearing rats either as a single intracarotid bolus injection in the presence or absence of 1- O-pentylglycerol (300 m M) or as an intracarotid infusion in conjunction with bradykinin." | 7.71 | Increased delivery of erucylphosphocholine to C6 gliomas by chemical opening of the blood-brain barrier using intracarotid pentylglycerol in rats. ( Eibl, H; Erdlenbruch, B; Jendrossek, V; Kugler, W; Lakomek, M, 2002) |
| "In the present study we investigate the effect of exogenous sphingosine, sphingosine 1-phosphate and sphingosylphosphorylcholine on phospholipase D (PLD) activity in glioma C6 cells." | 7.70 | Exogenous sphingosine 1-phosphate and sphingosylphosphorylcholine do not stimulate phospholipase D in C6 glioma cells. ( Barańska, J; Bobeszko, M; Dygas, A; Sidorko, M, 1999) |
| "The effect of sphingosine, sphingosylphosphorylcholine and sphingosine 1-phosphate on L-[U-14C]serine incorporation into phosphatidylserine and phosphatidylserine-derived phosphatidylethanolamine was investigated in intact glioma C6 cells." | 7.70 | Sphingosine, sphingosylphosphorylcholine and sphingosine 1-phosphate modulate phosphatidylserine homeostasis in glioma C6 cells. ( Barańska, J; Wójcik, M, 1999) |
| "Treatment with miltefosine resulted in increase in Ras, extracellular signal-regulated kinase (ERK) and p38MAPK activity." | 5.35 | Involvement of miltefosine-mediated ERK activation in glioma cell apoptosis through Fas regulation. ( Koul, N; Sen, E; Sharma, V; Tewari, R, 2008) |
| "Perifosine is an oral Akt inhibitor which exerts a marked cytotoxic effect on human tumor cell lines, and is currently being tested in several phase II trials for treatment of major human cancers." | 5.33 | Perifosine inhibits multiple signaling pathways in glial progenitors and cooperates with temozolomide to arrest cell proliferation in gliomas in vivo. ( Holland, EC; Momota, H; Nerio, E, 2005) |
| "Erucylphosphocholine (ErPC) is a promising anti-neoplastic drug for the treatment of malignant brain tumours." | 5.31 | Erucylphosphocholine-induced apoptosis in glioma cells: involvement of death receptor signalling and caspase activation. ( Eibl, H; Erdlenbruch, B; Heinemann, D; Jünemann, A; Kugler, W; Lakomek, M, 2002) |
| "Previous ex vivo spectroscopic data from tissue samples revealed differences in phospholipid metabolites between isocitrate dehydrogenase mutated (IDHmut) and IDH wildtype (IDHwt) gliomas." | 3.91 | In vivo Metabolic Profiles as Determined by ( Bähr, O; Franz, K; Hattingen, E; Pilatus, U; Steinbach, J; Wenger, KJ, 2019) |
| "ErPC (40 mg/kg) was given to C6 glioma-bearing rats either as a single intracarotid bolus injection in the presence or absence of 1- O-pentylglycerol (300 m M) or as an intracarotid infusion in conjunction with bradykinin." | 3.71 | Increased delivery of erucylphosphocholine to C6 gliomas by chemical opening of the blood-brain barrier using intracarotid pentylglycerol in rats. ( Eibl, H; Erdlenbruch, B; Jendrossek, V; Kugler, W; Lakomek, M, 2002) |
