phosphorylcholine has been researched along with Acute Myelogenous Leukemia in 6 studies
Phosphorylcholine: Calcium and magnesium salts used therapeutically in hepatobiliary dysfunction.
phosphocholine : The phosphate of choline; and the parent compound of the phosphocholine family.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To potentiate the response of acute myelogenous leukemia (AML) cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity, we have examined the efficacy of a combination with perifosine, a novel phosphatidylinositol-3-kinase (PI3K)/Akt signaling inhibitor." | 7.74 | Synergistic proapoptotic activity of recombinant TRAIL plus the Akt inhibitor Perifosine in acute myelogenous leukemia cells. ( Bontadini, A; Bortul, R; Chiarini, F; Cocco, L; Evangelisti, C; Martelli, AM; Martinelli, G; McCubrey, JA; Papa, V; Ricci, F; Tabellini, G; Tazzari, PL, 2008) |
| "Perifosine treatment induced cell death by apoptosis in AML cell lines." | 5.35 | Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cells. ( Billi, AM; Cappellini, A; Chiarini, F; Evangelisti, C; Martelli, AM; Martinelli, G; McCubrey, JA; Ottaviani, E; Papa, V; Ricci, F; Tazzari, PL; Testoni, N, 2008) |
| "To potentiate the response of acute myelogenous leukemia (AML) cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity, we have examined the efficacy of a combination with perifosine, a novel phosphatidylinositol-3-kinase (PI3K)/Akt signaling inhibitor." | 3.74 | Synergistic proapoptotic activity of recombinant TRAIL plus the Akt inhibitor Perifosine in acute myelogenous leukemia cells. ( Bontadini, A; Bortul, R; Chiarini, F; Cocco, L; Evangelisti, C; Martelli, AM; Martinelli, G; McCubrey, JA; Papa, V; Ricci, F; Tabellini, G; Tazzari, PL, 2008) |
| "Perifosine is a novel targeted oral Akt inhibitor." | 2.49 | Perifosine--a new option in treatment of acute myeloid leukemia? ( Freeman, CL; Giles, FJ; Keane, N; Krawczyk, J; O'Dwyer, M; Swords, R, 2013) |
| "Perifosine treatment induced cell death by apoptosis in AML cell lines." | 1.35 | Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cells. ( Billi, AM; Cappellini, A; Chiarini, F; Evangelisti, C; Martelli, AM; Martinelli, G; McCubrey, JA; Ottaviani, E; Papa, V; Ricci, F; Tazzari, PL; Testoni, N, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Meng, H | 1 |
| Jin, Y | 1 |
| Liu, H | 1 |
| You, L | 1 |
| Yang, C | 1 |
| Yang, X | 1 |
| Qian, W | 1 |
| Krawczyk, J | 1 |
| Keane, N | 1 |
| Swords, R | 1 |
| O'Dwyer, M | 1 |
| Freeman, CL | 1 |
| Giles, FJ | 1 |
| Tazzari, PL | 3 |
| Tabellini, G | 1 |
| Ricci, F | 3 |
| Papa, V | 3 |
| Bortul, R | 1 |
| Chiarini, F | 3 |
| Evangelisti, C | 3 |
| Martinelli, G | 3 |
| Bontadini, A | 1 |
| Cocco, L | 1 |
| McCubrey, JA | 3 |
| Martelli, AM | 3 |
| Grimaldi, C | 1 |
| Cappellini, A | 2 |
| Ottaviani, E | 2 |
| Pagliaro, P | 1 |
| Horn, S | 1 |
| Bäsecke, J | 1 |
| Lindner, LH | 1 |
| Eibl, H | 1 |
| Billi, AM | 1 |
| Testoni, N | 1 |
| Plo, I | 1 |
| Lautier, D | 1 |
| Levade, T | 1 |
| Sekouri, H | 1 |
| Jaffrézou, JP | 1 |
| Laurent, G | 1 |
| Bettaïeb, A | 1 |
1 review available for phosphorylcholine and Acute Myelogenous Leukemia
| Article | Year |
|---|---|
Perifosine--a new option in treatment of acute myeloid leukemia?
Topics: Antineoplastic Agents; Clinical Trials as Topic; Humans; Leukemia, Myeloid, Acute; Molecular Structu | 2013 |
5 other studies available for phosphorylcholine and Acute Myelogenous Leukemia
| Article | Year |
|---|---|
SNS-032 inhibits mTORC1/mTORC2 activity in acute myeloid leukemia cells and has synergistic activity with perifosine against Akt.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Cell Proliferation; Dr | 2013 |
Synergistic proapoptotic activity of recombinant TRAIL plus the Akt inhibitor Perifosine in acute myelogenous leukemia cells.
Topics: Apoptosis; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspase 8; Cell Survival; Drug Synergis | 2008 |
Erucylphosphohomocholine, the first intravenously applicable alkylphosphocholine, is cytotoxic to acute myelogenous leukemia cells through JNK- and PP2A-dependent mechanisms.
Topics: Animals; Apoptosis; Blotting, Western; Cell Cycle; Cell Proliferation; Cells, Cultured; Erucic Acids | 2010 |
Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cells.
Topics: Apoptosis; bcl-Associated Death Protein; Blotting, Western; Cell Proliferation; Colony-Forming Units | 2008 |
Phosphatidylcholine-specific phospholipase C and phospholipase D are respectively implicated in mitogen-activated protein kinase and nuclear factor kappaB activation in tumour-necrosis-factor-alpha-treated immature acute-myeloid-leukaemia cells.
Topics: Antineoplastic Agents; Cell Division; Cell Nucleus; Diglycerides; Dose-Response Relationship, Drug; | 2000 |