phosphorylcholine has been researched along with Aging in 49 studies
Phosphorylcholine: Calcium and magnesium salts used therapeutically in hepatobiliary dysfunction.
phosphocholine : The phosphate of choline; and the parent compound of the phosphocholine family.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We suggest that choline deficiency altered the protein kinase C-mediated signal transduction within liver and this contributed to hepatic carcinogenesis in these animals." | 5.29 | Effects of prolonged (1 year) choline deficiency and subsequent re-feeding of choline on 1,2-sn-diradylglycerol, fatty acids and protein kinase C in rat liver. ( Chang, J; da Costa, KA; Garner, SC; Zeisel, SH, 1995) |
| " The increase in PC50s of anti-phosphorylcholine PFC responses and their heterogeneities induced by certain antigens with aging is correlated with a decrease in T15 idiotype expression, suggesting that after the T15 dominant clone disappears no other clone takes control of the anti-PC response." | 3.69 | Interference between Neisseria meningitidis and PC-KLH induced anti-phosphorylcholine PFC responses in NZB/W autoimmune mice. ( Aguilera, A; Cancio, E; Eiras, A; Puentes, E; Quireza, O; Seoane, R, 1995) |
| "Aging in mice is accompanied by qualitative changes in the antibody repertoire to phosphorylcholine (PC), a natural epitope of certain pneumococci." | 3.68 | Repertoire diversity of antibody response to bacterial antigens in aged mice. III. Phosphorylcholine antibody from young and aged mice differ in structure and protective activity against infection with Streptococcus pneumoniae. ( Cerny, J; Nicoletti, C; Yang, X, 1993) |
| "Aging of mice is accompanied by both quantitative and qualitative changes in antibody responses to phosphorylcholine (PC), an immunodominant epitope of Streptococcus pneumoniae R36a strain (Pn)." | 3.68 | Repertoire diversity of antibody response to bacterial antigens in aged mice. II. Phosphorylcholine-antibody in young and aged mice differ in both VH/VL gene repertoire and in specificity. ( Borghesi-Nicoletti, C; Cerny, J; Nicoletti, C; Schulze, DH; Yang, XH, 1991) |
| "In order to quantify the changes that occur in the cholinergic central nervous system with aging, we have compared acetylcholine (Ach) formation in brain cortex slice preparations from 2-year-old aged CBF-1 mouse brains and compared the findings with those in 2-4-month-old young adult mouse brain slices." | 3.67 | Metabolism of choline in brain of the aged CBF-1 mouse. ( Karczmar, AG; Kindel, G; Rosenberg, A; Saito, M, 1986) |
| "Preliminary studies in Alzheimer's disease have demonstrated elevated levels of phosphomonoesters and phosphodiesters in the areas of Alzheimer's brain which exhibit neuropathological changes." | 2.37 | 31P nuclear magnetic resonance (NMR) spectroscopy of brain in aging and Alzheimer's disease. ( Panchalingam, K; Pettegrew, JW; Post, JF; Withers, G, 1987) |
| "We suggest that choline deficiency altered the protein kinase C-mediated signal transduction within liver and this contributed to hepatic carcinogenesis in these animals." | 1.29 | Effects of prolonged (1 year) choline deficiency and subsequent re-feeding of choline on 1,2-sn-diradylglycerol, fatty acids and protein kinase C in rat liver. ( Chang, J; da Costa, KA; Garner, SC; Zeisel, SH, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (42.86) | 18.7374 |
| 1990's | 17 (34.69) | 18.2507 |
| 2000's | 2 (4.08) | 29.6817 |
| 2010's | 8 (16.33) | 24.3611 |
| 2020's | 1 (2.04) | 2.80 |
| Authors | Studies |
|---|---|
| Narzt, MS | 1 |
| Kremslehner, C | 1 |
| Golabi, B | 1 |
| Nagelreiter, IM | 1 |
| Malikovic, J | 1 |
| Hussein, AM | 1 |
| Plasenzotti, R | 1 |
| Korz, V | 1 |
| Lubec, G | 1 |
| Gruber, F | 1 |
