phosphorus-radioisotopes and Uveal-Neoplasms

To evaluate whether nuclear activity as measured by the disodium phosphate 32P (32P) uptake test for uveal melanoma is of prognostic value and corresponds to known prognostic factors.. A retrospective analysis of 121 patients with choroidal and/or ciliary body melanoma, tested with the 32P uptake test before enucleation between January 1, 1973, and December 31, 1976, at the Leiden University Medical Center. We obtained the 25-year follow-up information of this group of patients and compared the 32P test results and histopathological variables with the long-term survival rates.. The cumulative 5-, 10-, and 20-year survival for melanoma-related death was 81.4%, 73.3%, and 63.9%, respectively. The results of the 32P uptake test were not significantly correlated with survival (P =.35). Of all prognostic factors under study, tumor diameter, cell type, and mitotic count were identified as the most important prognostic markers for uveal melanoma in this group.. The 32P isotope uptake test has no prognostic value for uveal melanoma. Moreover, the results of this study indicate that it is unlikely that cell activity as determined by 32P uptake involves mitotic activity of the tumor.

Topics: Adolescent; Adult; Aged; Aged, 80 and over; Diphosphates; Eye Enucleation; Female; Humans; Male; Melanoma; Middle Aged; Phosphorus Radioisotopes; Prognosis; Retrospective Studies; Survival Rate; Uveal Neoplasms

A 32P uptake test to diagnose an intraocular tumour was performed on a lactating woman. Breast feeding of her infant had been stopped and after injection of the 32P, a sample of breast milk on two consecutive days was collected. The concentration of 32P in the milk was greater in the second sample than the first, but it was calculated that the potential whole body radiation dose to her infant on the second day would not have exceeded 180 microSv (18 mrem).

Topics: Adult; Breast Feeding; Ciliary Body; Female; Humans; Infant; Melanoma; Milk, Human; Phosphorus Radioisotopes; Radiation Dosage; Radionuclide Imaging; Risk; Time Factors; Uveal Neoplasms

The 32P uptake test used in the differential diagnosis of 912 cases yielded an accuracy rate of 94.82% for intraocular lesions behind the equator, and 85.15% for lesions of the anterior uvea. The highest error rate occurred in patients with suspected tumors of the iris and ciliary body. It seems advisable to take a 40% difference on the uptake as the limit between a positive or negative test result.

Topics: Adenoma; Choroid Neoplasms; Ciliary Body; Diagnosis, Differential; Eye Neoplasms; False Negative Reactions; False Positive Reactions; Humans; Iris Diseases; Melanoma; Phosphorus Radioisotopes; Retinal Hemorrhage; Sarcoma, Kaposi; Uveal Neoplasms

Topics: Adult; Aged; Female; Humans; Male; Melanoma; Middle Aged; Phosphorus Radioisotopes; Prognosis; Radionuclide Imaging; Ultrasonography; Uveal Neoplasms

Topics: Adult; Aged; Female; Humans; Male; Melanoma; Middle Aged; Phosphorus Radioisotopes; Prognosis; Uveal Neoplasms

Topics: Adult; Aged; Humans; Melanoma; Middle Aged; Phosphorus Radioisotopes; Radioactivity; Uveal Neoplasms

The radioactive phosphorus (32P) uptake test used in ocular tumor evaluation in 408 cases achieved an overall percentage error rate of 3.6%. This compared favorably with the clinical error rate of 19.2% overall. The least accuracy was obtained in cases with ciliary body lesions.

Topics: Adolescent; Adult; Aged; Child; Choroid Neoplasms; Eye Neoplasms; False Negative Reactions; False Positive Reactions; Female; Humans; Male; Melanoma; Middle Aged; Nevus, Pigmented; Phosphorus Radioisotopes; Uveal Neoplasms

A report on results of 186 32P tests is given. Radiation increases of more than 30%, compared with tumor-free areas, were considered as positive. 95 eyes were histologically examined. The 32P test gave 90 correct positive answers and 1 correct negative answer. Faulty positive results were found in 2 cases; faulty negative results were also found in 2 cases. This means that the diagnosis was correct in 95%. The literature is discussed concerning reliability and methods. The dangers of the use of 32P are stressed, and the development of noninvasive nuclear-medical diagnostic methods is suggested.

Topics: Choroid Neoplasms; Ciliary Body; Diagnosis, Differential; Eye Neoplasms; Humans; Iris; Melanoma; Phosphorus Radioisotopes; Radionuclide Imaging; Uveal Neoplasms

Topics: Eye Neoplasms; Humans; Melanoma; Phosphorus; Phosphorus Radioisotopes; Uveal Neoplasms

Topics: Eye Neoplasms; Humans; Melanoma; Phosphorus; Phosphorus Radioisotopes; Radiometry; Scintillation Counting; Uveal Neoplasms