phosphorylcholine has been researched along with Cancer of Liver in 15 studies
Phosphorylcholine: Calcium and magnesium salts used therapeutically in hepatobiliary dysfunction.
phosphocholine : The phosphate of choline; and the parent compound of the phosphocholine family.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess the response rate and toxicity of the alkylphosphocholine analogue, perifosine, in patients with metastatic or recurrent malignant melanoma." | 9.11 | Phase II study of perifosine in previously untreated patients with metastatic melanoma. ( Baetz, T; Belanger, K; Davis, M; Eisenhauer, E; Ernst, DS; Lohmann, R; Smylie, M; Wainman, N, 2005) |
| "34 patients with metastatic colorectal cancer were treated with the ether lipid miltefosine (hexadecylphosphocholine)." | 9.07 | Phase II study of daily oral miltefosine (hexadecylphosphocholine) in advanced colorectal cancer. ( Planting, AS; Stoter, G; Verweij, J, 1993) |
| "To assess the response rate and toxicity of the alkylphosphocholine analogue, perifosine, in patients with metastatic or recurrent malignant melanoma." | 5.11 | Phase II study of perifosine in previously untreated patients with metastatic melanoma. ( Baetz, T; Belanger, K; Davis, M; Eisenhauer, E; Ernst, DS; Lohmann, R; Smylie, M; Wainman, N, 2005) |
| "34 patients with metastatic colorectal cancer were treated with the ether lipid miltefosine (hexadecylphosphocholine)." | 5.07 | Phase II study of daily oral miltefosine (hexadecylphosphocholine) in advanced colorectal cancer. ( Planting, AS; Stoter, G; Verweij, J, 1993) |
| "Choline deficiency is associated with triacylglycerol accumulation in the liver, and is the only nutritional state known to trigger hepatic cancer spontaneously." | 3.67 | 1,2-sn-diacylglycerol accumulates in choline-deficient liver. A possible mechanism of hepatic carcinogenesis via alteration in protein kinase C activity? ( Blusztajn, JK; Zeisel, SH, 1989) |
| "Patients with liver cirrhosis of different aetiologies are at a risk to develop HCC." | 2.66 | Role of lipids in pathophysiology, diagnosis and therapy of hepatocellular carcinoma. ( Aslanidis, C; Buechler, C, 2020) |
| "Animal studies in liver cancer xenograft model demonstrated significant suppression of tumor burden, reduced tumor cell and elevated TUNEL positive apoptosis with no toxicity concerns in animals treated with G-S27LN formulation." | 1.51 | Anti-GPC3 Antibody Tagged Cationic Switchable Lipid-Based Nanoparticles for the Co-Delivery of Anti-miRNA27a And Sorafenib in Liver Cancers. ( Duan, X; Wang, Z; Zhang, Y; Zhao, K; Zhao, Y, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.67) | 18.7374 |
| 1990's | 4 (26.67) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 6 (40.00) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, Z | 1 |
| Zhao, K | 1 |
| Zhang, Y | 1 |
| Duan, X | 1 |
| Zhao, Y | 1 |
| Buechler, C | 1 |
| Aslanidis, C | 1 |
| Herrick, WG | 1 |
| Nguyen, TV | 1 |
| Sleiman, M | 1 |
| McRae, S | 1 |
| Emrick, TS | 1 |
| Peyton, SR | 1 |
| Ríos-Marco, P | 2 |
| Ríos, A | 1 |
| Jiménez-López, JM | 2 |
| Carrasco, MP | 2 |
| Marco, C | 2 |
| Miyata, R | 1 |
| Ueda, M | 2 |
| Jinno, H | 2 |
| Konno, T | 1 |
| Ishihara, K | 2 |
| Ando, N | 1 |
| Kitagawa, Y | 1 |
| Grudzinski, JJ | 1 |
| Yoriyaz, H | 1 |
| Deluca, PM | 1 |
| Weichert, JP | 1 |
| Segovia, JL | 1 |
| Cheng, ML | 1 |
| Shiao, MS | 1 |
| Chiu, DT | 1 |
| Weng, SF | 1 |
| Tang, HY | 1 |
| Ho, HY | 1 |
| Ernst, DS | 1 |
| Eisenhauer, E | 1 |
| Wainman, N | 1 |
| Davis, M | 1 |
| Lohmann, R | 1 |
| Baetz, T | 1 |
| Belanger, K | 1 |
| Smylie, M | 1 |
| Chiba, N | 1 |
| Shimada, T | 1 |
| Watanabe, J | 1 |
| Kitajima, M | 1 |
| Bell, JD | 2 |
| Cox, IJ | 1 |
| Sargentoni, J | 1 |
| Peden, CJ | 1 |
| Menon, DK | 1 |
| Foster, CS | 1 |
| Watanapa, P | 1 |
| Iles, RA | 1 |
| Urenjak, J | 1 |
| Planting, AS | 1 |
| Stoter, G | 1 |
| Verweij, J | 1 |
| Dixon, RM | 1 |
| Tian, M | 1 |
| Bhakoo, KK | 1 |
| Blusztajn, JK | 1 |
| Zeisel, SH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase II Study Of Perifosine (D-21266) In Previously Untreated Patients With Metastatic Or Recurrent Malignant Melanoma[NCT00053781] | Phase 2 | 18 participants (Actual) | Interventional | 2003-06-20 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for phosphorylcholine and Cancer of Liver
| Article | Year |
|---|---|
Role of lipids in pathophysiology, diagnosis and therapy of hepatocellular carcinoma.