| Lubec, J | 1 |
| Fried, PJ | 1 |
| Pascual-Leone, A | 1 |
| Bolo, NR | 1 |
| Gonzalez-Covarrubias, V | 1 |
| Beekman, M | 1 |
| Uh, HW | 1 |
| Dane, A | 1 |
| Troost, J | 1 |
| Paliukhovich, I | 1 |
| van der Kloet, FM | 1 |
| Houwing-Duistermaat, J | 1 |
| Vreeken, RJ | 1 |
| Hankemeier, T | 1 |
| Slagboom, EP | 1 |
| Harper, DG | 1 |
| Jensen, JE | 1 |
| Ravichandran, C | 1 |
| Sivrioglu, Y | 1 |
| Silveri, M | 1 |
| Iosifescu, DV | 1 |
| Renshaw, PF | 2 |
| Forester, BP | 1 |
| Biedermann, SV | 1 |
| Weber-Fahr, W | 1 |
| Demirakca, T | 1 |
| Tunc-Skarka, N | 1 |
| Hoerst, M | 1 |
| Henn, F | 1 |
| Sartorius, A | 1 |
| Ende, G | 1 |
| Pontoizeau, C | 1 |
| Mouchiroud, L | 1 |
| Molin, L | 1 |
| Mergoud-Dit-Lamarche, A | 1 |
| Dallière, N | 1 |
| Toulhoat, P | 1 |
| Elena-Herrmann, B | 1 |
| Solari, F | 1 |
| Khomtchouk, K | 1 |
| Alter, S | 1 |
| Ratliff, M | 1 |
| Blomberg, BB | 1 |
| Riley, RL | 1 |
| Prieto, JMB | 1 |
| Tallmadge, RL | 1 |
| Felippe, MJB | 1 |
| Yang, H | 1 |
| Pang, W | 1 |
| Lu, H | 1 |
| Cheng, D | 1 |
| Yan, X | 1 |
| Cheng, Y | 1 |
| Jiang, Y | 1 |
| Kavok, NS | 1 |
| Krasilnikova, OA | 1 |
| Babenko, NA | 1 |
| Etlinger, HM | 1 |
| Heusser, CH | 3 |
| Zelenka, PS | 1 |
| Jernigan, HM | 3 |
| Köhler, H | 1 |
| Smyk, S | 1 |
| Fung, J | 1 |
| Kador, PF | 1 |
| Kinoshita, JH | 1 |
| Zhao, KS | 1 |
| Wang, YF | 1 |
| Guéret, R | 1 |
| Weksler, ME | 3 |
| Hatakeyama, A | 1 |
| Pricop, L | 1 |
| Kasturi, N | 1 |
| Bona, CA | 1 |
| Hu, A | 1 |
| Ehleiter, D | 1 |
| Ben-Yehuda, A | 1 |
| Schwab, R | 1 |
| Russo, C | 2 |
| Szabo, P | 1 |
| da Costa, KA | 1 |
| Garner, SC | 1 |
| Chang, J | 1 |
| Zeisel, SH | 1 |
| Nicoletti, C | 7 |
| Yang, X | 2 |
| Stedra, J | 1 |
| Cerny, J | 4 |
| Borghesi, C | 2 |
| Cherniack, EP | 1 |
| Wali, A | 1 |
| Dunlap, NE | 1 |
| Ballinger, S | 1 |
| Reed, T | 1 |
| Christian, JC | 1 |
| Koopman, WJ | 1 |
| Briles, DE | 2 |
| Seoane, R | 3 |
| Eiras, A | 3 |
| Quireza, O | 1 |
| Cancio, E | 1 |
| Aguilera, A | 1 |
| Puentes, E | 1 |
| Babb, SM | 1 |
| Wald, LL | 1 |
| Cohen, BM | 1 |
| Villafuerte, RA | 1 |
| Gruber, SA | 1 |
| Yurgelun-Todd, DA | 1 |
| Accolla, RS | 1 |
| Gearhart, PJ | 1 |
| Sigal, NH | 1 |
| Cancro, MP | 1 |
| Klinman, NR | 3 |
| Oldenborg, V | 1 |
| Van Golde, LM | 1 |
| McKearn, JP | 1 |
| Miller, GW | 1 |
| Quintáns, J | 1 |
| Ponnappan, U | 5 |
| Cinader, B | 5 |
| Gerber, V | 4 |
| Blaser, K | 4 |
| Borghesi-Nicoletti, C | 1 |
| Yang, XH | 1 |
| Schulze, DH | 1 |
| Van der Grond, J | 1 |
| Dijkstra, G | 1 |
| Roelofsen, B | 1 |
| Mali, WP | 1 |
| Zharhary, D | 2 |
| Kohno, A | 1 |
| Axelrad, AA | 1 |
| Van der Gaag, HC | 1 |
| Koh, SW | 1 |
| Riley, SC | 1 |
| Froscher, BG | 1 |
| Linton, PJ | 1 |
| Marcu, K | 1 |
| Cazenave, PA | 1 |
| Martinez, C | 1 |
| Coutinho, A | 1 |
| Zigler, JS | 1 |
| Nordenstam, G | 1 |
| Andersson, B | 1 |
| Bengtsson, C | 1 |
| Briles, D | 1 |
| Scott, G | 2 |
| Svanborg, A | 1 |
| Svanborg Edén, C | 1 |
| Faro, J | 2 |
| Lareo, I | 2 |
| Couceiro, J | 1 |
| Regueiro, BJ | 2 |
| Pettegrew, JW | 1 |
| Withers, G | 1 |
| Panchalingam, K | 1 |
| Post, JF | 1 |
| Gray, B | 1 |
| Crain, MJ | 1 |
| Blaese, M | 1 |
| Nahm, M | 1 |
| Scott, V | 1 |
| Haber, P | 1 |
| Saito, M | 1 |
| Kindel, G | 1 |
| Karczmar, AG | 1 |
| Rosenberg, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Combination of Cytidine and Omega-3 Fatty Acids in Bipolar Disorder: Are There Additive or Synergistic Mood Stabilizing Effects?[NCT00854737] | Phase 2 | 90 participants (Actual) | Interventional | 2004-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for phosphorylcholine and Aging
| Article | Year |
|---|---|
31P nuclear magnetic resonance (NMR) spectroscopy of brain in aging and Alzheimer's disease.
