phosphorylcholine has been researched along with Adenocarcinoma, Basal Cell in 18 studies
Phosphorylcholine: Calcium and magnesium salts used therapeutically in hepatobiliary dysfunction.
phosphocholine : The phosphate of choline; and the parent compound of the phosphocholine family.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Miltefosine (hexadecylphosphocholine) is used for topical treatment of breast cancers." | 3.71 | MDR1 causes resistance to the antitumour drug miltefosine. ( Grunicke, H; Hofmann, J; Liu, R; Lu, P; Pietro, AD; Rybczynska, M; Sharom, FJ; Spitaler, M; Steinfels, E, 2001) |
| "The treatment of localized colorectal cancer (CRC) depends on resection of the primary tumor with adequate margins and sufficient lymph node sampling." | 1.40 | Phospholipid ether analogs for the detection of colorectal tumors. ( Albrecht, DM; Clipson, L; Deming, DA; Grudzinski, JP; Halberg, RB; Hall, LT; Leystra, AA; Lubner, SJ; Maher, ME; Matkowskyj, KA; Washington, MK; Weichert, JP, 2014) |
| "Perifosine inhibits the growth of gastric cancer cells possibly through inhibition of the Akt/GSK3β/C-MYC signaling pathway-mediated down-regulation of AEG-1 that subsequently down-regulated cyclin D1." | 1.39 | AEG-1 is a target of perifosine and is over-expressed in gastric dysplasia and cancers. ( Chen, X; Huang, W; Li, P; Liang, S; Liu, D; Ma, Z; Wang, X; Yang, L; Zhai, S, 2013) |
| "Although prostate cancer in TRAMP mice shares some metabolic features with that in humans, it differs with respect to choline phospholipid metabolism, which could impact upon the interpretation of results from biomarker or chemotherapy/chemoprevention studies." | 1.35 | Metabolic profiling of transgenic adenocarcinoma of mouse prostate (TRAMP) tissue by 1H-NMR analysis: evidence for unusual phospholipid metabolism. ( Edwards, RE; Farmer, PB; Gant, TW; Gescher, AJ; Greaves, P; Jones, DJ; Keun, HC; Steward, WP; Teahan, O; Teichert, F; Verschoyle, RD; Wilson, ID, 2008) |
| "The histopathological change from tubular adenocarcinoma to malignant adenoacanthoma might be caused by an overgrowth of the primary epithelial tumor cells or by a real transformation in the morphological characteristics of the tumor, which may occur during repeated transplantation." | 1.28 | Effect of miltefosine on transplanted methylnitrosourea-induced mammary carcinoma growing in Fischer 344 rats. ( Amelung, F; Berger, MR; Heyl, P; Reinhardt, M, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (44.44) | 18.2507 |
| 2000's | 4 (22.22) | 29.6817 |
| 2010's | 6 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, W | 1 |
| Yang, L | 1 |
| Liang, S | 1 |
| Liu, D | 1 |
| Chen, X | 1 |
| Ma, Z | 1 |
| Zhai, S | 1 |
| Li, P | 1 |
| Wang, X | 1 |
| Trousil, S | 1 |
| Lee, P | 1 |
| Pinato, DJ | 1 |
| Ellis, JK | 1 |
| Dina, R | 1 |
| Aboagye, EO | 1 |
| Keun, HC | 3 |
| Sharma, R | 1 |
| Deming, DA | 1 |
| Maher, ME | 1 |
| Leystra, AA | 1 |
| Grudzinski, JP | 1 |
| Clipson, L | 1 |
| Albrecht, DM | 1 |
| Washington, MK | 1 |
| Matkowskyj, KA | 1 |
| Hall, LT | 1 |
| Lubner, SJ | 1 |
| Weichert, JP | 1 |
| Halberg, RB | 1 |
| Chen, YC | 1 |
| Tsai, TL | 1 |
| Ye, XH | 1 |
| Lin, TH | 1 |
| Al-Saffar, NM | 1 |
| Jackson, LE | 1 |
| Raynaud, FI | 1 |
| Clarke, PA | 1 |
| Ramírez de Molina, A | 1 |
| Lacal, JC | 1 |
| Workman, P | 1 |
| Leach, MO | 1 |
| Yakoub, D | 1 |
| Goldin, R | 1 |
| Hanna, GB | 1 |
| Chiba, N | 1 |
| Ueda, M | 1 |
| Shimada, T | 1 |
| Jinno, H | 1 |
| Watanabe, J | 1 |
| Ishihara, K | 1 |
| Kitajima, M | 1 |
| Marsh, Rde W | 1 |
| Rocha Lima, CM | 1 |
| Levy, DE | 1 |
| Mitchell, EP | 1 |
| Rowland, KM | 1 |
| Benson, AB | 1 |
| Teichert, F | 1 |
| Verschoyle, RD | 1 |
| Greaves, P | 1 |
| Edwards, RE | 1 |
| Teahan, O | 1 |
| Jones, DJ | 1 |
| Wilson, ID | 1 |
| Farmer, PB | 1 |
| Steward, WP | 1 |
| Gant, TW | 1 |
| Gescher, AJ | 1 |
| Spruss, T | 1 |
| Bernhardt, G | 1 |
| Schönenberger, H | 1 |
| Engel, J | 1 |
| Theischen, M | 1 |
| Bornfeld, N | 1 |
| Becher, R | 1 |
| Kellner, U | 1 |
| Wessing, A | 1 |
| Nakai, T | 1 |
| Ishima, R | 1 |
| Sakahara, H | 1 |
| Endo, K | 1 |
| Konishi, J | 1 |
| Akasaka, K | 1 |
| Street, JC | 1 |
| Alfieri, AA | 1 |
| Traganos, F | 1 |
| Koutcher, JA | 1 |
| Manuel, SM | 1 |
| Guo, Y | 1 |
| Matalon, S | 1 |
| Rybczynska, M | 1 |
| Liu, R | 1 |
| Lu, P | 1 |
| Sharom, FJ | 1 |
| Steinfels, E | 1 |
| Pietro, AD | 1 |
| Spitaler, M | 1 |
| Grunicke, H | 1 |
| Hofmann, J | 1 |
| Reinhardt, M | 1 |
| Heyl, P | 1 |
| Amelung, F | 1 |
| Berger, MR | 2 |
| Bishop, FE | 1 |
| Dive, C | 1 |
| Freeman, S | 1 |
| Gescher, A | 1 |
| Richter, H | 1 |
| Seelig, MH | 1 |
| Eibl, H | 1 |
| Schmähl, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase II Trial Of Perifosine In Locally Advanced, Unresectable Or Metastatic Pancreatic Adenocarcinoma[NCT00059982] | Phase 2 | 0 participants | Interventional | 2003-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for phosphorylcholine and Adenocarcinoma, Basal Cell
| Article | Year |
|---|---|
A phase II trial of perifosine in locally advanced, unresectable, or metastatic pancreatic adenocarcinoma.