| "The authors sought to compare 1H magnetic resonance spectroscopy (MRS) spectra from extracts of low-grade and high-grade gliomas, especially with respect to the signals of choline-containing compounds." | 3.70 | Characterization of choline compounds with in vitro 1H magnetic resonance spectroscopy for the discrimination of primary brain tumors. ( Berry, I; Breil, S; Delisle, MB; Gilard, V; Malet-Martino, M; Manelfe, C; Ranjeva, JP; Sabatier, J; Terral, C; Tremoulet, M, 1999) |
| "In the present study we investigate the effect of exogenous sphingosine, sphingosine 1-phosphate and sphingosylphosphorylcholine on phospholipase D (PLD) activity in glioma C6 cells." | 3.70 | Exogenous sphingosine 1-phosphate and sphingosylphosphorylcholine do not stimulate phospholipase D in C6 glioma cells. ( Barańska, J; Bobeszko, M; Dygas, A; Sidorko, M, 1999) |
| "The effect of sphingosine, sphingosylphosphorylcholine and sphingosine 1-phosphate on L-[U-14C]serine incorporation into phosphatidylserine and phosphatidylserine-derived phosphatidylethanolamine was investigated in intact glioma C6 cells." | 3.70 | Sphingosine, sphingosylphosphorylcholine and sphingosine 1-phosphate modulate phosphatidylserine homeostasis in glioma C6 cells. ( Barańska, J; Wójcik, M, 1999) |
| "It has been found that sphingosine and sphingosylphosphorylcholine (amphiphilic cations) have a stimulatory, and cholesterol 3-sulfate (an amphiphilic anion), an inhibitory, effect on [14C]serine incorporation into phosphatidylserine in glioma C6 and rat liver microsomes." | 3.69 | Serine base exchange enzyme activity is modulated by sphingosine and other amphiphilic compounds: possible role of positive charge in increasing the synthesis of phosphatidylserine. ( Banasiak, M; Barańska, J; Czarny, M; Stepkowski, D; Wiktorek-Wójcik, M, 1997) |
| "Treatment with miltefosine resulted in increase in Ras, extracellular signal-regulated kinase (ERK) and p38MAPK activity." | 1.35 | Involvement of miltefosine-mediated ERK activation in glioma cell apoptosis through Fas regulation. ( Koul, N; Sen, E; Sharma, V; Tewari, R, 2008) |
| "Perifosine is an oral Akt inhibitor which exerts a marked cytotoxic effect on human tumor cell lines, and is currently being tested in several phase II trials for treatment of major human cancers." | 1.33 | Perifosine inhibits multiple signaling pathways in glial progenitors and cooperates with temozolomide to arrest cell proliferation in gliomas in vivo. ( Holland, EC; Momota, H; Nerio, E, 2005) |
| "Erucylphosphocholine (ErPC) is a promising anti-neoplastic drug for the treatment of malignant brain tumours." | 1.31 | Erucylphosphocholine-induced apoptosis in glioma cells: involvement of death receptor signalling and caspase activation. ( Eibl, H; Erdlenbruch, B; Heinemann, D; Jünemann, A; Kugler, W; Lakomek, M, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (25.93) | 18.2507 |
| 2000's | 9 (33.33) | 29.6817 |
| 2010's | 7 (25.93) | 24.3611 |
| 2020's | 4 (14.81) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, H | 1 |
| Chao, Y | 1 |
| Zhao, H | 1 |
| Zhou, X | 1 |
| Zhang, F | 1 |
| Zhang, Z | 1 |
| Li, Z | 1 |
| Pan, J | 1 |
| Wang, J | 1 |
| Chen, Q | 1 |
| Liu, Z | 1 |
| Sandbhor, P | 1 |
| Goda, JS | 1 |
| Mohanty, B | 1 |
| Chaudhari, P | 1 |
| Dutt, S | 1 |
| Banerjee, R | 1 |
| Sola-Barrado, B | 1 |
| M Leite, D | 1 |
| Scarpa, E | 1 |
| Duro-Castano, A | 1 |