Topics: Aging; Alzheimer Disease; Animals; Brain; Ethanolamines; Humans; Magnetic Resonance Spectroscopy; Or | 1987 |
1 trial available for phosphorylcholine and Aging
| Article | Year |
|---|---|
Chronic citicoline increases phosphodiesters in the brains of healthy older subjects: an in vivo phosphorus magnetic resonance spectroscopy study.
Topics: Administration, Oral; Aged; Aging; Analysis of Variance; Brain; Brain Chemistry; Cytidine Diphosphat | 2002 |
47 other studies available for phosphorylcholine and Aging
| Article | Year |
|---|---|
Molecular species of oxidized phospholipids in brain differentiate between learning- and memory impaired and unimpaired aged rats.
Topics: Aged; Aging; Animals; Brain; Hippocampus; Humans; Memory Disorders; Phospholipids; Phosphorylcholine | 2022 |
Diabetes and the link between neuroplasticity and glutamate in the aging human motor cortex.
Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Creatine; Diabetes Mellitus, Type 2; Female; Glucose; | 2019 |
Lipidomics of familial longevity.
Topics: Adult; Aged; Aged, 80 and over; Aging; Antioxidants; Biomarkers; Chromatography, Liquid; Cohort Stud | 2013 |
Tissue-specific differences in brain phosphodiesters in late-life major depression.
Topics: Aged; Aged, 80 and over; Aging; Brain; Case-Control Studies; Depressive Disorder, Major; Ethanolamin | 2014 |
31P RINEPT MRSI and VBM reveal alterations in brain aging associated with major depression.
Topics: Aging; Algorithms; Brain; Depressive Disorder, Major; Female; Humans; Magnetic Resonance Spectroscop | 2015 |
Metabolomics analysis uncovers that dietary restriction buffers metabolic changes associated with aging in Caenorhabditis elegans.
Topics: Aging; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Caloric Restriction; Cholin | 2014 |
In old BALB/c mice, bone marrow pre-B cell and surrogate light chain reduction is associated with increased B cell reactivity to phosphorylcholine, but reduced T15 idiotype dominance.
Topics: Aging; Animals; Autoantibodies; Bone Marrow Cells; Immunoglobulin Light Chains; Mice; Mice, Inbred B | 2017 |
Developmental expression of B cell molecules in equine lymphoid tissues.
Topics: Aging; Animals; B-Lymphocyte Subsets; B-Lymphocytes; CD5 Antigens; Flow Cytometry; Horses; Immunoglo | 2017 |
Comparison of metabolic profiling of cyanidin-3-O-galactoside and extracts from blueberry in aged mice.
Topics: Aging; Animals; Anthocyanins; Blueberry Plants; Brain Chemistry; Choline; Fruit; Galactosides; gamma | 2011 |
Increase in diacylglycerol production by liver and liver cell nuclei at old age.
Topics: Aging; Animals; Cell Nucleus; Cells, Cultured; Culture Techniques; Diglycerides; Hepatocytes; Lipopr | 2003 |
Expression of a distinct B cell clonotype profile after recovery from antigen-induced unresponsiveness.
Topics: Aging; Animals; Antibody-Producing Cells; Antigens; B-Lymphocytes; Choline; Clone Cells; Hemolytic P | 1982 |
Phosphorylcholine and phosphorylethanolamine concentrations in the lens.
