phosphorylcholine has been researched along with Choline Deficiency in 13 studies
Phosphorylcholine: Calcium and magnesium salts used therapeutically in hepatobiliary dysfunction.
phosphocholine : The phosphate of choline; and the parent compound of the phosphocholine family.
Choline Deficiency: A condition produced by a deficiency of CHOLINE in animals. Choline is known as a lipotropic agent because it has been shown to promote the transport of excess fat from the liver under certain conditions in laboratory animals. Combined deficiency of choline (included in the B vitamin complex) and all other methyl group donors causes liver cirrhosis in some animals. Unlike compounds normally considered as vitamins, choline does not serve as a cofactor in enzymatic reactions. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study demonstrates that prenatal choline deficiency has profound effects by delaying neurodevelopment as evidenced by structural and metabolic MRI assessments." | 7.83 | Perinatal choline deficiency delays brain development and alters metabolite concentrations in the young pig. ( Dilger, RN; Getty, CM; Mudd, AT; Sutton, BP, 2016) |
| "Treatment of rats with choline during brain development results in long-lasting enhancement of spatial memory whereas choline deficiency has the opposite effect." | 7.71 | Choline deficiency induces apoptosis in primary cultures of fetal neurons. ( Fernandes, A; Mar, MH; Meeker, RB; Yen, CL; Zeisel, SH, 2001) |
| "The purpose of the present experiments was to test the hypothesis that diethanolamine (DEA), an alkanolamine shown to be hepatocarcinogenic in mice, induces hepatic choline deficiency and to determine whether altered choline homeostasis was causally related to the carcinogenic outcome." | 7.71 | Diethanolamine induces hepatic choline deficiency in mice. ( Gamsky, EA; Hicks, SM; Lehman-McKeeman, LD; Mar, MH; Vassallo, JD; Zeisel, SH, 2002) |
| "The effect of choline deficiency on the de novo pathway for phosphatidylcholine (PC) synthesis in the lung was investigated in rats fed a washed soy protein (lipotrophic) diet deficient in choline and methionine for 2-3 wk." | 7.67 | Synthesis of phosphatidylcholine by rat lung during choline deficiency. ( Chander, A; Dodia, C; Fisher, AB; Yost, RW, 1986) |
| "Choline is an important nutrient that is actively transported from mother to fetus across the placenta and from mother to infant across the mammary gland." | 5.29 | Pregnancy and lactation are associated with diminished concentrations of choline and its metabolites in rat liver. ( da Costa, KA; Mar, MH; Zeisel, SH; Zhou, Z, 1995) |
| "We suggest that choline deficiency altered the protein kinase C-mediated signal transduction within liver and this contributed to hepatic carcinogenesis in these animals." | 5.29 | Effects of prolonged (1 year) choline deficiency and subsequent re-feeding of choline on 1,2-sn-diradylglycerol, fatty acids and protein kinase C in rat liver. ( Chang, J; da Costa, KA; Garner, SC; Zeisel, SH, 1995) |
| "This study demonstrates that prenatal choline deficiency has profound effects by delaying neurodevelopment as evidenced by structural and metabolic MRI assessments." | 3.83 | Perinatal choline deficiency delays brain development and alters metabolite concentrations in the young pig. ( Dilger, RN; Getty, CM; Mudd, AT; Sutton, BP, 2016) |
| "Treatment of rats with choline during brain development results in long-lasting enhancement of spatial memory whereas choline deficiency has the opposite effect." | 3.71 | Choline deficiency induces apoptosis in primary cultures of fetal neurons. ( Fernandes, A; Mar, MH; Meeker, RB; Yen, CL; Zeisel, SH, 2001) |
| "The purpose of the present experiments was to test the hypothesis that diethanolamine (DEA), an alkanolamine shown to be hepatocarcinogenic in mice, induces hepatic choline deficiency and to determine whether altered choline homeostasis was causally related to the carcinogenic outcome." | 3.71 | Diethanolamine induces hepatic choline deficiency in mice. ( Gamsky, EA; Hicks, SM; Lehman-McKeeman, LD; Mar, MH; Vassallo, JD; Zeisel, SH, 2002) |
| " In an attempt to define the tumorigenic mechanism of DEA, N-nitrosodiethanolamine (NDELA) formation in vivo and development of choline deficiency were examined in mice." | 3.70 | Potential mechanisms of tumorigenic action of diethanolamine in mice. ( Bartels, MJ; Brzak, KA; Mar, M; Markham, DA; Stott, WT; Thornton, CM; Zeisel, SH, 2000) |
| "Choline deficiency is associated with triacylglycerol accumulation in the liver, and is the only nutritional state known to trigger hepatic cancer spontaneously." | 3.67 | 1,2-sn-diacylglycerol accumulates in choline-deficient liver. A possible mechanism of hepatic carcinogenesis via alteration in protein kinase C activity? ( Blusztajn, JK; Zeisel, SH, 1989) |
| "The effect of choline deficiency on the de novo pathway for phosphatidylcholine (PC) synthesis in the lung was investigated in rats fed a washed soy protein (lipotrophic) diet deficient in choline and methionine for 2-3 wk." | 3.67 | Synthesis of phosphatidylcholine by rat lung during choline deficiency. ( Chander, A; Dodia, C; Fisher, AB; Yost, RW, 1986) |
