phosphorylcholine has been researched along with Alzheimer Disease in 12 studies
Phosphorylcholine: Calcium and magnesium salts used therapeutically in hepatobiliary dysfunction.
phosphocholine : The phosphate of choline; and the parent compound of the phosphocholine family.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Preliminary studies in Alzheimer's disease have demonstrated elevated levels of phosphomonoesters and phosphodiesters in the areas of Alzheimer's brain which exhibit neuropathological changes." | 2.37 | 31P nuclear magnetic resonance (NMR) spectroscopy of brain in aging and Alzheimer's disease. ( Panchalingam, K; Pettegrew, JW; Post, JF; Withers, G, 1987) |
| "A major hallmark of Alzheimer's disease (AD) is the accumulation of extracellular aggregates of amyloid-β (Aβ)." | 1.72 | Ganglioside-Enriched Phospholipid Vesicles Induce Cooperative Aβ Oligomerization and Membrane Disruption. ( Bose, P; Dhakal, S; Ghosh, P; Rangachari, V; Saha, J, 2022) |
| "It has been shown that patients with Alzheimer's disease and other dementias have significantly lower serum anti-PC levels compared to controls, suggesting that low levels of atheroprotective anti-PC may play a role in AD and dementia." | 1.42 | Antibodies against phosphorylcholine are not altered in plasma of patients with Alzheimer's disease. ( Björkqvist, M; Hansson, O; Silajdžić, E, 2015) |
| "Brain cells in Alzheimer's disease (AD) exhibit a membrane defect characterized by accelerated phospholipid turnover." | 1.31 | Acceleration of phosphatidylcholine synthesis and breakdown by inhibitors of mitochondrial function in neuronal cells: a model of the membrane defect of Alzheimer's disease. ( Blusztajn, JK; Farber, SA; Slack, BE, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (16.67) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 5 (41.67) | 24.3611 |
| 2020's | 3 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yuan, R | 1 |
| Huang, H | 1 |
| Saha, J | 1 |
| Bose, P | 1 |
| Dhakal, S | 1 |
| Ghosh, P | 1 |
| Rangachari, V | 1 |
| Otoki, Y | 1 |
| Yu, D | 1 |
| Shen, Q | 1 |
| Sahlas, DJ | 1 |
| Ramirez, J | 1 |
| Gao, F | 1 |
| Masellis, M | 1 |
| Swartz, RH | 1 |
| Chan, PC | 1 |
| Pettersen, JA | 1 |
| Kato, S | 1 |
| Nakagawa, K | 1 |
| Black, SE | 1 |
| Swardfager, W | 1 |
| Taha, AY | 1 |
| Maurya, SR | 1 |
| Mahalakshmi, R | 1 |
| Kennedy, MA | 1 |
| Gable, K | 1 |
| Niewola-Staszkowska, K | 1 |
| Abreu, S | 1 |
| Johnston, A | 1 |
| Harris, LJ | 1 |
| Reggiori, F | 1 |
| Loewith, R | 1 |
| Dunn, T | 1 |
| Bennett, SA | 1 |
| Baetz, K | 1 |
| Silajdžić, E | 1 |
| Björkqvist, M | 1 |
| Hansson, O | 1 |
| Doert, A | 1 |
| Pilatus, U | 1 |
| Zanella, F | 1 |
| Müller, WE | 1 |
| Eckert, GP | 1 |
| Eriksson, UK | 1 |
| Sjöberg, BG | 1 |
| Bennet, AM | 1 |
| de Faire, U | 1 |
| Pedersen, NL | 1 |
| Frostegård, J | 1 |
| Farber, SA | 1 |
| Slack, BE | 2 |
| Blusztajn, JK | 2 |
| Nitsch, RM | 1 |
| Pittas, AG | 1 |
| Growdon, JH | 1 |
| Wurtman, RJ | 1 |
| Pettegrew, JW | 1 |
| Withers, G | 1 |
| Panchalingam, K | 1 |
| Post, JF | 1 |
| Kanfer, JN | 1 |
| McCartney, DG | 1 |
1 review available for phosphorylcholine and Alzheimer Disease
| Article | Year |
|---|---|
31P nuclear magnetic resonance (NMR) spectroscopy of brain in aging and Alzheimer's disease.
Topics: Aging; Alzheimer Disease; Animals; Brain; Ethanolamines; Humans; Magnetic Resonance Spectroscopy; Or | 1987 |
11 other studies available for phosphorylcholine and Alzheimer Disease
| Article | Year |
|---|---|
Anchoring of Amyloid-β onto Polyunsaturated Phospholipid Membranes.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Humans; Lipid Bilayers; Peptide Fragments; Phosphatidylcho | 2023 |
Ganglioside-Enriched Phospholipid Vesicles Induce Cooperative Aβ Oligomerization and Membrane Disruption.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Dimyristoylphosphatidylcholine; G(M1) Ganglioside; Ganglio | 2022 |
Quantitative Lipidomic Analysis of Serum Phospholipids Reveals Dissociable Markers of Alzheimer's Disease and Subcortical Cerebrovascular Disease.
Topics: Alzheimer Disease; Atrophy; Cerebrovascular Disorders; Humans; Lipidomics; Lysophospholipids; Magnet | 2023 |
Modulation of human mitochondrial voltage-dependent anion channel 2 (hVDAC-2) structural stability by cysteine-assisted barrel-lipid interactions.
Topics: Alzheimer Disease; Cysteine; Humans; Mutation; Phosphorylcholine; Protein Folding; Protein Stability | 2013 |
A neurotoxic glycerophosphocholine impacts PtdIns-4, 5-bisphosphate and TORC2 signaling by altering ceramide biosynthesis in yeast.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Cell Membrane; Ceramides; Humans; Mechanistic Target of Ra | 2014 |
Antibodies against phosphorylcholine are not altered in plasma of patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antibodies; Biomarkers; Case-Control Studies; Dementia; | 2015 |
¹H- and ¹³C-NMR spectroscopy of Thy-1-APPSL mice brain extracts indicates metabolic changes in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Br | 2015 |
Low levels of antibodies against phosphorylcholine in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Autoantibodies; Case-Control Studies; Dementia; Female; | 2010 |
Acceleration of phosphatidylcholine synthesis and breakdown by inhibitors of mitochondrial function in neuronal cells: a model of the membrane defect of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Choline; Cytidine Diphosphate | 2000 |
Evidence for a membrane defect in Alzheimer disease brain.
Topics: Aged; Alzheimer Disease; Brain; Brain Chemistry; Choline; Down Syndrome; Glycerylphosphorylcholine; | 1992 |
Reduced phosphorylcholine hydrolysis by homogenates of temporal regions of Alzheimer's brain.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Choline; Humans; Hydrogen-Ion Concentration; Hydr | 1986 |