phosphorus-radioisotopes and Remission--Spontaneous

Topics: Animals; Bone Marrow; Bone Marrow Cells; Cell Survival; Dogs; Granulocytes; Half-Life; Hematopoiesis; Humans; In Vitro Techniques; Injections, Intramuscular; Injections, Intravenous; Isoflurophate; Kinetics; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukocytes; Methods; Neutropenia; Neutrophils; Phosphorus Radioisotopes; Remission, Spontaneous; Time Factors

Topics: Hemorrhagic Disorders; Humans; Leukemia, Radiation-Induced; Leukopenia; Methods; Osteosclerosis; Phosphorus Radioisotopes; Polycythemia Vera; Prognosis; Radiotherapy; Radiotherapy Dosage; Remission, Spontaneous; Thrombocytopenia; Time Factors

Topics: Busulfan; Clinical Trials as Topic; Female; Humans; Leukemia; Male; Middle Aged; Phosphorus Radioisotopes; Polycythemia Vera; Remission, Spontaneous; Sex Factors

Thirty-two patients with meningeal leukaemia who achieved meningeal remission with intrathecal methotrexate (MTX) plus dexamethasone (DMT) were entered in a randomized study of two maintenance treatments: (a) I6 patients received intermittent intrathecal doses of MTX plus DMT, and (b) I6 patients received intermittent intrathecal doses of radioactive chromic phosphate (CROP). The population and clinical characteristics of the cases assigned to each maintenance regimen were similar. The duration of meningeal remission was 55-600 + d (median 550 d) for the MTX and DMT group and 56-555 d (median 360 d) for the CROP group. There was no statistical difference (P greater than 0.05) between the curves of the two groups. Intrathecal CROP seems to be as effective as intrathecal MTX plus DMT as maintenance treatment for intrathecal MTX plus DMT induced meningeal remission. Further uses of this compound should be explored but it seems to be dangerous to administer it by lumbar puncture.

Topics: Adolescent; Adult; Child; Child, Preschool; Colloids; Dexamethasone; Female; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Meningitis; Methotrexate; Phosphorus Radioisotopes; Remission, Spontaneous; Time Factors

Topics: Aged; Breast Neoplasms; Clinical Trials as Topic; Cyclophosphamide; Female; Fluorouracil; Humans; Lung Neoplasms; Male; Methotrexate; Middle Aged; Neoplasm Metastasis; Neoplasms; Phosphorus Radioisotopes; Remission, Spontaneous; Vincristine

Two patients with polycythemia vera received intravenously an accidental tenfold overdosage of radiophosphorus therapy (60 and 50 mCi 32P, respectively). In both patients, the occurrence of hemorrhagic complications 3 wk after the 32P medication led to detection of the error and referral to our hospital. Upon admission they showed an agranulocytosis, severe thrombocytopenia, and bone marrow aplasia. In both cases, spontaneous recovery of the hematopoiesis was observed from day 40 posttreatment onward. In one patient, a slow but ultimately complete normalization of blood counts and marrow morphology took place, whereas in the other, a mild thrombocytopenia persists. Nearly 5 yr after the accidental overdosage, both patients are clinically well. Symptoms of polycythemia vera have not reappeared up to now. Attempts were made to evaluate the radiation dose absorbed by the bone marrow. In the first patient, the daily 32P excretion was determined from day 22 to day 60, whereas in the other patient a whole body count was performed on day 78 after administration. From these results, an approximate cumulative bone marrow dose of 10 Sv (1000 rem) could be calculated.

Topics: Aged; Agranulocytosis; Bone Marrow; Bone Marrow Cells; Female; Humans; Medication Errors; Phosphorus Radioisotopes; Polycythemia Vera; Radiation Dosage; Radiation Injuries; Remission, Spontaneous; Thrombocytopenia

Topics: Adrenal Cortex; Adrenal Cortex Function Tests; Adult; Aged; Aziridines; Female; Humans; Male; Middle Aged; Organophosphorus Compounds; Phosphorus Radioisotopes; Polycythemia Vera; Radioisotope Teletherapy; Radiotherapy Dosage; Recurrence; Remission, Spontaneous

Experience with cytostatic treatment performed in patients with polycythaemia rubra vera is reviewed. The effectivity and side effects of the drugs applied are evaluated. Mannosulfan and mitobromitol were the drugs most sutiable for treatment. In certain special cases, 5-hydroxyurea was also satisfactory, while mitolactol was the least suitable.

Topics: Adolescent; Adult; Aged; Antibiotics, Antineoplastic; Drug Evaluation; Female; Humans; Hydroxyurea; Male; Mesylates; Middle Aged; Mitobronitol; Phosphorus Radioisotopes; Polycythemia Vera; Remission, Spontaneous

A review is presented of the clinical, physiopathological and therapeutic aspects of four varieties of chronic myeloproliferative syndrome: polycythemia vera, idiopathic thrombocythemia, chronic myelocytic leukemia and idiopathic myeloid metaplasia. Routine and experimental therapeutic approaches are discussed.

Topics: Aged; Bloodletting; Busulfan; Chlorambucil; Female; Humans; Leukemia, Myeloid; Male; Myeloproliferative Disorders; Phosphorus Radioisotopes; Polycythemia Vera; Primary Myelofibrosis; Remission, Spontaneous; Thrombocytosis

Retrospective studies were carried out in 52 patients with polycythemia vera who were treated with radioactive phosphorus (32-P) over periods ranging between 4 and 24 years. Control of hematopoiesis was achieved in all patients. Duration of the remission induced differed considerably in the individual patients. Mean remission lasted 3-4 years. After 13 years of 32-P treatment, the mean duration of remission lengthened due to gradual transition of some cases into "spent" polycythemia. The mean annual dose of 32-P was about 2.4 mCi. In patients with long-term remissions, the dose accumulated per year was markedly less. These patients probably represent optimal preconditions for 32-P therapy. Mean survival was 12.5 years. The majority of the patients died from thorombo-embolie events or hemorrhage; incidence of acute leukemia was about 4%.

Topics: Acute Disease; Adult; Aged; Female; Hemorrhage; Humans; Leukemia; Male; Methods; Middle Aged; Phosphorus Radioisotopes; Polycythemia Vera; Radiotherapy Dosage; Remission, Spontaneous; Splenomegaly; Thromboembolism; Time Factors

Topics: Female; Follow-Up Studies; Humans; Male; Phosphorus Radioisotopes; Polycythemia Vera; Remission, Spontaneous

Topics: Adult; Amitriptyline; Capillary Permeability; Chronic Disease; Drug Therapy, Combination; Female; Humans; Insulin; Male; Mental Disorders; Microcirculation; Phosphorus; Phosphorus Radioisotopes; Psychotropic Drugs; Remission, Spontaneous; Schizophrenia; Schizophrenia, Catatonic; Schizophrenia, Paranoid

Topics: Base Sequence; Burkitt Lymphoma; Cell Line; Cells, Cultured; Centrifugation, Density Gradient; Chromatography, DEAE-Cellulose; Genes; Humans; Lectins; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Lymphocyte Activation; Lymphocytes; Oligonucleotides; Pancreas; Phosphorus Radioisotopes; Purines; Remission, Spontaneous; Ribonucleases; RNA, Ribosomal

Topics: Adult; Aged; Female; Heart; Humans; Lung; Male; Middle Aged; Phosphorus Radioisotopes; Polycythemia Vera; Radiography; Remission, Spontaneous