| "Choline is an important nutrient that is actively transported from mother to fetus across the placenta and from mother to infant across the mammary gland." | 1.29 | Pregnancy and lactation are associated with diminished concentrations of choline and its metabolites in rat liver. ( da Costa, KA; Mar, MH; Zeisel, SH; Zhou, Z, 1995) |
| "We suggest that choline deficiency altered the protein kinase C-mediated signal transduction within liver and this contributed to hepatic carcinogenesis in these animals." | 1.29 | Effects of prolonged (1 year) choline deficiency and subsequent re-feeding of choline on 1,2-sn-diradylglycerol, fatty acids and protein kinase C in rat liver. ( Chang, J; da Costa, KA; Garner, SC; Zeisel, SH, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (23.08) | 18.7374 |
| 1990's | 3 (23.08) | 18.2507 |
| 2000's | 5 (38.46) | 29.6817 |
| 2010's | 2 (15.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mudd, AT | 1 |
| Getty, CM | 1 |
| Sutton, BP | 1 |
| Dilger, RN | 1 |
| Mehedint, MG | 1 |
| Craciunescu, CN | 1 |
| Zeisel, SH | 7 |
| Kulinski, A | 1 |
| Vance, DE | 1 |
| Vance, JE | 1 |
| Mar, MH | 3 |
| Zhou, Z | 1 |
| da Costa, KA | 2 |
| Jiménez, JV | 1 |
| Richards, TL | 1 |
| Heide, AC | 1 |
| Grierson, JR | 1 |
| Shankland, EG | 1 |
| Garner, SC | 1 |
| Chang, J | 1 |
| Stott, WT | 1 |
| Bartels, MJ | 1 |
| Brzak, KA | 1 |
| Mar, M | 1 |
| Markham, DA | 1 |
| Thornton, CM | 1 |
| Yen, CL | 1 |
| Meeker, RB | 1 |
| Fernandes, A | 1 |
| Lehman-McKeeman, LD | 1 |
| Gamsky, EA | 1 |
| Hicks, SM | 1 |
| Vassallo, JD | 1 |
| Ilcol, YO | 1 |
| Dilek, K | 1 |
| Yurtkuran, M | 1 |
| Ulus, IH | 1 |
| Fujimura, I | 1 |
| Behmer, OA | 1 |
| Fujimura, MD | 1 |
| Penteado, S | 1 |
| Ferrarini, E | 1 |
| Lemos, PC | 1 |
| Tolosa, EM | 1 |
| Blusztajn, JK | 1 |
| Yost, RW | 1 |
| Chander, A | 1 |
| Dodia, C | 1 |
| Fisher, AB | 1 |
13 other studies available for phosphorylcholine and Choline Deficiency
| Article | Year |
|---|---|
Perinatal choline deficiency delays brain development and alters metabolite concentrations in the young pig.
Topics: Animals; Animals, Newborn; Brain; Choline; Choline Deficiency; Diet; Diffusion Tensor Imaging; Disea | 2016 |
Maternal dietary choline deficiency alters angiogenesis in fetal mouse hippocampus.
Topics: Angiogenesis Inducing Agents; Animals; Blood Vessels; Cell Count; Cell Proliferation; Cells, Culture | 2010 |
A choline-deficient diet in mice inhibits neither the CDP-choline pathway for phosphatidylcholine synthesis in hepatocytes nor apolipoprotein B secretion.
Topics: Albumins; Animals; Apolipoproteins B; Calnexin; Centrifugation, Density Gradient; Choline; Choline D | 2004 |
Pregnancy and lactation are associated with diminished concentrations of choline and its metabolites in rat liver.
Topics: Animals; Betaine; Choline; Choline Deficiency; Female; Lactation; Liver; Male; Maternal-Fetal Exchan | 1995 |
Incorporation of a phosphonium analogue of choline into the rat brain as measured by magnetic resonance spectroscopy.
Topics: Animals; Aspartic Acid; Brain; Choline; Choline Deficiency; Creatinine; Glycerylphosphorylcholine; H | 1995 |
Effects of prolonged (1 year) choline deficiency and subsequent re-feeding of choline on 1,2-sn-diradylglycerol, fatty acids and protein kinase C in rat liver.
Topics: Aging; Animals; Cell Membrane; Choline; Choline Deficiency; Diglycerides; Fatty Acids; gamma-Glutamy | 1995 |
Potential mechanisms of tumorigenic action of diethanolamine in mice.
Topics: Administration, Cutaneous; Administration, Oral; Alanine Transaminase; Animals; Aspartate Aminotrans | 2000 |
Choline deficiency induces apoptosis in primary cultures of fetal neurons.
Topics: Animals; Apoptosis; Cell Membrane; Cells, Cultured; Ceramides; Cerebral Cortex; Choline; Choline Def | 2001 |
Diethanolamine induces hepatic choline deficiency in mice.
Topics: Administration, Cutaneous; Animals; Betaine; Carcinogens; Choline Deficiency; Dose-Response Relation | 2002 |
Changes of plasma free choline and choline-containing compounds' concentrations and choline loss during hemodialysis in ESRD patients.
Topics: Adult; Choline; Choline Deficiency; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Phos | 2002 |
[Renal changes induced by the acute lack of choline in adult rats].
Topics: Acute Disease; Animals; Choline; Choline Deficiency; Diet; Female; Kidney; Liver; Liver Regeneration | 1978 |
1,2-sn-diacylglycerol accumulates in choline-deficient liver. A possible mechanism of hepatic carcinogenesis via alteration in protein kinase C activity?
Topics: Animals; Carcinogens; Choline; Choline Deficiency; Diglycerides; Enzyme Activation; Glycerides; Live | 1989 |
Synthesis of phosphatidylcholine by rat lung during choline deficiency.
Topics: Animals; Carbon Radioisotopes; Choline; Choline Deficiency; Cytidine Diphosphate Choline; Glucose; L | 1986 |