Topics: Adenocarcinoma; Administration, Oral; Aged; Antiemetics; Child; Disease Progression; Drug Administra | 2007 |
Hexadecylphosphocholine may produce reversible functional defects of the retinal pigment epithelium.
Topics: Adenocarcinoma; Antineoplastic Agents; Colorectal Neoplasms; Electrooculography; Electroretinography | 1993 |
16 other studies available for phosphorylcholine and Adenocarcinoma, Basal Cell
| Article | Year |
|---|---|
AEG-1 is a target of perifosine and is over-expressed in gastric dysplasia and cancers.
Topics: Adenocarcinoma; Adult; Aged; Cell Adhesion Molecules; Cell Line; Cell Line, Tumor; Cell Proliferatio | 2013 |
Alterations of choline phospholipid metabolism in endometrial cancer are caused by choline kinase alpha overexpression and a hyperactivated deacylation pathway.
Topics: Adenocarcinoma; Cell Line; Cell Line, Tumor; Choline; Choline Kinase; Endometrial Neoplasms; Female; | 2014 |
Phospholipid ether analogs for the detection of colorectal tumors.
Topics: Adenocarcinoma; Animals; Colorectal Neoplasms; Female; Humans; Indoles; Intestinal Neoplasms; Iodobe | 2014 |
Anti-proliferative effect on a colon adenocarcinoma cell line exerted by a membrane disrupting antimicrobial peptide KL15.
Topics: Adenocarcinoma; Amino Acid Sequence; Antimicrobial Cationic Peptides; Bacterial Proteins; Caco-2 Cel | 2015 |
The phosphoinositide 3-kinase inhibitor PI-103 downregulates choline kinase alpha leading to phosphocholine and total choline decrease detected by magnetic resonance spectroscopy.
Topics: Adenocarcinoma; Cell Line, Tumor; Choline; Choline Kinase; Down-Regulation; Furans; HCT116 Cells; Hu | 2010 |
Metabolic profiling detects field effects in nondysplastic tissue from esophageal cancer patients.
Topics: Adenocarcinoma; Barrett Esophagus; Cell Transformation, Neoplastic; Diagnosis, Differential; Esophag | 2010 |
Development of gene vectors for pinpoint targeting to human hepatocytes by cationically modified polymer complexes.
Topics: Adenocarcinoma; Animals; Carcinoma, Hepatocellular; Cations; Cell Line, Tumor; Female; Gene Expressi | 2007 |
Metabolic profiling of transgenic adenocarcinoma of mouse prostate (TRAMP) tissue by 1H-NMR analysis: evidence for unusual phospholipid metabolism.
Topics: Adenocarcinoma; Animals; Biomarkers, Tumor; Choline; Choline Kinase; Disease Models, Animal; Gene Ex | 2008 |
Antitumour activity of miltefosine alone and after combination with platinum complexes on MXT mouse mammary carcinoma models.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Cisplatin; Drug | 1993 |
1H-magnetic resonance spectroscopic observation of cultured malignant cells pharmacologically induced to different phenotypes.
Topics: Adenocarcinoma; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Butyrates; Butyric Acid; Cho | 1996 |
In vivo and ex vivo study of metabolic and cellular effects of 5-fluorouracil chemotherapy in a mouse mammary carcinoma.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Cycle; Ethanolamines; Fluorouracil; Magnetic Re | 1997 |
Exosurf enhances adenovirus-mediated gene transfer to alveolar type II cells.
Topics: Adenocarcinoma; Adenoviridae; Animals; Cells, Cultured; Drug Combinations; Epithelial Cells; Fatty A | 1997 |
MDR1 causes resistance to the antitumour drug miltefosine.
Topics: Adenocarcinoma; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Ca | 2001 |
Effect of miltefosine on transplanted methylnitrosourea-induced mammary carcinoma growing in Fischer 344 rats.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Biomarkers, Tumor; Body Weight; Female; Keratins; Ma | 1992 |
Is metabolism an important arbiter of anticancer activity of ether lipids? Metabolism of SRI 62-834 and hexadecylphosphocholine by [31P]-NMR spectroscopy and comparison of their cytotoxicities with those of their metabolites.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Membrane; Cell Survival; Dose-Response Relation | 1992 |
New cytostatics--more activity and less toxicity.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Colorectal Neoplasms; Female; Male; Mammary Neoplasm | 1990 |