| Battaglia, G | 1 |
| Ban, J | 1 |
| Li, S | 1 |
| Zhan, Q | 1 |
| Li, X | 1 |
| Xing, H | 1 |
| Chen, N | 1 |
| Long, L | 1 |
| Hou, X | 1 |
| Zhao, J | 1 |
| Yuan, X | 1 |
| Wang, N | 1 |
| Sun, P | 1 |
| Lv, M | 1 |
| Tong, G | 1 |
| Jin, X | 1 |
| Zhu, X | 1 |
| Becher, OJ | 2 |
| Millard, NE | 1 |
| Modak, S | 1 |
| Kushner, BH | 1 |
| Haque, S | 1 |
| Spasojevic, I | 1 |
| Trippett, TM | 1 |
| Gilheeney, SW | 1 |
| Khakoo, Y | 1 |
| Lyden, DC | 1 |
| De Braganca, KC | 1 |
| Kolesar, JM | 1 |
| Huse, JT | 2 |
| Kramer, K | 1 |
| Cheung, NV | 1 |
| Dunkel, IJ | 1 |
| Wenger, KJ | 1 |
| Hattingen, E | 1 |
| Franz, K | 1 |
| Steinbach, J | 1 |
| Bähr, O | 1 |
| Pilatus, U | 1 |
| Swanson, KI | 1 |
| Clark, PA | 1 |
| Zhang, RR | 1 |
| Kandela, IK | 1 |
| Farhoud, M | 1 |
| Weichert, JP | 1 |
| Kuo, JS | 1 |
| Zhou, Z | 1 |
| Ho, SL | 1 |
| Singh, R | 1 |
| Pisapia, DJ | 1 |
| Souweidane, MM | 1 |
| Tewari, R | 1 |
| Sharma, V | 1 |
| Koul, N | 1 |
| Sen, E | 1 |
| Hambardzumyan, D | 1 |
| Walker, TR | 1 |
| Helmy, K | 1 |
| Nazarian, J | 1 |
| Albrecht, S | 1 |
| Hiner, RL | 1 |
| Gall, S | 1 |
| Jabado, N | 1 |
| MacDonald, TJ | 1 |
| Holland, EC | 2 |
| Mirbahai, L | 1 |
| Wilson, M | 1 |
| Shaw, CS | 1 |
| McConville, C | 1 |
| Malcomson, RD | 1 |
| Griffin, JL | 2 |
| Kauppinen, RA | 2 |
| Peet, AC | 1 |
| Erdlenbruch, B | 3 |
| Jendrossek, V | 2 |
| Kugler, W | 3 |
| Eibl, H | 3 |
| Lakomek, M | 3 |
| Jünemann, A | 1 |
| Heinemann, D | 1 |
| Lehtimäki, KK | 1 |
| Valonen, PK | 1 |
| Väisänen, TH | 1 |
| Gröhn, OH | 1 |
| Kettunen, MI | 1 |
| Vepsäläinen, J | 1 |
| Ylä-Herttuala, S | 1 |
| Nicholson, J | 1 |
| Naumann, U | 1 |
| Wischhusen, J | 1 |
| Weit, S | 1 |
| Rieger, J | 1 |
| Wolburg, H | 1 |
| Massing, U | 1 |
| Weller, M | 1 |
| Momota, H | 1 |
| Nerio, E | 1 |
| de la Peña, L | 1 |
| Burgan, WE | 1 |
| Carter, DJ | 1 |
| Hollingshead, MG | 1 |
| Satyamitra, M | 1 |
| Camphausen, K | 1 |
| Tofilon, PJ | 1 |
| Go, KG | 1 |
| Kamman, RL | 1 |
| Mooyaart, EL | 1 |
| Heesters, MA | 1 |
| Pruim, J | 1 |
| Vaalburg, W | 1 |
| Paans, AM | 1 |
| Gillies, RJ | 1 |
| Barry, JA | 1 |
| Ross, BD | 1 |
| Wiktorek-Wójcik, M | 1 |
| Banasiak, M | 1 |
| Czarny, M | 1 |
| Stepkowski, D | 1 |
| Barańska, J | 3 |
| Sabatier, J | 1 |
| Gilard, V | 1 |
| Malet-Martino, M | 1 |
| Ranjeva, JP | 1 |
| Terral, C | 1 |
| Breil, S | 1 |
| Delisle, MB | 1 |
| Manelfe, C | 1 |
| Tremoulet, M | 1 |
| Berry, I | 1 |
| Dygas, A | 1 |
| Sidorko, M | 1 |
| Bobeszko, M | 1 |
| Wójcik, M | 1 |
| Son, BC | 1 |
| Kim, MC | 1 |
| Choi, BG | 1 |
| Kim, EN | 1 |
| Baik, HM | 1 |
| Choe, BY | 1 |
| Naruse, S | 1 |
| Kang, JK | 1 |
| Zeller, WJ | 1 |
| Bauer, S | 1 |
| Remmele, T | 1 |
| Wowra, B | 1 |
| Sturm, V | 1 |
| Stricker, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Molecular Analysis of Samples From Patients With Diffuse Intrinsic Pontine Glioma and Brainstem Glioma[NCT01106794] | 100 participants (Anticipated) | Observational | 2010-04-30 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for phosphorylcholine and Glioma
| Article | Year |
|---|---|
A phase I study of single-agent perifosine for recurrent or refractory pediatric CNS and solid tumors.