Topics: Animals; Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cell Prolif | 2020 |
Metabolic changes underlying 31P MR spectral alterations in human hepatic tumours.
Topics: Ethanolamines; Humans; Liver Neoplasms; Magnetic Resonance Spectroscopy; Phospholipids; Phosphorus R | 1998 |
2 trials available for phosphorylcholine and Cancer of Liver
| Article | Year |
|---|---|
Phase II study of perifosine in previously untreated patients with metastatic melanoma.
Topics: Adult; Aged; Aged, 80 and over; Arthralgia; Chondrocalcinosis; Female; Humans; Liver Neoplasms; Lung | 2005 |
Phase II study of daily oral miltefosine (hexadecylphosphocholine) in advanced colorectal cancer.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents; Colorectal Neoplasms; Female; Humans; Leuk | 1993 |
11 other studies available for phosphorylcholine and Cancer of Liver
| Article | Year |
|---|---|
Anti-GPC3 Antibody Tagged Cationic Switchable Lipid-Based Nanoparticles for the Co-Delivery of Anti-miRNA27a And Sorafenib in Liver Cancers.
Topics: Animals; Antagomirs; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Apoptos | 2019 |
PEG-phosphorylcholine hydrogels as tunable and versatile platforms for mechanobiology.
Topics: Biocompatible Materials; Biophysics; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Elastic Mo | 2013 |
Cholesterol homeostasis and autophagic flux in perifosine-treated human hepatoblastoma HepG2 and glioblastoma U-87 MG cell lines.
Topics: Autophagy; Brain Neoplasms; Cell Line, Tumor; Cholesterol; Glioblastoma; Hepatoblastoma; Homeostasis | 2015 |
Selective targeting by preS1 domain of hepatitis B surface antigen conjugated with phosphorylcholine-based amphiphilic block copolymer micelles as a biocompatible, drug delivery carrier for treatment of human hepatocellular carcinoma with paclitaxel.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biocompatible Materials; Carcinoma, Hepatocellular; Cell | 2009 |
Patient specific treatment planning for systemically administered radiopharmaceuticals using PET/CT and Monte Carlo simulation.
Topics: Humans; Iodine Radioisotopes; Liver; Liver Neoplasms; Monte Carlo Method; Phantoms, Imaging; Phospho | 2010 |
Disruption of cellular cholesterol transport and homeostasis as a novel mechanism of action of membrane-targeted alkylphospholipid analogues.
Topics: Antineoplastic Agents; Biological Transport; Blotting, Western; Carcinoma, Hepatocellular; Cell Line | 2010 |
Biochemical disorders associated with antiproliferative effect of dehydroepiandrosterone in hepatoma cells as revealed by LC-based metabolomics.
Topics: Anticarcinogenic Agents; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Proliferation; Chrom | 2011 |
Development of gene vectors for pinpoint targeting to human hepatocytes by cationically modified polymer complexes.
Topics: Adenocarcinoma; Animals; Carcinoma, Hepatocellular; Cations; Cell Line, Tumor; Female; Gene Expressi | 2007 |
A 31P and 1H-NMR investigation in vitro of normal and abnormal human liver.
Topics: Biopsy; Ethanolamines; Humans; Liver; Liver Neoplasms; Magnetic Resonance Spectroscopy; Pancreatitis | 1993 |
Phospholipid synthesis in the lymphomatous mouse liver studied by 31P nuclear magnetic resonance spectroscopy in vitro and by administration of 14C-radiolabelled compounds in vivo.
Topics: Animals; Body Weight; Carbon Radioisotopes; Choline; Ethanolamine; Ethanolamines; Liver Neoplasms; L | 1993 |
1,2-sn-diacylglycerol accumulates in choline-deficient liver. A possible mechanism of hepatic carcinogenesis via alteration in protein kinase C activity?
Topics: Animals; Carcinogens; Choline; Choline Deficiency; Diglycerides; Enzyme Activation; Glycerides; Live | 1989 |