Topics: Aging; Animals; Cataract; Chickens; Choline; Culture Techniques; Ethanolamines; Female; Humans; Lens | 1982 |
Immune response to phosphorylcholine. VIII. The response CBA/N mice to PC-LPS.
Topics: Aging; Animals; Antibody Formation; Antibody Specificity; Choline; Female; Immunoglobulin G; Immunog | 1981 |
Carrier mediated transport of choline in rat lens.
Topics: Aging; Animals; Biological Transport, Active; Choline; Culture Techniques; Ethanolamines; Lens, Crys | 1981 |
Dysregulation of the humoral immune response in old mice.
Topics: Aging; Animals; Antibodies, Anti-Idiotypic; Antibodies, Antinuclear; Antibody-Producing Cells; Autoa | 1995 |
Study of self reactive antibodies in kappa-light chain deficient mice.
Topics: Aging; Animals; Antigens, T-Independent; Autoantibodies; Hemocyanins; Immunoglobulin kappa-Chains; I | 1995 |
Effect of age on the expressed B cell repertoire: role of B cell subsets.
Topics: Aging; Animals; Antigens, CD; B-Lymphocyte Subsets; B-Lymphocytes; CD5 Antigens; Cells, Cultured; Er | 1993 |
Effects of prolonged (1 year) choline deficiency and subsequent re-feeding of choline on 1,2-sn-diradylglycerol, fatty acids and protein kinase C in rat liver.
Topics: Aging; Animals; Cell Membrane; Choline; Choline Deficiency; Diglycerides; Fatty Acids; gamma-Glutamy | 1995 |
Antibody response in aged C57BL/6 mice: T helper cells are responsible for the decline of the primary antibody response to a bacterial antigen in aging.
Topics: Aging; Animals; Antibodies, Bacterial; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Lymphocyt | 1994 |
Repertoire diversity of antibody response to bacterial antigens in aged mice. IV. Study of VH and VL gene utilization in splenic antibody foci by in situ hybridization.
Topics: Aging; Animals; Antibodies, Bacterial; Antibody Diversity; Antibody-Producing Cells; Antigens, Bacte | 1994 |
Increase of cross(auto)-reactive antibodies after immunization in aged mice: a cellular and molecular study.
Topics: Aging; Animals; Antibodies, Monoclonal; Antibody Affinity; Antibody-Producing Cells; Antigens, Bacte | 1994 |
Age-dependent appearance of non-major histocompatibility complex-restricted helper T cells.
Topics: Aging; Animals; Antigens, Surface; B-Lymphocytes; Cells, Cultured; Female; Hemocyanins; Immunization | 1993 |
Repertoire diversity of antibody response to bacterial antigens in aged mice. III. Phosphorylcholine antibody from young and aged mice differ in structure and protective activity against infection with Streptococcus pneumoniae.
Topics: Aging; Animals; Antibodies, Bacterial; Antibodies, Monoclonal; Antibody Affinity; Antigens, Bacteria | 1993 |
The use of monozygotic and dizygotic twins to estimate the effects of inheritance on the levels of immunoglobulin isotypes and antibodies to phosphocholine.
Topics: Aged; Aging; Antibodies; Humans; Immunoglobulin Isotypes; Male; Middle Aged; Phosphorylcholine; Pneu | 1993 |
Antibody protection in aging: influence of idiotypic repertoire and antibody binding activity to a bacterial antigen.
Topics: Aging; Animals; Animals, Newborn; Antibodies, Bacterial; Antibodies, Monoclonal; Antigen-Antibody Re | 1995 |
Interference between Neisseria meningitidis and PC-KLH induced anti-phosphorylcholine PFC responses in NZB/W autoimmune mice.
Topics: Aging; Animals; Antibody Formation; Antibody-Producing Cells; Antigens; Antigens, Bacterial; Autoimm | 1995 |
In vivo and in vitro study of the primary and secondary antibody response to a bacterial antigen in aged mice.
Topics: Aging; Animals; Antibodies, Bacterial; Antigens, Bacterial; B-Lymphocytes; Cell Culture Techniques; | 1995 |
Idiotype-specific neonatal suppression of phosphorylcholine-responsive B cells.
Topics: Aging; Animals; Animals, Newborn; Antibody Formation; B-Lymphocytes; Choline; Clone Cells; Epitopes; | 1977 |
The enzymes of phosphatidylcholine biosynthesis in the fetal mouse lung. Effects of dexamethasone.
Topics: Aging; Animals; Choline Kinase; Cytidine Triphosphate; Dexamethasone; Diacylglycerol Cholinephosphot | 1977 |
The immune response in NZB mice of different ages to thymus-dependent and thymus-independent phosphorylcholine antigens.