Topics: Adolescent; Antineoplastic Agents; Central Nervous System Neoplasms; Child; Child, Preschool; Drug A | 2017 |
26 other studies available for phosphorylcholine and Glioma
| Article | Year |
|---|---|
Smart Nanomedicine to Enable Crossing Blood-Brain Barrier Delivery of Checkpoint Blockade Antibody for Immunotherapy of Glioma.
Topics: Animals; Antibodies; Blood-Brain Barrier; Brain Neoplasms; Cell Line, Tumor; Glioma; Immunotherapy; | 2022 |
Bio-polymeric transferrin-targeted temozolomide nanoparticles in gel for synergistic post-surgical GBM therapy.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Delayed-Action Preparations; Glioblastoma; Glioma; Hydro | 2022 |
Combinatorial Intracellular Delivery Screening of Anticancer Drugs.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Drug Carriers; Drug Screening Assa | 2020 |
PMPC Modified PAMAM Dendrimer Enhances Brain Tumor-Targeted Drug Delivery.
Topics: Animals; Blood-Brain Barrier; Brain Neoplasms; Cell Line, Tumor; Dendrimers; Doxorubicin; Drug Carri | 2021 |
Mustard-inspired delivery shuttle for enhanced blood-brain barrier penetration and effective drug delivery in glioma therapy.
Topics: Animals; Antineoplastic Agents, Alkylating; Biological Transport; Blood-Brain Barrier; Brain Neoplas | 2017 |
In vivo Metabolic Profiles as Determined by
Topics: Adult; Aged; Analysis of Variance; Astrocytoma; Biomarkers, Tumor; Brain Neoplasms; Diagnosis, Diffe | 2019 |
Fluorescent cancer-selective alkylphosphocholine analogs for intraoperative glioma detection.
Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Flow Cytometry; Fluorescent Dyes; Glioma; Heterograft | 2015 |
Toxicity evaluation of convection-enhanced delivery of small-molecule kinase inhibitors in naïve mouse brainstem.
Topics: Animals; Animals, Newborn; Brain Stem; Cell Line, Tumor; Cell Proliferation; Convection; Dasatinib; | 2015 |
Involvement of miltefosine-mediated ERK activation in glioma cell apoptosis through Fas regulation.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Line, Tumor; Enzyme Activation; Extracellu | 2008 |
Preclinical evaluation of radiation and perifosine in a genetically and histologically accurate model of brainstem glioma.
Topics: Animals; Brain Stem Neoplasms; Combined Modality Therapy; Disease Models, Animal; Genetic Engineerin | 2010 |
1H magnetic resonance spectroscopy metabolites as biomarkers for cell cycle arrest and cell death in rat glioma cells.
Topics: Amino Acids; Animals; Biomarkers, Tumor; Cell Death; Cell Line, Tumor; Cisplatin; G1 Phase; Glioma; | 2011 |
Increased delivery of erucylphosphocholine to C6 gliomas by chemical opening of the blood-brain barrier using intracarotid pentylglycerol in rats.
