phosphorus-radioisotopes and Nevus--Pigmented

Topics: Choroid Neoplasms; Diagnosis, Differential; Humans; Melanoma; Neoplasm Metastasis; Nevus, Pigmented; Phosphorus Radioisotopes

A complex examination by radio-isotope (32P) and thermographic methods was carried out in 252 patients, 122 patients underwent surgery. The complex diagnostic study established the following three groups: test-positive, test-negative and test-suspected patients. Application of the complex (radioisotope and thermographic) examination technique provides a more adequate visualization of tumor process and, therefore, a better opportunity for selection of correct treatment. The application of the thermographic method is recommended for screening for subjects at high risk of malignant disease of the skin.

Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Diagnosis, Differential; Female; Humans; Lymphatic Metastasis; Male; Melanoma; Middle Aged; Nevus, Pigmented; Phosphorus Radioisotopes; Pigmentation Disorders; Radionuclide Imaging; Skin Neoplasms; Thermography

A 57-year-old Caucasian woman was found, on a routine ophthalmoscopic examination, to have a pigmented ciliary body mass suggestive of a malignant melanoma. The eye was enucleated primarily because a radioactive phosphorus test yielded a 79% greater uptake over the lesion than over a control area-a result regarded as positive at that time. Histopathologically, the lesion proved to be a benign melanocytoma of the ciliary body. Electron microscopy clearly revealed a large complement of inflammatory cells (macrophages) within the tumor. This case reemphasizes the advisability of carefully documenting tumor growth before enucleating eyes harboring pigmented lesions.

Topics: Ciliary Body; Diagnostic Errors; Eye Neoplasms; False Positive Reactions; Female; Humans; Melanoma; Middle Aged; Nevus, Pigmented; Phosphorus Radioisotopes; Radionuclide Imaging; Uveal Diseases

Topics: Adult; Diagnosis, Differential; Female; Humans; Male; Melanoma; Methods; Middle Aged; Nevus, Pigmented; Phosphorus Radioisotopes; Skin Neoplasms

The radioactive phosphorus (32P) uptake test used in ocular tumor evaluation in 408 cases achieved an overall percentage error rate of 3.6%. This compared favorably with the clinical error rate of 19.2% overall. The least accuracy was obtained in cases with ciliary body lesions.

Topics: Adolescent; Adult; Aged; Child; Choroid Neoplasms; Eye Neoplasms; False Negative Reactions; False Positive Reactions; Female; Humans; Male; Melanoma; Middle Aged; Nevus, Pigmented; Phosphorus Radioisotopes; Uveal Neoplasms

A 62-year-old white female was found to have a small, flat pigmented choroidal tumor. After fluorescein angiography and a positive P-32 test, the eye was enucleated for presumed malignant melanoma. Histologically, the tumor proved to be a choroidal nevus with a break in Bruch's membrane and a subretinal-pigment-epithelial neovascular membrane.

Topics: Diagnosis, Differential; Eye Neoplasms; Female; Humans; Melanoma; Middle Aged; Nevus, Pigmented; Phosphorus Radioisotopes; Pigment Epithelium of Eye

In 21 patients with a variety of skin tumors (squamous cell carcinomas, malignant melanomas, basal cell epitheliomas and mycosis fungoides) or pre-cancerous lesions (Bowen's disease, actinic keratosis, junctional nevus cell nevus) the radioactive phosphorus uptake test demonstrates a significantly increased concentration of P32 in those tumors. There were no false negative tests. The possibility of differentiation of malignant melanoma from benign nevus cell nevus and the early recognition of cutaneous metastases is described. Furthermore recurrence of previously irradiated or excised basal cell epitheliomas can be detected without a biopsy. No hematological side-effects were observed.

Topics: Aged; Bowen's Disease; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Diagnosis, Differential; False Negative Reactions; Female; Humans; Keratosis; Male; Melanoma; Middle Aged; Mycosis Fungoides; Neoplasm Metastasis; Neoplasm Recurrence, Local; Nevus, Pigmented; Phosphorus; Phosphorus Radioisotopes; Precancerous Conditions; Radionuclide Imaging; Skin Neoplasms

Topics: Diagnosis, Differential; Eye Neoplasms; Humans; Nevus; Nevus, Epithelioid and Spindle Cell; Nevus, Pigmented; Phosphorus; Phosphorus Radioisotopes; Skin Neoplasms

Topics: Diagnosis, Differential; Humans; Melanoma; Nevus; Nevus, Pigmented; Phosphorus; Phosphorus Radioisotopes; Skin Neoplasms

Topics: Capillaries; Humans; Nevus; Nevus, Pigmented; Phosphorus; Phosphorus Radioisotopes; Skin Neoplasms

Topics: Humans; Melanoma; Nevus; Nevus, Pigmented; Phosphorus; Phosphorus Radioisotopes; Skin Neoplasms