Topics: Aging; Animals; Antibody Formation; Antigens; Choline; Female; Haptens; Hemolytic Plaque Technique; | 1978 |
Polymorphism of age-related changes in the antibody response to the hapten phosphorylcholine.
Topics: Aging; Animals; Enzyme-Linked Immunosorbent Assay; Female; Haptens; Immunoglobulin Idiotypes; Immuno | 1992 |
Repertoire diversity of antibody response to bacterial antigens in aged mice. II. Phosphorylcholine-antibody in young and aged mice differ in both VH/VL gene repertoire and in specificity.
Topics: Aging; Animals; Antibodies, Bacterial; Antibodies, Monoclonal; Antibody Specificity; Antigens, Bacte | 1991 |
The repertoire diversity and magnitude of antibody responses to bacterial antigens in aged mice: I. Age-associated changes in antibody responses differ according to the mouse strain.
Topics: Aging; Animals; Antibodies, Bacterial; Antibody Diversity; Antibody Formation; Antigens, Bacterial; | 1991 |
31P-NMR determination of phosphomonoesters in relation to phospholipid biosynthesis in testis of the rat at different ages.
Topics: Aging; Animals; Ethanolamines; Kinetics; Magnetic Resonance Spectroscopy; Male; Phospholipids; Phosp | 1991 |
A selective increase in the generation of phosphorylcholine-specific B cells associated with aging.
Topics: Aging; Animals; Antibodies, Monoclonal; B-Lymphocytes; Bone Marrow; Bone Marrow Cells; Choline; Epit | 1986 |
Immune response, tolerance circumvention and autoantibodies in aging MRL/Mp-lpr and MRL/Mp-+ mice.
Topics: Aging; Animals; Antibodies, Antinuclear; DNA, Single-Stranded; Female; gamma-Globulins; Immune Toler | 1985 |
Immunosuppression after injection of Friend virus into C57BL/6 mice of different ages.
Topics: Aging; Animals; Female; Friend murine leukemia virus; gamma-Globulins; Hemolytic Plaque Technique; I | 1989 |
Altered VH gene segment utilization in the response to phosphorylcholine by aged mice.
Topics: Aging; Animals; Antibody Specificity; Bone Marrow; Cells, Cultured; Choline; Clone Cells; Epitopes; | 1989 |
Differential L chain expression in the antibody responses to phosphorylcholine of adult bone marrow or peritoneum-derived B lymphocytes.
Topics: Aging; Animals; Antibody Formation; B-Lymphocytes; Bone Marrow; Bone Marrow Transplantation; Choline | 1989 |
Phosphorylcholine and phosphorylethanolamine in human and rhesus monkey lenses.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Animals; Child; Child, Preschool; Choline; Cultur | 1989 |
Age-dependent changes of isotype and idiotype expression in the antibody response to the phosphorylcholine hapten in BALB/c mice.
Topics: Aging; Animals; Choline; Female; Haptens; Immunoglobulin A; Immunoglobulin E; Immunoglobulin G; Immu | 1989 |
Age-related change in anti-carbohydrate antibody levels.
Topics: ABO Blood-Group System; Adult; Aged; Aged, 80 and over; Aging; Antibodies; Choline; Female; Humans; | 1989 |
Effects of antigen and internal environment on anti-phosphorylcholine immune responses of autoimmune aged NZB/W F1 mice.
Topics: Aging; Animals; Antibody Formation; Antigens; B-Lymphocytes; Choline; Female; Hemolytic Plaque Techn | 1986 |
[Anti-phosphorylcholine response of autoimmune NZB/W mice: variations with age of serum titers and homogeneity].
Topics: Aging; Animals; Antibody Affinity; Antigens, Bacterial; Choline; Female; Hemocyanins; Immune Sera; M | 1987 |
Naturally occurring antibodies to phosphocholine as a potential index of antibody responsiveness to polysaccharides.
Topics: ABO Blood-Group System; Adolescent; Adult; Aged; Aged, 80 and over; Aging; Antibodies; Antibodies, B | 1987 |
Age- and strain-dependent polymorphism in IgE antibody against the phosphorylcholine hapten.
Topics: Aging; Animals; Choline; Crosses, Genetic; Female; Haptens; Immunoglobulin E; Immunoglobulin G; Immu | 1986 |
Metabolism of choline in brain of the aged CBF-1 mouse.
Topics: Acetylcholine; Aging; Animals; Brain; Choline; Chromatography, Thin Layer; Male; Mice; Mice, Inbred | 1986 |