Topics: Animals; Antineoplastic Agents; Blood-Brain Barrier; Brain; Brain Neoplasms; Glioma; Glycerol; Injec | 2002 |
Erucylphosphocholine-induced apoptosis in glioma cells: involvement of death receptor signalling and caspase activation.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Caspases; Cell Death; Enzyme Activation; Enzyme Inhibito | 2002 |
Metabolite changes in BT4C rat gliomas undergoing ganciclovir-thymidine kinase gene therapy-induced programmed cell death as studied by 1H NMR spectroscopy in vivo, ex vivo, and in vitro.
Topics: Animals; Apoptosis; Brain; Brain Neoplasms; Cell Line, Tumor; Choline; Diffusion; Ganciclovir; Genet | 2003 |
Alkylphosphocholine-induced glioma cell death is BCL-X(L)-sensitive, caspase-independent and characterized by massive cytoplasmic vacuole formation.
Topics: Antineoplastic Agents; Apoptosis; Astrocytes; bcl-X Protein; Brain Neoplasms; Caspases; Cell Line, T | 2004 |
Perifosine inhibits multiple signaling pathways in glial progenitors and cooperates with temozolomide to arrest cell proliferation in gliomas in vivo.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; CDC2-CDC28 Kinases; Cell G | 2005 |
Inhibition of Akt by the alkylphospholipid perifosine does not enhance the radiosensitivity of human glioma cells.
Topics: Animals; Apoptosis; Brain Neoplasms; Combined Modality Therapy; Female; Glioma; Humans; Immunohistoc | 2006 |
Localised proton spectroscopy and spectroscopic imaging in cerebral gliomas, with comparison to positron emission tomography.
Topics: Aspartic Acid; Brain; Brain Chemistry; Brain Edema; Carbon Radioisotopes; Creatine; Deoxyglucose; Fl | 1995 |
In vitro and in vivo 13C and 31P NMR analyses of phosphocholine metabolism in rat glioma cells.
Topics: Animals; Carbon Isotopes; Cell Division; Choline; Ethanolamines; Glioma; Magnetic Resonance Spectros | 1994 |
Serine base exchange enzyme activity is modulated by sphingosine and other amphiphilic compounds: possible role of positive charge in increasing the synthesis of phosphatidylserine.
Topics: Animals; Cholesterol Esters; Glioma; Kinetics; Microsomes; Microsomes, Liver; Nitrogenous Group Tran | 1997 |
Characterization of choline compounds with in vitro 1H magnetic resonance spectroscopy for the discrimination of primary brain tumors.
Topics: Adult; Aged; Brain Neoplasms; Choline; Female; Glioma; Humans; In Vitro Techniques; Magnetic Resonan | 1999 |
Exogenous sphingosine 1-phosphate and sphingosylphosphorylcholine do not stimulate phospholipase D in C6 glioma cells.
Topics: Brain Neoplasms; Enzyme Activation; Glioma; Lysophospholipids; Phospholipase D; Phosphorylcholine; S | 1999 |
Sphingosine, sphingosylphosphorylcholine and sphingosine 1-phosphate modulate phosphatidylserine homeostasis in glioma C6 cells.
Topics: Brain Neoplasms; Glioma; Homeostasis; Lysophospholipids; Phosphorylcholine; Sphingosine; Tumor Cells | 1999 |
Proton magnetic resonance chemical shift imaging (1H CSI)-directed stereotactic biopsy.
Topics: Adult; Aspartic Acid; Biopsy, Needle; Brain; Brain Neoplasms; Creatine; Diagnosis, Differential; Ene | 2001 |
Induction of differentiation and tetraploidy by long-term treatment of C6 rat glioma cells with erucylphosphocholine.
Topics: Animals; Antineoplastic Agents; Apoptosis; Astrocytes; Brain Neoplasms; Cell Differentiation; Cell D | 2001 |
Interstitial chemotherapy of experimental gliomas.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Drug Carriers; Drug Screening Assays, Antitumor; Gl | 1990 |